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| 1 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 2 | Heterotaxy Patients With Total Anomalous Pulmonary Venous Return: Improving Surgical Results显示文摘 | David L.S. Morales Brandi E. Braud Justin H. Booth Daniel E. Graves Jeffrey S. Heinle E. Dean McKenzie Charles D. Fraser | 2006 | The Annals of Thoracic Surgery2006，，5： | 2 |
| 3 | Lessons from the ( ' Iressa' expanded access programme: Gefitinib in special non-small-cell lung cancer patient populations 显示文摘 | Stahel R Rossi A Petruzelka L Kosimidis P de Braud F Bernardo MM | 2003 | Br J Cancer2003，89，2： | 1 |
| 4 | Influence of past reproductive performance on risk of spontaneous abortion 显示文摘 | Regan L Braude P R Trembath P L | 1989 | BMJ1989，299，6698： | 1 |
| 5 | High copper mineral mixture for fattening pigs显示文摘 | Barber R S Braude R Mitchell K G | 1955 | Chemistry and Industry1955，21，： | 1 |
| 6 | Diagnosis and management of squamous cell carcinoma of unknown primary tumor site of the neck显示文摘 | Braud FD Sarraf MA | 1993 | Semi Oncol1993，20，3： | 1 |
| 7 | Surface expression of HLA-E,an inhibitor of natural killer cells,enhanced by human cytomegalovirus gpUL40显示文摘 | Tomasec P Braud VM Richards C | 2000 | Science2000，287，545： | 1 |
| 8 | Low-dimensional analysis,using POD,for two mixing layer-wake interactions显示文摘 | Braud C Heitz D Arroyo G | 2004 | International Journal of Heat and Fluid Flow2004，25，： | 1 |
| 9 | Enhanced phytoex-traction of an agricultural Cr, Hg-and Pb-contaminated soil by bio-augmentation with siderophore-producing bacteria 显示文摘 | BRAUD A jfiZfiQUEL K BAZOT S | 2009 | Chemo-sphere2009，74，2： | 1 |
| 10 | Surface expression of HLA-E,an inhibitor of natural killer cells,enhanced by human cytomegalovirus gpUL40显示文摘 | Tomasec P Braud VM Rickards C | 2000 | Science2000，287，5455： | 1 |
| 11 | Phase Ⅱ study of the etoposide,leucovorin and fluorouracil combination for patients with advanced gastric cancer unsuitable for aggressive chemotherapy显示文摘 | Di Bartolomeo M Bajetta E de Braud F | 1995 | Oncology1995，52，： | 1 |
| 12 | Some observations on the need for copper in the diet of fattening pigs显示文摘 | Braude R | 1945 | The Journal of Agricultural Science1945，35，3： | 1 |
| 13 | Human gene expression first occurs between the four-and eight-cell stages of preimplantation development显示文摘 | Braude P Bohon V Moore S | 1988 | Nature1988，332，31： | 1 |
| 14 | Some Observations on the need for copper in the diet of fattening pigs显示文摘 | Braude R | 1945 | J Agric Sci1945，35，： | 1 |
| 15 | Surgical care, morbidity, mortality and follow-up after nephrectomy for renal cancer with extension of tumor thrombus into the inferior vena cava: retrospective study since 1990s 显示文摘 | Rigaud J Hetet JF Braud G | 2006 | Eur Urol2006，50，2： | 1 |
| 16 | Preimplantation geneticdiagnosis显示文摘 | Braude P Picketing S Flinter F | 2002 | Nat Rev Genet2002，3，： | 1 |
| 17 | Low serum estra- diol concentrations after five days of controlled ovarian hyper- stimulation for in vitro fertilization are associated with poor out- come 显示文摘 | KHRLAF Y TAYLOR A BRAUDE P | 2000 | Fertility & Sterility2000，74，1： | 1 |
| 18 | Hyperfractionated radio- therapy in locally advanced nasopharyngeal cancer: an analysis of 43 consecutive patient显示文摘 | Jereczek-Fossa BA Morra A De- Braud F | 2004 | Strahlenther Onkol2004，180，7： | 1 |
| 19 | Combination of vinorelbine, Epirubicin, and cyclophesphamide as neoadjuvant chemotherapy for locally advanced breast cancer显示文摘 | Braud AC Levy E Feuilhade F | 2002 | Am J Clin Oncol2002，25，3： | 1 |
| 20 | Some observation on the need for copper in the diet of fattening pigs显示文摘 | Braude R | 1945 | Agri Sci1945，35，： | 1 |
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