| 1 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 15 | 青春晚期超重和吸烟影响成年后病死率的联合效应:全国队列研究显示文摘研究目的研究青春晚期超重和吸烟影响成年后病死率的联合效应。研究设计用经过肌力、社会经济地位、年龄等因素校正的Cox比例风险模型进行连锁分析。研究地点瑞典军队征兵登记,死亡原因登记和普查数据。研究对象45920名瑞典人(平均年龄18.7岁,标准差为0.5),随访38年。主要观察指标体重指数(Body mass index,BMI)(低体重(BMI〈18.5),正常体重(18.5~24.9),超重(25~29.9),肥胖(≥30));肌力,在1969-1970年间军队征兵的强制性测试中自报的吸烟状况(不吸烟者,轻度吸烟者(1~10支/天),重度吸烟者(〉10支/天);全因死亡。结果在170万人年中,有2897人死亡。与正常体重的人群(病死率为17/10000,95%可信区间为16~18)相比,超重(风险比为1.33,1.15~1.53;病死率为23,20~26)和肥胖(风险比为2.14,1.61-2.85;病死率为38,27~48)的人群死亡的风险增高,同样,对吸烟者与非吸烟者的分析也得出类似的结论。尽管消瘦(BMI〈17)被认为与病死率增加有关(风险比为1.33,1.07~1.64;病死率为24,19~29),并没有发现低体重的人群中死亡风险增加(风险比为0.97,0.86~1.08;病死率为18,16~19)。源于体重指数和吸烟状况联合效应增加的相对危险度在任何一组人群中并不显著。同时,除了肥胖和重度吸烟(增加的相对危险度1.5,-1.7~3.7)以外,其他任何组合的联合效应与其单独存在时相比,差异均无统计学意义。与不吸烟者(病死率为14,13~15)相比,轻度(风险比为1.54,1.41—1.70;病死率为15,14~16)和重度(风险比为2.11,1.92—2.31;病死率为26,24—27)吸烟者的死亡风险均有所增加。结论无论吸烟状况如何,在青春晚期超重和肥胖均可致成年后的病死率增加。肥胖、超重的危害分别与重度吸烟、轻度吸烟相当,但是,体重指数和吸烟情况并没有交互影响。青少年中全球性的肥胖流行和吸烟仍然是促进公共卫生健康必须关注和解决的问题。 | Martin Neovius Johan Sundstrom Finn Rasmussen 何璇(译) 代华平(校) | 2010 | 英国医学杂志中文版2010，13，1： | 0 |
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