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225篇 您的检索式:作者名="Yekebas"
    题名 作者 年代 出处 被引量
1Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki 2006World Journal of Gastroenterology2006,12,40:3
2HER-2 amplification is highly homogenous in gastric cancer显示文摘Andreas H. Marx Lars Tharun Johanna Muth Ana-Maria Dancau Ronald Simon Emre Yekebas Jussuf T. Kaifi Martina Mirlacher Tim H. Brümmendorf Carsten Bokemeyer Jakob R. Izbicki Guido Sauter 2009Human Pathology2009,,6:3
3Epoetin alia inproves survival after chemoradiation for stage III esophageal cancer:final results of a prospective observational study 显示文摘Rades D Tribius S Yekebas EF 2006Int J Radiat Oncol Biol Phys2006,65,:1
4Attenuation of sepsis-related immunoparalysis by continuous veno-venous hemofiltration in experimental porcine pancreatitis 显示文摘Yekebas EF Eisenberger CF Ohnesorge H 2001Crit Care Med2001,29,7:1
5Influence of zerobalanced hemofiltration on the course of severe experimental pancreatitis in pigs显示文摘Yekebas E F Treede H Knoefel W T 1999Ann Surg1999,229,:1
6Extra-hepatic portal hypertension in chronic pancreatitis:an old problem revisited显示文摘Izbicki JR Yekebas EF Strate T 2002Ann Surg2002,236,1:1
7Attenuation of sepsis-related immunoparalysis by continuous venovenous hemofiltration in experimental porcine pancreatitis 显示文摘Yekebas EF Eisenbeger CF Ohnesorge H 2001Crit Care Med2001,29,7:1
8Chronic pancreatitis:modern surgical management显示文摘Bachmann K Izbicki JR Yekebas EF 0,,02:1
9En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels:perioperative outcome and long-term survival in 136 pafients显示文摘Yekebas EF Bogoevski D Cataldegirmen G 2008Ann Surg2008,247,2:1
10Attention of Sepsis - related immunoparalysis by continuous veno - venous hemofihration in experimental porcine pancreatitis显示文摘YEKEBAS E F EISENBERGER C F OHNESORGE H 2001Crit Care Med2001,29,7:1
11Chronic pancreatitis:etiology,pathogenesis,diagnosis and treatment显示文摘Strate T Knoefel WT Yekebas E 2009Int Colorectal Dis2009,18,1:1
12LI is a potential markerfor poorly - differentiated pancreatic neuroendocrine carcinoma显示文摘Kaifi JT Zinnkann U Yekebas EF 2006World J Gastroenterol2006,12,1:1
13Postpancreatectomyhemotrhage : diagnosisand treatment- an analysis in 1669 consecutive pancreatic resections 显示文摘Yekebas EF Wolfram L Cataldegirmen G 2007Ann Surg2007,26,2:1
14Epoetin-alpha during radiotherapy for stage III esophageal carcinoma显示文摘Rades D Schild SE Yekebas EF 2005Cancer2005,103,11:1
15Postpancreatectomy hemorrhage:diagnosis and treatment:an analysis in 1669consecutive pancreatic resections显示文摘Yekebas EF Wolfram L Cataldeginnen G 20072007,,02:1
16Attenuation of sepsis-related immunoparalysis by continuous venovenous hemofiltration in experimental porcine pancreatitis显示文摘Emre F Yekebas MD Claus F 2001Crit Care Med2001,29,7:1
17En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels:perioperative outcome and longterm survival in 136 patients显示文摘Yekebas EF Bogoevski D Cataldegirmen G 2008Ann Surg2008,247,2:1
18Postpancreatectomy hemorrhage:diagnosis and treatment:an analysis in 1669 consecutive pancreatic resections显示文摘Yekebas EF Wolfram L Cataldegirmen G 0,,02:1
19Crossing the Rubicon: When Pancreatic Resection with Curative Intent Ends in an R2 Status显示文摘Maximilian Bockhorn MD Guellue Cataldegirmen MD Asad Kutup MD Andreas Marx MD Christoph Burdelski MD Jogesh K. Vashist MD Oliver Mann MD Lena Liebl MD Alexandra K?nig MD Jakob R. Izbicki MD Emre F. Yekebas MD 2009Annals of Surgical Oncology2009,,5:1
20Influence of zero-balanced hemofiltration on the course of severe experimental pancreatitis in pigs显示文摘Yekebas EF Treede H Knoefel WT et a1 1999Ann Surg1999,229,5:1
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