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| 1 | 绿色助推(英文)显示文摘我们人类当前的生活方式不是可持续的。提升可持续性的途径之一是发展更绿色的科学技术,另一种补充性途径是改变人们的态度、习惯和行为。在本文中,我们讨论了6种心理技术,其宗旨是推动或助推(nudge)人们做出更环保的选择和行为。这些心理技术涵盖范围非常广泛,有些可以远程使用,如在通知公告中建构沟通信息,有些则涉及对人们的决策情境做出的改变。因此,本综述关乎到各行业从业人员,如市场营销人员、政策制定者、消费者代表等。对于每项心理技术,我们讨论了其认知和(或)情绪的理论性基础。此外,我们探讨了目前文献中存在的空白,并提出了可填补这些空白的未来研究方向。 | Nicolao Bonini Constantinos Hadjichristidis Michele Graffeo | 2018 | 心理学报2018，50，8： | 21 |
| 2 | An alternative surgical approach to a difficult case of Mirizzi syndrome: A case report and review of the literature显示文摘Mirizzi syndrome (MS) is an uncommon complication of gallstone disease and occurs in approximately 1% of all patients suffering from cholelithiasis. The syndrome is characterized by extrinsic compression of the common hepatic duct frequently resulting in clinical presentation of intermittent or constant jaundice. Most cases are not identifi ed preoperatively. Surgery is the indicated treat- ment for patients with MS. We report here a 71-year- old male patient referred to the surgical outpatient department for diffuse upper abdominal pain and mild jaundice (bilirubin rate: 4.2 mg/dL). Ultrasound examina- tion revealed a stone in the cystic duct compressing the common hepatic duct. The patient had a history of gas- trectomy for gastric ulcer 30 years ago. MRCP revealed a stone impacted in the cystic duct causing obstruction of the common hepatic duct by extrinsic compression. With these fi ndings the preoperative diagnosis was indicative of MS. At laparotomy a moderately shrunken gallbladder was found embedded in adhesions containing a large stone which was palpable in the common bile duct. The anterior wall of the body of the gallbladder was opened by an incision which extended longitudinally along the gallbladder towards the common bile duct. The stone measuring 3.0 cm in diameter, was then removed set- ting astride a large communication with the common bile duct. A Roux-en-Y cholecysto-choledocho-jejunostomy was performed. The subhepatic region was drained. The patient had an uneventful recovery. He was discharged eleven days after operation and remained well after a 30-mo follow-up. | Michael Safioleas Michael Stamatakos Constantinos Revenas Constantinos Chatziconstantinou Constantinos Safioleas Alkiviades Kostakis | 2006 | World Journal of Gastroenterology2006，12，34： | 13 |
| 3 | Infiltrative xanthogranulomatous cholecystitis mimicking aggressive gallbladder carcinoma: A diagnostic and therapeutic dilemma显示文摘Xanthogranulomatous cholecystitis(XGC) is an uncommon variant of chronic cholecystitis. The perioperative findings in aggressive cases may be indistinguishable from those of gallbladder or biliary tract carcinomas. Three patients presented mass lesions that infiltrated the hepatic hilum,provoked biliary dilatation and jaundice,and were indicative of malignancy. Surgical excision was performed following oncological principles and included extirpation of the gallbladder,extrahepatic bile duct,and hilar lymph nodes,as well as partial hepatectomy. Postoperative morbidity was minimal. Surgical pathology demonstrated XGC and absence of malignancy in all three cases. All three patients are alive and well after years of follow-up. XGC may have such an aggressive presentation that carcinoma may only be ruled out on surgical pathology. In such cases,the best option may be radical resection following oncological principles performed by expert surgeons,in order that postoperative complications may be minimized if not avoided altogether. | Lucas Souto Nacif Amelia Judith Hessheimer Sonia Rodríguez Gómez Carla Montironi Constantino Fondevila | 2017 | World Journal of Gastroenterology2017，23，48： | 13 |
