|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 冰岛北部陆架3000年以来夏季表层海水温度及古气候事件显示文摘冰岛北部陆架MD992271孔沉积硅藻中喜暖硅藻数量持续减少以及喜冷藻类数量不断增加,反映了该区近3000年来气候变冷的趋势,而硅藻组合中这两类硅藻数量呈周期性的此消彼长,指示在趋冷的背景下,气候的冷暖交替过程.转换函数计算结果表明,该孔夏季表层海水温度变化大致可分3个阶段,在1400cal.aBP以前,温度基本高于平均值;在1400~700cal.aBP之间,温度在平均值上下起伏,而在700cal.aBP后,温度均处于平均值之下.在这3000多年间,还存在着4次明显的降温事件,降温事件的中心分别位于约2600,1900,1300和600cal.aBP.上述夏季表层海水温度变化和冰岛北部陆架HM107—03和MD992275孔资料相对比,明显具有一致性,同时也可与GISP2冰芯氧同位素及北大西洋深海沉积记录对比,说明冰岛北部陆架晚全新世夏季表层海水温度变化,受区域性气候变化的控制.直接导致上述海水温度变化,是影响该区暖流和寒流作用此消彼长的结果,而冰岛周边海域3000年来海流分布的基本格局未有明显改变. | 蒋辉 任健 Karen Luise Knudsen Jón Eiríksson 冉莉华 | 2006 | 科学通报2006，51，22： | 11 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates显示文摘Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity,prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows' breed and the survival and growth rates of their litters.Results: Colostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using1 H–NMR spectroscopy. Principal Components Analysis(PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets' performances.Twenty-five metabolites were identified, comprehending monosaccharides, disaccharides(such as lactose), organic acids(lactate, citrate, acetate and formate), nitrogenous organic acids(such as creatine) and other compounds,including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets' performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets' survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns' impaired ability to survive.Conclusions: The results obtained suggest that colostrum composition is affected by breed, which, together with environmental conditions, may cause changes in colostrum metabolites content with possible consequences on piglets' performances. Among the identified metabolites, acetate, taurine, dimethylamine and cis-aconitate showed consistent associations with piglets' survival rate and litter weight gain, implying that these compounds may affect new-borns' ability to survive. | Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli Leonardo Nanni Costa Paolo Bosi Paolo Trevisi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 6 |
| 4 | Trefoil factors in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),which comprises ulcerative colitis and Crohn’s disease,is characterized by inflammation of the gastrointestinal tract.The trefoil factors 1,2,and 3(TFF1-3)are a family of peptides that play important roles in the protection and repair of epithelial surfaces,including the gastrointestinal tract.TFFs may be involved in IBD pathogenesis and are a potential treatment option.In the present review,we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression,possible function and pharmacological role in IBD. | Luise Aamann Else Marie Vestergaard Henning Grφnbk | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 5 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 6 | A break in the clouds显示文摘 | Luis M. Vaquero Luis Rodero-Merino Juan Caceres Maik Lindner | 2008 | ACM SIGCOMM Computer Communication Review2008，，1： | 5 |
| 7 | GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees显示文摘 | Robert E. Lanford Bernadette Guerra Deborah Chavez Luis Giavedoni Vida L. Hodara Kathleen M. Brasky Abigail Fosdick Christian R. Frey Jim Zheng Grushenka Wolfgang Randall L. Halcomb Daniel B. Tumas | 2013 | Gastroenterology2013，，7： | 5 |
| 8 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 9 | How much does performance matter? A meta-analysis of CEO pay studies显示文摘 | Henry L. Tosi Steve Werner Jeffrey P. Katz Luis R. Gomez-Mejia | 2000 | Journal of Management2000，，2： | 4 |
| 10 | Systemic, renal, and hepatic hemodynamic derangement in cirrhotic patients with spontaneous bacterial peritonitis显示文摘 | Luis Ruiz-del-Arbol Jesús Urman Javier Fernández Mónica González Miguel Navasa Alberto Monescillo Agustín Albillos Wladimiro Jiménez Vicente Arroyo | 2003 | Hepatology2003，，5： | 4 |
