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| 1 | Abscisic Acid-mediated Epigenetic Processes in Plant Development and Stress Responses显示文摘Abscisic acid (ABA) regulates diverse plant processes, growth and development under non-stress conditions and plays a pivotal role in abiotic stress tolerance. Although ABA-regulated genetic processes are well known, recent discoveries reveal that epigenetic processes are an integral part of ABA-regulated processes. Epigenetic mechanisms, namely, histone modifications and cytosine DNA methylation-induced modification of genome give rise to epigenomes, which add diversity and complexity to the genome of organisms. Histone monoubiquitination appears to regulate ABA levels in developing seeds through histone H2B monoubiquitination. ABA and H2B ubiquitination dependent chromatin remodeling regulate seed dormancy. Transcription factor networks necessary for seed maturation are repressed by histone deacetylases (HDACs)-dependent and PICKLE chromatin remodeling complexes (CRCs), whereas ABA induces the expression of these genes directly or through repression of HDACs. Abiotic stress-induced ABA regulates stomatal response and stress-responsive gene expression through HDACs and HOS15-dependent histone deacetylation, as well as through the ATP-dependent SWITCH/SUCROSE NONFERMENTING CRC. ABA also probably regulates the abiotic stress response through DNA methylation and short interfering RNA pathways. Further studies on ABA-regulated epigenome will be of immense use to understand the plant development, stress adaptation and stress memory. | Viswanathan Chinnusamy Zhizhong Gong Jian-Kang Zhu | 2008 | Journal of Integrative Plant Biology2008，50，10： | 43 |
| 2 | 血压变异性与脑小血管病:人群队列的系统回顾和荟萃分析显示文摘脑小血管疾病(cerebral small vessel disease,CSVD)是一种常见的、具有破坏性的亚临床疾病,对卒中和痴呆都有重要影响。血压的变异性可能会增加卒中和痴呆的风险,但血压变异性是否与CSVD有关尚无定论。该研究针对前瞻性队列研究进行了系统回顾和荟萃分析,这些研究考察了血压变异性与CSVD标志物(包括磁共振成像上的白质高信号、腔隙和微出血)的存在或进展之间的关系。该研究搜索了Medline、Embase和Web of Science三大数据库。筛选出10项研究符合综合定性标准,并有7项研究可纳入荟萃分析。这些研究共包括2796例年龄为(74±4)岁的患者,平均随访时间为4.0年。经统计学分析,收缩期血压变异性与白质高信号存在或进展的概率增加相关,约增加1个标准差[优势比1.26(95%CI:1.06~1.50)]。而收缩压血压变异性与腔隙的存在[优势比0.93(95%CI:0.74~1.16)]和微出血的存在[优势比1.13(95%CI:0.89~1.44)]之间的相关性没有统计学意义。结果证明,大的血压变异性与更高的脑白质高信号(WMH)负担相关,这可能为探究卒中和痴呆的早期诱因提供重要的支持。二者的因果关系,则需要未来的纵向研究进行探究。如果观察到因果关系是成立的,则表明通过保持稳定的血压,可以很大程度上预防CSVD,从而预防卒中和痴呆。 | Ma Y Song A Viswanathan A 李铁梅(编译) | 2020 | 中华医学杂志2020，100，43： | 32 |
| 3 | SDN在IP网络演进中的作用显示文摘Web已经改变了一切。新的服务每天都在出现,并且有些服务一夜之间就能够获得巨大的用户量,导致网络中的使用方式和流量模式完全难以预测。过去所建立的基础设施难以适应这些新变化,为了满足这些需求,网络必须能够快速、自动、经济地适应新的变化。软件定义网络(SDN)和网络功能虚拟化(NFV)就是其中两个能灵活地使能上述需求的技术。本文描述了SDN在IP网络领域中所起的作用(包括在实现NFV方面的关键作用),并介绍了关于网络如何引入SDN和NFV的场景和多个使用案例,用于说明SDN和NFV如何使得网络更加敏捷、可编程、优化地支持业务和用户的特殊需求。 | Mark M.Clougherty Christopher A.White Harish Viswanathan Colin L.Kahn | 2014 | 电信科学2014，30，5： | 25 |
| 4 | RNA-directed DNA methylation and demethylation in plants显示文摘RNA-directed DNA methylation (RdDM) is a nuclear process in which small interfering RNAs (siRNAs) direct the cytosine methylation of DNA sequences that are complementary to the siRNAs. In plants, double stranded-RNAs (dsRNAs) generated by RNA-dependent RNA polymerase 2 (RDR2) serve as precursors for Dicer-like 3 dependent biogenesis of 24-nt siRNAs. Plant specific RNA polymerase IV (Pol IV) is presumed to generate the initial RNA transcripts that are substrates for RDR2. siRNAs are loaded onto an argonaute4-containing RISC (RNA-induced silencing complex) that targets the de novo DNA methyltransferase DRM2 to RdDM target loci. Nascent RNA transcripts from the target loci are generated by another plant-specific RNA polymerase, Pol V, and these transcripts help recruit com- plementary siRNAs and the associated