| 4 | Closure of a persistent sphincterotomy-related duodenal perforation by placement of a covered self-expandable metallic biliary stent显示文摘Retroperitoneal duodenal perforation as a result of endoscopic biliary sphincterotomy is a rare complication, but it is associated with a relatively high mortality risk, if left untreated. Recently, several endoscopic techniques have been described to close a variety of perforations. In this case report, we describe the closure of a persistent sphincterotomy-related duodenal perforation by using a covered self-expandable metallic biliary (CEMB) stent. A 61-year-old Greek woman underwent an endoscopic retrograde cholangiopancreatography (ERCP) and sphincterotomy for suspected choledo-cholithiasis, and a retroperitoneal duodenal perforation (sphincterotomy-related) occurred. Despite initial conservative management, the patient underwent a laparotomy and drainage of the retroperitoneal space. After that, a high volume duodenal fistula developed. Six weeks after the initial ERCP, the patient underwent a repeat endoscopy and placement of a CEMB stent with an indwelling nasobiliary drain. The fistula healed completely and the stent was removed two weeks later. We suggest the transient use of CEMB stents for the closure of sphincterotomy-related duodenal perforations. They can be placed either during the initial ERCP or even later if there is radiographic or clinical evidence that the leakage persists. | Antonios Vezakis Georgios Fragulidis Constantinos Nastos Anneza Yallourou Andreas Polydorou Dionisios Voros | 2011 | World Journal of Gastroenterology2011，17，40： | 11 |
| 5 | Inferior vena cava obstruction and collateral circulation as unusual manifestations of hepatobiliary cystadenocarcinoma显示文摘BACKGROUND: Hepatobiliary cystadenocarcinoma represents a rare epithelial malignant tumor derived from the intrahepatic bile duct. METHODS: A 71-year-old woman, who had undergone laparoscopic drainage of a cystic lesion of the right hepatic lobe, was misdiagnosed as having hepatic echinococcal disease, and received intracystic infusion of 95% ethanol four years ago. She was admitted to our hospital for further treatment. RESULTS: Physical examination revealed dilated superficial veins across the right abdominal wall. After mapping the direction of blood flow in these vessels, we assumed that this was a sign of inferior vena cava obstruction. Abdominal ultrasound, computed tomography, magnetic resonance imaging combined with magnetic resonance angiography showed a large cystic mass in the right upper quadrant and epigastrium, displacing the adjacent structures, adherent to the inferior vena cava, which was not patent, resulting in dilation of superficial epigastric veins. The patient underwent an exploratory laparotomy. Total excision of the huge mass measuring 16×15 cm was possible under selective vascular exclusion of the liver. Removal of the tumor resulted in immediate restoration of flow in the inferior vena cava. On the basis of the pathology and findings of immunohistochemical analysis, a hepatobiliary cystadenocarcinoma was diagnosed.CONCLUSIONS: In the present case, hepatobiliary cystadenocar-cinoma was accompanied by dilated superficial venous collaterals due to inferior vena cava obstruction. Selective vascular exclusion of the liver allowed a safe oncological resection of the tumor. | Nikolaos Arkadopoulos Anneza I Yiallourou Constantinos Palialexis Emmanouil Stamatakis Evi Kairi-Vassilatou Vassilis Smyrniotis | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 10 |