| 11 | Summer sea-surface temperatures and climate events on the North Icelandic shelf through the last 3000 years显示文摘Diatom data from core MD992271 on the North Icelandic shelf record a cooling trend through the last 3000 years. This is indicated by a general decrease in warm water species and an increase in cold water taxa. The relative abundance of these two diatom groups changed periodically, suggesting that the climate also fluctuated within this time period. The results of diatom-based transfer function calculation show that the summer sea-surface temperatures (SSTs) before 1400 cal. a BP were generally higher than the mean value for the last 3000 years and the summer SSTs fluctuated around the mean between 1400 and 700 cal. a BP, and dropped to the values below the mean after 700 cal. a BP. Four cooling events were distinguished, centered at around 2600, 1900, 1300 and 600 cal. a BP respectively. The results are not only consistent with the data from neighbouring cores HM107-03 and MD992275, but also comparable with those from the GISP2 ice core and from other marine sediment records in the North Atlantic. This suggests that changes in the summer SSTs reflect regional climate variations in the North Atlantic. On the North Icelandic shelf, the summer SST variation is a result of changes in the in-teraction between the cold and the warm currents in the area. | JIANG Hui REN Jian Karen Luise KNUDSEN Jon EIRiKSSON RAN LiHua | 2007 | Chinese Science Bulletin2007，52，6： | 4 |
| 12 | Alb4 of Arabidopsis Promotes Assembly and Stabilization of a Non Chlorophyll-Binding Photosynthetic Complex, the CF1CF0-ATP Synthase显示文摘 | Monique Benz Thomas Bals Irene Luise Gugel Markus Piotrowski Andreas Kuhn Danja Schunemann Jurgen Soll Elisabeth Ankele | 2009 | Molecular Plant2009，2，6： | 4 |
| 13 | Methodology and application of Escherichia coli F4 and F18 encoding infection models in post-weaning pigs显示文摘The enterotoxigenic Escherichia coli (ETEC) expressing F4 and F18 fimbriae are the two main pathogens associated with post-weaning diarrhea (PWD) in piglets.The growing global concern regarding antimicrobial resistance (AMR) has encouraged research into the development of nutritional and feeding strategies as well as vaccination protocols in order to counteract the PWD due to ETEC.A valid approach to researching effective strategies is to implement piglet in vivo challenge models with ETEC infection.Thus,the proper application and standardization of ETEC F4 and F18 challenge models represent an urgent priority.The current review provides an overview regarding the current piglet ETEC F4 and F18 challenge models;it highlights the key points for setting the challenge protocols and the most important indicators which should be included in research studies to verify the effectiveness of the ETEC challenge.Based on the current review,it is recommended that the setting of the model correctly assesses the choice and preconditioning of pigs,and the timing and dosage of the ETEC inoculation.Furthermore,the evaluation of the ETEC challenge response should include both clinical parameters (such as the occurrence of diarrhea,rectal temperature and bacterial fecal shedding) and biomarkers for the specific expression of ETEC F4/F18 (such as antibody production,specific F4/F18 immunoglobulins (lgs),ETEC F4/F18 fecal enumeration and analysis of the F4/F18 receptors expression in the intestinal brush borders).On the basis of the review,the piglets' response upon F4 or F18 inoculation differed in terms of the timing and intensity of the diarrhea development,on ETEC fecal shedding and in the piglets' immunological antibody response.This information was considered to be relevant to correctly define the experimental protocol,the data recording and the sample collections.Appropriate challenge settings and evaluation of the response parameters will allow future research studies to comply with the replacement,reduction and refinement (3R) approach,and to be able to evaluate the efficiency of a given feeding,nutritional or vaccination intervention in order to combat ETEC infection. | Diana Luise Charlotte Lauridsen Paolo Bosi Paolo Trevisi | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 4 |
