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| 1 | Mast Cell-Derived Exosomes at the Stimulated Acupoints Activating the Neuro-immune Regulation显示文摘Exosomes are cell-derived vesicles that take part in intercellular signaling. Research has shown that acupuncture is closely related to affecting the functions of the mast cells in the local region of the acupoint, and stimulating the afferent nerve. Mast cells have a connection with the conduction within the meridians, and play an important role in immuno-regulation. The 'synapse-like' connection between the mast cells and nerve endings is the basis for the exchange of information between these two tissues. Exosome mediates mast exchange of information between mast cells and the nerves, starting the process of neuro-immuno regulation. Therefore, we propose that mast cell-derived exosomes mediate the neuro-immuno regulation at the local site of acupuncture, and this is one of the key factors resulting in the effectiveness of acupuncture. | CHEN Bo LI Ming-yue GUO Yi ZHAO Xue LIM Hui-min Calista | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 15 |
| 2 | Treatment for gastric ‘indefinite for neoplasm/dysplasia' lesions based on predictive factors显示文摘BACKGROUND Gastric ‘indefinite for neoplasm/dysplasia'(IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management.AIM To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions.METHODS In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection(n = 134), surgery(n = 22), and follow-up endoscopic biopsy(n = 305) were performed to confirm the diagnosis.The time interval from initial biopsy to cancer diagnosis was measured, and diagnostic delays were categorized as > 2 wk, > 2 mo, > 6 mo, and > 1 year. The IFND lesions presenting as regenerating atypia(60%) or atypical epithelia(40%)at initial biopsy were adenocarcinomas in 22.6%, adenomas in 8.9%, and gastritis in 68.5% of the cases.RESULTS Four clinical factors [age ≥ 60 years(2.445, 95%CI: 1.305-4.580, P = 0.005),endoscopic size ≥ 10 mm(3.519, 95%CI: 1.891-6.548, P < 0.001), single lesion(5.702, 95%CI: 2.212-14.696, P < 0.001), and spontaneous bleeding(4.056, 95%CI:1.792-9.180, P = 0.001)], and two pathologic factors [atypical epithelium(25.575,95%CI: 11.537-56.695, P < 0.001], and repeated IFND diagnosis [6.022, 95%CI:1.822-19.909, P = 0.003)] were independent risk factors for gastric cancer. With two or more clinical factors, the sensitivity and specificity for carcinoma were91.3% and 54.9%, respectively. Ten undifferentiated carcinomas were initially diagnosed as IFND. In the subgroup analysis, fold change(5.594, 95%CI: 1.458-21.462, P = 0.012) predicted undifferentiated or invasive carcinoma in the submucosal layers or deeper. Diagnostic delays shorter than 1 year were not associated with worse prognoses. Extremely well-differentiated adenocarcinomas accounted for half of the repeated IFND cases and resulted in low diagnostic accuracy even on retrospective blinded review.CONCLUSION More than two clinical and pathologic factors each had significant cut-off values for gastric carcinoma diagnosis; in such cases, endoscopic resection should be considered. | Mi Jung Kwon Ho Suk Kang Hyeon Tae Kim Jin Woo Choo Bo Hyun Lee Sung Eun Hong Kun Ha Park Dong Min Jung Hyun Lim Jae Seung Soh Sung Hoon Moon Jong Hyeok Kim Hye-Rim Park Soo Kee Min Jin won Seo Ji-Young Choe | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 3 | Predisposing Factors of Hepatocellular Carcinoma Recurrence Following Complete Remission in Response to Transarterial Chemoembolization显示文摘 | Young-Joo Jin Young-Hwa Chung Jeong A. Kim Wonhyeong Park Don Lee Ju Hyun Shim Danbi Lee Kang Mo Kim Young-Suk Lim Han Chu Lee Yung Sang Lee Pyo Nyun Kim Kyu Bo Sung | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 4 | Equivalent-circuit Analysis of a Broadband Printed Dipole with Adjusted Integrated Balun and an Array for Base Station Applications显示文摘 | Rong Lin Li Terence Wu Bo Pan Kyutae Lim | | 0，，： | 1 |
