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| 1 | Molecular genetics and targeted therapeutics in biliary tractcarcinoma显示文摘The primary malignancies of the biliary tract, cholangio-carcinoma and gallbladder cancer, often present at an advanced stage and are marginally sensitive to radiation and chemotherapy. Accumulating evidence indicates that molecularly targeted agents may provide new hope for improving treatment response in biliary tract carcinoma(BTC). In this article, we provide a critical review of the pathogenesis and genetic abnormalities of biliary tract neoplasms, in addition to discussing the current and emerging targeted therapeutics in BTC. Genetic studies of biliary tumors have identified the growth factors and receptors as well as their downstream signaling pathways that control the growth and survival of biliary epithelia. Target-specific monoclonal antibodies and small molecules inhibitors directed against the signaling pathways that drive BTC growth and invasion have been developed. Numerous clinical trials designed to test these agents as either monotherapy or in combination with conventional chemotherapy have been completed or are currently underway. Research focusing on understanding the molecular basis of biliary tumorigenesis will continue to identify for targeted therapy the key mutations that drive growth and invasion of biliary neoplasms. Additional strategies that have emerged for treating this malignant disease include targeting the epigenetic alterations of BTC and immunotherapy. By integrating targeted therapy with molecular profiles of biliary tumor, we hope to provide precision treatment for patients with malignant diseases of the biliary tract. | Eric I Marks Nelson S Yee | 2016 | World Journal of Gastroenterology2016，22，4： | 13 |
| 2 | Immunotherapeutic approaches in biliary tract carcinoma:Current status and emerging strategies显示文摘For biliary tract carcinoma(BTC),complete surgical resection of tumor is only feasible in a minority of patients,and the treatment options for patients with unresectable or metastatic disease are limited.Advances in cancer immunology have led to identification of tumor-infiltrating immune cells as indicators of prognosis and response to treatment in BTC.This has also facilitated development of immunotherapy that focuses on enhancing the immune system against biliary tumors.This includes peptide- and dendritic cell-based vaccines that stimulate in-vivo immune responses against tumorspecific antigens.Adoptive immunotherapy,which entails the ex-vivo expansion of tumor-infiltrating immune cells for subsequent reintroduction,and cytokinebased therapies have been developed in BTC.Clinical studies indicate that this type of therapy is generally well tolerated.Combination therapy with dendritic cell-based vaccines and adoptive immunotherapy has shown particularly good potential.Emerging strategies through discovery of novel antigen targets and by reversal of tumor-associated immunosuppression are expected to improve the efficacy of immunotherapy in BTC.Collaborative efforts by integration of targeted immunotherapeutics with molecular profiling of biliary tumor will hopefully make a positive impact on advancing towards the goal of developing precision treatment of patients with this highly lethal disease. | Eric I Marks Nelson S Yee | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 11 |
| 3 | Hepatocellular carcinoma,human immunodeficiency virus and viral hepatitis in the HAART era显示文摘The incidence of hepatocellular carcinoma(HCC)in patients with human immunodeficiency virus(HIV) is rising.HCC in HIV almost invariably occurs in the context of hepatitis C virus(HCV)or hepatitis B virus (HBV)co-infection and,on account of shared modes of transmission,this occurs in more than 33% and 10% of patients with HIV worldwide respectively.It has yet to be clearly established whether HIV directly accelerates HCC pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy(HAART)era,wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to develop.Answering this question will have implications for HCC surveillance and the timing of HCV/HBV therapy,which in HIV co-infection presents unique challenges.Once HCC develops,there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies,including liver transplantation. | Douglas C Macdonald Mark Nelson Mark Bower Thomas Powles | 2008 | World Journal of Gastroenterology2008，14，11： | 9 |
