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| 1 | Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis显示文摘Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic epithelial.UC-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal cancer.In fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite instability.Hypermethylation of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory carcinogenesis.Moreover,p53 is frequently mutated in the early stages of UC-associated cancer.Aneuploidy is an independentrisk factor for forthcoming carcinogenesis in UC.Epithelial cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis. | Marco Scarpa Ignazio Castagliuolo Carlo Castoro Anna Pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 2 | Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma:An intricate pathway显示文摘The histo-pathologic and molecular mechanisms leading to initiation and progression of hepatocellular carcinoma(HCC)are still ill-defined;however,there is increasing evidence that the gradual accumulation of mutations,genetic and epigenetic changes which occur in preneoplastic hepatocytes results in the development of dysplastic foci,nodules,and finally,overt HCC.As well as many other neoplasias,liver cancer is considered an'inflammatory cancer',arising from a context of inflammation,and characterized by inflammation-related mechanisms that favor tumor cell survival,proliferation,and invasion.Molecular mechanisms that link inflammation and neoplasia have been widely investigated,and it has been well established that inflammatory cells recruited at these sites with ongoing inflammatory activity release chemokines that enhance the production of reactive oxygen species.The latter,in turn,probably have a major pathogenic role in the continuum starting from hepatitis followed by chronic inflammation,and ultimately leading to cancer.The relationship amongst chronic liver injury,free radical production,and development of HCC is explored in the present review,particularly in the light of the complex network that involves oxidative DNA damage,cytokine synthesis,telomere dysfunction,and microRNA regulation. | Romilda Cardin Marika Piciocchi Marina Bortolami Andromachi Kotsafti Luisa Barzon Enrico Lavezzo Alessandro Sinigaglia Kryssia Isabel Rodriguez-Castro Massimo Rugge Fabio Farinati | 2014 | World Journal of Gastroenterology2014，20，12： | 14 |
| 3 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 4 | Safety,immunogenicity and kinetics of immune response to 7-valent pneumococcal conjugate vaccine in children with idiopathic nephrotic syndrome显示文摘 | Christina DL Varvara A Andromachi M | 2011 | Vaccine2011，29，40： | 1 |
| 5 | Damage Control Surgery: An Alternative Approach for the Management of Critically Injured Patients显示文摘 | Gregory Kouraklis Spiros Spirakos Andromachi Glinavou | 2002 | Surgery Today2002，，3： | 1 |
| 6 | The effects of rosuvastatin alone or in combination with fenofibrate or omega 3 fatty acids on inflammation and oxidative stress in patients with mixed dyslipidemia显示文摘 | Aris P Agouridis Vasilis Tsimihodimos Theodosios D Filippatos Andromachi A Dimitriou Costantinos C Tellis Moses S Elisaf Dimitri P Mikhailidis Alexandros D Tselepis | 2011 | Expert Opinion on Pharmacotherapy2011，，17： | 1 |
| 7 | Damage control surgery : an ahemative approach for the management of critically injured patients 显示文摘 | Gregory K Spiros S Andromachi G | 2007 | Critical Care2007，11，1： | 1 |
| 8 | Damage Control Surgery: An Alternative Approach for the Management of Critically Injured Patients 显示文摘 | Gregory K Spiros S Andromachi G | 2002 | Surgery Today2002，32，3： | 1 |
| 9 | Damage Control Surgery: An Alternative Approach for the Management of Critically Injured Patients显示文摘 | Gregory Kouraklis Spiros Spirakos Andromachi Glinavou | 2002 | Surgery Today2002，，3： | 1 |
| 10 | Damage Control Surgery: An Alternative Approach for the Management of Critically Injured Patients显示文摘 | Gregory Kouraklis Spiros Spirakos Andromachi Glinavou | 2002 | Surgery Today2002，，3： | 1 |
| 11 | Damage control surgery: an alternative app roach for the management of critically injured pa- tients显示文摘 | Gregory K Spiros S Andromachi G | 2007 | Critical Care2007，11，1： | 1 |
| 12 | Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study显示文摘 | Mary Eapen Pablo Rubinstein Mei-Jie Zhang Cladd Stevens Joanne Kurtzberg Andromachi Scaradavou Fausto R Loberiza Richard E Champlin John P Klein Mary M Horowitz John E Wagner | 2007 | The Lancet . 2007 (9577)2007，，9577： | 1 |
| 13 | Mucosal immune environment in colonic carcinogenesis: CD80 up-regulation in colonic dysplasia in ulcerative colitis显示文摘 | Marco Scarpa Marina Bortolami Attilio Cecchetto Diego Faggian Andromachi Kotsafti Cesare Ruffolo Filippo Navaglia Anna Pozza Renata D’Incà Mario Plebani Giacomo C. Sturniolo Imerio Angriman | 2010 | European Journal of Cancer2010，，4： | 1 |
| 14 | Damage Control Surgery:An Alternative Approach for the Management of Critically Injured Patients显示文摘 | Gregory Kouraklis Spiros Spirakos Andromachi Glinavou | 2012 | Surgery Today2012，14，3： | 1 |
| 15 | Damage control surgery:an alternative approach for the management of critically injured patients 显示文摘 | Gregory K Spiros S Andromachi G | 2007 | Critical Care2007，11，1： | 1 |
| 16 | Damage control surgery: an al- ternative approach for the management of critically injured patients 显示文摘 | Gregory K Spiros S Andromachi G | 2007 | Critical care2007，11，1： | 1 |
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