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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | 黑荆树和野生相思树制硫酸盐浆适应性的研究显示文摘黑荆树和野生相思树用13%活性碱进行硫酸盐法制浆,在卡伯值20左右时,它们的细浆得率约为53%;使用CEHD漂白程序对纸浆进行漂白,白度达81%ISO,漂后浆得率为50%(以绝干木片计).这两种试材的未漂和漂白硫酸盐浆的强度性能和抄造性能十分相似,且都适宜于多种纸张和纸板产品.研究表明.这两个树种制浆废液化学品回收较桉树制浆黑液容易。 | 房桂干 王静霞 Balodis V Clark N | 1992 | 林产化学与工业1992，12，3： | 3 |
| 3 | 高密度脂蛋白可追踪脑卒中恢复情况显示文摘前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。 | Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ Fazio S Pamir N 刘青(译) 刘莉(摘/审校) | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Removal of enteric viruses from sewage by activated sludge treatment 显示文摘 | Clarke N A Stevenson an E | 1961 | Am J public Health1961，51，10： | 2 |
| 6 | Six-month progression-free survival as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide显示文摘 | Polley MY Lamborn KR Chang SM Butowski N Clarke JL Prados M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 2 |
| 7 | Insulin and insulin-like growth factor-1 stimulate dephosphorylation of paxillin in parallel with focal adhesion kinase显示文摘 | Clark S | 1996 | Biochem J1996，314，： | 1 |
| 8 | Lipidomic analysis of the molecular specificity of a cholinephosphotransferase in situ显示文摘 | FENN H C CLARK G T | 2004 | Biochem Soc Trans2004，32，6： | 1 |
| 9 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 10 | Trace element levels in adults from the west coast of C-nada and associations with age,gender,diet,activities and levels of other trace elements显示文摘 | CLARK N A TESCHKE K RIDEOUT K | 2007 | Chemosphere2007，70，1： | 1 |
| 11 | Coring of laminated lake sediments for pigment and mineral magnetic analyses, Sondre Stromfjord, southern West Greenland 显示文摘 | Anderson N J Clarke A Juhler RK | 2000 | Geology of Greenland Survey Bulletin2000，186，： | 1 |
| 12 | Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells显示文摘 | CLARK M A JEPSON M A SIMMONS N L | 1994 | Res Microbiol1994，145，7： | 1 |
| 13 | Recent Advances in Therapy for Glioblastoma显示文摘 | Clarke J Butowski N Chang S | 2010 | Archives of Neurology2010，67，3： | 1 |
| 14 | Flight string models for aircraft fleeting and routing 显示文摘 | C Bamhart N L Boland L W Clarke | 1998 | Transportation Science1998，32，3： | 1 |
| 15 | Amantadine for dyskinesia in Parkinson' s disease显示文摘 | Crosby N J Deane KH Clarke CE | 2003 | Cochrane Database Syst Rev2003，2，00： | 1 |
| 16 | High Purity Water Using H2O2 and UV Radiation显示文摘 | CLARKE N KNOWLES G | 1982 | Effluent and Water Treatment Journal1982，，9： | 1 |
| 17 | Reflectance spectroscopy:quantitative analysis technique for remote sensing application显示文摘 | Clark R N Roush T L | 1984 | Journal of Geophysical Research1984，89，： | 1 |
| 18 | Spectroscopic determination of leaf biochemistry using band-depth analysis of absorption features and stepwise multiple linear regression显示文摘 | Kokaly R F Clark R N | 1999 | Remote Sensing of Environment1999，67，： | 1 |
| 19 | Cell fate in the chick limb bud and relationship to gene expression 显示文摘 | Vargesson N Clarke J D W Vincent K | 1997 | Development1997，124，： | 1 |
| 20 | The Harvard binocular head显示文摘 | Ferrier N J Clark J J | 1993 | International Journal of Pattern Recognition and Artificial Intelligence1993，7，1： | 1 |
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