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| 1 | 风沙移动与植物生物量的关系以及植物固沙能力研究(英文)显示文摘荒漠化是植被覆盖退化、风蚀水蚀加剧的过程。适应流沙条件的植物能够逆转荒漠化 (沙化 )过程 ,能够固沙。可用于研究植物固沙能力的数据不多。为了研究与植物生物量相关的植株周围的“风成沙移置 (wind_inducedsanddisplacement)” ,在研究中 ,将植株周围的风沙移动与 3种植物的生物量配置格局联系起来。并发展了一种新方法 ,以对植物固沙能力进行实验研究。风沙移动与生物量的关系不是线性的。除了植物生物量大小外 ,种类特异的植物特征 ,如生物量配置格局和植物枝叶的结构特征 ,在确定植物固沙能力方面也很重要。 | 董鸣 Bas ROELS Sebastiaan DONDERS Marinus J.A.W ERGER | 2001 | Acta Botanica Sinica2001，43，9： | 16 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 4 | The Need of Industry to Go FAIR显示文摘The industry sector is a very large producer and consumer of data,and many companies traditionally focused on production or manufacturing are now relying on the analysis of large amounts of data to develop new products and services.As many of the data sources needed are distributed and outside the company,FAIR data will have a major impact,both by reducing the existing internal data silos and by enabling the efficient integration with external(public and commercial)data.Many companies are still in the early phases of internal data”FAIRification”,providing opportunities for SMEs and academics to apply and develop their expertise on FAIR data in collaborations and public-private partnerships.For a global Internet of FAIR Data&Services to thrive,also involving industry,professional tools and services are essential.FAIR metrics and certifications on individuals,data,organizations,and software,must ensure that data producers and consumers have independent quality metrics on their data.In this opinion article we reflect on some industry specific challenges of FAIR implementation to be dealt with when choices are made regarding”Industry GOing FAIR”. | Herman van Vlijmen Albert Mons Arne Waalkens Wouter Franke Arie Baak Gerbrand Ruiter Christine Kirkpatrick Luiz Olavo Bonino da Silva Santos Bert Meerman Renger Jellema Derk Arts Martijn Kersloot Sebastiaan Knijnenburg Scott Lusher Rudi Verbeeck Jean-Marc Neefs | 2020 | Data Intelligence2020，2，1： | 4 |
| 5 | Pulmonary hypertension in hereditary haemorrhagic telangiectasia显示文摘Hereditary haemorrhagic telangiectasia(HHT) is an autosomal dominant inherited disorder characterised by vascular malformations in predominantly the brain,liverand lungs.Pulmonary hypertension(PH) is increasingly recognised as a severe complication of HHT.PH may be categorised into two distinct types in patients with HHT.Post-capillary PH most often results from a high pulmonary blood flow that accompanies the high cardiac output state associated with liver arteriovenous malformations.Less frequently,the HHT-related gene mutations in ENG or ACVRL1 appear to predispose patients with HHT to develop pre-capillary pulmonary arterial hypertension.Differentiation between both forms of PH by right heart catheterisation is essential,since both entities are associated with severe morbidity and mortality with different treatment options.Therefore all HHT patients should be referred to an HHT centre. | Veronique MM Vorselaars Sebastiaan Velthuis Repke J Snijder Jan Albert Vos Johannes J Mager Martijn C Post | 2015 | World Journal of Cardiology2015，7，5： | 4 |
| 6 | Chromium does not belong in the diabetes treatment arsenal: Current evidence and future perspectives显示文摘Chromium is considered to have positive effects on insulin sensitivity and is marketed as an adjunctive therapy for inducing glucose tolerance in cases of insulin resistance('the glucose tolerance factor'). Case reports on patients who received prolonged parenteral nutrition indeed showed that the absence of trivalent chromium caused insulin resistance and diabetes. However, whether patients with type 2 diabetes can develop a clinically relevant chromium deficiency is unclear. This review summarizes the available evidence regarding the potential effectiveness of chromium supplementation on glycemic control(Hemoglobin A1c levels) in patients with type 2 diabetes. No studies investigating the longterm safety of chromium in humans were found. All clinical trials that have been performed had a relative short follow-up period. None of the trials investigated whether the patients had risk factors for chromium deficiency.The evidence from randomized trials in patients with type 2 diabetes demonstrated that chromium supplementation does not effectively improve glycemic control. The meta-analyses showed that chromium supplementation did not improve fasting plasma glucose levels. Moreover, there were no clinically relevant chromium effects on body weight in individuals with or without diabetes. Future studies should focus on reliable methods to estimate chromium status to identify patients at risk for pathological alterations in their metabolism associated with chromium deficiency. Given the present data, there is no evidence that supports advising patients with type 2 diabetes to take chromium supplements. | Gijs WD Landman Henk JG Bilo Sebastiaan T Houweling Nanne Kleefstra | 2014 | World Journal of Diabetes2014，5，2： | 3 |
