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| 1 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 2 | Offshore wind energy in urope-a yeview of the state-of-the-art 显示文摘 | ANDREW R HENDERSON COLIN MOEGAN BERNIE SMITH | 2003 | Wind Energy2003，，6： | 1 |
| 3 | High levels of ripening-specific reporter gene expression directed by tomato fruit polygalacturonase gene-flanking regions显示文摘 | Fiona J. Nicholass Christopher J.S. Smith Wolfgang Schuch Colin R. Bird Donald Grierson | 1995 | Plant Molecular Biology1995，，3： | 1 |
| 4 | XCMS:Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment,Matching and Identification显示文摘 | Colin A Smith Elizabeth J Want Grace O'Maille | 2006 | Analytical Chemistry2006，78，3： | 1 |
| 5 | Validation and Implementation of Targeted Capture and Sequencing for the Detection of Actionable Mutation, Copy Number Variation, and Gene Rearrangement in Clinical Cancer Specimens显示文摘 | Colin C. Pritchard Stephen J. Salipante Karen Koehler Christina Smith Sheena Scroggins Brent Wood David Wu Ming K. Lee Suzanne Dintzis Andrew Adey Yajuan Liu Keith D. Eaton Renato Martins Kari Stricker Kim A. Margolin Noah Hoffman Jane E. Churpek Jonathan | 2014 | The Journal of Molecular Diagnostics2014，，1： | 1 |
| 6 | Meningiomas显示文摘 | Ian R Whittle Colin Smith Parthiban Navoo Donald Collie | 2004 | The Lancet2004，，9420： | 1 |
| 7 | Theoretical investigation of the role of the RANK–RANKL–OPG system in bone remodeling显示文摘 | Peter Pivonka Jan Zimak David W. Smith Bruce S. Gardiner Colin R. Dunstan Natalie A. Sims T. John Martin Gregory R. Mundy | 2009 | Journal of Theoretical Biology2009，，： | 1 |
| 8 | Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging显示文摘 | Joanna M Wardlaw Colin Smith Martin Dichgans | 2013 | Lancet Neurology2013，，： | 1 |
| 9 | Risk, gap and strength: key concepts in knowledge management显示文摘 | Ian McBriar Colin Smith Geoff Bain Peter Unsworth Stephen Magraw John L Gordon | 2002 | Knowledge-Based Systems2002，，1： | 1 |
| 10 | Surgical strategies in paediatric inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) comprises two distinct but related chronic relapsing inflammatory conditions affecting different parts of the gastrointestinal tract. Crohn's disease is characterised by a patchy transmural inflammation affecting both small and large bowel segments with several distinct phenotypic presentations. Ulcerative colitis classically presents as mucosal inflammation of the rectosigmoid(distal colitis), variably extending in a contiguous manner more proximally through the colon but not beyond the caecum(pancolitis). This article highlights aspects of the presentation, diagnosis, and management of IBD that have relevance for paediatric practice with particular emphasis on surgical considerations. Since 25% of IBD cases present in childhood or teenage years, the unique considerations and challenges of paediatric management should be widely appreciated. Conversely, we argue that the organizational separation of the paediatric and adult healthcare worlds has often resulted in late adoption of new approaches particularly in paediatric surgical practice. | Colin T Baillie Jennifer A Smith | 2015 | World Journal of Gastroenterology2015，21，20： | 1 |
| 11 | The Effect of Suture Coated With Mesenchymal Stem Cells and Bioactive Substrate on Tendon Repair Strength in a Rat Model显示文摘 | Jeffrey Yao Colin Yi-Loong Woon Anthony Behn Tatiana Korotkova Don-Young Park Varun Gajendran R. Lane Smith | 2012 | Journal of Hand Surgery2012，，8： | 1 |
| 12 | Risk, Gap and Strength: Key Concepts in Knowledge Management 显示文摘 | Ian McBriar Colin Smith | 2003 | Knowledge - based Systems2003，，16： | 1 |
| 13 | In situ protection of Splash Zones-30 years on显示文摘 | Martin Smith Colin Bowley Lucian Williams | 2002 | MP2002，41，10： | 1 |
| 14 | Risk,gap and strength:key words in knowledge management显示文摘 | IAN MERBRIAR COLIN SMITH GEOFF BAIN | 2003 | Knowledge-based systems2003，16，1： | 1 |
| 15 | Impact of paroxysmal sympathetic hyperactivity on nutrition management after brain injury: A case series显示文摘 | Sheena B. Caldwell Daniel Smith F. Colin Wilson | 2013 | Brain Injury2013，，3： | 1 |
| 16 | Inheritance and effect on ripening of antisense polygalacturonase genes in transgenic tomatoes显示文摘 | Christopher J. S. Smith Colin F. Watson Peter C. Morris Colin R. Bird Graham B. Seymour Julie E. Gray Christine Arnold Gregory A. Tucker Wolfgang Schuch Steven Harding Donald Grierson | 1990 | Plant Molecular Biology1990，，3： | 1 |
| 17 | Meningiomas显示文摘 | Ian R Whittle Colin Smith Parthiban Navoo Donald Collie | 2004 | The Lancet2004，，9420： | 1 |
| 18 | Risk,gap and strength:key concepts in knowledge management显示文摘 | Ian McBriar Colin Smith | 2003 | Knowledge-Based Systerns2003，16，1： | 1 |
| 19 | Statics of a three component mooring line显示文摘 | Russell J Smith Colin J MacFarlane | 2001 | Ocean Engineering2001，28，： | 1 |
| 20 | Diagnosis and pathogenesis of gliomas显示文摘 | Colin Smith James W Ironside | 2007 | Current Diagnostic Pathology2007，13，3： | 1 |
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