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| 1 | 0Adipose-derived stem cells: Implications in tissue regeneration显示文摘Adipose-derived stem cells(ASCs) are mesenchymal stem cells(MSCs) that are obtained from abundant adipose tissue, adherent on plastic culture flasks, can be expanded in vitro, and have the capacity to differ-entiate into multiple cell lineages. Unlike bone marrow-derived MSCs, ASCs can be obtained from abundant adipose tissue by a minimally invasive procedure, which results in a high number of cells. Therefore, ASCs are promising for regenerating tissues and organs dam-aged by injury and diseases. This article reviews the implications of ASCs in tissue regeneration. | Wakako Tsuji J Peter Rubin Kacey G Marra | 2014 | World Journal of Stem Cells2014，6，3： | 19 |
| 2 | challenges of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an aggressive malignancy,resulting as the third cause of death by cancer each year. The management of patients with HCC is complex,as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging,clinical and biochemical parameters is routinely performed,a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice,several phase Ⅲ clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Locoregional therapies have also been tested as first line treatment,but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally,robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. | Stefano Colagrande Andrea L Inghilesi Sami Aburas Gian G Taliani Cosimo Nardi Fabio Marra | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 3 | Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction显示文摘我们以前在范畴 II 长期的细菌的前列腺炎(CBP ) 表明了 fluoroquinolone-macrolide 联合治疗的安全和功效。这研究的目的是回顾地基于 azithromycin 的联合为 CBP 比较 microbiological 和二个处理计划的临床的调查结果(500 mg,三次每周) 与一次每日的 500-mg 或 ciprofloxacin 的 750-mg 剂量(Cipro-500 或 Cipro-750 队,分别地) 。azithromycin 的联合管理(1500 有以 750 的率的 ciprofloxacin 的 mg 星期 −1) ;为 4 个星期而非在 500 的 mg 天 −1 ;为 6 个星期的 mg 天 −1 从 62.35 % 增加了根除率;到 77.32 %并且从 71.76 % 的全部的细菌学的成功;到 85.57 %。在煽动性的白血球计数和浆液的疼痛和 voiding 症状 / 症状和重要减小地的重要减少前列腺特定的抗原(PSA ) 在两个组在整个 18 月的后续经期被支撑。射精的疼痛, haemospermia 和早泄显著地在两个组在 microbiological 根除上被稀释,但是后者在 Cipro-750 队更即时减退了。总共, 59 个 Cipro-750 病人显示出 mild-to-severe 在基线的可勃起的机能障碍(编辑) ,当 22 个病人没在 microbiological 根除上并且在整个后续时期有编辑时。在结论 fluoroquinolone-macrolide,治疗在病原体根除和 CBP 症状变细导致了,包括疼痛, voiding 骚乱和性机能障碍。为 4 个星期的 ciprofloxacin 的一次每日的 750-mg 剂量与 500-mg 剂量相比显示出提高的根除率和更低的煽动性的白血房间计数 6 个星期。我们的结果是开的推进未来的确认。 | Vittorio Magri Emanuele Montanari Visnja Skerk Alemka Markotic Emanuela Marras Antonella Restelli Kurt G Naber Gianpaolo Perletti | 2011 | Asian Journal of Andrology2011，13，6： | 12 |
| 4 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 5 | Application of Trichoderma harzianum (T22) and Trichoderma atroviride (P1) as plant growth promoters, and their compatibility with copper oxychloride显示文摘Trichoderma strains are used in agriculture because they provide to the plants the following benefits: i) are rhizosphere competence and establish stable rhizosphere microbial communities; ii) control plant disease caused by pathogenic and competitive microflora, by using a variety of mechanisms; iii) improve vegetative growth, root development and yield; iv) make nutrients more available to the plant. In this work we have investigated the ability of T. harzianum T22 and T. atroviride P1 to improve plant growth of locally important horticultural crops: lettuce, tomatoes and peppers and to prevent disease in the greenhouse and field. The effect of the Trichoderma treatment was evaluated by determining the weight of fresh and dry roots and above ground plant biomass, measuring plants height, counting the number of emerged