| 7 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 8 | Three-Dimensional Speckle Tracking Echocardiography for Automatic Assessment of Global and Regional Left Ventricular Function Based on Area Strain显示文摘 | Sebastiaan A. Kleijn Mohamed F.A. Aly Caroline B. Terwee Albert C. van Rossum Otto Kamp | 2011 | Journal of the American Society of Echocardiography2011，，3： | 2 |
| 9 | Comparison between three-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging for quantification of left ventricular volumes and function显示文摘 | Sebastiaan A. Kleijn Wessel P. Brouwer Mohamed F.A. Aly Iris K. Rüssel Gerben J. de Roest Aernout M. Beek Albert C. van Rossum Otto Kamp | 2012 | European Heart Journal – Cardiovascular Imaging2012，，10： | 2 |
| 10 | Treatment of grade III and IV haemorrhoidal disease with PPH or THD. A randomized trial on postoperative complications and short-term results显示文摘 | Sebastiaan Festen M. J. Hoogstraten A. A. W. Geloven M. F. Gerhards | 2009 | International Journal of Colorectal Disease2009，，12： | 2 |
| 11 | Three-Dimensional Speckle Tracking Echocardiography for Automatic Assessment of Global and Regional Left Ventricular Function Based on Area Strain显示文摘 | Sebastiaan A. Kleijn Mohamed F.A. Aly Caroline B. Terwee Albert C. van Rossum Otto Kamp | 2011 | Journal of the American Society of Echocardiography2011，，3： | 2 |
| 12 | Validation of material point method for soil fluidisation analysis显示文摘The main aim of this paper is to describe and analyse the modelling of vertical column tests that undergo fluidisation by the application of a hydraulic gradient.A recent advancement of the material point method(MPM),allows studying both stationary and non-stationary fluid flow while interacting with the solid phase.The fluidisation initiation and post-fluidisation processes of the soil will be investigated with an advanced MPM formulation(Double Point)in which the behavior of the solid and the liquid phase is evaluated separately,assigning to each of them a set of material points(MPs).The result of these simulations are compared to analytic solutions and measurements from laboratory experiments.This work is used as a benchmark test for the MPM double point formulation in the Anura3D software and to verify the feasibility of the software for possible future engineering applications. | Marco Bolognin Mario Martinelli Klaas J.Bakker Sebastiaan N.Jonkman | 2017 | Journal of Hydrodynamics2017，29，3： | 2 |
| 13 | Diagnostic performance of PET, SPECT and CMR per?fusion imaging for the detection of significant coronary artery disease - a meta - analysis显示文摘 | CarolineJaarsma Tim Leiner Sebastiaan Bekkers | 2011 | Journal Of Cardiovascular Magnetic Resonance2011，13，1： | 1 |
| 14 | Plant species loss in an urban area (Turnhout, Belgium) from 1880 to 1999 and its environmental determinants 显示文摘 | Sebastiaan V V Kris V Martin H | 2004 | Flora-Morphology Distribution Functional Ecology of Plants2004，199，6： | 1 |
| 15 | Cryopreservation of human embryos and its contribution to in vitro fertilization success rates显示文摘 | Kai MW Sebastiaan M Sjoerd R | 2014 | Fertil Steril2014，102，： | 1 |
| 16 | Epithelioid sarcoma:still an only surgically curable disease显示文摘 | Sebastiaan A Robbert J Theo W | 2006 | Am Cancer Society2006，107，3： | 1 |
| 17 | Detection and classification of infrared decoys and small targets in a sea background显示文摘 | Van den BROEK Sebastiaan P BAKKER Eric J de LANGE Dirk-Jan | 2000 | SPIE2000，4029，： | 1 |
| 18 | The role of personality traits in insomnia 显示文摘 | Merijn van de Laar Ingrid Verbeek Dirk Pevernagie Al- bert Aldenkamp Sebastiaan Overeem | 2010 | Sleep Medicine Reviews2010，14，1： | 1 |
| 19 | No association of CSF biomarkers with APOEε4,plaque and tangle burden in definite Alzheimer's disease显示文摘 | Kristel S Patrick C | 2007 | Brain2007，130，： | 1 |
| 20 | Three-dimensionalspeckle - tracking echocardiography for automatic assessment ofglobal and regional left ventricular function based on area strain显示文摘 | Sebastiaan A Mohamed F Caroline B | 2011 | J Am Soc Echocardiogr2011，24，3： | 1 |
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