RdDM effector complex to the target loci in a transcrip- tion-coupled DNA methylation process. Small RNA binding proteins such as ROS3 may direct tar- get-specific DNA demethylation by the ROS1 family of DNA demethylases. Chromatin remodeling en- zymes and histone modifying enzymes also participate in DNA methylation and possibly demethylation. One of the well studied functions of RdDM is transposon silencing and genome stability. In addition, RdDM is important for paramutation, imprinting, gene regulation, and plant development. Lo- cus-specific DNA methylation and demethylation, and transposon activation under abiotic stresses suggest that RdDM is also important in stress responses of plants. Further studies will help illuminate the functions of RdDM in the dynamic control of epigenomes during development and environmental stress responses. | CHINNUSAMY Viswanathan | 2009 | Science China(Life Sciences)2009，52，4： | 22 |
| 5 | A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS_1 in Arabidopsis显示文摘DNA methylation is typically regarded as a repressive epigenetic marker for gene expression.Genome-wide DNA methylation patterns in plants are dynamically regulated by the opposing activities of DNA methylation and demethylation reactions. In Arabidopsis, a DNA methylation monitoring sequence(MEMS) in the promoter of the DNA demethylase gene ROS_1 functions as a methylstat that senses these opposing activities and regulates genome DNA methylation levels by adjusting ROS_1 expression. How DNA methylation in the MEMS region promotes ROS_1 expression is not known. Here, we show that several Su(var)3-9 homologs(SUVHs) can sense DNA methylation levels at the MEMS region and function redundantly to promote ROS_1 expression. The SUVHs bind to the MEMS region, and the extent of binding is correlated with the methylation level of the MEMS.Mutations in the SUVHs lead to decreased ROS_1 expression, causing DNA hypermethylation at more than 1,000 genomic regions. Thus, the SUVHs function to mediate the activation of gene transcription by DNA methylation. | Xinlong Xiao Jieqiong Zhang Tao Li Xing Fu Viswanathan Satheesh Qingfeng Niu Zhaobo Lang Jian-Kang Zhu Mingguang Lei | 2019 | Journal of Integrative Plant Biology2019，61，2： | 11 |
| 6 | ROP11 GTPase Negatively Regulates ABA Signaling by Protecting ABI1 Phosphatase Activity from Inhibition by the ABA Receptor RCAR1/PYL9 in Arabidopsis显示文摘The phytohormone abscisic acid (ABA) regulates many key processes in plants, such as seed germina- tion, seedling growth, and abiotic stress tolerance. In recent years, a minimal set of core components of a major ABA signaling pathway has been discovered. These components include a RCAR/PYR/PYL family of ABA receptors, a group of PP2C phosphatases, and three SnRK2 kinases. However, how the interactions between the receptors and their targets are regulated by other proteins remains largely unknown. In a companion paper published in this issue, we showed that ROP11, a member of the plant- specific Rho-like small GTPase family, negatively regulates multiple ABA responses in Arabidopsis. The current work demonstrated that the constitutively active ROP11 (CA-ROP11) can modulate the RCAR1/PYL9-mediated ABA signaling pathway based on reconstitution assays in Arabidopsis thaliana protoplasts. Furthermore, using luciferase complementation imaging, yeast two-hybrid assays, co- immunoprecipitation assays in Nicotiana benthamiana and bimolecular fluorescence complementation assays, we demonstrated that CA-ROP11 directly interacts with ABI1, a signaling component downstream of RCAR1/PYL9. Finally, we provided biochemical evidence that CA-ROP11 protects ABI1 phosphatase activity from inhibition by RCAR1/PYL9 and thus negatively regulates ABA signaling in plant cells. A model of how ROP11 acts to negatively regulate ABA signaling is presented. | Zixing Li Zheng Li Xiang Gao Viswanathan ChinnusamyI Ray Bressant Zhi-Xin Wang Jian-Kang Zhu Jia-Wei Wu Dong Liu | 2012 | Journal of Integrative Plant Biology2012，54，3： | 11 |