leaves (lettuce, tomatoes and peppers) and quantifying production (tomatoes and peppers). No disease symptoms were found during production, although Fusarium sp. strains pathogenic to tomato were detected in the soil. Compounds containing copper oxychloride are frequently used for fungal disease control in agriculture. In order to investigate the compatibility of T. harzianum T22 and T. atroviride P1 with copper oxychloride applications, the effect on mycelia growth was monitored in both liquid and solid medium. In general, the tests indicated a high level of tolerance of the Trichoderma strains to concentrations of copper oxychloride varying from 0.1 to 5 mmol/L. | Francesco Vinale Gaetano D'Ambrosio Khalid Abadi Felice Scala Roberta Marra David Turrà Sheridan L Woo Matteo Lorito | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 7 |
| 6 | The Long Noncoding MALAT-1 RNA Indicates a Poor Prognosis in Non-small Cell Lung Cancer and Induces Migration and Tumor Growth显示文摘 | Lars Henning Schmidt Tilmann Spieker Steffen Koschmieder Julia Humberg Dominik Jungen Etmar Bulk Antje Hascher Danielle Wittmer Alessandro Marra Ludger Hillejan Karsten Wiebe Wolfgang E. Berdel Rainer Wiewrodt Carsten Muller-Tidow | 2011 | Journal of Thoracic Oncology2011，，12： | 6 |
| 7 | The genome sequence of the SARS-associated coronavirus显示文摘 | Marra M A Jones S J Astell C R | | 0，，： | 6 |
| 8 | Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells显示文摘 | Erica Novo Stefania Cannito Elena Zamara Lorenzo Valfrè di Bonzo Alessandra Caligiuri Carlo Cravanzola Alessandra Compagnone Sebastiano Colombatto Fabio Marra Massimo Pinzani Maurizio Parola | 2007 | The American Journal of Pathology2007，，6： | 6 |
| 9 | 20例原发性脑脓肿立体定向治疗的临床观察显示文摘目的探讨立体定向引流技术治疗原发性脑脓肿的临床效果。方法回顾分析20例原发性脑脓肿患者立体定向治疗资料,脓液进行细菌培养病原体分析。结果本组病人无1例死亡,术前颅内压增高者症状很快消失,2例术后发生癫痫。随访1~15年,所有患者均未出现脓肿复发,局灶性神经功能缺损者病例症状完全消失。16例吸取脓液的细菌培养结果为阴性4,例培养阳性患者分别是葡萄球菌、β-溶血性链球菌、肺炎球菌和非溶血性链球菌。结论无菌的脑脓肿即使没有存活的细菌仍然可能表现出自我维持增长的病变趋势。立体定向引流治疗可通过吸取病灶内壁周围的感染刺激因子而达到治疗目的。 | 马辉 夏鹤春 付健敏 孙涛 贾培磊 Carlo Marras Angelo Franzini | 2010 | 宁夏医科大学学报2010，32，9： | 5 |
| 10 | Voltage rise mitigation for solar PV integration at LV grids Studies from PVNET.dk显示文摘Solar energy from photovoltaic(PV)is among the fastest developing renewable energy systems worldwide.Driven by governmental subsidies and technological development,Europe has seen a fast expansion of solar PV in the last few years.Among the installed PV plants,most of them are situated at the distribution systems and bring various operational challenges such as power quality and power flow management.The paper discusses the modelling requirements for PV system integration studies,as well as the possible techniques for voltage rise mitigation at low voltage(LV)grids for increasing PV penetration.Potential solutions are listed and preliminary results are presented. | Guangya YANG Francesco MARRA Miguel JUAMPEREZ Søren Bækhøj KJÆR Seyedmostafa HASHEMI JacobØSTERGAARD Hans Henrik IPSEN Kenn H.B.FREDERIKSEN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 5 |
| 11 | Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms显示文摘Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:'F'and'f'for Fok I,'B'and'b'for Bsm I,'A'and'a'for ApaI,and 'T'and't'for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future. | Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni Chiriacò Diego Serraino Carla Di Loreto Sabina Cauci | 2017 | Cancer Biology & Medicine2017，14，2： | 5 |
| 12 | Cognitive impairment in chronic obstructive pulmonary disease显示文摘 | Raffaele Antonelli Incalzi Camillo Marra Alessandro Giordano Maria Lucia Calcagni Antonella Cappa Salvatore Basso Gabriella Pagliari Leonello Fuso | 2003 | Journal of Neurology2003，，3： | 2 |
