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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | 沥青混合料低温临界开裂温度的确定显示文摘为了同时考虑沥青混合料在降温过程中温度应力的累积和松弛作用,确定临界开裂温度,对试件进行了线收缩系数试验,并利用间接拉伸试验确定其抗拉强度和蠕变柔量,由蠕变柔量和松弛模量的关系得到松弛模量的Prony系列表达式;由Boltzmann叠加原理,得到温度应力公式,计算出不同降温速率下产生的温度应力,根据低温抗拉强度曲线,确定出沥青混合料的临界开裂温度,并对结果予以验证。结果表明:该方法考虑了应力累积和松弛二者的综合作用,能够较好地反映沥青混合料的低温开裂特性,其计算结果与约束试件温度应力试验结果相近;该方法不仅适用于恒定降温速率,还适用于现场连续变速降温工况;随温度的降低或降温速率的增加沥青混合料内部温度应力累积速度加快,临界开裂温度随降温速率增加而升高。 | 付国志 曹丹丹 赵延庆 ALAE Mohsen | 2019 | 复合材料学报2019，36，4： | 11 |
| 3 | Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning显示文摘Background: There is increasing research interest in using short-chain fatty acids(SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate(SB) in liquid feeds(milk, milk replacer, and the mixture of both)on the growth performance, rumen fermentation, and serum antioxidant capacity and immunoglobins in dairy calves before weaning. Forty healthy female Holstein calves(4-day-old, 40 ± 5 kg of body weight) were housed in individual hutches and randomly allocated to 1 of 4 treatment groups(n = 10 per group) using the RAND function in Excel. The control group was fed no SB(SB0), while the other three groups were supplemented with 15(SB15),30(SB30), or 45(SB45) g/d of SB mixed into liquid feeds offered. The calves were initially fed milk only(days 2 to 20), then a mixture of milk and milk replacer(days 21 to 23), and finally milk replacer only(days 24 to 60).Results: The SB supplementation enhanced growth and improved feed conversion into body weight gain compared with the SB0 group, and the average daily gain increased quadratically with increasing SB supplementation. No significant effect on rumen pH;concentrations of NH_3-N, individual and total VFAs;or acetate:propionate(A:P) ratio was found during the whole experimental period. Serum glutathione peroxidase activity increased linearly with the increased SB supplementation, while the serum concentration of maleic dialdehyde linearly decreased. Serum concentrations of immunoglobulin A, immunoglobulin G, or immunoglobulin M were not affected by the SB supplementation during the whole experimental period.Conclusions: Under the conditions of this study, SB supplementation improved growth performance and antioxidant function in pre-weaned dairy calves. We recommended 45 g/d as the optimal level of SB supplementation mixed into liquid feeds(milk or milk replacer) to improve the growth and antioxidant function of dairy calves before weaning. | Wenhui Liu ALa Teng Zhu La Alexander Evans Shengtao Gao Zhongtang Yu Dengpan Bu Lu Ma | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 10 |
| 4 | 内蒙古额济纳盆地戈壁10Be暴露年龄与洪积作用的演化显示文摘重建干旱地区洪积成因戈壁的形成历史能够揭示控制洪积作用时空演化的构造、气候变化.对额济纳盆地不同地貌单元的戈壁石英砾石宇宙成因核素10Be浓度的测量和暴露年龄的估算表明,盆地北缘戈壁阿尔泰洪积平原上的戈壁至少在420ka前就已出现;而盆地内黑河流域洪积平原上的戈壁则形成于约190ka以来,并逐步向北和向东现代低海拔、尾闾湖方向发展,这种演化趋势可能是在青藏高原隆升和盆地内构造活动的影响下洪积作用和洪积扇发育空间变化的结果;420ka以来气候冰期/间冰期的冷暖旋回造成的周边高山地区冰川的前进与后退,可能主导了盆地洪积作用的强弱变化和水体的大小,大规模、高能量的洪水主要发生在高山冰雪消融时期(冰消期),可能也是盆地水体最大时期. | 吕延武 顾兆炎 ALDAHAN Ala 张虎才 POSSNERT Goran 雷国良 | 2010 | 科学通报2010，55，27： | 10 |
| 5 | Use of rifaximin in gastrointestinal and liver diseases显示文摘Rifaximin is a broad spectrum oral antibiotic with antimicrobial activity against Gram-positive and Gramnegative aerobic and anaerobic bacteria. It is poorly absorbed and thus has a highly favorable safety profile. Rifaximin has been shown to be effective in the treatment of traveler's diarrhea, functional bloating and irritable bowel syndrome, small bowel bacterial overgrowth and in the prevention of recurrent overt hepatic encephalopathy. In addition, there is emerging evidence for a possible beneficial effect of rifaximin in the treatment of uncomplicated diverticular disease and in the prevention of recurrent diverticulitis. The use of rifaximin is associated with a low incidence of development, or persistence of spontaneous bacterial mutants. Moreover, the development of important drug resistance among extra-intestinal flora during rifaximin therapy is unlikely because of minimal systemic absorption and limited cross-resistance of rifaximin with other antimicrobials. This review addresses the current and emerging role of rifaximin in the treatment of gastrointestinal and liver disorders. | Rani H Shayto Rachel Abou Mrad Ala I Sharara | 2016 | World Journal of Gastroenterology2016，22，29： | 10 |
