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| 1 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome显示文摘 | Mark Pimentel Evelyn J Chow Henry C Lin | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 3 | Methane Production During Lactulose Breath Test Is Associated with Gastrointestinal Disease Presentation显示文摘 | Mark Pimentel Andrew G. Mayer Sandy Park Evelyn J. Chow Aliya Hasan Yuthana Kong | 2003 | Digestive Diseases and Sciences2003，，： | 2 |
| 4 | Rifaximin versus Other Antibiotics in the Primary Treatment and Retreatment of Bacterial Overgrowth in IBS显示文摘 | Janet Yang Hyo-Rang Lee Kimberly Low Soumya Chatterjee Mark Pimentel | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 5 | “Pre-cebo”: An Unrecognized Issue in the Interpretation of Adequate Relief During Irritable Bowel Syndrome Drug Trials显示文摘 | Sharon E. Kim Scott Kubomoto Kathleen Chua Meridythe M. Amichai Mark Pimentel | 2012 | Journal of Clinical Gastroenterology2012，，8： | 1 |
| 6 | Report From the Multinational Irritable Bowel Syndrome Initiative 2012显示文摘 | Mark Pimentel Nicholas J. Talley Eamonn M.M. Quigley Albis Hani Ala Sharara Varocha Mahachai | 2013 | Gastroenterology2013，，7： | 1 |
| 7 | Proton Pump Inhibitor Therapy Does Not Affect Hydrogen Production on Lactulose Breath Test in Subjects with IBS显示文摘 | David Law Mark Pimentel | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
| 8 | Identification of a prodromal period in Crohn’s disease but not ulcerative colitis显示文摘 | Mark Pimentel Michael Chang Evelyn J Chow Siamak Tabibzadeh Viorelia Kirit-Kiriak Stephan R Targan Henry C Lin | 2000 | The American Journal of Gastroenterology2000，，12： | 1 |
| 9 | Methane and the Gastrointestinal Tract显示文摘 | Ara B. Sahakian Sam-Ryong Jee Mark Pimentel | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
| 10 | Inflammation and Microflora显示文摘 | Mark Pimentel Christopher Chang | 2011 | Gastroenterology Clinics of North America2011，，1： | 1 |
| 11 | A new rat model links two contempo rary theories in irritable bowel syndrome显示文摘 | MARK PIMENTEL SOUMYA CHATTERJEE CHRISTO PHER CHANG | 2008 | Digestive Disea ses and Sciences2008，53，4： | 1 |
| 12 | Abnormal Breath Testing in IBS: A Meta-Analysis显示文摘 | Eric D. Shah Robert J. Basseri Kelly Chong Mark Pimentel | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 13 | Rifaximin versus Other Antibiotics in the Primary Treatment and Retreatment of Bacterial Overgrowth in IBS显示文摘 | Janet Yang Hyo-Rang Lee Kimberly Low Soumya Chatterjee Mark Pimentel | 2008 | Digestive Diseases and Sciences2008，，： | 1 |
| 14 | A New Rat Model Links Two Contemporary Theolqes in Irritable Bowel Syn- drome显示文摘 | Mark Pimentel Soumya Chatterjee Christopher Chang | 2008 | Digestive Diseases and Sciences2008，53，4： | 1 |
| 15 | A 14-Day Elemental Diet Is Highly Effective in Normalizing the Lactulose Breath Test显示文摘 | Mark Pimentel Tess Constantino Yuthana Kong Meera Bajwa Abolghasem Rezaei Sandy Park | 2004 | Digestive Diseases and Sciences2004，，1： | 1 |
| 16 | Antibiotic Treatment of Constipation-Predominant Irritable Bowel Syndrome显示文摘 | Mark Pimentel Christopher Chang Kathleen Shari Chua James Mirocha John DiBaise Satish Rao Meridythe Amichai | 2014 | Digestive Diseases and Sciences2014，，： | 1 |
| 17 | Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome显示文摘 | Mark Pimentel Evelyn J Chow Henry C Lin | 2000 | The American Journal of Gastroenterology2000，，： | 1 |
| 18 | Lower Frequency of MMC Is Found in IBS Subjects with Abnormal Lactulose Breath Test, Suggesting Bacterial Overgrowth显示文摘 | Mark Pimentel Edy E. Soffer Evelyn J. Chow Yuthana Kong Henry C. Lin | 2002 | Digestive Diseases and Sciences2002，，12： | 1 |
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