| 13 | Satellite monitoring of land-use and land-cover changes in northern Togo protected areas显示文摘Remote-sensing data for protected areas in northern Togo, obtained in three different years(2007, 2000, and 1987), were used to assess and map changes in land cover and land use for this drought prone zone. The normalized difference vegetation index(NDVI) was applied to the images to map changes in vegetation. An unsupervised classification, followed by classes recoding, filtering, identifications, area computing and post-classification process were applied to the composite of the three years of NDVI images. Maximum likelihood classification was applied to the 2007 image(ETM+2007) using a supervised classification process. Seven vegetation classes were defined from training data sets. The seven classes included the following biomes: riparian forest, dry forest, flooded vegetation, wooded savanna, fallows, parkland, and water. For these classes, the overall accuracy and the overall kappa statistic for the classified map were 72.5% and 0.67, respectively. Data analyses indicated a great change in land resources; especially between 1987 and 2000 probably due to the impact of democratization process social, economic, and political disorder from 1990. Wide-scale loss of vegetation occurred during this period. However, areas of vegetation clearing and regrowth were more visible between 2000 and 2007. The main source of confusion in the contingency matrix was due to heterogeneity within certain classes. It could also be due to spectral homogeneity among the classes. This research provides a baseline for future ecological landscape research and for the next management program in the area. | Fousseni Folega Chun-yu Zhang Xiu-hai Zhao Kperkouma Wala Komlan Batawila Hua-guo Huang Marra Dourma Koffi Akpagana | 2014 | Journal of Forestry Research2014，25，2： | 2 |
| 14 | Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer显示文摘 | F. Marra T. Steffen N. Kalak R. Warschkow I. Tarantino J. Lange M. Zünd | 2009 | European Journal of Surgical Oncology2009，，10： | 2 |
| 15 | Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications显示文摘意义和在长期的细菌的前列腺炎的精液分析的诊断价值广泛地被辩论了并且仍然保持争论。在前列腺炎病人的细菌学的 workup 调查精液文化的诊断关联,我们回顾地分析了 696 个征兆的病人的一个临床的数据库。所有病人习惯性地受到四眼镜的测试,由精液文化和分析列在后面。这允许从数据库把,并且把三种不同诊断情形测试的“二眼镜”的 pre-/post- 按摩和标准“四眼镜”的测试与“五眼镜”的测试(四眼镜的正 post-VB3 精液文化) 作比较。“五眼镜”的测试在相对敏感和更小的减小显示出 3.6 褶层或 6.5 褶层增加(在为传统的 uropathogens (TU ) 的相对特性的 -13.2% 或 -14.7%) 与四眼镜或二眼镜的测试相比分别地。在 ROC 曲线和 Jouden 下面的区域是索引而积极、否定的可能性的比率比比较仪低,被增加,显示“五眼镜”的试金可能在证实两标准测试的否定结果是优异的。五 -- ,四 -- ,并且二眼镜的测试检测了 TU (Enterobacteriaceae, Enterococci,等等) 在在 130, 56,和 45 个病人的 120, 33,和 20 个病人和不平常的病原体(Streptococci,另外的克积极的种类, Mycoplasmata,和其它) 分别地。当病人们受到药理学治疗时,包括 fluoroquinolone 和 macrolide 的联合,处于根除率的差别都没在与不同测试诊断的组之间被观察,不管病原体范畴。根除与长期的症状 / 症状宽恕被联系;在症状 / 症状分数的重要团体之间的差别都没在整个一个 24 月的离开治疗后续时期被观察。在结论,我们的数据当这测试被用来补充四眼镜的 Meares 和 Stamey 测试时,在前列腺炎病人的诊断 workup 支持精液分析的实用性。microbiological 试金的改进传送重要诊断、治疗学的含意。 | Vittorio Magri Florian M. E. Wagenlehner Emanuele Montanari Emanuela Marras Viviana Orlandi Antonella Restelli Erminio Torresani Kurt G. Naber Gianpaolo Perletti | 2009 | Asian Journal of Andrology2009，11，4： | 2 |
| 16 | 用于脂肪移植及脂肪干细胞分离获取与处理技术的对比显示文摘背景与目的脂肪获取和处理技术的差异可能会影响脂肪移植的成功率。本研究利用裸鼠模型,对比不同处理方法获取的脂肪移植物的性质,并评估移植脂肪组织中存活组织的体积。方法第一阶段,通过负压吸引辅助脂肪抽吸或超声辅助脂肪抽吸2种方式获取脂肪,并利用2种孔隙尺寸的筛网进行过滤。对移植材料的如下方面进行分析:平均团块大小,油脂、脂肪和水溶性成分的构成比,以及基质血管细胞群(stromalvascularfraction,SVF)的产量。将过滤物及滤液注入无胸腺的裸鼠皮下。第二阶段,将仅通过负压吸引吸脂术中获取脂肪抽吸物,进行离心、纱布摇匀或过滤处理,然后利用相似的规范进行研究。结果与负压吸引脂肪抽吸术相比,超声辅助的脂肪抽吸术获取的脂肪在SVF含量和脂肪移植体内研究成活量情况均相似。通过超声辅助的脂肪抽吸术仅比负压脂肪抽吸术产生稍微多的油脂;通过500μm或800μm孔径的滤网进行过滤均可有效去除液体和油脂。利用纱布法处理的脂肪,其体内移植成活率和SVF产量均最高。对所有移植物的组织学分析均显示为完整的脂肪组织。结论通过超声辅助及负压吸引行脂肪抽吸术获取的脂肪,其在异种移植模型中具有相似的成活率。对于少量填充移植而要求最佳成活率的身体敏感区域而言,利用纱布摇匀的处理方式可能是用于美容性脂肪移植的最佳方法。过滤法和离心法均可有效去除液体成分,其处理过的脂肪具有相似的移植成活率,当所需移植体积较大时,这2种方法均可行。 | Christine Fisher Tara L. Grahovac Mark E. Schafer Ron D. Shippert Kacey G. Marra J. Peter Rubin 魏峰 高景恒 张晨 | 2014 | 中国美容整形外科杂志2014，25，4： | 2 |