| 6 | Clinical considerations and therapeutic strategy for sigmoid volvulus in the elderly:A study of 33 cases显示文摘AIM: To evaluate different types of treatment for sigmoid volvulus and clarify the role of endoscopic intervention versus surgery. METHODS: A retrospective review of the clinical presentation and imaging characteristics of 33 sigmoid volvulus patients was presented, as well as their diagnosis and treatment, in combination with a literature review. RESULTS: In 26 patients endoscopic detorsion was achieved after the first attempt and one patient died because of uncontrollable sepsis despite prompt operative treatment. Seven patients had unsuccessful endoscopic derotation and were operated on. On two patients with gangrenous sigmoid, Hartmann's procedure was performed. In five patients with viable colon, a sigmoid resection and primary anastomosis was carried out. Three patients had a lavage 'on table' prior to anastomosis, while in the remaining 2 patients a diverting stoma was performed according to the procedure of the first author. Ten patients were operated on during their first hospital stay (3 to 8 d after the deflation). All patients had viable colon; 7 patients had a sigmoid resection and primary anastomosis, 2 patients had sigmoidopexy and one patient underwent a near-total colectomy. Two patients (sigmoidectomy-sigmoidopexy) had recurrences of volvulus 43 and 28 mo after the initial surgery. Among 15 patients who were discharged from the hospital after non-operative deflation, 3 patients were lost to follow-up. Of theremaining 12 patients, 5 had a recurrence of volvulus at a time in between 23 d and 14 mo. All the five patients had been operated on and in four a gangrenous sigmoid was found. Three patients died during the 30 d postoperative course. The remaining seven patients were admitted to our department for elective surgery. In these patients, 2 subtotal colectomies, 3 sigmoid resections and 2 sigmoidopexies were carried out. One patient with subtotal colectomy died. Taken together of the results, it is evident that after 17 elective operations we had only one death (5.9%), whereas after 15 emergency operations 6 patients died, which means a mortality rate of 40%. CONCLUSION: Although sigmoid volvulus causing intestinal obstruction is frequently successfully encountered by endoscopic decompression, however, the principal therapy of this condition is surgery. Only occasionally in patients with advanced age, lack of bowel symptoms and multiple co-morbidities might surgical repair not be considered. | Michael Safioleas Constantinos Chatziconstantinou Evangelos Felekouras Michael Stamatakos Ioannis Papaconstantinou Anastasios Smirnis Panagiotis Safioleas Alkiviades Kostakis | 2007 | World Journal of Gastroenterology2007，13，6： | 10 |
| 7 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 8 | Current evidence for histone deacetylase inhibitors in pancreatic cancer显示文摘Pancreatic cancer is one of the most aggressive human cancers,with more than 200 000 deaths worldwide every year.Despite recent efforts,conventional treatment approaches,such as surgery and classic chemotherapy,have only slightly improved patient outcomes.More effective and well-tolerated therapies are required to reverse the current poor prognosis of this type of neoplasm.Among new agents,histone deacetylase inhibitors (HDACIs) are now being tested.HDACIs have multiple biological effects related to acetylation of histones and many non-histone proteins that are involved in regulation of gene expression,apoptosis,cell cycle progression and angiogenesis.HDACIs induce cell cycle arrest and can activate the extrinsic and intrinsic pathways of apoptosis in different cancer cell lines.In the present review,the main mechanisms by which HDACIs act in pancreatic cancer cells in vitro,as well as their antiproliferative effects in animal models are presented.HDACIs constitute a promising treatment for pancreatic cancer with encouraging anti-tumor ef-fects,at well-tolerated doses. | Ioannis Koutsounas Constantinos Giaginis Efstratios Patsouris Stamatios Theocharis | 2013 | World Journal of Gastroenterology2013，19，6： | 9 |
