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| 1 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 2 | Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study显示文摘 | Mats Lindblad Luis A. García Rodríguez Jesper Lagergren | 2005 | Cancer Causes & Control2005，，3： | 3 |
| 3 | Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population‐based study显示文摘 | Jesper Lagergren Anna Lindam Robert M. Mason | 2012 | Int J Cancer2012，，6： | 2 |
| 4 | Transpiration response to soil moisture in pine and spruce trees in Sweden显示文摘 | Fredrik Lagergren Anders Lindroth | 2002 | Agricultural and Forest Meteorology2002，，2： | 2 |
| 5 | 急性上消化道出血显示文摘每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消化道出血的初期处理以及消化性溃疡出血的后续管理提供了指导。 | Emma Sverden Sheraz R Markar Lars Agreus Jesper Lagergren 龚亮(译) 吴东(校) 无 | 2019 | 英国医学杂志中文版2019，22，7： | 1 |
| 6 | Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma显示文摘 | Lagergren J Bergstrom R Lindgren A | 1999 | N Engl J Med1999，340，11： | 1 |
| 7 | Fruit and vegetable consumption in the prevention of esophageal and cardia cancers显示文摘 | Terry P Lagergren J Hansen H | 2001 | Eur J Cancer Prev2001，10，4： | 1 |
| 8 | Fruit and vegetable consump- tion in the prevention of oesophageal and cardia cancers 显示文摘 | Terry P Lagergren J Hansen H | 2001 | Eur J Cancer Prey2001，10，4： | 1 |
| 9 | Zur theorie der sogenannten adsorption geloester stoffe显示文摘 | Lagergren S Svenska B K | | Veterskapsakad Handlingar0，24，： | 1 |
| 10 | Zur theorie der sogenannten adsorption geltister stoffe显示文摘 | Lagergren S | | K Sven Vetenskapsakad Handl0，24，4： | 1 |
| 11 | About the theory of so-called adsorption of soluble substance 显示文摘 | Lagergren S | | Kungliga Svenska Vetenskap- sakademiens Handlingar0，24，4： | 1 |
| 12 | Risk of obesity-related cancer after obesity surgery in a population-based cohort study显示文摘 | OSTLUND MP LU Y LAGERGREN J | 2010 | Ann Surg2010，52，6： | 1 |
| 13 | About the theory of so-called adsorption of sol- uble substances显示文摘 | Lagergren S | | Kungliga Svenska Vetenskapsakademiens Handlingar0，24，4： | 1 |
| 14 | Cracking Tendency and Drying Shrinkage of Silica Fume Concrete for Bridge Deck Application显示文摘 | Whiting D A Detwiler R J Lagergren E S | 2000 | ACI Materials Journal2000，97，1： | 1 |
| 15 | Human papillomavirus infection and esophageal cancer: a nationwide seroepidemiologic case- control study in Sweden 显示文摘 | Lagergren J Wang Z Bergstrom R | 1999 | J Nail Cancer Inst1999，91，2： | 1 |
| 16 | About the theory of so-called adsorption of soluble substances显示文摘 | Lagergren S | | Kungliga Svenska Vetenskapsakademiens Handlingar0，24，4： | 1 |
| 17 | Dietary intake of lig- nans and risk of adenocarcinoma of the esophagus and gastroesophageal junction显示文摘 | Lin Y Yngve A Lagergren J | 2012 | Cancer Causes Control2012，23，6： | 1 |
| 18 | Variation in sap flow and stem growth in relation to tree size, competition and thinning in a mixed forest of pine and spruce in Sweden显示文摘 | Lagergren F Lindroth A | 2004 | Forest Ecology and Management2004，188，13： | 1 |
| 19 | Helicobacter pylori infection and gastric atrophy, risk of adenocarcinoma and squamous cell carcinoma of the esopha- gus and adenocarcinoma of the gastric eardia显示文摘 | Ye W Held M Lagergren J | 2004 | JNCI2004，96，5： | 1 |
| 20 | Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma显示文摘 | Lagergren J Bergstrom R Lindgren | 1999 | N Engl J Med1999，340，： | 1 |
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