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| 1 | 前瞻性和回顾性心电门控冠状动脉64层CT成像:影像质量和病人放射剂量的对照性研究显示文摘目的比较一组接受前瞻性心电门控64层CT冠状动脉成像病人及另一组接受回顾性心电门控64层CT冠状动脉病人的成像质量及病人放射剂量。方法本研究依从HIPAA法案并得到了机构审查委员会的批准。由于设计是回顾性研究故不需要知情同意。2位独立阅片者分别对100例病人心脏CT成像(每组各50例)的冠状动脉进行分段影像质量评分和综合评分。计算观察者间偏差。记录对应实际扫描Z轴长度的病人放射剂量,以Z轴长度为12cm的典型心脏计算标准化剂量。结果2组病例的临床特征及CT参数匹配良好。 | W.P. Shuman K.R. Branch J.M. May L.M. Mitsumori D.W. Lockhart T.J.Dubinsky 邱建星(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 129 |
| 2 | 以便秘和腹泻为主的肠易激综合征与5-羟色胺信号改变显示文摘Background &Aims: Evidence suggests that postprandial platelet-depleted plasma 5-hydroxytryptamine (5-HT) concentrations may be abnormal in irritable bowel syndrome (IBS). However, interpretation of the data has been hampered by the variable methodology and rather small numbers used in previous studies. Therefore, the aim of this study was to measure concentrations of platelet-depleted plasma 5-HT and its metabolite 5-HIAA under fasting and fed conditions in a large group of patients with diarrhea-predominant (d-) and constipation-predominant (c-) IBS, compared with controls. The ratio of plasma 5-HIAA:5-HT and platelet stores was also assessed. Methods: Twenty-nine c-IBS patients (aged, 19-53 years), 55 d-IBS patients (aged, 19-52 years), and 35 healthy volunteers (aged, 18-46 years) had platelet-depleted plasma 5-HT/5-HIAA concentrations measured using reverse-phase, high-performance liquid chromatography with fluorimetric detection before and after a standard meal. Results: d-IBS patients had raised platelet-depleted plasma 5-HT concentrations under fasting and fed conditions (P < .05). However, the postprandial relative to fasting concentration was similar to controls. In contrast, c-IBS patients failed to show an increase in platelet-depleted plasma 5-HT concentration with meal ingestion compared with controls (P < .01). c-IBS was associated with decreased 5-HIAA (P < .01) but normal 5-HIAA:5-HT ratio and d-IBS with normal 5-HIAA concentrations but reduced 5-HIAA:5-HT ratio (P < .005). c-IBS but not d-IBS patients had increased platelet 5-HT. Conclusions: These results support the concept that d-IBS is characterized by reduced 5-HT reuptake, whereas impaired release may be a feature of c-IBS. These results also provide a rational basis for current pharmacologic approaches involving modulation of different 5-HT receptors in c-and d-IBS. | Atkinson W. Lockhart S. Whorwell P. J. L.A. Houghton. 李宏宇(译) 郑世成(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 8 |
| 3 | A Perspective on Smart Process Manufacturing Research Challenges forProcess Systems Engineers显示文摘The challenges posed by smart manufacturing for the process industries and for process systems engineering(PSE) researchers are discussed in this article. Much progress has been made in achieving plant- and site-wide optimization, hut benchmarking would give greater confidence. Technical challenges confrontingprocess systems engineers in developing enabling tools and techniques are discussed regarding flexibilityand uncertainty, responsiveness and agility, robustness and security, the prediction of mixture propertiesand function, and new modeling and mathematics paradigms. Exploiting intelligence from big data to driveagility will require tackling new challenges, such as how to ensure the consistency and confidentiality ofdata through long and complex supply chains. Modeling challenges also exist, and involve ensuring that allkey aspects are properly modeled, particularly where health, safety, and environmental concerns requireaccurate predictions of small but critical amounts at specific locations. Environmental concerns will requireus to keep a closer track on all molecular species so that they are optimally used to create sustainablesolutions. Disruptive business models may result, particularly from new personalized products, but that isdifficult to predict. | Ian David Lockhart Bogle | 2017 | Engineering2017，3，2： | 7 |