| 6 | Role of vitamins in gastrointestinal diseases显示文摘A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases.For instance,most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials,however interventional trials failed to prove a clear beneficial preventive role.On the other hand,more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities.Examples for this include the therapeutic role of vitamin E in patients with nonalcoholic steatohepatitis,the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus,the role of vitamin C in reducing the risk of gallstones,the positive outcome with vitamin B12 in patients with aphthous stomatitis,and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease.Other potential uses are yet to be elaborated,like those on celiac disease,pancreatic cancer,pancreatitis,cholestasis and other potential fields.Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years.Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost,their use should be encouraged in the fields where positive data are available. | Omar A Masri Jean M Chalhoub Ala I Sharara | 2015 | World Journal of Gastroenterology2015，21，17： | 8 |
| 7 | Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions显示文摘Obesity is a global health epidemic with considerable economic burden.Surgical solutions have become increasingly popular following technical advances leading to sustained efficacy and reduced risk.Sleeve gastrectomy accounts for almost half of all bariatric surgeries worldwide but concerns regarding its relationship with gastroesophageal reflux disease(GERD)has been a topic of debate.GERD,including erosive esophagitis,is highly prevalent in the obese population.The role of pre-operative endoscopy in bariatric surgery has been controversial.Two schools of thought exist on the matter,one that believes routine upper endoscopy before bariatric surgery is not warranted in the absence of symptoms and another that believes that symptoms are poor predictors of underlying esophageal pathology.This debate is particularly important considering the evidence for the association of laparoscopic sleeve gastrectomy(LSG)with de novo and/or worsening GERD compared to the less popular Roux-en-Y gastric bypass procedure.In this paper,we try to address 3 burning questions regarding the inter-relationship of obesity,GERD,and LSG:(1)What is the prevalence of GERD and erosive esophagitis in obese patients considered for bariatric surgery?(2)Is it necessary to perform an upper endoscopy in obese patients considered for bariatric surgery?And(3)What are the long-term effects of sleeve gastrectomy on GERD and should LSG be done in patients with pre-existing GERD? | Halim Bou Daher Ala I Sharara | 2019 | World Journal of Gastroenterology2019，25，33： | 6 |
| 8 | Use of platelet lysate for bone regeneration-are we ready for clinical translation?显示文摘Current techniques to improve bone regeneration following trauma or tumour resection involve the use of autograft bone or its substitutes supplemented with osteoinductive growth factors and/or osteogenic cells such as mesenchymal stem cells(MSCs).Although MSCs are most commonly grown in media containing fetal calf serum,human platelet lysate(PL) offers an effective alternative.Bone marrow- derived MSCs grown in PLcontaining media display faster proliferation whilst maintaining good osteogenic differentiation capacity.Limited pre-clinical investigations using PL-expanded MSCs seeded onto osteoconductive scaffolds indicate good potential of such constructs to repair bone in vivo.In an alternative approach,nude PL-coated scaffolds without seeded MSCs have been proposed as novel regenerative medicine devices.Even though methods to coat scaffolds with PL vary,in vitro studies suggest that PL allows for MSC adhesion,migration and differentiation inside these scaffolds.Increased new bone formation and