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| 1 | 墨西哥红豆杉愈伤组织的诱导和器官发生显示文摘 | 肖尊安 Héctor Barrios Consuelo Sandoval Garc姫a | 2000 | 植物生理学通讯2000，36，6： | 9 |
| 2 | Small incision lenticule extraction(SMILE)in the correction of myopic astigmatism:outcomes and limitations-an update显示文摘Small Incision Lenticule Extraction(SMILE)is a flap-free intrastromal technique for the correction of myopia and myopic astigmatism.To date,this technique lacks automated centration and cyclotorsion control,so several concerns have been raised regarding its capability to correct moderate or high levels of astigmatism.The objective of this paper is to review the reported SMILE outcomes for the correction of myopic astigmatism associated with a cylinder over 0.75 D,and its comparison with the outcomes reported with the excimer laser-based corneal refractive surgery techniques.A total of five studies clearly reporting SMILE astigmatic outcomes were identified.SMILE shows acceptable outcomes for the correction of myopic astigmatism,although a general agreement exists about the superiority of the excimer laser-based techniques for low to moderate levels of astigmatism.Manual correction of the static cyclotorsion should be adopted for any SMILE astigmatic correction over 0.75 D. | Jorge L.Aliódel Barrio Verónica Vargas Olena Al-Shymali Jorge L.Alió | 2017 | Eye and Vision2017，4，1： | 8 |
| 3 | Second-line rescue triple therapy with levofloxacin after failure of non-bismuth quadruple “sequential” or “concomitant” treatment to eradicate H. pylori infection显示文摘 | Javier P. Gisbert Javier Molina-Infante Alicia C. Marin Gemma Vinagre Jesus Barrio Adrian Gerald McNicholl | 2013 | Scandinavian Journal of Gastroenterology2013，，6： | 6 |
| 4 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 5 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 6 | Corneal surgery in keratoconus: which type, which technique, which outcomes?显示文摘Keratoconus is a disease characterized by progressive thinning,bulging,and distortion of the cornea.Advanced cases usually present with loss of vision due to high irregular astigmatism.A majority of these cases require surgical intervention.This review provides an update on the current treatment modalities of corneal surgery available for the management of advanced corneal ectasias. | Francisco Arnalich-Montiel Jorge L.Aliodel Barrio Jorge L.Alio | 2016 | Eye and Vision2016，3，1： | 4 |
| 7 | Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement显示文摘 | J. Esquivel R. Sticca P. Sugarbaker E. Levine T. D. Yan R. Alexander D. Baratti D. Bartlett R. Barone P. Barrios S. Bieligk P. Bretcha-Boix C. K. Chang F. Chu Q. Chu S. Daniel E. Bree M. Deraco L. Dominguez-Parra D. Elias R. Flynn J. Foster A. Garofalo F. | 2007 | Annals of Surgical Oncology2007，，1： | 4 |
| 8 | Accommodative intraocular lenses:where are we and where we are going显示文摘Presbyopia still remains the last frontier of refractive surgery.Its surgical management is under constant evolution due to the limitations that exist today with respect to its management,which is probably in relation with the multifactorial basis in which presbyopia is clinically developed in the human.Until currently,virtually all surgical techniques that have been proposed for its correction are based on the induction of pseudoaccommodation in the presbyopic eye,including multifocality.However,the real restoration of accommodation is more complex,and it has been tried by the use of different,so called,“accommodative”pseudophakic intraocular lenses(AIOL).Overall,the reported results with these lenses by independent authors have been modest in relation with the restoration of the accommodative power of the eye and these modest benefits are usually lost with time due to the long term changes in the capsular bag.This fact made these lenses to be almost abandoned in the last few years,but there are currently other AIOL models being used with innovative mechanisms of action and different anatomical support outside the capsular bag that offer encouraging preliminary results that could bring a new potential of application to these types of lenses.In this article,we will update the modern refractive surgeon about the fundamentals and provide updated information about the outcomes of AIOLs by reviewing the concept of accommodation,the different attempts that have been accomplished in the past,their demonstrated published results in human clinical trials,and the future alternatives that may arrive in the near future. | Jorge L.Alió Jorge L.Aliódel Barrio Alfredo Vega-Estrada | 2017 | Eye and Vision2017，4，1： | 4 |