| 9 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 10 | Surgical approaches of resectable synchronous colorectal liver metastases:Timing considerations显示文摘AIM: To compare the safety and efficacy of simultaneous versus two stage resection of primary colorectal tumors and liver metastases. METHODS: From January 1996 to May 2004, 103 colorectal tumor patients presented with synchronous liver metastases. Twenty five underwent simultaneous colorectal and liver surgery and 78 underwent liver surgery 1-3 mo after primary colorectal tumor resection. Data were retrospectively analyzed to assess and compare the morbidity and mortality between the surgical strategies. The two groups were comparable regarding the age and sex distribution, the types of liver resection and stage of primary tumors, as well as the number and size of liver metastases. RESULTS: In two-stage procedures more transfusions were required (4 ± 1.5 vs 2 ± 1.8, pRBCs, P < 0.05). Chest infection was increased after the two-stage approach (26% vs 17%, P < 0.05). The two-stage procedure was also associated with longer hospitalization (20 ± 8 vs 12 ± 6 d, P < 0.05). Five year survival in both groups was similar (28% vs 31%). No hospital mortality occurred in our series. CONCLUSION: Synchronous colorectal liver metastases can be safely treated simultaneously with the primary tumor. Liver resection should be prioritized over colon resection. It is advisable that complex liver resections with marginal liver residual volume should be dealt with at a later stage. | Ioannis Vassiliou Nick Arkadopoulos Theodosios Theodosopoulos Georgios Fragulidis Athanasios Marinis Agathi Kondi-Paphiti Lazaros Samanides Andreas Polydorou Constantinos Gennatas Dionysios Voros Vassilios Smyrniotis | 2007 | World Journal of Gastroenterology2007，13，9： | 8 |
| 11 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 12 | A case of splenic abscess after radiofrequency ablation显示文摘Radiofrequency 脱离(RFA ) 是首先为 unresectable 肝肿瘤的矫形疗法使用的一种创新技术。它不管多么的治疗学的指示,被扩展了并且现在包括许多其他的机关和疾病。有关于在怒气的 RFA 的使用的技术细节和复杂并发症的数据的少量。我们为脾的棘球蚴病用射频脱离报导部分脾切除术的一个案例,由脓肿形成复杂。 | Dimitris Zacharoulis Emmanuel Katsogridakis Constantinos Hatzitheofilou | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 13 | Ammonium Ion Adsorption and Settleability Improvement Achieved in a Synthetic Zeolite-Amended Activated Sludge显示文摘Municipal wastewater treatment plants typically exhibit two classic problems: high ammonium concentration in water after conventional biological treatment and,in some cases,poor activated sludge sediment ability.Potential solutions to these problems were investigated by adding a synthetic zeolite obtained from coal fly ash to different steps of activated sludge treatment.The experimental results for ammonium removal fit well with the theoretical adsorption isotherms of the Freundlich model with a maximum adsorption capacity of 13.72 mg·g 1.Utilization of this kind of zeolite to improve activated sludge sediment ability is studied for the first time in this work.It is found that the addition of the zeolite(1 g·L 1) to an activated sludge with settling problems significantly enhances its sediment ability and compact ability.This is confirmed by the sludge volume index(SVI),which was reduced from 163 ml·g 1to 70 ml·g 1,the V60value,which was reduced from 894 ml·L 1to 427 ml·L 1,and the zeta potential(ζ),which was reduced from 19.81 mV to 14.29 mV.The results indicate that the addition of this synthetic zeolite to activated sludge,as an additional waste management practice,has a positive impact on both ammonium removal and sludge settleability. | Emilia Otal Luls F. Vilches Yolanda Luna Rodrigo Poblete Juan M. Garcia-Maya Constantino Ferneindez-Pereira | 2013 | Chinese Journal of Chemical Engineering2013，21，9： | 5 |
