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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | The neurochemistry of Alzheimer's disease 显示文摘 | Engelborghs S de Deyn PP | 1997 | Acta Neurol Belg1997，97，2： | 2 |
| 4 | Pathophysiology of language switching and mixing in an early bilingual child with subcortical aphasia显示文摘 | Marien P Abutalebi J Engelborghs S | 2005 | Neurocase2005，11，6： | 1 |
| 5 | Correlations between cognitive,behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia显示文摘 | Engelborghs S Vloeberghs E Maertens K | 2004 | Int J Geriatr Psychiatry2004，19，4： | 1 |
| 6 | Numerical bifurcation analysis of delay differential equations arising from physiological modeling显示文摘 | Engelborghs K Lemaire V Belair J | | 0，，04： | 1 |
| 7 | Impairment of syntax and lexical semantics in a patient with bilateral paramedian alamic infarction显示文摘 | De Witte L Wilssens I Engelborghs S | 2006 | Brain Lang2006，96，1： | 1 |
| 8 | APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease显示文摘 | Bettens K Brouwers N Engelborghs S | 2009 | Hum Mutat2009，30，8： | 1 |
| 9 | Loss of psychic self-activation after paramedian bithalamic infarction显示文摘 | Engelborghs S Marien P Pickut BA | 2000 | Stroke2000，31，7： | 1 |
| 10 | Stability and rupture of bifurcation bridges in semiconductor lasers subject to optical feedback显示文摘 | Haegeman B Engelborghs K Roose D Pieroux D Erneux T | 2002 | Phys Rev E2002，66，04： | 1 |
| 11 | Alzheimer risk associated with a copy number variation in the complement recep- tor 1 increasing C3b/C4b binding sites显示文摘 | Brouwers N Van Cauwenberghe C Engelborghs S | 2012 | Mol Psychiatry2012，17，2： | 1 |
| 12 | Anomalous cerebral language organization:acquired crossed aphasia in a dextral child显示文摘 | Marien P Engelborghs S Paquier P | 2001 | Brain Lang2001，76，2： | 1 |
| 13 | The neurochemistry of Alzheimer's disease显示文摘 | Engelborghs S de Deyn PP | 1997 | Acta Neurol Belg1997，97，2： | 1 |
| 14 | The neurochemistry of Alzheimer's disease显示文摘 | Engelborghs S De Deyn P P | 1997 | Acta Neurol Belg1997，97，2： | 1 |
| 15 | Impairment of syntax and lexical semantics in a patient with bilateral paramedian thalamic infarction显示文摘 | De Witte L Wilssens I Engelborghs S | 2006 | Brain Lang2006，96，1： | 1 |
| 16 | The conformation and the aggregation kinetics of alpha-synuclein depend on the proline residues in its C-terminal region显示文摘 | Meuvis J Gerard M Desender L Baekelandt V Engelborghs Y | 2010 | Biochemistry2010，49，： | 1 |
| 17 | Interac- tions between oligonucleotides and cationic polymers in- vestigated by fluorescence correlation spectroscopy 显示文摘 | Rompaey E V Engelborghs Y Sanders N | 2001 | Pharmaceutical Research2001，18，7： | 1 |
| 18 | On the mechanism of activator of human plasminogen by recombinant staphylokinase显示文摘 | Collen D Schlott B Engelborghs Y | 1993 | J Biol Chen1993，268，： | 1 |
| 19 | Loss of psychic self-activation after paramedian bithalamic infarction显示文摘 | Engelborghs S Marian P Pickut BA | 2000 | Stroke2000，31，： | 1 |
| 20 | A role for the cerebellum in motor speech planning:evidence from foreign accentsyndrome显示文摘 | Marien P Verhoeven J Engelborghs S | | 0，，： | 1 |
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