vascularisation in comparison to uncoated scaffolds have also been observed in vivo.This review outlines the state-of-the-art research in the field of PL for ex vivo MSC expansion and in vivo bone regeneration.To minimise inconsistency between the studies,further work is required towards standardisation of PL preparation in terms of the starting material,platelet concentration,leukocyte depletion,and the method of platelet lysis.PL quality control procedures and its 'potency' assessment are urgently needed,which could include measurements of key growth and attachment factors important for MSC maintenance and differentiation.Furthermore,different PL formulations could be tailor-made for specific bone repair indications.Such measures would undoubtedly speed up clinical translation of PL-based treatments for bone regeneration. | Ala Altaie Heather Owston Elena Jones | 2016 | World Journal of Stem Cells2016，8，2： | 6 |
| 9 | ^(10)Be in quartz gravel from the Gobi Desert and evolutionary history of alluvial sedimentation in the Ejina Basin,Inner Mongolia,China显示文摘Reconstructing the evolutionary history of the Gobi deserts developed from alluvial sediments in arid regions has great significance in unraveling changes in both tectonic activity and climate.However,such work is limited by a lack of suitable dating material preserved in the Gobi Desert,but cosmogenic 10Be has great potential to date the Gobi deserts.In the present study,10Be in quartz gravel from the Gobi deserts of the Ejina Basin in Inner Mongolia of China has been measured to assess exposure ages.Results show that the Gobi Desert in the northern margin of the basin developed 420 ka ago,whereas the Gobi Desert that developed from alluvial plains in the Heihe River drainage basin came about during the last 190 ka.The latter developed gradually northward and eastward to modern terminal lakes of the river.These temporal and spatial variations in the Gobi deserts are a consequence of alluvial processes influenced by Tibetan Plateau uplift and tectonic activities within the Ejina Basin.Possible episodes of Gobi Desert development within the last 420 ka indicate that the advance/retreat of alpine glaciers during glacial/interglacial cycles might have been the dominant factor to influencing the alluvial intensity and water volume in the basin.Intense floods and large water volumes would mainly occur during the short deglacial periods. | LU YanWu GU ZhaoYan ALDAHAN Ala ZHANG HuCai POSSNERT Goran LEI GuoLiang | 2010 | Chinese Science Bulletin2010，55，33： | 6 |
| 10 | 三座多跨简支桥抗震性能和承载力/需求分析显示文摘介绍新泽西州三座多跨简支桥的地震响应。主要目标是确定各种构件的承载力/需求比以评估地震的易损性和研究修复策略。另外一个主要目标是研究这些响应特性的效果,对这类桥的地震性能分析上响应特性是唯一的。此外,考虑桥与桥墩之间的刚性界面,对建模方法的效果和采用现有的需求曲线进行推覆分析的适当性也进行分析。研究包括具有代表性的三座2~4跨桥的非线性时程分析,这类桥在新泽西州和美国东部普遍存在。为了评估建模的效果,2维和3维建模分别被应用。许多参数被证明对多跨简支桥梁的地震响应有重大影响,例如,土与结构物的相互作用、邻跨之间的影响、钢支座和桥墩的可塑性。因此,根据综合参数研究,通过采用承载力/需求比对关键元素的量化,评估多跨简支桥的地震响应。此外,对与地震评估、修复和多跨简支桥设计有关的研究也进行了论述。 | M. Ala Saadeghvaziri A.R. Yazdani-Motlagh | 2008 | 钢结构2008，23，8： | 5 |
| 11 | Robust Leader-Following Output Regulation of Uncertain Multi-Agent Systems With Time-Varying Delay显示文摘In this paper, the robust analysis and design of leader-following output regulation for multi-agent systems described by general linear models is given in presence of timevarying delay and model uncertainty. To this aim, a new regulation protocol for the closed-loop multi-agent system under a directed graph is proposed. An important specification of the proposed protocol is to guarantee the leader-following output regulation for uncertain multi-agent systems with both stable and unstable agents. Since many signals can be approximated by a combination of the stationary and ramp signals, the presented results work for adequate variety of the leaders. The analysis and design conditions are presented in terms of certain matrix inequalities. The method proposed can be used for both stationary and ramp leaders. Simulation results are presented to show the effectiveness of the proposed method. | Ala Shariati Qing Zhao | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，4： | 5 |