| 14 | Molecular aspects of carcinogenesis in pancreatic cancer显示文摘BACKGROUND:Pancreatic cancer(PCa)is one of the most aggressive human solid tumors,with rapid growth and metastatic spread as well as resistance to chemotherapeutic drugs,leading rapidly to virtually incurable disease.Over the last 20 years,however,significant advances have been made in our understanding of the molecular biology of PCa,with a focus on the cytogenetic abnormalities in PCa cell growth and differentiation. DATA SOURCES:A MEDLINE search and manual cross- referencing were utilized to identify published data for PCa molecular biology studies between 1986 and 2008, with emphasis on genetic alterations and developmental oncology. RESULTS:Activation of oncogenes,deregulation of tumor suppressor and genome maintenance genes,upregulation of growth factors/growth factor receptor signaling cascade systems,and alterations in cytokine expression,have been reported to play important roles in the process of pancreatic carcinogenesis.Alterations in the K-ras proto- oncogene and the p16INK4a,p53,FHIT,and DPC4 tumor suppressor genes occur in a high percentage of tumors. Furthermore,a variety of growth factors are expressed at increased levels.In addition,PCa often exhibits alterations in growth inhibitory pathways and evades apoptosis through p53 mutations and aberrant expression of apoptosis-regulating genes,such as members of the Bcl family.Additional pathways in the development of an aggressive phenotype,local infiltration and metastasis are still under ongoing genetic research.The present paper reviews recent studies on the pathogenesis of PCa,and includes a brief reference to alterations reported for other types of pancreatic tumor. CONCLUSIONS:Advances in molecular genetics and biology have improved our perception of the pathogenesis of PCa.However,further studies are needed to better understand the fundamental changes that occur in PCa,thus leading to better diagnostic and therapeutic management. | Alexandros Koliopanos Constantinos Avgerinos Constantina Paraskeva Zisis Touloumis Dionisisa Kelgiorgi Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 4 |
| 15 | 高校科研评价指标体系研究显示文摘科研评价是对科技创新工作价值判断的重要过程。针对高校科研评价现状,采用平衡计分卡对高校科研评价指标体系进行设计,构建了包含科研经费、科研成果、科研项目和科研交流与培养等指标的高校科研评价指标体系。利用变异系数法对指标进行赋权,通过TOPSIS法对该高校的科研成果进行最终排序评价,寻找其中的不足,并给予相关建议。 | 张龙 Constantino Naroiso HSanchez 李文燕 唐洁 | 2019 | 六盘水师范学院学报2019，31，6： | 4 |
| 16 | 肥胖对全髋置换术后假体周围骨溶解影响的5年和10年随访观察显示文摘背景:全髋关节置换术后最主要的远期并发症是假体周围的骨溶解。相当多的接受关节置换术的患者为体型肥胖者。目前认为,导致骨溶解的危险因素包括患者的活动、植入物的类型以及固定质量等。但关于肥胖因素对骨溶解的影响鲜见相关文献报道,而且颇受争议。本文的目的是评估肥胖对全髋关节骨水泥型假体柄置换术后5年和10年骨溶解的危险因素;其次是对临床结果及患者的满意度作出评价。方法:我们对1996至2003午期间行第三代骨水泥型假体柄全髋关节置换术的患者进行前瞻性研究。所有患者均于术后5年或10年进行随访观察,获取X线、体重指数(BMI:〈25kg/m^2=正常,25~29.9kg/m^2=超重,≥30kg/m^2=肥胖)资料以及髋关节活动度情况。对活动度的评估采用洛杉矶加利福尼亚大学(UCLA)评分方法予以评定。临床结果采用Harris髋关节评分系统和Merled’Aubign6和Postel评分系统进行分析。结果:本文对433例患者中503髋关节置换术进行研究,其中241髋(47.9%)于术后5年,262髋(52.1%)于术后10年进行评估。181髋正常体重患者中的24髋(13.3%)、205髋超重患者中的11髋(5.4%)以及117髋肥胖患者中的9髋(7.7%)发生了骨溶解,共44髋。正常体重患者髋关节活动度最高【平均UCLA活动评分(±标准差)为(5.5+2.0)分];肥胖患者评分最低[平均UCLA活动评分为(5.0±1.7)分]。当调整了活动度、骨水泥质量、患者年龄和性别因素后,肥胖患者发生骨溶解的概率并不比超重患者高(调整比值比为1.4,95%置信区间为0.6-3.7),而发现正常体重患者发生股骨骨溶解的风险明显高于超重患者(调整比值比为2.6,95%置信区间为1.2-5.7)。各组之间临床结果没有显著性差异。结论:我们发现肥胖患者在行骨水泥型股骨柄全髋置换术后5年和10年后,假体周围骨溶解的风险并未增加;而正常体重患者骨溶解的发生率反而最高。 | Anne Lubbeke Guido Garavaglia Christophe Barea Constantinos Roussos 俞鹏飞(译) 姜宏(译) | 2010 | 中华骨科杂志2010，30，12： | 4 |
| 17 | Audit effort and earnings management显示文摘 | Constantinos Caramanis Clive Lennox | 2007 | Journal of Accounting and Economics2007，，1： | 3 |
