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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | A Novel RGL2-DOF6 Complex Contributes to Primary Seed Dormancy in Arabidopsis thaliana by Regulating a GATA Transcription Factor显示文摘 | Pratibha Ravindran Vivek Verma Petra Stamm Prakash P. Kumar | 2017 | Molecular Plant2017，10，10： | 12 |
| 3 | Divergent DNA Methylation Patterns Associated with Abiotic Stress in Hevea brasiliensis显示文摘Cytosine methylation 在植物是为基因表示规定和开发的基本 epigenetic 机制。这里,我们第一次在树庄稼 Hevea brasiliensis (在世界上的 99% 自然橡胶的来源) 报导有不能生活的应力的 DNA methylation 模式和他们的通常认为的关系的鉴定。涉及 mevalonate 小径(橡胶生合成小径) 的四主要基因和三 high-yielding 的一一般防卫相关的基因的规章的序列以二个不同 agroclimatic 条件种的流行橡胶克隆为 methylation 的存在被分析。我们在所有五基因以内在核心 DNA 有约束力的主题在 methylation 模式发现几重要变化。几个一致克隆特定、地点特定的 methylation 模式被识别。在在某些枢轴的 cis 规章的地点观察的 methylation 模式的差别在染色体上显示应力的直接影响并且支持地点特定的导致压力的 DNA methylation 的假设。一些观察的 methylation 模式可以在他们由适应极端条件的植物涉及压力应答的机制,这被假定。学习尽管有他们的很类似的基因组成,也在 Hevea 克隆之中向高度分叉的 phenotypic 人物的存在提供线索。总的来说,从这研究的观察在疑问以外证明在那里存在在 Hevea 和环境因素的 epigenetic 变化在它的染色体在地点特定的 epigenetic 变化的正式就职起一个重要作用。 | Thomas K. Uthup Minimol Ravindran, K. Bini Saha Thakurdas | 2011 | Molecular Plant2011，4，6： | 8 |
| 4 | Risk modification of colorectal cancer susceptibility by interleukin-8-251T>A polymorphism in Malaysians显示文摘AIM: To investigate the allele and genotype frequencies and associated risk of interleukin (IL)-8-251T>A polymorphism on colorectal cancer (CRC) susceptibility risk. METHODS: Peripheral blood samples of 255 normal controls and 255 clinically and histopathologically confirmed CRC patients were genotyped for IL-8-251T>A polymorphism employing allele-specific polymerase chain reaction. The relative association of variant allele and genotypes with CRC susceptibility risk was determined by calculating the odds ratios (ORs). Corresponding χ 2 tests on the CRC patients and controls were carried out and 95% confidence intervals (CIs) were determined using Fisher's exact test. The allele frequencies and its risk association were calculated using FAMHAP, haplotype association analysis software. RESULTS: On comparing the frequencies of genotypesof patients and controls, the homozygous variant AA was significantly higher in CRC patients (P = 0.002) compared to controls. Investigation on the association of the polymorphic genotypes with CRC susceptibility risk, showed that the homozygous variant IL-8 -251AA had a significantly increased risk with OR 3.600 (95% CI: 1.550-8.481, P = 0.001). In the case of allele frequencies, variant allele A of IL-8 -251 showed a significantly increased risk of CRC predisposition with OR 1.32 (95% CI: 1.03-1.69,P = 0.003). CONCLUSION: Variant allele and genotype of IL-8 (-251 T>A) was significantly associated with CRC susceptibility risk and could be considered as a high-risk variant for CRC predisposition. | Mohd Aminudin Mustapha Siti Nurfatimah Mohd Shahpudin Ahmad Aizat Abdul Aziz Ravindran Ankathil | 2012 | World Journal of Gastroenterology2012，18，21： | 6 |
| 5 | 饲料酶制剂在动物营养中的应用——最新动态及展望显示文摘饲料添加酶制剂用以提高畜禽的生产性能已有20年的历史,人们对酶所作用的底物结构及化学性质有了深入的认识。作者对饲料酶制剂在畜禽营养中广泛应用的最新动态以及未来发展的趋势进行系统的阐述。 | Ravi Ravindran 何梅 赵世芳 | 2005 | 中国家禽2005，27，17： | 4 |
| 6 | Regulation of Seed Germination:The Involvement of Multiple Forces Exerted via Gibberellic Acid Signaling显示文摘Seed germination is a key step in the life cycle of all seed plants, and it is of immense significance in agriculture.Germination is controlled by multiple environmental cues such as light and moisture,and endogenous factors,especially phytohormones.Gibberellic acid (GA)has long been identified as a critical hormone in the regulation of seed germination by countering the inhibition imposed by abscisic acid (ABA)(Holdsworth et al.,2008;Lee et al.,2010). | Pratibha Ravindran Prakash P.Kumar | 2019 | Molecular Plant2019，12，1： | 4 |
| 7 | Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients显示文摘AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes. | Mohd Nizam Zahary Ravindran Ankathi Human Genome Centre Gurjeet Kaur Muhammad Radzi Abu Hassan Harjinder Singh Venkatesh R Naik | 2012 | World Journal of Gastroenterology2012，18，8： | 3 |
