|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting autophagy in breast cancer显示文摘Macroautophagy(referred to as autophagy here) isan intracellular degradation pathway enhanced in response to a variety of stresses and in response to nutrient deprivation. This process provides the cell withnutrients and energy by degrading aggregated anddamaged proteins as well as compromised organelles.Since autophagy has been linked to diverse diseasesincluding cancer, it has recently become a very interesting target in breast cancer treatment. Indeed, currentclinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugsto inhibit autophagy during breast cancer therapy sincechemotherapy and radiation, regimens that are used totreat breast cancer, are known to induce autophagy incancer cells. Importantly, in breast cancer, autophagyhas been involved in the development of resistance tochemotherapy and to anti-estrogens. Moreover, a closerelationship has recently been described between autophagy and the HER2 receptor. Here, we discuss someof the recent findings relating autophagy and cancerwith a particular focus on breast cancer therapy. | Paola Maycotte Andrew Thorburn | 2014 | World Journal of Clinical Oncology2014，5，3： | 9 |
| 2 | Identifying specific receptors for cargo-mediated autophagy显示文摘Macroautophagy 在众多的疾病被含有,然而,我们为由 autophagy 的特定的货物的周转负责的蛋白质的理解被限制。在在自然出版的一篇最近的论文, Mancias 等。使用量的 proteomics 识别充实 autophagosome 的蛋白质的一个队,哪个之一,(NCOA4 ) 原子受体激活剂 4 被显示为 ferritin 的选择交货被要求到 lysosome,由 ferritin 的 autophagic 周转的最终调整的细胞内部的铁,或 ferritinophagy。 | Megan Goodall Andrew Thorburn | 2014 | Cell Research2014，24，7： | 6 |
| 3 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 4 | Autophagy and apoptosis: what is the connection?显示文摘 | Jacob M. Gump Andrew Thorburn | 2011 | Trends in Cell Biology2011，，7： | 2 |
| 5 | Inhibitionof a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase显示文摘 | Thorburn J Carlson M Mansour SJ | 1995 | Mol Biol Cell1995，6，： | 1 |
| 6 | Merger negotiations and thetoehold puzzle显示文摘 | Betton S Eckbo BE Thorburn KS | 2009 | Journal of Financial Economics2009，91，： | 1 |
| 7 | The tyrosine kinase inhibitor,genistein,prevents α-adrenergic-induced cardiac muscle cell hypertrophy by inhibiting activation of the Ras-MAP kinase signaling pathway显示文摘 | THORBURN J THORBURN A | 1994 | Biochem Biophys Res Commun1994，202，3： | 1 |
| 8 | Targeting chaperone-mediated autophagy in cancer显示文摘 | Thorburn A Debnath J | | 0，，109： | 1 |
| 9 | Death receptor-induced cell killing显示文摘 | Thorburn A | 2004 | Cell Signal2004，16，： | 1 |
| 10 | The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolisn following chronic treatment in obese mice and β3-AR knock-out mece显示文摘 | Heffernan M Summers RJ Thorburn A | 2001 | Endocrinology2001，142，12： | 1 |
| 11 | RAGE-induced eytosolic ROS promote mitochondrial superoxide generation in diabetes显示文摘 | COUGHLAN M T THORBURN D R PENFOLD S A | 2009 | J Am Soc Nephrol2009，20，4： | 1 |
| 12 | High incidenceof pulmonary bacterial co-infection in children with severerespiratory syncytial virus (RSV) bronchiolitis显示文摘 | Thorburn K Harigopal S Reddy V | 2006 | Thorax2006，61，7： | 1 |
| 13 | Rapid Analysis of Ecstasy and Related Phenethylamines in Seizedtablets by Raman Spectroscopy显示文摘 | BELL S E J THORBURN B D | 2000 | Analyst2000，125，3： | 1 |
| 14 | Biochemical analyses of the electron transport chain complexes by spectrophotometry 显示文摘 | Frazier AE Thorburn DR | 2012 | Methods Mol Biol2012，837，： | 1 |
| 15 | Spinal and general anaesthesia in total hip replacement:frequency of deep vein thrombosis显示文摘 | Thorburn J Louden J R Vallance R | 1980 | Br J anaesth1980，52，： | 1 |
| 16 | Risk factors for ectopic preg- nancy in assisted reproduction 显示文摘 | Strandell A Thorburn J 14amberger L | 1999 | Fertil Steril1999，7，2： | 1 |
| 17 | RAGE- induced cytosolic ROS promote mitochondrial superoxide generation in diabetes 显示文摘 | COUGHLAN M T THORBURN D R PENFOLD S A | 2009 | journal of the American society of nephrology2009，20，4： | 1 |
| 18 | Aetiology,course and outcome of children admitted to paediatric intensive care with convulsive status epilepticus:a retrospective 5-year review显示文摘 | Hussain N Appleton R Thorburn K | | 0，，： | 1 |
| 19 | Autoph-agy in cancer good, bad, or both? 显示文摘 | Hippert M M (YToole P S Thorburn A | 2006 | Cancer Res2006，66，19： | 1 |
| 20 | Ultrastructural and cytological study of the bovine corpus luteum显示文摘 | Parry D M Willcox D L Thorburn G D | 1980 | J Reprod Fertil1980，60，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员