| 9 | Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients显示文摘AIM:To evaluate the effectiveness of adalimumab in preventing recurrence after intestinal resection for Crohn's disease in high-risk patients.METHODS:A multicenter,prospective,observational study was conducted from June 2009 until June 2010.We consecutively included high-risk Crohn's disease patients who had undergone an ileal/ileocolonic resection.High-risk patients were defined as two or more criteria:smokers,penetrating pattern,one or more previous surgical resections or prior extensive resection.Subcutaneous adalimumab was administered 2 wk(± 5 d) after surgery at a dose of 40 mg eow,with an initial induction dose of 160/80 mg at weeks 0 and 2.Demographic data,previous and concomitant treatments(antibiotics,5-aminosalicylates,corticosteroids,immunomodulators or biologic therapies),smoking status at the time of diagnosis and after the index operation and number of previous resections(type and reason for surgery) were all recorded.Biological status was assessed with C-reactive protein,erythrocyte sedimentation rate and fecal calprotectin.One year(± 3 mo) after surgery,an ileocolonoscopy and/or magnetic resonance enterography was performed.Endoscopic recurrence was defined as Rutgeerts score ≥ i2.Morphological recurrence was based on magnetic resonance(MR) score ≥ MR1.RESULTS:Twenty-nine patients(55.2% males,48.3% smokers at diagnosis and 13.8% after the index operation),mean age 42.3 years and mean duration of the disease 13.8 years were included in the study.A mean of 1.76(range:1-4) resections previous to adalimumab administration and in 37.9% was considered extensive resection.51.7% had previously received infliximab.Immunomodulators were given concomitantly to 17.2% of patients.Four of the 29(13.7%) developed clinical recurrence,6/29(20.7%) endoscopic recurrence and 7/19(36.8%) morphological recurrence after 1-year.All patients with clinical recurrence showed endoscopic and morphological recurrence.A high degree of concordance was found between clinical-endoscopic recurrence(k = 0.76,P < 0.001) and clinical-morphological recurrence(k = 0.63,P = 0.003).Correlation between endoscopic and radiological findings was good(comparing the 5-point Rutgeerts score with the 4-point MR score,a score of i4 was classified as MR3,i3 as MR2,and i2-i1 as MR1)(P < 0.001,r s = 0.825).During follow-up,five(17.2%) patients needed adalimumab dose intensification(40 mg/wk);Mean time to intensification after the introduction of adalimumab treatment was 8 mo(range:5 to 11 mo).In three cases(10.3%),a biological change was needed due to a worsening of the disease after the dose intensification to 40 mg/wk.One patient suffered an adverse event.CONCLUSION:Adalimumab seems to be effective and safe in preventing postoperative recurrence in a selected group of patients who had undergone an intestinal resection for their CD. | Mariam Aguas Guillermo Bastida Elena Cerrillo Belén Beltrán Marisa Iborra Cristina Sánchez-Montes Fernando Muoz Jesús Barrio Sabino Riestra Pilar Nos | 2012 | World Journal of Gastroenterology2012，18，32： | 3 |
| 10 | Peptidomic analysis of whey protein hydrolysates and prediction of their antioxidant peptides显示文摘Enzymatic hydrolysis of proteins is a breakdown process of peptide bond in proteins,releasing some peptides with potential biological functions.Previous studies on enzymatic hydrolysis of whey proteins have not identified the complete peptide profiles after hydrolysis.In this study,we reconstructed a profile of peptides from whey hydrolysates with two enzymes and different processing conditions.We also developed an ensemble machine learning predictor to classify peptides obtained from whey hydrolysis.A total of 2572 peptides were identified over three process conditions with two enzymes in duplicate.499 peptides were classified and chosen as potential antioxidant peptides from whey proteins.The peptides classified as antioxidants in the hydrolysates had a proportion of 13.1%-24.5%regarding all peptides identified.These results facilitate the selection of promising peptides involved in the antioxidant properties during the enzymatic hydrolysis of whey proteins,aiding the discovery of novel antioxidant peptides. | Jesus Morales García Chibuike C.Udenigwe Jorge Duitama Andrés Fernando González Barrios | 2022 | Food Science and Human Wellness2022，11，2： | 3 |
| 11 | Supporting and strengthening research on urban health interventions for the prevention and control of vector-borne and other infectious diseases of poverty:scoping reviews and research gap analysis显示文摘Background:More than half of the world’s population currently lives in urban settlements that grow both in size and number.By 2050,approximately 70%of the global population will be living in urban conglomerations,mainly in low-and middle-income countries.Mobility,poverty,different layers of inequalities as well as climate variability and change are some of the social and environmental factors that influence the exposure of human populations in urban settings to vector-borne diseases,which pose eminent public health threats.Accurate,consistent,and evidencebased interventions for prevention and control of vector-borne and other infectious diseases of poverty in urban settings are needed to implement innovative and cost-effective public policy and to promote inclusive and equitable urban health services.Main body:While there is growing awareness of