| 4 | 创新性淀粉节约方案——通过纤维中的淀粉回收提高纸板生产的可持续性显示文摘用于制造再生纸和纸板的纤维原材料中含有大量淀粉。由于微生物的活性,使用回收纤维的纸浆中的过程水通常含有大量淀粉水解酶。这经常导致大多数淀粉在回收纤维进入造纸机之前水解掉,因此潜在地增加了废水中的化学需氧量COD、pH值降低,并且由于碳酸钙溶解使得电导率变高。在本文中,我们提出了一种新颖的提高淀粉再利用及包装纸强度的理念。该理念包括使用特定的淀粉酶抑制剂,防止回收纤维和损纸中的淀粉水解,以及全新的助留系统用以提高淀粉在最终产品中的保留率。淀粉酶抑制剂自身或与杀菌剂组合能够有效防止淀粉水解。这在实验室研究和工厂试验均有所体现。此外,留着率和强度实验表明混凝剂、微聚物和新的高分子聚合物的组合提高了淀粉的留着率和滤水性。 | Jaakko Ekman Matti Hietaniemi Marko Kolari Mark Nelson Ken Keegan | 2018 | 中华纸业2018，39，2： | 7 |
| 5 | Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography显示文摘 | Lawrence G. Rudski Wyman W. Lai Jonathan Afilalo Lanqi Hua Mark D. Handschumacher Krishnaswamy Chandrasekaran Scott D. Solomon Eric K. Louie Nelson B. Schiller | 2010 | Journal of the American Society of Echocardiography2010，，7： | 6 |
| 6 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 7 | Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma显示文摘 | Roniel Cabrera Miguel Ararat Yiling Xu Todd Brusko Clive Wasserfall Mark A. Atkinson Lung Ji Chang Chen Liu David R. Nelson | 2013 | Cancer Immunology Immunotherapy2013，，4： | 3 |
| 8 | Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography显示文摘 | Lawrence G. Rudski Wyman W. Lai Jonathan Afilalo Lanqi Hua Mark D. Handschumacher Krishnaswamy Chandrasekaran Scott D. Solomon Eric K. Louie Nelson B. Schiller | 2010 | Journal of the American Society of Echocardiography2010，，7： | 2 |
| 9 | A Meta-analysis of Transient Elastography for the Detection of Hepatic Fibrosis显示文摘 | Justin Stebbing Lavanta Farouk George Panos Mike Anderson Long R. Jiao Sundhiya Mandalia Mark Bower Brian Gazzard Mark Nelson | 2010 | Journal of Clinical Gastroenterology2010，，3： | 2 |
| 10 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 11 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 12 | Practice Parameters for the Treatment of Perianal Abscess and Fistula-in-Ano ?(Revised)显示文摘 | Mark H. Whiteford M.D. John Kilkenny M.D. Neil Hyman M.D. W. Donald Buie M.D. Jeffrey Cohen M.D. Charles Orsay M.D. Gary Dunn M.D. W. Brian Perry M.D. C. Neal Ellis M.D. Jan Rakinic M.D. Sharon Gregorcyk M.D. Paul Shellito M.D. Richard Nelson M.D. Joe J. | 2005 | Diseases of the Colon & Rectum2005，，7： | 2 |
| 13 | PC-SPES : Herbal formulation for prostate cancer 显示文摘 | Marks L S DiPaola R S Nelson P | 2002 | Urology2002，60，3： | 1 |
| 14 | Continuing evolution of therapy for coronary artery disease显示文摘 | Mark DB Nelson CL Califf RM | 1994 | Circulation1994，89，： | 1 |
| 15 | Mercury and methylmercury bioaccumulation by polychaete worms is governed by both feeding ecology and mercury bioavailability in coastal mudflats显示文摘 | Tom Sizmur Jo?o Canário Travis G. Gerwing Mark L. Mallory Nelson J. O’Driscoll | 2013 | Environmental Pollution2013，，： | 1 |
| 16 | PC-SPES: herbal formulation for prostate cancer显示文摘 | Marks L S DiPaola R S Nelson P | 2002 | Urology2002，60，3： | 1 |
| 17 | Practical use of SRTM data in the tropics-Comparisons with digital elevation models generated from cartographic data显示文摘 | Andy Jarvis Jorge Rubiano Andy Nelson Andrew Farrow Mark Mulligan | 2004 | Working Document2004，，8： | 1 |
| 18 | Capacity Development Briefs显示文摘 | Mark Nelson | 2006 | World Bank Institute2006，，： | 1 |
| 19 | Studies of degradation enhancement of polystyrene by flame retardant addi- tives 显示文摘 | Mark W Beach Nelson G Rondan Robert D Froese | 2008 | Polymer Degradation and Stability2008，93，： | 1 |
| 20 | Global Bathymetry and Elevation Data at 30 Arc Seconds Resolution: SRTM30_PLUS显示文摘 | J. J. Becker D. T. Sandwell W. H. F. Smith J. Braud B. Binder J. Depner D. Fabre J. Factor S. Ingalls S-H. Kim R. Ladner K. Marks S. Nelson A. Pharaoh R. Trimmer J. Von Rosenberg G. Wallace P. Weatherall | 2009 | Marine Geodesy2009，，： | 1 |
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