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| 1 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 2 | Management of hepatocellular carcinoma with portal vein thrombosis显示文摘Management of hepatocellular carcinoma(HCC) with portal vein thrombosis(PVT) is complex andrequires an understanding of multiple therapeutic options. PVT is present in 10%-40% of HCC at the time of diagnosis, and is an adverse prognostic factor. Management options are limited, as transplantation is generally contraindicated, and surgical resection is only rarely performed in select centers. Systemic medical therapy with sorafenib has been shown to modestly prolong survival. Transarterial chemoembolization has been performed in select cases but has shown a high incidence of complications. Emerging data on treatment of PVT with Y-90 radioembolization suggest that this modality is well-tolerated and associated with favorable overall survival. Current society guidelines do not yet specifically recommend radioembolization for patients with PVT, but this may change with the development of newer staging systems and treatment algorithms. In this comprehensive literature review, we present current and available management options with the relative advantages, disadvantages and contraindications of these treatment options with summarized data on overall survival. | Matthew Quirk Yun Hwan Kim Sammy Saab Edward Wolfgang Lee | 2015 | World Journal of Gastroenterology2015，21，12： | 12 |
| 3 | Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients. | Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 4 | Serum Urate as an Independent Predictor of Poor Outcome and Future Vascular Events After Acute Stroke显示文摘 | Christopher J. Weir Scott W. Muir Matthew R. Walters Kennedy R. Lees | 2003 | Stroke: Journal of the American Heart Association2003，，8： | 5 |
| 5 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 6 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 7 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 8 | Contemporary approach to soft-tissue reconstruction of the lower extremity after trauma显示文摘The complex lower extremity wound is frequently encountered by orthopedic and plastic surgeons.Innovations in wound care,soft tissue coverage and surgical fixation techniques allow for improved functional outcomes in this patient population with highly morbid injuries.In this review,the principles of reconstruction of complex lower extremity traumatic wounds are outlined.These principles include appropriate initial evaluation of the patient and mangled extremity,as well as appropriate patient selection for limb salvage.The authors emphasize proper planning for reconstruction,timing of reconstruction and the importance of an understanding of the most appropriate reconstructive option.The role of different reconstructive and wound care modalities is discussed,notably negative pressure wound therapy and dermal substitutes.The role of pedicled flaps and microvascular free-tissue transfer are discussed,as are innovations in understanding of perforator anatomy and perforator flap surgery that have broadened the reconstruction surgeon’s armamentarium.Finally,the importance of a multidisciplinary team is highlighted via the principle of the orthoplastic approach to management of complex lower extremity wounds.Upon completion of this review,the reader should have a thorough understanding of the principles of contemporary lower extremity reconstruction. | Matthew R.Zeiderman Lee L.Q.Pu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 9 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
| 10 | The impact of electronic word-of-mouth显示文摘 | Cheung Christy M K Lee Matthew K O Rabjohn Neil | 2008 | Internet Research2008，，3： | 3 |
| 11 | Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease显示文摘瞄准:低剂量的阿司匹林的使用很好被建立阻止心血管的疾病事件。然而,上面的胃肠的流血的发生和有它的使用的预言者(UGIB ) 是未知的。我们有希望地在低剂量的阿司匹林用户学习了消化剂溃疡的发生和结果。方法:有低剂量的阿司匹林上的冠的动脉疾病(CAD ) 的 991 个病人的一个总数是有希望地跟随起来的为出现和 UGIB 的首先就医的事件的临床的特征的二年了。结果:UGIB 有一个双性人有 45% 发生在四月阿司匹林开始以内的形式的表示并且每年有 1.5% 的全面流行。没有 UGIB 相关的死亡。高血压(或= 4.6 , 95%CI 1.5-14.7 , P = 0.009 ),消化剂溃疡的历史(或= 3.1 , 95%CI 1.1-9.0 , P = 0.039 ),第三级的教育(或= 3.08 , 95%CI 1.1-9.0 , P = 0.039 )并且更高瘦的身体质量( P = 0.016 )独立因素与 UGIB 被联系。硝酸盐的使用没减少 UGIB。结论:在有长期的低剂量的阿司匹林上的 CAD 的病人的 UGIB 的发生是低的,但是伴有重要病态。与阿司匹林的延长使用, UGIB 继续是为有风险因素并且特别在有消化性溃疡, UGIB 在趋于在阿司匹林治疗以后早发生的历史的病人的那些的一个问题。 | William Ng Wai-Man Wong Wai-Hong Chen Hung-Fat Tse Pui-Yin Lee Kam-Chuen Lai Sheung-Wai Li Matthew Ng Kwok-Fai Lam Xi Cheng Chu-Pak Lau | 2006 | World Journal of Gastroenterology2006，12，18： | 3 |
| 12 | The role of FAST in pulsar timing arrays显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) will become one of the world-leading telescopes for pulsar timing array(PTA) research. The primary goals for PTAs are to detect(and subsequently study) ultra-low-frequency gravitational waves, to develop a pulsar-based time standard and to improve solar system planetary ephemerides. FAST will have the sensitivity to observe known pulsars with significantly improved signal-to-noise ratios and will discover a large number of currently unknown pulsars. We describe how FAST will contribute to PTA research and show that jitter-and timing-noise will be the limiting noise processes for FAST data sets. Jitter noise will limit the timing precision achievable over data spans of a few years while timing noise will limit the precision achievable over many years. | George Hobbs Shi Dai Richard N.Manchester Ryan M.Shannon Matthew Kerr Ke-Jia Lee Ren-Xin Xu | 2019 | Research in Astronomy and Astrophysics2019，19，2： | 2 |