| 5 | Clinical Useful- ness of Serum Cystatin C as a Marker of Renal Function 显示文摘 | Kwang Sook Woo Jae Lim CHoi Bo Ram Kim | 2014 | 38:278-2842014，38，： | 1 |
| 6 | ANTIOXIDANT ACTIVITY OF BENINCASA HISPIDA SEEDS显示文摘 | NADIRA BINTE SAMAD TRISHNA DEBNATH HAI LAN JIN BO RAM LEE PYO JAM PARK SEUNG YUAN LEE BEONG OU LIM | 2013 | Journal of Food Biochemistry2013，，4： | 1 |
| 7 | ANTIOXIDANT ACTIVITY OF INONOTUS OBLIQUUS GROWN ON GERMINATED BROWN RICE EXTRACTS显示文摘 | TRISHNA DEBNATH DONG KI PARK BO RAM LEE HAI LAN JIN SEUNG YUAN LEE NADIRA BINTE SAMAD BEONG OU LIM | 2013 | Journal of Food Biochemistry2013，，4： | 1 |
| 8 | Neuro endocrine responses to the insulin tolerance 显示文摘 | Bixter BO Lim W Hong S | 2004 | J Psychosom Res2004，56，4： | 1 |
| 9 | In vitro human digestion models forfood applications显示文摘 | Hur SJ Lim BO Eric A | | 0，，： | 1 |
| 10 | The effect of power- walking in phase 2 cardiac rehabilitation program显示文摘 | Kim C Kim BO Lim KB | 2012 | Ann Rehabil Med2012，36，1： | 1 |
| 11 | Dieary fiber modulate indeces of intestinal immune function in rats显示文摘 | Lim BO Yamada K Nonaka M | 1997 | Nutrition1997，127，5： | 1 |
| 12 | Energy management and control of electric vehicles,using hybrid power source in regenerative braking operation显示文摘 | LONG Bo LIM S T BAI Zhifeng | 2014 | Energies2014，7，7： | 1 |
| 13 | Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: A comparison with patients with alcohol use disorder and healthy controls显示文摘 | Heejung Kim Yu Kyeong Kim Ah Reum Gwak Jae-A Lim Jun-Young Lee Hee Yeon Jung Bo Kyung Sohn Sam-Wook Choi Dai Jin Kim Jung-Seok Choi | 2015 | Progress in Neuropsychopharmacology & Biological2015，，： | 1 |
| 14 | Fluorescence energy transfer inhibition bioassay for cholera toxin based on galactose-stabilized gold nanoparticles and amine-terminated quantum dots显示文摘 | Kwang-Soo Ahn Kyung Rae Lim Daeho Jeong Bo Young Lee Kwan Soo Kim Won-Yong Lee | 2016 | Microchemical Journal2016，，： | 1 |
| 15 | Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia显示文摘 | Yoo KY Hwang IK Lim BO | 2006 | Biol Pharm Bu112006，29，： | 1 |
| 16 | The anti-inflammatory effects of Pyrolae herba extract through the inhibition of the expression of inducible nitric oxide synthase (iNOS) and NO production显示文摘 | Mu Hong Lee Jeong Min Lee Sung Hoon Jun Seung Ha Lee Nam Wook Kim Jun Ho Lee Na Young Ko Se Hwan Mun Bo Kyung Kim Beong Ou Lim Dong Kug Choi Wahn Soo Choi | 2007 | Journal of Ethnopharmacology2007，，1： | 1 |
| 17 | Berberry ectract reduces neuro- nal damage and N-Methy-D-aspartate receptor 1 immunore activity in the gerbil hippocampus after transient forebrain ischemia 显示文摘 | Yoo KY Hwang IK Lim Bo | 2006 | Bi- ol Pharrn Bull2006，29，4： | 1 |
| 18 | The role of capsule endoscopy after negative CT enterography in patients with obscure gastrointestinal bleeding显示文摘 | Hyun Heo Chan Park Joon Lim Jin Lee Bo Kim Jae Cheon Tae Kim Won Kim Sung Hong | 2012 | European Radiology2012，，6： | 1 |
| 19 | Relationship between various surrogate indices of insulin resistance and mitochondrial DNA content in the peripheral blood of 18 healthy volunteers显示文摘 | Soo Lim Kyong Soo Park Min Seon Kim Bo Youn Cho Hong Kyu Lee | 2001 | Mitochondrion2001，，1： | 1 |
| 20 | Dietary fibers modulate indices of intestinal immune function in rats显示文摘 | Lim BO Yamada K Nonaka M | 1997 | J Nutr1997，127，5： | 1 |
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