vector-borne diseases epidemiology at the urban level,there is still a paucity of research and action being undertaken in this area,hindering evidence-based public health policy decisions and practice and strategies for active community engagement.This paper describes the collaboration and partnership of the Special Programme for Research and Training in Tropical Diseases(TDR)hosted by the World Health Organization(WHO)and the“VEctor boRne DiseAses Scoping reviews”(VERDAS)Research Consortium as they joined efforts in response to filling this gap in knowledge and evidence by supporting the development of a series of scoping reviews that highlight priority research gaps and policy implications to address vector-borne and other infectious diseases at the urban level.Conclusions:The set of scoping reviews proposed in this special issue presents a critical analysis of the state-of-the-art of research on urban health interventions for the prevention and control of vector-borne and other infectious diseases of poverty.The authors of the 6 reviews highlighted severe gaps in knowledge and identified organizational and theoretical limitations that need to be urgently tackled to improve cities preparedness and vector control response.The more pressing need at present is to ensure that more implementation research on vector-borne diseases in urban settings is conducted,addressing policy and practice implications and calling for more political commitment and social mobilization through adequate citizen engagement strategies. | Mariam Otmani del Barrio Frederic Simard Andrea Caprara | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 12 | Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry显示文摘Background:To study and compare the clinical optical image quality following implantation with different premium IOLs by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based aberrometer.Methods:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 LENTIS Mplus LS-313 MF30;(d)33 LENTIS Mplus LS-313 MF15;(e)17 AkkoLens Lumina;(f)31 AT LISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis Eyhance.Main outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(LOA)and high-order aberration(HOA)RMS measured by PWS aberrometer.Results:AT LISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;P<0.05),followed by SA60AT(0.41±0.11 and 0.28±0.07)and PanOptix(0.4±0.07 and 0.26±0.04).AT LISA Tri was found to provide a significantly better retinal image quality than PanOptix at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.004).Mplus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.002).Total RMS,LOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(P<0.001).Conclusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted lens.AT LISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic. | Jorge L.Alio Francesco D’Oria Francesca Toto Joan Balgos Antonio Palazon Francesco Versaci Jorge L.Alio del Barrio | 2021 | Eye and Vision2021，8，1： | 3 |
| 13 | Convergent Agency:Encouraging Transdisciplinary Approaches for Effective Climate Change Adaptation and Disaster Risk Reduction显示文摘Three recent global agreements have been established to facilitate the implementation of global-level responsibilities to deal with disaster risk reduction(DRR),human development,and climate change adaptation(CCA)respectively.While these agreements have a common goal of reducing social,economic,and environmental vulnerability,they have been developed by largely independent communities of practice.This has limited cross-fertilization despite the inherent multidimensional nature of global challenges and the considerable thematic overlap.We argue that developing a transdisciplinary strategy that effectively integrates disciplines,approaches,and knowledge systems will lead to greater and more sustainable impacts,together with a more efficient use of financial resources.Hybrid approaches should be encouraged during planning of future development efforts so that risk reduction is conducted simultaneously with CCA.Transdisciplinary processes are central to generating contextsensitive knowledge to support decisions on CCA and DRR options that minimize trade-offs and maximize synergies and complementarities required to guide sustainable development trajectories.Finally,building codes together with climate and risk-smart research,education,and awareness raising,are identified as priority entry points to materialize the blending of DRR and CCA approaches and effectively reduce risk while mitigating and adapting to climate change. | América Bendito Edmundo Barrios | 2016 | International Journal of Disaster Risk Science2016，7，4： | 2 |