| 13 | Contemporary reconstruction after complex facial trauma显示文摘Complex facial trauma requires complex repair and solutions.This process is challenging for the surgeon who seeks to manage the expectations of the patient and family while achieving the best possible result.Historically,the use of pedicled flaps,and then free tissue transfer,were the primary techniques utilized.Advancements in soft-tissue reconstruction,such as perforator flaps and pre-expanded and prefabricated flaps,allow refinement of the soft-tissue reconstruction process to create the best initial soft-tissue coverage.The advent of contemporary technologies,such as virtual surgical planning,stereolithography and customized implants and plates,facilitates a tailored approach to the patient’s reconstructive needs for precise bony reconstruction.When surgical and technological techniques are combined in complementary multistage reconstructions,better reconstructive and aesthetic outcomes are achievable than ever before.In this review,the authors present a summary of the management of complex facial trauma based on the senior author’s broad experience.Initial management and contemporary reconstructive techniques and technology to provide optimal outcomes are reviewed.A case series of complex facial traumas and their reconstructive process is also presented to demonstrate how complementary staged procedures can yield an optimal result.We believe the reconstructive surgeon managing complex facial trauma should strive to incorporate contemporary technologies and techniques into their armamentarium to provide the best patient care. | Matthew R.Zeiderman Lee L.Q.Pu | 2020 | Burns & Trauma2020，8，1： | 2 |
| 14 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 2 |
| 15 | Cavity optomechanics on a microfluidic resonator with water and viscous liquids显示文摘Currently,optical or mechanical resonances are commonly used in microfluidic research.However,optomechanical oscillations by light pressure were not shown with liquids.This is because replacing the surrounding air with water inherently increases the acoustical impedance and hence,the associated acoustical radiation losses.Here,we bridge between microfluidics and optomechanics by fabricating a hollow-bubble resonator with liquid inside and optically exciting vibrations with 100 MHz rates using only mW optical-input power.This constitutes the first time that any microfluidic system is optomechanically actuated.We further prove the feasibility of microfluidic optomechanics on liquids by demonstrating vibrations on organic fluids with viscous dissipation higher than blood viscosity while measuring density changes in the liquid via the vibration frequency shift.Our device will enable using cavity optomechanics for studying non-solid phases of matter,while light is easily coupled from the outer dry side of the capillary and fluid is provided using a standard syringe pump. | Kyu Hyun Kim Gaurav Bahl Wonsuk Lee Jing Liu Matthew Tomes Xudong Fan Tal Carmon | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 16 | Functional Recovery After Partial Nephrectomy: Effects of Volume Loss and Ischemic Injury显示文摘 | Matthew N. Simmons Shahab P. Hillyer Byron H. Lee Amr F. Fergany Jihad Kaouk Steven C. Campbell | 2012 | The Journal of Urology2012，，： | 2 |
| 17 | Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators显示文摘 | Matthew H. G. Katz Jason B. Fleming Priya Bhosale Gauri Varadhachary Jeffrey E. Lee Robert Wolff Huamin Wang James Abbruzzese Peter W. T. Pisters Jean‐Nicolas Vauthey Chusilp Charnsangavej Eric Tamm Christopher H. Crane Aparna Balachandran | 2012 | Cancer2012，，23： | 2 |
| 18 | Impact of liver cirrhosis on mortality in patients with community-acquired bacteremia显示文摘 | Shey-Ying Chen Chu-Lin Tsai Chien-Hao Lin Chien-Chang Lee Wen-Chu Chiang Jiun-Ling Wang Matthew Huei-Ming Ma Shyr-Chyr Chen Wen-Jone Chen Shan-Chwen Chang | 2009 | Diagnostic Microbiology & Infectious Disease2009，，2： | 1 |
| 19 | Borderline Resectable Pancreatic Cancer: The Importance of This Emerging Stage of Disease显示文摘 | Matthew H.G. Katz Peter W.T. Pisters Douglas B. Evans Charlotte C. Sun Jeffrey E. Lee Jason B. Fleming J. Nicolas Vauthey Eddie K. Abdalla Christopher H. Crane Robert A. Wolff Gauri R. Varadhachary Rosa F. Hwang | 2008 | Journal of the American College of Surgeons2008，，5： | 1 |
| 20 | Regulated Intracellular Ligand Transport and Proteolysis Control EGF Signal Activation in Drosophila显示文摘 | Jeffrey R. Lee Sinisa Urban Clare F. Garvey Matthew Freeman | 2001 | Cell2001，，2： | 1 |
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