|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 66例原位肝脏移植及围手术期处理分析显示文摘目的 总结 6 6例肝移植及围手术期处理的经验 ,探讨适合我国目前及今后提高肝移植成活率和康复率的方法。方法 6 6例接受肝移植手术患者 ,12例行劈离式肝移植 (SL T)术 ,5 4例行原位肝移植 (OL T)术。结果 移植的 6 6例肝脏 ,术后无 1例发生肝脏功能衰竭 ,也无重大并发症发生 ,病人全部存活 ,多数已康复。结论 改善供肝条件 ,严格受体选择 ,提高手术水平 。 | 伍晓汀 严律南 Carl-Gustav Groth Bo-Gran Ericzon 周勇 庄文 张明鸣 | 2002 | 华西医科大学学报2002，33，4： | 2 |
| 2 | Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution显示文摘AIM:To optimize a xeno-free cryopreservation protocol for primary human hepatocytes.METHODS:The demand for cryopreserved hepatocytes is increasing for both clinical and research purposes.Despite several hepatocyte cryopreservation protocols being available,improvements are urgently needed.We first compared controlled rate freezing to polystyrene box freezing and did not find any significant change between the groups.Using the polystyrene box freezing,we compared two xeno-free freezing solutions for freezing of primary human hepatocytes:a new medium(STEM-CELLBANKER,CB),which contains dimethylsulphoxide(DMSO) and anhydrous dextrose,both permeating and non-permeating cryoprotectants,and the frequently used DMSO-University of Wisconsin(DMSOUW) medium.The viability of the hepatocytes was assessed by the trypan blue exclusion method as well as a calcein-esterase based live-dead assay before and after cryopreservation.The function of the hepatocytes was evaluated before and after cryopreservation by assessing enzymatic activity of 6 major cytochrome P450 isoforms(CYPs):CYP1A2,CYP2C9,CYP2C19,CYP2D6,CYP3A4 and CYP3A7.RESULTS:The new cryoprotectant combination preserved hepatocyte viability significantly better than the standard DMSO-UW protocol(P < 0.01).There was no significant difference in viability estimation between both the trypan blue(TB) and the Live-Dead Assay methods.There was a correlation between viability of fresh hepatocytes and the difference in cell viability between CB and DMSO protocols(r 2 = 0.69) using the TB method.However,due to high within-group variability in the activities of the major CYPs,any statistical between-group differences were precluded.Cryopreservation of human hepatocytes using the cryoprotectant combination was a simple and xeno-free procedure yielding better hepatocyte viability.Thus,it may be a better alternative to the standard DMSO-UW protocol.Estimating CYP activities did not seem to be a relevant way to compare hepatocyte function between different groups due to high normal variability between different liver samples.CONCLUSION:The cryoprotectant combination may be a better alternative to the standard DMSO-UW protocol in primary human hepatocyte cryopreservation. | Mohammed Saliem Frida Holm Rosita Bergstrm Tengzelius Carl Jorns Lisa-Mari Nilsson Bo-Gran Ericzon Ewa Ellis Outi Hovatta | 2012 | World Journal of Hepatology2012，4，5： | 2 |
| 3 | Infections in human liver recipients: different patterns early and late after transplantation显示文摘 | L. Barkholt B -G. Ericzon J. Tollemar A -S. Malmborg A. Ehrnst H. Wilczek J. Andersson | 1993 | Transplant International1993，，2： | 1 |
| 4 | High dose acyclovir prophylaxis reduces cytomegalovirus disease in liver transplant patients 显示文摘 | Barkholt L Lewensohn-Fuchs I Ericzon BG | 1999 | Transpl Infect Dis1999，，2： | 1 |
| 5 | High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production on interleukin 6显示文摘 | XU B Broome U Ericzon BG | 2002 | Gut2002，51，1： | 1 |
| 6 | Primary amyloidosis with spontaneous splenic rupture, cholestasis and liver failure treated with emergency liver transplantation显示文摘 | Sandberg-GertzSn H Ericzon BG Blomberg B | 1998 | Am J Gastroenterol1998，93，11： | 1 |
| 7 | Relevance of a positive cro-ssmatch in liver transplantation显示文摘 | Karuppan S Ericzon BG Moller E | 1991 | Transpl Int1991，4，1： | 1 |
| 8 | Enteral donor pre-treatment with ursodeoxycholic acid protects the liver against ischaemia-reperfusion injury in rats显示文摘 | Grzegorz Nowak Ulf G. Norén Annika Wernerson Hanns-Ulrich Marschall Lennart M?ller Bo-G?ran Ericzon | 2005 | Transplant International2005，，12： | 1 |
