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| 1 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 2 | 鉴别短暂性脑缺血发作后发生早期卒中高危人群的简单方法(ABCD) | Rothwell P.M. Giles M.F. Flossmann E. 谢琰臣 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，11： | 13 |
| 3 | Non-invasive brain stimulation to promote motor and functional recovery following spinal cord injury显示文摘We conducted a systematic review of studies using non-invasive brain stimulation(NIBS: repetitive transcranial magnetic stimulation(r TMS) and transcranial direct current stimulation(t DCS)) as a research and clinical tool aimed at improving motor and functional recovery or spasticity in patients following spinal cord injury(SCI) under the assumption that if the residual corticospinal circuits could be stimulated appropriately, the changes might be accompanied by functional recovery or an improvement in spasticity. This review summarizes the literature on the changes induced by NIBS in the motor and functional recovery and spasticity control of the upper and lower extremities following SCI. | Aysegul Gunduz John Rothwell Joan Vidal Hatice Kumru | 2017 | Neural Regeneration Research2017，12，12： | 7 |
| 4 | 美国国家卒中协会短暂性脑缺血发作处理指南显示文摘目的:短暂性脑缺血发作(TIA)是常见和重要的卒中先兆。其处理方法多样,大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法:根据一种客观标准(可以预测在该研究领域中执业医师对专家提名的文献测量学方法)挑选出15名专家组成员。通过系统回顾检索到过去发表的指南,由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见,然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订,从而对新的修改达成共识。给专家们提供近期临床研究的系统评价,要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果:通过系统回顾检索到257个指南,其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论:对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的,考虑到了快速更新并能减少偏倚。 | S. Claiborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle Peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra Peter M. Rothwell Harold P. Adams Gregory W. Albers 李海峰(译) | 2007 | 国际脑血管病杂志2007，15，3： | 5 |
| 5 | 动脉粥样硬化性血栓形成与缺血性卒中——不稳定斑块是颈动脉狭窄患者脑卒中的主要发病机制显示文摘“不稳定”的动脉粥样硬化斑块导致血栓形成是引起急性冠状动脉综合征的主要因素,目前血管病的研究多集中于这方面。尽管脑卒中有多种机制的参与,甚至有时“稳定”斑块也可以导致卒中,但斑块仍是大部分缺血性脑卒中的原因。例如,在基底动脉和大脑中动脉近端,稳定斑块的缓慢生长可以闭塞次级小血管管腔。缓慢生长的稳定斑块也可以引起狭窄和低灌注从而导致缺血性脑卒中,其间并没有血栓栓塞的参与。而且,最近的证据表明脑卒中的主要发病机制与冠状动脉疾病类似,至少对于颈动脉狭窄患者不稳定斑块是重要的因素。这一发现对于我们治疗和预防卒中有一定的指导意义。 | P M Rothwell 倪俊(译) 高晶(校) | 2007 | 英国医学杂志中文版2007，10，3： | 4 |
| 6 | 短暂性脑缺血发作或微小卒中后再发卒中的早期危险:公共教育及机构组建意义的人群研究显示文摘目的:通过评估短暂性脑缺血发作(TIA)或微小脑卒中后再发卒中的早期危险,从而提高对建立有效的脑卒中预防机构的认识。 | A J Coull J K Lovett P M Rothwell 袁晶 | 2004 | 英国医学杂志中文版2004，7，4： | 4 |
| 7 | Survival outcomes of cemented compared to uncemented stems in primary total hip replacement显示文摘Total hip replacement(THR) is a successful and reliable operation for both relieving pain and improving function in patients who are disabled with end stage arthritis.The ageing population is predicted to significantly increase the requirement for THR in patients who have a higher functional demand than those of the past. Uncemented THR was introduced to improve the long term results and in particular the results in younger, higher functioning patients. There has been controversy about the value of uncemented compared to cemented THR although there has been a world-wide trend towards uncemented fixation. Uncemented acetabular fixation has gained wide acceptance, as seen in the increasing number of hybrid THR in joint registries, but there remains debate about the best mode of femoral fixation.In this article we review the history and current worldwide registry data, with an in-depth analysis of the New Zealand Joint Registry, to determine the results of uncemented femoral fixation in an attempt to provide an evidence-based answer as to the value of this form of fixation. | Michael Wyatt Gary Hooper Christopher Frampton Alastair Rothwell | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 8 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | 2007 (9558)2007，，9558： | 3 |
| 9 | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack显示文摘 | PM Rothwell MF Giles E Flossmann CE Lovelock JNE Redgrave CP Warlow Z Mehta | 2005 | The Lancet2005，，9479： | 3 |
| 10 | Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery显示文摘 | PM Rothwell M Eliasziw SA Gutnikov CP Warlow HJM Barnett | 2004 | The Lancet2004，，9413： | 3 |
| 11 | Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation显示文摘 | A. Denes P. Thornton N.J. Rothwell S.M. Allan | 2009 | Brain Behavior and Immunity2009，，5： | 3 |
| 12 | Self-perceived employability: development and validation of a scale显示文摘 | Andrew Rothwell John Arnold | 2007 | Personnel Review2007，，1： | 2 |
| 13 | Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials显示文摘 | Peter M Rothwell Michelle Wilson Jacqueline F Price Jill FF Belch Tom W Meade Ziyah Mehta | 2012 | The Lancet . 2012 (9826)2012，，： | 2 |
| 14 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet . 2007 (9558)2007，，9558： | 2 |
| 15 | Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials显示文摘 | Peter M Rothwell F Gerald R Fowkes Jill FF Belch Hisao Ogawa Charles P Warlow Tom W Meade | 2011 | The Lancet2011，，9759： | 2 |
| 16 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet2007，，9558： | 2 |
| 17 | Towards the Fifth-generation Innovation Process显示文摘 | Roy Rothwell | 1994 | International Marketing Review1994，，1： | 2 |
| 18 | Interrelation Between Plaque Surface Morphology and Degree of Stenosis on Carotid Angiograms and the Risk of Ischemic Stroke in Patients With Symptomatic Carotid Stenosis显示文摘 | P. M. Rothwell R. Gibson C. P. Warlow | 2000 | Stroke: Journal of the American Heart Association2000，，3： | 2 |
| 19 | Angiographically Defined Collateral Circulation and Risk of Stroke in Patients With Severe Carotid Artery Stenosis显示文摘 | Robert D. Henderson Michael Eliasziw Allan J. Fox Peter M. Rothwell Henry J. M. Barnett | 2000 | Stroke: Journal of the American Heart Association2000，，1： | 2 |
| 20 | Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery显示文摘 | Rothwell PM Eliasziw M Gutnikov SA | 2004 | Lancet2004，363，9413： | 1 |
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