| 8 | Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro显示文摘 | Sudha Ponnusamy Remya Ravindran Smita Zinjarde Shobha Bhargava Ameeta Ravi Kumar | 2010 | Evidence-Based Complementary and Alternative Medicine2010，，： | 3 |
| 9 | Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats显示文摘The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar rats.Thirty rats were categorized as control,diabetic control supplemented with 0,20 mg/kg chrysoeriol and 600μg/kg BW of glibenclamide for 45-day trial period.Our results indicated that the inclusion of chrysoeriol(20 mg/kg)showed a significant reduction in plasma glucose,hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin sensitivity.Further,downregulated enzymes including glucose 6-phosphatase,fructose 1,6-bisphosphatase,and glycogen phosphorylase as well upregulated enzymes such as hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,and hepatic glycogen content.There was a diminish action found in liver glycogen synthase of tested rat with a rise in gamma-glutamyl transpeptidase,towards normal levels upon treatment with chrysoeriol.The histopathological study confirmed that renewal of the beta cells of pancreatic of chrysoeriol and glibenclamide treated rats.In addition,the molecular docking of chrysoeriol against glycolytic enzymes including hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,using Argus software shows chrysoeriol had greatest ligand binding energy as equivalent to glibenclamide,as a standard drug.Thus,chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes. | Baskaran Krishnan Abirami Ramu Ganesan Ravindran Balasubramani Dinh Duc Nguyen Soon Woong Chang Shaoyun Wang Jianbo Xiao Balamuralikrishnan Balasubramanian | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 10 | Regulation of Seed Germination:The Involvement of Multiple Forces Exerted via Gibberellic Acid Signaling显示文摘(Molecular Plant 12,24–26;January 2019)In Figure 1,we highlight that the DELLA protein RGL2 interacts with DOF6,and this novel complex regulates GATA12 and other unidentified targets to inhibit dormancy release.However,we mistakenly used an arrowhead(suggesting positive regulation)towards dormancy release instead of the bar-ended line(suggesting negative regulation).The figure has thus been rectified with a bar-ended line.The authors apologize for this error. | Pratibha Ravindran Prakash P.Kumar | 2019 | Molecular Plant2019，12，10： | 3 |
| 11 | Free radical scavenging potential and HPTLC analysis of Indigofera tinctoria linn(Fabaceae)显示文摘The objective of this study was to evaluate the free radical scavenging potential and high performance thin layer chromatography(HPTLC) fingerprinting of Indigofera tinctoria(I. tinctoria). Phytochemical analysis was carried out using standard methods, and free radical scavenging activity of the plant was determined using 2,2-diphenyl-1-picrylhydrazy(DPPH), nitric oxide(NO) and superoxide anion(O_2^-)radical scavenging capacities. HPTLC plate was kept in CAMAG TLC Scanner 3 and the Rf values at fingerprint data were recorded by WINCATS software. Aqueous extract of I. tinctoria reliably showed the total phenolics(267.2±2.42 mg/g), flavonoids(75.43±3.36 mg/g) and antioxidants(349.11±8.04 mg/g). The extract was found to have DPPH(52.08%), NO(23.12%) and O_2^-(26.79%) scavenging activities at the concentration of 250 μg/m L and the results were statistically signi ficant compared with ascorbic acid standard(p<0.05). HPTLC results con firmed that the extract contained several potential active components such as phenols, flavonoids, saponins and terpenoids as the slides revealed multi-colored bands of varying intensities. This study confirmed that the plant had multipotential antioxidant and free radicals scavenging activities. | Sakthivel Srinivasan Wankupar Wankhar Sheeladevi Rathinasamy Ravindran Rajan | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 12 | Hybrid membrane filtration process for leachate treatment显示文摘 | Massoud Pirbazari Varadarajan ravindran Badriyha Badri N | 1996 | Wat Res1996，30，11： | 2 |
