|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Robinson Crusoe's 'Original Sin' 显示文摘 | Novak Maximillian E | 1900 | Studies in English Literature1900，1961，3： | 1 |
| 2 | Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe 显示文摘 | Diane R W Maximillian T F | 2005 | Cancer Research2005，65，12： | 1 |
| 3 | Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration显示文摘AIM:To investigate the molecular events involved in liver regeneration following subtotal hepatectomy (SH) as previous studies have largely focused on partial hepatectomy (PH). METHODS: Male Wistar rats were subjected to 70% PH or 90% SH, respectively, and sacrificed at different times after surgery. Untreated and sham-operated animals served as controls. Serum and liver samples were obtained to investigate liver function, apoptosis (TUNEL assay) and transcription factors (NF-κB,Stat3; ELISA) or cytokines (HGF, TNF-a,IL-6,TGF-a,TGF-b; quantitative RT-PCR) involved in liver regeneration. RESULTS:Serum levels of ALT and AST in animals with 70% PH differed significantly from sham-operated and control animals. We found that the peak concentration 12 h after surgery returned to control levels 7 d after surgery. LDH was increased only at 12 h after 70% PH compared to sham. Bilirubin showed no differences between the sham and 70% resection. After PH, early NF-κB activation was detected 12 h after surgery (313.21±17.22 ng/mL), while there was no activation after SH (125.22 ± 44.36 ng/mL) compared to controls (111.43±32.68 ng/mL) at this time point. In SH, however, NF-κB activation was delayed until 24 h (475.56±144.29 ng/mL). Stat3 activation was similar in both groups. These findings correlated with suppressed and delayed induction of regenerative genes after SH (i.e. TNF-a 24 h postoperatively: 2375±1220 in 70% and 88±31 in 90%; IL-6 12h postoperatively:2547±441 in 70% and 173±82 in 90%). TUNEL staining revealed elevated apoptosis rates in SH (0.44% at 24 h;0.63% at 7d) compared to PH (0.27% at 24h; 0.15% at 7d). CONCLUSION: The molecular events involved in liver regeneration are significantly influenced by the extent of resection as SH leads to suppression and delay of liver regeneration compared to PH, which is associated with delayed activation of NF-κB and suppression of proregenerative cytokines. | Jan-Peter Sowa Jan Best Tamas Benko Maximillian Bockhorn Yanli Gu Eva-Maria Niehues Agnieska Bucchi Eva-Maria Benedetto-Castro Guido Gerken Ursula Rauen Jorg Friedrich Schlaak | 2008 | World Journal of Gastroenterology2008，14，46： | 1 |
| 4 | Quo Vadis STARR? A Prospective Long-Term Follow-Up of Stapled Transanal Rectal Resection for Obstructed Defecation Syndrome显示文摘 | Oliver Zehler Yogesh K. Vashist Dean Bogoevski Maximillian Bockhorn Emre F. Yekebas Jakob R. Izbicki Asad Kutup | 2010 | Journal of Gastrointestinal Surgery2010，，9： | 1 |
| 5 | Transesophageal Echocardiography During Orthotopic Liver Transplantation in Patients With Esophagoastric Varices显示文摘 | Ursula Burger-Klepp Rastko Karatosic Maximillian Thum Remy Schwarzer Valentin Fuhrmann Hubert Hetz Andreas Bacher Gabriela Berlakovich Claus G. Krenn Peter Faybik | 2012 | Transplantation Journal2012，，2： | 1 |
| 6 | Eflfciency in Japanese banking: An enyirical analysis显示文摘 | LEIGH DRAKE MAXIMILLIAN J B HALL | 2003 | Journal of Banking&Finance2003，，27： | 1 |
| 7 | Radioembolization in Patients with Hepatic Metastases from Breast Cancer显示文摘 | Tobias F. Jakobs Ralf-Thorsten Hoffmann Ton Fischer Hans-Joachim Stemmler Klaus Tatsch Christian La Fougere Ravi Murthy Maximillian F. Reiser Thomas K. Helmberger | 2008 | Journal of Vascular and Interventional Radiology2008，，5： | 1 |
| 8 | Portal vein embolization with plug/coils improves hepatectomy outcome显示文摘 | Maciej Malinowski Dominik Geisel Victoria Stary Timm Denecke Daniel Seehofer Maximillian Jara Annekathrin Baron Johann Pratschke Bernhard Gebauer Martin Stockmann | 2014 | Journal of Surgical Research2014，，： | 1 |
| 9 | Robinson Crusoe's Fear and the Search for Natural Man显示文摘 | Maximillian E | 1961 | Modern1961，，19： | 1 |
| 10 | Fabrication of biomimetic placental barrier structures within a microfluidic device utilizing two-photon polymerization显示文摘The placenta is a transient organ,essential for development and survival of the unborn fetus.It interfaces the body of the pregnant woman with the unborn child and secures transport of endogenous and exogenous substances.Maternal and fetal blood are thereby separated at any time,by the so-called placental barrier.Current in vitro approaches fail to model this multifaceted structure,therefore research in the field of placental biology is particularly challenging.The present study aimed at establishing a novel model,simulating placental transport and its implications on development,in a versatile but reproducible way.The basal membrane was replicated using a gelatin-based material,closely mimicking the composition and properties of the natural extracellular matrix.The microstructure was produced by using a high-resolution 3D printing method– the two-photon polymerization(2PP).In order to structure gelatin by 2PP,its primary amines and carboxylic acids are modified with methacrylamides and methacrylates(GelMOD-AEMA),respectively.High-resolution structures in the range of a few micrometers were produced within the intersection of a customized microfluidic device,separating the x-shaped chamber into two isolated cell culture compartments.Human umbilical-vein endothelial cells(HUVEC)seeded on one side of this membrane simulate the fetal compartment while human choriocarcinoma cells,isolated from placental tissue(BeWo B30)mimic the maternal syncytium.This barrier model in combination with native flow profiles can be used to mimic the microenvironment of the placenta,investigating different pharmaceutical,clinical and biological scenarios.As proof-of-principle,this bioengineered placental barrier was used for the investigation of transcellular transport processes.While high molecular weight substances did not permeate,smaller molecules in the size of glucose were able to diffuse through the barrier in a time-depended manner.We envision to apply this bioengineered placental barrier for pathophysiological research,where altered nutrient transport is associated with health risks for the fetus. | Denise Mandt Peter Gruber Marica Markovic Maximillian Tromayer Mario Rothbauer Sebastian Rudi Adam Kratz Syed Faheem Ali Jasper Van Hoorick Wolfgang Holnthoner Severin Mühleder Peter Dubruel Sandra Van Vlierberghe Peter Ertl Robert Liska Aleksandr Ovsianikov | 2018 | International Journal of Bioprinting2018，4，2： | 1 |
