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| 1 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 2 | Mortality in ulcerative colitis and Crohn’s disease. A population-based study in Finland显示文摘 | Pia Manninen Anna-Liisa Karvonen Heini Huhtala Martin Rasmussen Maarit Salo Leena Mustaniemi Ismo Pirttiniemi Pekka Collin | 2011 | Journal of Crohn’s and Colitis2011，，5： | 3 |
| 3 | Analytic approach to the problem of convergence of truncated L6vy flights towards the Gaussian stochastic process 显示文摘 | Koponen Ismo | 1995 | Phys Rev E1995，52，： | 1 |
| 4 | 5-HT3 Receptor antagonists in the prophylaxis of acute vomiting induced by moderately emetogenic chemotherapy a randomised study显示文摘 | Timo J Vesa V | 1993 | Eur J Cancer1993，29，12： | 1 |
| 5 | Formation of PCDDs and PCDFs in municipal waste incineration and its inhibition mechanisms: A review显示文摘 | Kari Tuppurainen Ismo Halonen P?ivi Ruokoj?rvi Juhani Tarhanen Juhani Ruuskanen | 1998 | Chemosphere1998，，7： | 1 |
| 6 | Formation of aromatic chlorinated compounds catalyzed by copper and iron 显示文摘 | Ismo H Karl T Jnhani R | 1997 | Chemosphere1997，34，12： | 1 |
| 7 | Bi-isotropic constitutive relations 显示文摘 | Sihvoia Ari H Lindell Ismo V | 1991 | Microwave and Optical Technology letters1991，4，8： | 1 |
| 8 | The effects of feedback and goal setting on safety performance at two construction sites显示文摘 | Heikki Laitinen Ismo Ruohomaki | 1996 | Safety Science1996，124，1： | 1 |
| 9 | Management informa- tion system based on the balanced scorecard 显示文摘 | Juha Kettunen Ismo Kantola | 2005 | Cam- pus-Wide Information Systems2005，22，5： | 1 |
| 10 | High sensitivity in gas analysis with photoacoustic detection显示文摘 | Jyrki Kauppinen Klaus Wilcken Ismo Kauppinen etc | 2004 | Mi- crochemical Journal2004，76，12： | 1 |
| 11 | Analytic approach to the problem of convergence of truncated Lévy flights towards the gaussian stochastic process显示文摘 | Ismo Koponen | 1995 | Physical Review E1995，52，： | 1 |
| 12 | The effect of feedback and goal setting on safety performance at two construction sites显示文摘 | Heikki Laitinen Ismo Buohomaki | 1996 | Safety Science1996，24，1： | 1 |
| 13 | Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 (KDR/Flk-1) in Ischemic Skeletal Muscle and Its Regeneration显示文摘 | Tuomas T. Rissanen Ismo Vajanto Mikko O. Hiltunen Juha Rutanen Mikko I. Kettunen Mari Niemi Pia Lepp?nen Mikko P. Turunen Johanna E. Markkanen Katja Arve Esko Alhava Risto A. Kauppinen Seppo Yl?-Herttuala | 2002 | The American Journal of Pathology2002，，4： | 1 |
| 14 | Random swap EM algorithm for Gaussian Mixture Models 显示文摘 | ] Zhao Qin-pei Ville H Ismo K | 2012 | Pattern Recognition Letters2012，33，16： | 1 |
| 15 | Surgical care quality and oncologic outcome after D2 gastrectomy for gastric cancer显示文摘AIM: To examine the quality of surgical care and longterm oncologic outcome after D2 gastrectomy for gastric cancer.METHODS: From 1999 to 2008, a total of 109 consecutive patients underwent D2 gastrectomy without routine pancreaticosplenectomy in a multimodal setting at our institution. Oncologic outcomes together with clinical and histopathologic data were analyzed in relation to the type of surgery performed. Staging was carried out according to the Union for International Cancer Control criteria of 2002. Patients were followedup for five years at the outpatient clinic. The primary measure of outcome was long-term survival with the quality of surgery as a secondary outcome measure. Clinical data were retrospectively collected from the patient records, and causes of death were obtained from national registries.RESULTS: A total of 109 patients(58 men) with a mean age of 67.4 ± 11.2 years underwent total gastrectomy or gastric resection with D2 lymph node dissection. The tumor stage distribution was as follows: stageⅠ,(27/109) 24.8%; stage Ⅱ,(31/109) 28.4%; stage Ⅲ,(41/109) 37.6%; and stage Ⅳ,(10/109) 9.2%. Forty patients(36.7%) received chemotherapy or chemoradiotherapy. The five-year overall survival rate for all 109 patients was 45.0%, and was 47.1% for the 104 patients treated with curative R0 resection. The five-year disease-specific survival rates were 53.0% and 55.8%, respectively. In a multivariate analysis, body mass index and tumor stage were independent prognostic factors for overall survival(both P < 0.01), whereas body mass index, tumor stage, tumor site, Lauren classification, and lymph node invasion were prognostic factors for cancer-specific survival(all P < 0.05). Postoperative 30-d mortality was 1.8% and 30-d, surgical(including three anastomotic leaks, two of which were treated conservatively), and general morbidities were 26.6%, 12.8%, and 14.7%, respectively.CONCLUSION: D2 dissection is a safe surgical option for gastric cancer, providing quality surgical care and long-term oncologic outcomes that are in line with current Western standards. | Johanna Mrena Anne Mattila Jan B?hm Ismo Jantunen Ilmo Kellokumpu | 2015 | World Journal of Gastroenterology2015，21，47： | 1 |
| 16 | On-line monitoring of continuous beer fermentation process using auto- matic membrane inlet mass spectrometric system显示文摘 | Virpi Tarkiainen Tapio Kotiaho Ismo Mattila | 2005 | Talanta2005，65，5： | 1 |
| 17 | Formation of PCDDs and PCDFs in municipal waste incineration and its inhibition mechanisms: a review 显示文摘 | Kari Tuppurainen Ismo Halonen Paivi Ruokojarvi | 1998 | Chemosphere1998，36，7： | 1 |
| 18 | Formation of PCDDs and PCDFs in municipal waste incineration and its inhibition mechanisms: A review显示文摘 | Kari Tuppurainen Ismo Halonen P?ivi Ruokoj?rvi Juhani Tarhanen Juhani Ruuskanen | 1998 | Chemosphere1998，，7： | 1 |
| 19 | 显示文摘 | Kari T Ismo H Paivi R | 1998 | Chemosphere1998，36，： | 1 |
| 20 | Class-Discrminafive Weighted Distortion Measure for VQ-based Speaker Identification显示文摘 | Tomi Kinnunen Ismo Karkkainen | 2002 | LNCS2002，，2396： | 1 |
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