| 4 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 5 | Expressionmonitoring by hybridization to high-density oligonu-cleotide arrays显示文摘 | Lockhart DJ Dong H Byme MC | | 0，，： | 3 |
| 6 | Suagrcane yellow leaf virus : a novel member of the Luteoviridae that probably arose by inter-species recombination 显示文摘 | Smith G R Borg Z Lockhart B E | 2000 | J Gen Virol2000，81，： | 1 |
| 7 | Simplified rapid procedure for determination of agmatine and other guanidino-containing compounds 显示文摘 | GOLDSCHMIDT M C LOCKHART B M | 1971 | Anal Chem1971，43，11： | 1 |
| 8 | Quantifying DNA-protein interactions by double-stranded DNA arrays 显示文摘 | Bulyk M L Gentalen E Lockhart D J | 1999 | Nature Biotechnol1999，17，6： | 1 |
| 9 | Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism显示文摘 | Lockhart PJ Bounds R Hulihan M | 2004 | Mov Disord2004，19，9： | 1 |
| 10 | Manipulation of immune responses to Mycobacterium bovis by vaccination with IL-2- and IL-18-secreting recombinant bacillus Calmette Guerin显示文摘 | Young S O'Donnell M Lockhart E | 2002 | Immunol Cell Biol2002，80，： | 1 |
| 11 | The Hickman peel-away sheath:alternative for pediatric percutaneous nephrolithotomy显示文摘 | Helal M Blank T Lockhart J | 1997 | J Endourol1997，11，3： | 1 |
| 12 | A new hemostatic a- gent initial life-saving experience with Celox(Chitosan) in cardio- thoracic surgery 显示文摘 | Millner RW Lockhart AS Bird H | 2009 | Ann Thorac Surg2009，87，2： | 1 |
| 13 | Elucidating the origins of nosocomial infections with Candida albicans by DNA fingerprinting with the complex probe Ca3显示文摘 | Lockhart SR Pfaller MA | 1999 | J Clin Microbiol1999，37，9： | 1 |
| 14 | Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent,pirfenidone:results of a prospective,open-label Phase Ⅱ study显示文摘 | Raghu G Johnson W C Lockhart D | 1999 | Am J Respir Crit Care Med1999，159，41： | 1 |
| 15 | Inhibition of rabies virus transcription in rat cortical neurons with the dissociative anesthetic ketamine显示文摘 | Lockhart BP Tordo N Tsiang H | 1992 | Antimicrob Agents Chemother1992，36，8： | 1 |
| 16 | Protection from contraction-induced injury provided to skeletal muscles of young and old mice by passive stretch is not due to a decrease in initial mechanical damage显示文摘 | Lockhart NC Brooks SV | 2006 | Journals of Gerontology Series A:Biological Sciences and Medical Sciences2006，61，6： | 1 |
| 17 | Polytetrafluoroethylene injection for urinary incontinence in children显示文摘 | Vorstman B Lockhart J Kaufman MR | 1985 | J Urol1985，133，2： | 1 |
| 18 | Two Meth- ods for Calculating the Amount of Refrigerant Required for Cyclic Temperature Testing of Insulated Packages显示文摘 | MATSUNAGA K BURGESS G LOCKHART H | 2007 | Packag- ing Technology & Science2007，20，20： | 1 |
| 19 | Renal imaging with ultrasound contrast显示文摘 | Michelle L Robbin Mark E Lockhart Richard G Barr | 2003 | Radiologic Clinics of North America2003，，5： | 1 |
| 20 | Incidence of yellow leaf syndrome in CP cultivars based on polymerase chain reaction and serological techniques显示文摘 | Comstock J C Irey M S Lockhart B E L | 1998 | Sugar Cane1998，，4： | 1 |
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