| 11 | Efficacy of in tranacal human calcitonin in patients with disease refractory to salmon calcitonin显示文摘 | Muff T Maximillian AD Alain P | 1990 | Am J Med1990，89，： | 1 |
| 12 | Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183显示文摘 | Rigobert Klett Jens Kordelle Ulrich Stahl Alexander Khalisi Maximillian Puille Dagmar Steiner Richard Bauer | 2003 | European Journal of Nuclear Medicine and Molecular Imaging2003，，11： | 1 |
| 13 | A glacial control on the eruption rate of Mt Erebus, Antarctica显示文摘Mt Erebus is the most active Antarctic volcano, on the flanks of the world's largest ice sheet. Despite this, the interactions between its eruptions and the ice cover have not been studied in detail. Focusing on the most recent deglaciation, we build a glacial retreat model and compare this to recent lava geochemistry measurements to investigate the processes involved. This analysis exposes a previously unknown link between Antarctic glaciation and eruptions, of vital importance to the understanding of volcanism in this context. We find that deglaciation led to rapid emptying of the shallow magma plumbing system and a resulting peak in eruption rates synchronous with ice retreat. We also find that the present day lavas do not represent steady state conditions, but originate from a source with up to 30% more partial melting than older >4 ka eruptions. This finding that deglaciation affects volcanism both on short and longer timescales may prompt a re-evaluation of eruptions in glaciated and previously glaciated terrains both in Antarctica and beyond. | Maximillian VAN WYK de VRIES | 2018 | Advances in Polar Science2018，29，3： | 0 |
| 14 | Modulus spectroscopy for the detection of parallel electric responses in electroceramics显示文摘Impedance spectroscopy has become one of the most versatile and essential investigation methods concerning electrical properties of materials for electronic and energy applications.Deriving knowledge about physical mechanisms,however,often demands excellent expertise in evaluating the spectra.Investigating different representations of the same data set can help elucidate the underlying physics,but this is rarely applied.In this work,the importance of using the modulus representation to identify parallel electric responses is rationalized.Those responses result from parallel conducting pathways,e.g.,at grain boundaries,or from regions with differing permittivity,e.g.,in composites.Qualitative and quantitative data can be obtained,as it is illustrated based on experimental data from electroceramics and respective physical simulation results using the finite element method.The findings should help to study intricate electric responses of materials with chemical or structural heterogeneity. | Till Fromling Yao Liu An-Phuc Hoang Maximillian Gehringer Sebastian Steiner Mikalai Zhuk Julia Glaum Bai-Xiang Xu | 2022 | Journal of Materiomics2022，8，3： | 0 |
| 15 | Superior Conjugative Plasmids Delivered by Bacteria to Diverse Fungi显示文摘Fungi are nature’s recyclers,allowing for ecological nutrient cycling and,in turn,the continuation of life on Earth.Some fungi inhabit the human microbiome where they can provide health benefits,while others are opportunistic pathogens that can cause disease.Yeasts,members of the fungal kingdom,have been domesticated by humans for the production of beer,bread,and,recently,medicine and chemicals.Still,the great untapped potential exists within the diverse fungal kingdom.However,many yeasts are intractable,preventing their use in biotechnology or in the development of novel treatments for pathogenic fungi.Therefore,as a first step for the domestication of new fungi,an efficient DNA delivery method needs to be developed.Here,we report the creation of superior conjugative plasmids and demonstrate their transfer via conjugation from bacteria to 7 diverse yeast species including the emerging pathogen Candida auris.To create our superior plasmids,derivatives of the 57 kb conjugative plasmid pTA-Mob 2.0 were built using designed gene deletions and insertions,as well as some unintentional mutations.Specifically,a cluster mutation in the promoter of the conjugative gene traJ had the most significant effect on improving conjugation to yeasts.In addition,we created Golden Gate assembly-compatible plasmid derivatives that allow for the generation of custom plasmids to enable the rapid insertion of designer genetic cassettes.Finally,we demonstrated that designer conjugative plasmids harboring engineered restriction endonucleases can be used as a novel antifungal agent,with important applications for the development of next-generation antifungal therapeutics. | Ryan R.Cochrane Arina Shrestha Mariana M.Severo de Almeida Michelle Agyare-Tabbi Stephanie L.Brumwell Samir Hamadache Jordyn S.Meaney Daniel P.Nucifora Henry Heng Say Jehoshua Sharma Maximillian P.M.Soltysiak Cheryl Tong Katherine Van Belois Emma J.L.Walker Marc-AndréLachance Gregory B.Gloor David R.Edgell Rebecca S.Shapiro Bogumil J.Karas | 2022 | BioDesign Research2022，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员