| 14 | Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells显示文摘AIM To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells(PSCs).METHODS Quiescent PSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures(early-activated PSCs) and upon re-culturing(fullyactivated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining. Expression of α-smooth muscle actin(α-SMA), a marker of PSC activation, was monitored by immunofluorescence and immunoblot analysis. The rate of DNA synthesis was quantified by 5-bromo-2'-deoxyuridine(Brd U) incorporation assays. Real-time PCR was employed to monitor gene expression, and protein levels of interleukin-6(IL-6) were measured by ELISA. Uptake of proline was determined using 18 F-proline.RESULTS Sustained culture of originally quiescent PSCs inducedcell proliferation, loss of lipid droplets and exhibition of stress fibers, indicating cell activation. When added to PSCs in primary culture, all three D-vitamins diminished expression of α-SMA(to 32%-39% of the level of control cells; P < 0.05) and increased the storage of lipids(scores from 1.97-2.15 on a scale from 0-3; controls: 1.49; P < 0.05). No such effects were observed when D-vitamins were added to fully-activated cells, while incorporation of Brd U remained unaffected under both experimental conditions. Treatment of re-cultured PSCs with D-vitamins was associated with lower expression of IL-6(-42% to-49%; P < 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene(209%-321% vs controls; P < 0.05). There was no effect of D-vitamins on the expression of transforming growth factor-β1 and collagen type 1(chain α1). The lowest uptake of proline, a main component of collagen, was observed in calcipotriol-treated PSCs.CONCLUSION The three D-vitamins inhibit, with similar efficiencies, activation of PSCs in vitro, but cannot reverse the phenotype once the cells are fully activated. | Peter Wallbaum Sarah Rohde Luise Ehlers Falko Lange Alexander Hohn Carina Bergner Sarah Marie Schwarzenbock Bernd Joachim Krause Robert Jaster | 2018 | World Journal of Gastroenterology2018，24，2： | 3 |
| 15 | Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study显示文摘 | Mats Lindblad Luis A. García Rodríguez Jesper Lagergren | 2005 | Cancer Causes & Control2005，，3： | 3 |
| 16 | Antiviral activity of maca ( Lepidium meyenii ) against human influenza virus显示文摘 | Juana del Valle Mendoza Tomàs Pumarola Libertad Alzamora Gonzales Luis J. del Valle | 2014 | Asian Pacific Journal of Tropical Medicine2014，，： | 3 |
| 17 | A methodology to determine the elastic properties of anisotropic rocks from a single uniaxial compression test显示文摘This paper introduces a new methodology to measure the elastic constants of transversely isotropic rocks from a single uniaxial compression test.We first give the mathematical proof that a uniaxial compression test provides only four independent strain equations.As a result,the exact determination of all five independent elastic constants from only one test is not possible.An approximate determination of the Young’s moduli and the Poisson’s ratios is however practical and efficient when adding the Saint-Venant relation as the fifth equation.Explicit formulae are then developed to calculate both secant and tangent definitions of the five elastic constants from a minimum of four strain measurements.The results of this new methodology applied on three granitic samples demonstrate a significant stress-induced nonlinear behavior,where the tangent moduli increase by a factor of three to four when the rock is loaded up to 20 MPa.The static elastic constants obtained from the uniaxial compression test are also found to be significantly smaller than the dynamic ones obtained from the ultrasonic measurements. | Morteza Nejati Marie Luise Texas Dambly Martin OSaar | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，6： | 3 |
| 18 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 3 |
| 19 | 北大西洋北部中全新世以来古海洋环境记录显示文摘利用主成分分析法对冰岛北部陆架MD99-2275孔中全新世以来沉积物硅藻数据进行研究发现,5000—3000aB.P.,冰岛北部陆架表层古海水温度逐渐上升,来自印明格暖流的北大西洋暖水对该区域的影响有所增强。自3000aB.P.以来,表层海水温度开始稳步下降,北大西洋暖水水团的影响逐步减弱,而来自东格陵兰寒流和东冰岛海流的极地冷水水团的影响显著加强。在晚全新世气候逐渐变冷的过程中,发生了几次短期而显著的气候变冷事件,分别出现在3000—2600aB.P.,1300—1000aB.P.及600—200aB.P.。该中晚全新世古海洋环境记录与格陵兰冰芯(GSIP2)氧同位素气候记录存在良好的对应关系,也与冰岛北部陆架其他海水温度记录有较好的一致性。而冰岛北部陆架区域海底地形的复杂性和海流分布的差异性,以及所采用研究方法的不同则导致该区域各古海水温度记录之间也存在一定的差异性。 | 冉莉华 蒋辉 Karen luise Knudsen Jón Eiríksson | 2008 | 海洋通报2008，27，5： | 3 |
| 20 | MAMMALIAN CASPASES: Structure, Activation, Substrates, and Functions During Apoptosis显示文摘 | William C. Earnshaw Luis M. Martins Scott H. Kaufmann | 1999 | Annual Review of Biochemistry1999，，： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员