| 14 | Fuzzy C-means Rule Generation for Fuzzy Entry Temperature Prediction in a Hot Strip Mill显示文摘Variable estimation for finishing mill set-up in hot rolling is greatly affected by measurement uncertainties,variations in the incoming bar conditions and product changes.The fuzzy C-means algorithm was evaluated for rulebase generation for fuzzy and fuzzy grey-box temperature estimation.Experimental data were collected from a reallife mill and three different sets were randomly drawn.The first set was used for rule-generation,the second set was used for training those systems with learning capabilities,while the third one was used for validation.The performance of the developed systems was evaluated by five performance measures applied over the prediction error with the validation set and was compared with that of the empirical rule-base fuzzy systems and the physical model used in plant.The results show that the fuzzy C-means generated rule-bases improve temperature estimation;however,the best results are obtained when fuzzy C-means algorithm,grey-box modeling and learning functions are combined.Application of fuzzy C-means rule generation brings improvement on performance of up to 72%. | Jose Angel BARRIOS Cesar VILLANUEVA Alberto CAVAZOS Rafael COLAS | 2016 | Journal of Iron and Steel Research(International)2016，23，2： | 2 |
| 15 | Comparing Land Degradation and Regeneration Trends in China Drylands显示文摘The aim of this paper is to offer a statistically sound method to make a precise account of the speed of land degradation and regeneration processes.Most common analyses of land degradation focus instead on the extent of degraded areas,rather than on the intensity of degradation processes.The study was implemented for the Potential Extent of Desertification in China(PEDC),composed by arid,semi-arid,and dry sub-humid regions and refers to the period 2002 to 2012.The metrics were standard partial regression coefficients from stepwise regressions,fitted using Net Primary Productivity as the dependent variable,and year number and aridity as predictors.The results indicate that:①the extension of degrading lands(292896 km 2 or 9.12%of PEDC)overcomes the area that is recovering(194560 km 2 or 6.06%of PEDC);and②the intensity of degrading trends is lower than that of increasing trends in three land cover types(grassland,desert,and crops)and in two aridity levels(semi-arid and dry sub-humid).Such an outcome might pinpoint restoration policies by the Chinese government,and document a possible case of hysteresis. | Gabriel Del BARRIO Zhihai GAO Jaime Martinez-VALDERRAMA Xiaosong LI Maria ESANJUAN Bin SUN Alberto RUIZ Bengyu WANG Juan PUIGDEFABREGAS | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 16 | Acid activation of a palygorskite with HCl:development of physico-chemical,textural and surface properties显示文摘 | BARRIOS M S GONZALEZ F VICENTE-RODRIGUEZ M A | 1995 | Appl Clay Sci1995，30，10： | 2 |
| 17 | Cellular therapy of the corneal stroma: a new type of corneal surgery for keratoconus and corneal dystrophies显示文摘Cellular therapy of the corneal stroma,with either ocular or extraocular stem cells,has been gaining a lot of interest over the last decade.Multiple publications from different research groups are showing its potential benefits in relation to its capacity to improve or alleviate corneal scars,improve corneal transparency in metabolic diseases by enhancing the catabolism of the accumulated molecules,generate new organized collagen within the host stroma,and its immunosuppressive and immunomodulatory properties.Autologous extraocular stem cells do not require a healthy contralateral eye and they do not involve any ophthalmic procedures for their isolation.Mesenchymal stem cells have been the most widely assayed and have the best potential to differentiate into functional adult keratocytes in vivo and in vitro.While embryonic stem cells have been partially abandoned due to ethical implications,the discovery of the induced pluripotent stem cells(iPSC)has opened a new and very promising field for future research as they are pluripotent cells with the capacity to theoretically differentiate into any cell type,with the special advantage that they are obtained from adult differentiated cells.Cellular delivery into the corneal stroma has been experimentally assayed in vivo in multiple ways:systemic versus local injections with or without a carrier.Encouraging preliminary human clinical data is already available although still very limited,and further research is necessary in order to consolidate the clinical applications of this novel therapeutic line. | Jorge L.Aliódel Barrio Jorge L.Alió | 2018 | Eye and Vision2018，5，1： | 2 |
| 18 | Textural and structural modifications of saponite from Cerro del Aguila by acid treatment 显示文摘 | BARRIOS M S BUEY C S ROMERO E G | 2001 | Clay Miner2001，36，： | 2 |
| 19 | Four-food group elimination diet for adult eosinophilic esophagitis: A prospective multicenter study显示文摘 | Javier Molina-Infante Angel Arias Jesus Barrio Joaquín Rodríguez-Sánchez Marta Sanchez-Cazalilla Alfredo J. Lucendo | 2014 | The Journal of Allergy and Clinical Immunology2014，，： | 2 |
| 20 | Identification of the source of androgen excess in hyperandrogenic type 1 diabetic patients显示文摘 | Roldan B Escobar-Morreale HF Barrio R | 2001 | Diabetes Care2001，24，7： | 1 |
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