| 7 | Inositol Pyrophosphate lnsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis显示文摘The maintenance of cellular phosphate(Pi)homeostasis is of great importance in living organisms.The SPX domain-containing protein 1(SPX1)proteins from both Arabidopsis and rice have been proposed to act as sensors of Pi status.The molecular signal indicating the cellular Pi status and regulating Pi homeostasis in plants,however,remains to be identified,as Pi itself does not bind to the SPX domain.Here,we report the identification of the inositol pyrophosphate lnsP8 as a signaling molecule that regulates Pi homeostasis in Arabidopsis.Polyacrylamide gel electrophoresis profiling of InsPs revealed that lnsP8 level positively correlates with cellular Pi concentration.We demonstrated that the homologs of diphosphoinositol pentaki-sphosphate kinase(PPIP5K),VIH1 and VIH2,function redundantly to synthesize lnsP8,and that the vih1 vih2 double mutant overaccumulates Pi.SPX1 directly interacts with PHR1,the central regulator of Pi starvation responses,to inhibit its function under Pi-replete conditions.However,this interaction is compromised in the vih1 vih2 double mutant,resulting in the constitutive induction of Pi starvation-induced genes,indicating that plant cells cannot sense cellular Pi status without lnsP8.Furthermore,we showed that lnsP8 could directly bind to the SPX domain of SPX1 and is essential for the interaction between SPX1 and PHR1.Collectively,our study suggests that lnsP8 is the intracellular Pi signaling molecule serving as the ligand of SPX1 for controlling Pi homeostasis in plants. | Jinsong Dong Guojie Ma Liqian Sui Mengwei Wei Viswanathan Satheesh Ruyue Zhang Shenghong Ge Jinkai Li Tong-En Zhang Christopher Wittwer Henning JJessen Huiming Zhang Guo-Yong An Dai-Yin Chao Dong Liu Mingguang Lei | 2019 | Molecular Plant2019，12，11： | 8 |
| 8 | Electrochemical behavior of Co-Cr and Ni-Cr dental cast alloys显示文摘The cast structures influencing the electrochemical corrosion behavior of Co-Cr and Ni-Cr dental alloys were studied using potentiodynamic polarization and AC impedance in 0.9% (mass fraction) NaCl solution at (37±1) ℃. The phase and microstructure of the alloys that were fabricated using two different casting methods viz. centrifugal casting and high frequency induction casting, were examined using X-ray diffraction analysis, scanning electron microscopy and energy dispersive spectroscopy. The roles of alloying elements and the passive film homogeneity on the corrosion resistance of Co-Cr-Mo and Ni-Cr-Mo dental cast alloys were reviewed. The results of electrochemical study show that the dependence of corrosion resistance on the microstructure associated with the casting methods is marginal. The Co-Cr alloy exhibits more desirable corrosion resistance properties than the Ni-Cr alloy. There is severe preferential dissolution of Ni-rich, Cr and Mo depleted zones in the Ni-Cr alloy. | Viswanathan S. SAJI Han-Cheol CHOE | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 8 |
| 9 | 优化下肢慢性创面愈合中的技术应用:共识文件(译文)显示文摘目的:慢性创面处理中技术创新随处可见。尽管多种技术得到了广泛的应用,但并不总是能够确保创面愈合的结局。这份共识文件为创面标准化处理的相关诊疗技术应用提供了循证研究依据。 | Raj Mani Divid J.Margolis Vijay Shukla Sadanori Akita Miltos Lazarides Alberto Piaggesi Vincent Falanga Luc Teot 谢挺 付小兵 Marco Romanelli Chris Attinger 韩春茂 陆树良 Sylvie Meaume 许樟荣 Vijay Viswanathan 孙晓芳 肖娴 | 2017 | 感染.炎症.修复2017，18，2： | 7 |