| 12 | Accuracy of space-for-time substitution for vegetation state prediction following shrub restoration显示文摘Aims:Space-for-time substitution(SFT)is often used for vegetation status estimation during the recovery process of deserts.However,the evaluated accuracy of SFT remains uncertain.An eight-year located observation was used to assess the validity of SFT for vegetation state prediction.Methods:This study analyzed a chronosequence of Caragana microphylla Lam.plantings using the located observation method to test the accuracy of SFT for vegetation state prediction in the mobile sand dunes of the Horqin Sandy Land in northeastern China from July 2005 to June 2013.Important Findings:According to SFT,simple vegetation parameters(density,coverage and biomass)were found to be unstable,while sophisticated veg-etation parameters(species diversity and evenness)were relatively stable across the experimental treatments during the study period.Conversely,both the simple and sophisticated parameters were found to be relatively stable when tested using the located obser-vation method.Furthermore,most simple vegetation parameters slightly increased,while sophisticated parameters slightly decreased after eight years of field observations.Thus,long-term restoration management facilitated improvements in the simple parameters,but may have adversely impacted the sophisticated parameters in the post-restoration community.Our results suggest that sophisticated vegetation parameter states can be predicted by SFT,while simple vegetation parameter states are not well predicted by SFT.in conclusion,located observations or other effective evaluation methods must be employed to offset the deficiency of the SFT method for the prediction of vegetation parameters. | Renhui Miao Xueli Qiu Meixia Guo Ala Musa Deming Jiang | 2018 | Journal of Plant Ecology2018，11，2： | 5 |
| 13 | The Effects of Groundwater Depth on the Soil Evaporation in Horqin Sandy Land, China显示文摘The interactions between groundwater depth and soil hydrological processes, play an important role in both arid and semi-arid ecosystems. The effect of groundwater depth on soil water variations were neglected or not explicitly treated. In this paper, we combine a simulation experiment and a water flow module of HYDRUS-1D model to study the variation in soil evaporation under different groundwater depth conditions and the relationship between groundwater depth and evaporation efficiency in Horqin Sandy Land, China.The results showed that with an increase in groundwater depth, the evaporation of soil and the recharge of groundwater decrease. In this study, the groundwater recharge did not account for more than 21% of the soil evaporation for the depths of groundwater examined. The soil water content at 60 cm was less affected by the evaporation efficiency when the mean groundwater depth was 61 cm during the experimental period. In addition, the evaporation efficiency(the ratio of actual evaporation to potential evaporation) decreases with the increase in groundwater depth during the experiment. Furthermore, the soil evaporation was not affected by groundwater when the groundwater depth was deeper than 239 cm. | YANG Tingting ALA Musa GUAN Dexin WANG Anzhi | 2021 | Chinese Geographical Science2021，31，4： | 5 |
| 14 | Synthesis of Single-Walled Carbon Nanotubes by Induction Thermal Plasma显示文摘The production of high quality single-walled carbon nanotubes(SWCNTs)on a bulk scale has been an issue of considerable interest.Recently,it has been demonstrated that high quality SWCNTs can be continuously synthesized on large scale by using induction thermal plasma technology.In this process,the high energy density of the thermal plasma is employed to generate dense vapor-phase precursors for the synthesis of SWCNTs.With the current reactor system,a carbon soot product which contains approximately 40 wt%of SWCNTs can be continuously synthesized at the high production rate of~100 g/h.In this article,our recent research efforts to achieve major advances in this technology are presented.Firstly,the processing parameters involved are examined