| 13 | Hematopoietic stem cell transplantation for auto immune rheumatic diseases显示文摘Stem cells have their origins in the embryo and during the process of organogenesis, these differentiate into specialized cells which mature to form tissues. In addition, stem cell are characterized by an ability to indefinitely self renew. Stem cells are broadly classified into embryonic stem cells and adult stem cells. Adult stem cells can be genetically reprogrammed to form pluripotent stem cells and exist in an embroyonic like state. In the early phase of embryogenesis, human embryonic stem cells only exist transiently. Adult stem cells are omnipresent in the body and function to regenerate during the process of apoptosis or tissue repair. Hematopoietic stem cells(HSC) are adult stem cells that form blood and immune cells. Autoimmune responses are sustained due to the perennial persistence of tissue self autoantigens and/or auto reactive lymphocytes. Immune reset is a process leading to generation of fresh self-tolerant lymphocytes after chemotherapy induced elimination of self or autoreactive lymphocytes. This forms the basis for autologous HSC transplantation(HSCT). In the beginning HSCT had been limited to refractory autoimmune rheumatic diseases(AIRD) due to concern about transplant related mortality and morbidity. However HSCT for AIRD has come a long way with better understanding of patient selection, conditioning regime and supportive care. In this narrative review we have examined the available literature regarding the HSCT use in AIRD. | Subramanian Ramaswamy Sandeep Jain Vinod Ravindran | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 14 | Influence of feed form and conditioning temperature on performance, apparent metabolisable energy and ileal digestibility of starch and nitrogen in broiler starters fed wheat-based diet显示文摘 | M.R. Abdollahi V. Ravindran T.J. Wester G. Ravindran D.V. Thomas | 2011 | Animal Feed Science and Technology2011，，1： | 2 |
| 15 | ^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy显示文摘Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian counterparts.There is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad P.Methods: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with CWU.Results: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT alone.Conclusions: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(< 1.0 ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease. | Janice S.H.Tan Charles X.Y.Goh Yen Sin Koh Youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.Wang Lui Shiong Lee Kae Jack Tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong Winnie W.C.Lam Melvin L.K.Chua | 2019 | Cancer Biology & Medicine2019，16，1： | 2 |
| 16 | 老年癌症患者的免疫治疗显示文摘癌症常见于老年人。初诊为恶性肿瘤的患者的中位年龄为66岁,癌症相关死亡的中位年龄为72岁[1]。老年人是癌症患病率增长最快的人群之一[2]。免疫治疗的发展,尤其是免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)的问世,彻底改变了所有年龄层包括老年人在内的肿瘤患者的常规治疗方案。细胞毒性T淋巴细胞相关抗原4、程序性死亡受体1(programmed death receptor-1,PD-1)及其配体(programmed death-ligand 1,PD-L1)的抑制剂可改善多种肿瘤患者的总生存期(overall survival,OS)[3],且部分患者可获得持续缓解[4]。 | Carolyn J.PRESLEY Fabio GOMES Christin E.BURD Ravindran KANESVARAN Melisa L.WONG 李昕(翻译) 陈军(校对) | 2021 | 中国肺癌杂志2021，24，10： | 2 |
| 17 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 18 | Strain Limit of Extra Galvannealed Interstitial-Free and Bake Hardened Steel Sheets Under Different Stress Conditions显示文摘The formability of bake hardened steel (thickness 0.82 mm), and the extra galvannealed IF steel (thickness 0.82 mm) have been studied. The suitability of the above steels for forming applications has been critically examined. The microstructure, tensile properties, and formability parameters of the above sheet metals were determined. The manufacturing process of the steels and the significance with reference to its formability were studied. | R Narayanasamy N L Parthasarathi R Ravindran C Sathiya Narayanan | 2008 | Journal of Iron and Steel Research(International)2008，15，5： | 2 |
| 19 | Chemical-Bonding and High-Pressure Studies on Hydrogen-Storage Materials 显示文摘 | Ravindran P Vajeeston P Fjellvag H | 2004 | Computational Mater Sci2004，30，： | 1 |
| 20 | Primary dysthymia:a study of several psychosocial,endocrine and immune correlates显示文摘 | Ravindran AV Griffiths J Meralin Z | 1996 | J Affect Disord1996，40，12： | 1 |
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