| 10 | 国际糖尿病足工作组:糖尿病足溃疡减压指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘1999年,国际糖尿病足工作组(IWGDF)根据循证医学证据发表了采用减压治疗促进糖尿病足溃疡愈合的预防和管理指南,这一版指南是在此基础上的更新。我们遵循GRADE方法学,采用患者-干预-比较-结果(PICO)模式设计临床问题和关键的重要结局,对医学科学文献进行系统评价分析后撰写了建议并阐述其理由。这些建议是基于系统评价、专家意见(尚无有效证据时)的基础上建立,并在患者依从性、可行性、实用性以及干预的成本等方面进行了利弊权衡。针对糖尿病患者前足或中足底的溃疡愈合,我们建议不可拆卸齐膝高减压装置作为减压治疗的首选。若出现禁忌或患者不耐受不可拆卸减压装置,则可拆卸齐膝高和齐踝高减压装置可作为二线或三线减压治疗方法。合适的鞋袜结合泡沫毡垫可被视为四线减压治疗选择。如果非外科手术减压失败,我们建议通过外科减压干预以促进跖骨头和足趾溃疡愈合。我们还增加了采用减压治疗促进合并感染、缺血的复杂足溃疡和足跟溃疡愈合的新的推荐意见。减压是促进糖尿病神经性足底溃疡愈合诸多干预措施中最重要的手段。遵循这些建议将帮助医务人员和团队,为那些具有感染、住院和截肢风险的糖尿病足溃疡患者提供更好的治疗。 | Sicco A.Bus David G.Armstrong Catherine Gooday Gustav Jarl Carlo F.Caravaggi Vijay Viswanathan Peter A.Lazzarini 无 姜晓燕 向柯旭 徐俊 邓武权(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，3： | 6 |
| 11 | Cold stress regulation of gene expression in plants显示文摘 | Viswanathan Chinnusamy Jianhua Zhu Jian-Kang Zhu | 2007 | Trends in Plant Science2007，，10： | 4 |
| 12 | 超超临界火电厂锅炉用材的开发显示文摘传统锅炉/蒸气轮机燃矿型火电厂的发电效率主要取决于蒸气温度和压力。自20世纪70年代发生能源危机以来,提高蒸气温度和压力一直是全球范围的研究热点。近年来,对CO2排放量的限制是促进发电效率提高的又一重要原因。目前,大多数燃矿型火电厂的蒸气温度在600℃左右,这表明,蒸气温度在30年内提高了近60℃。预计在未来30年内,蒸气温度有望再提高50~100℃。主要的技术保障是开发更高强度的高温材料,以抵抗更高的温度和压力。美国电力研究所(EPRI)对用于超超临界火力发电厂(先进锅炉/汽轮机火电厂)的材料技术发展现状进行了综合调查。结果表明:商品化的用于厚壁构件的高强铁素体(9~12)Cr钢的最高使用温度达620℃。对两种试验阶段的12Cr铁素体钢的初步研究显示,可以在650℃的温度条件下长期服役,但尚需更多数据加以证实。应用于过热器和再热器的高级别奥氏体不锈钢的最高服役温度为650℃,最高甚至可达700℃。迄今为止,上述钢种尚未获得美国机械工程师协会(ASME)认证。对于锅炉水冷壁顶排管,由于管内压力在24MPa以上,需采用更高强度级别的材料。日前,一种牌号为T23的含5/2 Cr的高强钢通过了ASME认证,成为较好的候选材料。 | R Viswanathan(美) W T Bakker(美) 钱余海(译) 齐慧滨(校) | 2007 | 世界钢铁2007，7，2： | 3 |
| 13 | Recent progress in superhydrophobic and superamphiphobic coatings for magnesium and its alloys显示文摘Superhydrophobic coatings are projected as a practical approach to tackle the weak aqueous corrosion resistance of Mg/Mg alloys.The present review provides the most recent updates in this area.The various low surface energy treatments reported are presented first,followed by the methods employed for developing hierarchical surface micro/nanostructuring.Reported works in different application areas,including anti-corrosion,biomedical and anti-icing are systematically discussed.Concise descriptions of self-healing characteristics and long-term durability of the superhydrophobic surfaces provided.Reports on superamphiphobic surfaces also deliberated. | Viswanathan S.Saji | 2021 | Journal of Magnesium and Alloys2021，9，3： | 3 |
| 14 | A novel compound from Casearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocin-diabetic rats显示文摘 | Govindasamy Chandramohan Savarimuthu Ignacimuthu Kodukkur Viswanathan Pugalendi | 2008 | European Journal of Pharmacology2008，，1： | 3 |
| 15 | Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis显示文摘我们在一张多样的临床的人口评估了同样需要的 tadalafil 的功效和安全(与改变耐心的人口分布,疾病严厉,和 comorbid 医药条件) 有可勃起的机能障碍(编辑) 的亚洲人。五双窗帘的综合分析,控制安慰剂的试用(N = 1 046 ) 被执行。病人们随机被分配收到 10 mg tadalafil (N = 185 ) , 20 mg tadalafil (N = 510 ) ,或安慰剂(N = 351 ) 。功效评价包括了可勃起的功能(IIEF ) 的国际索引,性相遇侧面(9 月) 日记和全球评价问题(GAQ ) 。收到 10 mg 或 20 mg tadalafil 从 baseline-to-end 看了重要改进的病人指在在分析的所有临床的亚人口的可勃起的功能(IIEF-EF ) 领域 20 的国际索引的可勃起的功能领域上,与收到安慰剂的病人相比(P < 0.001 ) 。给吝啬的成功看的 10-mg 和 20-mg tadalafil 组为性交尝试64.1%和70.5%评价( SEP3 ,成功的性交)分别地,在安慰剂与33.4%相比组织( P < 0.001 ),并且分别地,在结束的85.5%和85.4%报导改进勃起削尖 GAQ 对43.5%在安慰剂组织( P < 0.001 )。Tadalafil 很好越过学习的所有组被容忍。头疼和背疼痛是最经常报导的不利事件。总的来说, tadalafil 越过有编辑的亚洲男人的一个多样的临床的系列有效、很好容忍。 | Ying-Lu Guo Vijay P Viswanathan Han-Sun Chiang Hyung Ki Choi Andrew Wai Chun Yip Wei Shen Vladimir Kopernicky | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 16 | Osa-miR167d facilitates infection of Magnaporthe oryzae in rice显示文摘MicroRNAs(miRNAs)play important roles in rice response to Magnaporthe oryzae,the causative agent of rice blast disease.Studying the roles of rice miRNAs is of great significance for the disease control.Osa-miR167d belongs to a conserved miRNA family targeting auxin responsive factor(ARF)genes that act in developmental and stress-induced responses.Here,we show that OsamiR167d plays a negative role in rice immunity against M.oryzae by suppressing its target gene.The expression of Osa-miR167d was significantly suppressed in a resistant accession at and after 24 h post inoculation(hpi),however,its expression was significantly increased at 24 hpi in the susceptible accession upon M.oryzae infection.Transgenic rice lines over-expressing Osa-miR167d were highly susceptible to multiple blast fungal strains.By contrast,transgenic lines expressing a target mimicry to block OsamiR167d enhanced resistance to rice blast disease.In addition,knocking out the target gene ARF12 led to hypersusceptibility to multiple blast fungal strains.Taken together,our results indicate that Osa-miR167d negatively regulate rice immunity to facilitate the infection of M.oryzae by downregulating ARF12.Thus,Osa-miR167d-ARF12 regulatory module could be valuable in improvement of blast-disease resistance. | Zhi-Xue Zhao Qin Feng Xiao-Long Cao Yong Zhu He Wang Viswanathan Chandran Jing Fan Ji-Qun Zhao Mei Pu Yan Li Wen-Ming Wang | 2020 | Journal of Integrative Plant Biology2020，62，5： | 3 |
| 17 | Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats显示文摘Objective:To investigate the protective role of Cardiospermum halicacabum(C.halicacabum) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic rats.Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ.The C.halicacabum leaf extract(CHE) was administered orally to normal and STZ-diabetic rats for 45 days.The effects of C.halicacabum leaf extract(CHE) on plasma and tissue glycoproteins (hexose,hexosamine,fucose and sialic acid) were determined.Results:The levels of plasma and tissues glycoproteins containing hexose,hexosamine and fucose were significantly increased in STZ-induced diabetic rats.In addition,the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats.After administration of CHE to diabetic rats,the metabolic alteration of glycoprotein reverted towards normal levels. Conclusions:The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity. | Chinnadurai Veeramani Khalid S Al-Numair Mohammed A Alsaif Govindasamy Chandramohan Nouf S Al-Numair Kodukkur Viswanathan Pugalendi | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 2 |
| 18 | A signature of immune function genes associated with recurrence-free survival in breast cancer patients显示文摘 | Maria Libera Ascierto Maciej Kmieciak Michael O. Idowu Rose Manjili Yingdong Zhao Margaret Grimes Catherine Dumur Ena Wang Viswanathan Ramakrishnan Xiang-Yang Wang Harry D. Bear Francesco M. Marincola Masoud H. Manjili | 2012 | Breast Cancer Research and Treatment2012，，3： | 2 |
| 19 | Heart-Type Fatty Acid-Binding Protein Predicts Long-Term Mortality and Re-Infarction in Consecutive Patients With Suspected Acute Coronary Syndrome Who Are Troponin-Negative显示文摘 | Karthik Viswanathan Niamh Kilcullen Christine Morrell Sue J. Thistlethwaite Mohan U. Sivananthan Tajek B. Hassan Julian H. Barth Alistair S. Hall | 2010 | Journal of the American College of Cardiology2010，，23： | 2 |
| 20 | Association between conventional risk factors and different ultrasound-based markers of atherosclerosis at carotid and femoral levels in a middle-aged population显示文摘 | Patrick Yerly Nicolas Rodondi Barathi Viswanathan Walter Riesen Pierre Vogt Pascal Bovet | 2013 | The International Journal of Cardiovascular Imaging2013，，3： | 2 |
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