systematically in order to evaluate their individual inuences on the SWCNT synthesis.Based on these results,the appropriate operating conditions of the induction thermal plasma process for an effective synthesis of SWCNTs are discussed.A characterization study has also been performed on the SWCNTs produced under the optimum processing conditions.Finally,a mathematical model of the process currently under development is described.The model will help us to better understand the synthesis of SWCNTs in the induction plasma process. | Keun Su Kim Ala Moradian Javad Mostaghimi Yasaman Alinejad Ali Shahverdi Benoit Simard Gervais Soucy | 2009 | Nano Research2009，2，10： | 4 |
| 15 | 基于MEPDG的温拌发泡沥青混合料性能研究显示文摘为探究泡沫沥青温拌技术对沥青混合料性能及沥青路面设计厚度的影响,通过力学-经验路面设计指南(MEPDG)软件对温拌发泡沥青混合料(WMA Foam)路面和热拌沥青混合料(HMA)路面在相同设计条件下的车辙、疲劳开裂以及国际平整度指标(IRI)等进行预测比较,并根据MEPDG路面设计方法分别得出了温拌发泡沥青混合料和热拌沥青混合料在相同情况下的路面设计厚度。结果表明:采用石灰岩碎石作集料时,WMA Foam与HMA表现出相近的性能。而对以天然砾石为集料的PG 64-22原样沥青混合料,发泡沥青温拌技术的采用使得混合料的车辙深度和国际平整度指数(IRI)相比HMA混合料有显著增加。此外,采用天然砾石和PG 64-22原样沥青的温拌发泡沥青路面设计厚度远大于对应热拌沥青路面的设计厚度。 | 周维祥 Munir Nazzal Ala R.Abbas Ayman W.Ali Arjun Roy | 2016 | 中外公路2016，36，4： | 4 |
| 16 | 赫尔辛基Oodi中央图书馆显示文摘1建筑设计概念这是图书馆的新纪元。赫尔辛基Oodi中央图书馆坐落于赫尔辛基市中心,几乎全部由公共空间组成,同时也提供了多种多样的功能服务供选择。图书馆的主体功能被分为三个不同的层次:活跃的首层、平静的顶层以及这两层之间包含更多具体功能的封闭体块。这样的功能布局衍生出一个拱形的空间形式,吸引人们使用其上、下和内部的不同功能空间。 | ALA Architects 建筑事务所 侯梦瑶(译) | 2019 | 建筑技艺2019，0，4： | 3 |
| 17 | Wilson’s disease显示文摘 | Aftab Ala Ann P Walker Keyoumars Ashkan James S Dooley Michael L Schilsky | 2007 | The Lancet . 2007 (9559)2007，，9559： | 3 |
| 18 | Hepatocellular carcinoma in Lebanon: Etiology and prognostic factors associated with short-term survival显示文摘瞄准:在黎巴嫩和早死亡预兆的预示的因素学习 HCC 的传染病学。方法:在一个五年的时期上诊断的 HCC 盒子的观察后续队研究被执行。Multivariate 分析被进行与肝意大利的程序(片断) 分数的癌症相比识别预示的因素。包括内在的肝疾病,病人的人口统计的特征,和孩子呸评估的肝疾病的严厉的病原学的多重变量得分被学习。肿瘤参数包括了小瘤,门静脉血栓的存在,和治疗形式的 HCC, alpha-fetoprotein 水平,数字和尺寸的诊断的时间。后续的死亡或损失被看作一个端点事件。结果:92 个病人(平均数 60.5 +/- 22.3 年) 被包括。内在的疾病的病原学分别地是在 67% , 20% ,和 23.5% 的肝炎 B, C,和酒精。在诊断的孩子呸班分别地是在 34.8% , 39.3% 和 25.8% 的 A, B,和 C。全面幸存分别地在 1, 2 和 3 年是 44.8% , 32.8% 和 17.6%( 吝啬的 F/U 40.2 +/- 23.5 瞬间) 。Multivariate 分析识别了早死亡的三个预言者(<
6 瞬间) :胆红素 >
3.2 mg/dL (P <
0.01 ) , HCC 作为肝疾病的第一个演讲(P = 0.035 ) ,并且肌酸酐 >
1 mg/dL (P = 0.017 ) 。一个分数由考克斯基于这些变量超过了片断分数比例的危险。巨鸟曲线显示了两个模型相等、中等精确。结论:HBV 是在黎巴嫩的 HCC 的领先的原因。早死亡的独立预言者是象疾病的第一表明的提高的胆红素,肌酸酐和 HCC。一个分数的未来的确认基于在预言短期的幸存的这些临床的参数被需要。 | César Yaghi Ala I Sharara Paul Rassam Rami Moucari Khalil Honein Joseph BouJaoude Rita Slim Roger Noun Heitham Abdul-Baki Mohamad Khalifeh Sami Ramia Raymond Sayegh | 2006 | World Journal of Gastroenterology2006，12，22： | 3 |
| 19 | 正磷酸活化木质素吸附Cr(Ⅵ)的固定床实验和模型(英文)显示文摘The advantage of using an available and abundant residual biomass,such as lignin,as a raw material for activated carbons is that it provides additional economical interest to the technical studies.In the current investigation,a more complete understanding of adsorption of Cr(VI) from aqueous systems onto H3PO4-acid activated lignin has been achieved via microcolumns,which were operated under various process conditions.The practice of using microcolumn is appropriate for defining the adsorption parameters and for screening a large number of potential adsorbents.The effects of solution pH(2-8),initial metal ion concentration(0.483-1.981 mmol·L-1),flow rate(1.0-3.1 cm3·min-1),ionic strength(0.01-0.30 mmol·L-1) and adsorbent mass(0.11-0.465 g) on Cr(VI) adsorption were studied by assessing the microcolumn breakthrough curve.The microcolumn data were fitted by the Thomas model,the modified Dose model and the BDST model.As expected,the adsorption capacity increased with initial Cr(VI) concentration.High linear flow rates,pH values and ionic strength led to early breakthrough of Cr(VI).The model constants obtained in this study can be used for the design of pilot scale adsorption process. | Ahmad B.Albadarin Chirangano Mangwandi Ala'a H.Al-Muhtaseb Gavin M.Walker Stephen J.Allen Mohammad N.M.Ahmad | 2012 | Chinese Journal of Chemical Engineering2012，20，3： | 3 |
| 20 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
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