| 17 | Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease显示文摘 | P. Loria L.E. Adinolfi S. Bellentani E. Bugianesi A. Grieco S. Fargion A. Gasbarrini C. Loguercio A. Lonardo G. Marchesini F. Marra M. Persico D. Prati G. Svegliati- Baroni | 2010 | Digestive and Liver Disease2010，，4： | 2 |
| 18 | Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?显示文摘 | G. Targher F. Marra G. Marchesini | 2008 | Diabetologia2008，，11： | 2 |
| 19 | Therapeutic application of stem cells in gastroenterology:An up-date显示文摘Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastro-enterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immunemediated conditions,further studies are needed to fully understand the biology of stem cellsand carefully assess their put ativeonco- genicproperties.Moreover,there searchonstemcellsarousesferventethical,socialandpoliticaldebate.TheItalianSocietyofGastroenterologysponsoredaworkshoponstemcellsheldinVeronaduringtheⅩⅥCongressoftheFederationofItalianSocietiesofDigestiveDiseases(March 6-9,2010).Here,we report on the issues discussed,including liver and intestinal diseases that may benefit from stemcell therapy,the biology of hepatic and intestinal tissue repair,and stem cell usage inclinical trials. | Patrizia Burra Debora Bizzaro Rachele Ciccocioppo Fabio Marra Anna Chiara Piscaglia Laura Porretti Antonio Gasbarrini Francesco Paolo Russo | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 20 | Long Term Evaluation of Green Vegetation Cover Dynamic in the Atacora Mountain Chain(Togo) and its Relation to Carbon Sequestration in West Africa显示文摘The research was done in the Atacora Mountain chain in Togo which tended to assess the change of vegetation cover during a 24-year period.It also aims to evaluate the dynamic of the net primary productivity(NPP) of the living plants over the same period.The Landsat imagery covering three different periods(1987, 2000, and 2011) was pre-processed to correct atmospheric and radiometric parameters as well as gapfilling the 2011 SCL-off images.Then, the vegetation indices such as NDVI(normalized difference vegetation index), SR(simple ratiovegetation index), SAVI(soil-adjusted vegetation index), and CASA(carnegie- ames- stanford approach)model for NPP were applied on these images after masking the study area.The results showed a quiet decrease in the vegetation cover.The vegetation loss was more significant from 2000 to 2011 than from1987 to 2000, and anthropogenic activities can be deemed as the main cause of the vegetation loss.The biomass assessment by NPP computation also showed a decrease over the time.Similar to the change of the vegetation cover, the ecosystem net productivity was very low in 2011 compared to 2000 and 1987.It seems that the general health condition of thevegetation, including its potentiality in carbon sinking,was negatively affected in this area, which has already been under threatened.A perpetual monitoring of these ecosystems by means of efficient techniques could enhance the sustainable management tools of in the framework of reducing emissions from deforestation and forest degradation(REDD). | Fousseni FOLEGA Yao Agbélessessi WOEGAN Dourma MARRA Kperkouma WALA Komlan BATAWILA Jean Leonardo SEBURANGA ZHANG Chun-yu PENG Dao-li ZHAO Xiu-hai Koffi AKPAGANA | 2015 | Journal of Mountain Science2015，12，4： | 2 |
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