| 9 | Ursodeoxycholic acid increased bile flow and affects bile composition in the early postoperative phase following liver transplantation显示文摘 | G. S?derdahl G. Nowak F. Duraj F.-H. Wang C. Einarsson B.-G. Ericzon | 1998 | Transplant International1998，，1： | 1 |
| 10 | Bile cytology in orthotopic liver transplantation显示文摘 | Kubota K Ericzon BG Barkholt L | 1989 | Transplantation1989，48，6： | 1 |
| 11 | Bile acid formation in primary human hepatocytes显示文摘AIM To evaluate a culture system for bile acidformation in primary human hepatocytes incomparison with HepG2 cells.METHODS Hepatocytes were isolated fromnormal human liver tissue and were cultured inserum-free William’s E medium.The medium wascollected and renewed every 24 h.Bile acids andtheir precursors in media were finally analysed bygas chromatography-mass spectrometry.RESULTS Cholic acid(CA)andchenodeoxycholic acid(CDCA)conjugated withglycine or taurine accounted for 70% and 25% oftotal steroids.A third of CDCA was alsoconjugated with sulphuric acid.Dexamethasoneand thyroid hormone alone or in combination didnot significantly effect bile acid formation.Theaddition of cyclosporin A(10 μmol/L)inhibited thesynthesis of CA and CDCA by about 13% and30%,respectively.CONCLUSION Isolated human hepatocytes inprimary culture behave as in the intact liver byconverting cholesterol to conjugated CA andCDCA.This is in contrast to cultured HepG2 cells,which release large amounts of bile acidprecursors and unconjugated bile acids into themedium. | Curt Einarsson Ewa Ellis Anna Abrahamsson Bo-Gran Ericzon Ingemar Bjrkhem Magnus Axelson | 2000 | World Journal of Gastroenterology2000，6，4： | 1 |
| 12 | Hepatic cell membrane damage during cold preservation sensitizes liver grafts to rewarming injury显示文摘 | Grzegorz Nowak Johan Ungerstedt Annika Wernerson Urban Ungerstedt Bo-G?ran Ericzon | 2003 | Journal of Hepato - Biliary - Pancreatic Surgery2003，，3： | 1 |
| 13 | Efficacy and Safety of Maribavir Dosed at 100 mg Orally Twice Daily for the Prevention of Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized, Double‐Blind, Multicenter Controlled Trial显示文摘 | D. J. Winston F. Saliba E. Blumberg M. Abouljoud J. B. Garcia‐Diaz J. A. Goss L. Clough R. Avery A. P. Limaye B. G. Ericzon M. Navasa R. I. Troisi H. Chen S. A. Villano M. E. Uknis | 2012 | American Journal of Transplantation2012，，11： | 1 |
| 14 | High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD4+4 and production of interleukin 6显示文摘 | Xu B Broome U Ericzon BG | 2002 | Gut2002，51，1： | 1 |
| 15 | Treatment of hepatic venoocclusive disease with recombinant human tissue plasminogen activator or orthotopic liver transplantation after allogeneic bone marrow transplantation 显示文摘 | Hagglund H Ringden O Ericzon B G | 1996 | Transplantation1996，62，8： | 1 |
| 16 | Biliary epithelial cell antibodies induce expression of toll-like receptors 2 and 3: a mechanism for post-liver transplantation cholangitis? 显示文摘 | Ge X Uzunel M Ericzon B G | 2005 | Liver Transpl2005，11，8： | 1 |
| 17 | Long term data from the Familial Amyloidotic Polyneuropathy World Transplant Registry (FAPWTR)显示文摘 | Wilczek HE Larsson M Ericzon BG | 2011 | Amyloid2011，1，： | 1 |
| 18 | 多米诺肝移植术的临床应用显示文摘目的:介绍一种新的术式—多米诺肝移植手术(Domino liver transplantation),也称为连续性肝移植(Sequential liver transplantation),为解决供肝缺乏的问题开辟一条新路。方法:该术式是将供体肝脏移植到第一个受体,第一个受体的肝脏,再移植到第二个受体,第二个受体的肝脏,再移植到第三个受体(多米诺供肝和受体),因多米诺供肝尽管存在某些代谢性障碍,但肝脏本身形态、结构、解毒、合成等大致正常,故特别适合先天性代谢性疾病、硬化性胆管炎、原发性肝癌的治疗。第一组:先天性代谢性疾病患者得到供肝,而其肝脏做为供肝,移植给硬化性胆道炎患者,该患者肝脏做为供肝,移植给原发性肝癌患者;第二组:布加氏综合征患者得到供肝,而其肝脏做为供肝,移植给肝硬化患者,该患者肝脏做为供肝,移植给肝癌患者;第三组:胆汁性肝硬化患者得到供肝,而其肝脏做为供肝,移植给酒精性肝硬化患者,该患者肝脏做为供肝,移植给原发性肝癌患者。结果:手术时间供者和受者手术时间分别为584min;680min;650min全部受者均顺利康复,受者出现肝动脉栓塞1例,胆道并发症1例,感染3例,急性排斥反应4例,无围手术期死亡。结论:多米诺肝移植术对解决供肝的缺乏非常有效,值得进一步临床探索。 | 王晓临 B G Ericzon | 2013 | 青海医药杂志2013，43，7： | 1 |
| 19 | New immunosuppressive drugs in transplantation显示文摘 | Groth CG Oh lman S Gannedahl G Ericzon BG | 1993 | Transplant Proc1993，25，： | 1 |
| 20 | Report from the familial amyloidotic polyneuropathy world transplant registry (FAPWTR) and the Domino liver transplant registry (DLTR)显示文摘 | Ericzon B G Larsson M Herlenius G | 2003 | Amyloid2003，10，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员