| 18 | A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon)显示文摘 | Constantinos Simillis Panayiotis Symeonides Andrew J. Shorthouse Paris P. Tekkis | 2010 | Surgery2010，，6： | 3 |
| 19 | Radiofrequency ablation-assisted liver resection a step toward bloodless liver resection显示文摘BACKGROUND: Liver resection is currently the most efficient curative approach for a wide variety of liver tumors. The application of modern techniques and new surgical devices has improved operative outcomes. Radiofrequency ablation is used more often for liver parenchymal transection. This study aimed to assess the efficacy and safety of radiofrequency ablation-assisted liver resection.METHODS: A retrospective study of 145 consecutive patients who underwent radiofrequency ablation-assisted liver resection was performed. Intraoperative blood loss, need for transfusion or intraoperative Pringle maneuver, the duration of liver parenchymal transection, perioperative complications, and postoperative morbidity and mortality were all evaluated.RESULTS: Fifty minor and ninety-five major liver resections were performed. The mean intraoperative blood loss was 251 m L, with a transfusion rate of 11.7%. The Pringle maneuver was necessary in 12 patients(8.3%). The mean duration for parenchymal transection was 51.75 minutes. There were 47 patients(32.4%) with postoperative complications. There is no mortality within 30 days after surgery. CONCLUSIONS: Radiofrequency ablation-assisted liver resection permits both major and minor liver resections with minimal blood loss and without occlusion of hepatic inflow. Furthermore it decreases the need for blood transfusion and reduces morbidity and mortality. | Athanasios Petrou Kyriakos Neofytou Constantinos Mihas Jessamy Bagenal Michael Kontos John Griniatsos Evangelos Felekouras | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，1： | 3 |
| 20 | Histone deacetylase inhibitors and pancreatic cancer:Are there any promising clinical trials?显示文摘Pancreatic cancer,although not very frequent,has an exceptionally high mortality rate,making it one of the most common causes of cancer mortality in developed countries.Pancreatic cancer is difficult to diagnose,allowing few patients to have the necessary treatment at a relatively early stage.Despite a marginal benefit in survival,the overall response of pancreatic cancer to current systemic therapy continues to be poor,and new therapies are desperately needed.Histone deacetylase(HDAC) enzymes play an important role in the development and progression of cancer and HDAC inhibitors(HDACIs) have been shown to induce differentiation and cell cycle arrest,activate the extrinsic or intrinsic pathways of apoptosis,and inhibit invasion,migration and angiogenesis in different cancer cell lines.As a result of promising preclinical data,various HDACIs are being tested as either monotherapeutic agents or in combination regimens for both solid and hematological malignancies.Vorinostat was the first HDACI approved by the Food and Drug Administration for patients with cutaneous T-cell lymphoma.The use of HDACIs in clinical trials,in pretreated and relapsed patients suffering from advanced pancreatic cancer is discussed.Unfortunately,clinical data for HDACIs in patients with pancreatic cancer are inadequate,because only a few studies have included patients suffering from this type of neoplasm and the number of pancreatic cancer patients that entered HDACIs phase Ⅱ/Ⅲ trials,among others with advanced solid tumors,is very limited.More studies recruiting patients with pancreatic cancer remain to determine the efficiency of these therapies. | Ioannis Koutsounas Constantinos Giaginis Stamatios Theocharis | 2013 | World Journal of Gastroenterology2013，19，8： | 3 |
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