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| 1 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 2 | Predictors of poor outcomes in patients with wild mushroom-induced acute liver injury显示文摘AIM To identify early predictive markers of poor outcomes in patients with acute liver injury from wild mushroom intoxication.METHODS This observational, retrospective record review involved adults aged ≥ 18 years admitted to emergency department with mushroom intoxication from January 2005 to December 2015. The diagnosis of mushroom intoxication was based on the following:(1) a positive history of recent wild mushroom intake(either raw or cooked);(2) the onset of gastrointestinal symptoms, such as watery diarrhea, vomiting, and/or abdominal pain, after ingestion; and(3) the exclusion of other possible causes of acute liver injury. Acute liver injury was defined by a > 5-fold elevation of liver enzymes or moderate coagulopathy [international normalized ratio(INR) > 2.0]. Clinical and laboratory findings were compared in survivors and non-survivors.RESULTS Of 93 patients with mushroom intoxication, 23, 11 men(47.8%) and 12 women(52.2%), of median age 61 years, developed acute liver injury. The overall inhospital mortality rate was 43.5%(10/23). Among thelaboratory variables, mean serum alkaline phosphatase(73.38 ± 10.89 mg/dL vs 180.40 ± 65.39 mg/dL, P < 0.01), total bilirubin(2.312 ± 1.16 mg/dL vs 7.16 ± 2.94 mg/d L, P < 0.01) concentrations and indirect/direct bilirubin(2.45 ± 1.39 mg/dL vs 0.99 ± 0.45 mg/dL, P < 0.01) ratio as well as prothrombin time(1.88 ± 0.83 mg/dL vs 10.43 ± 4.81 mg/dL, P < 0.01), and activated partial thromboplastin time(a PTT; 32.48 ± 7.64 s vs 72.58 ± 41.29 s, P = 0.01), were significantly higher in non-survivors than in survivors. Logistic regression analysis showed that total bilirubin concentration(OR = 3.58, 95%CI: 1.25-10.22), indirect/direct bilirubin ratio(OR = 0.14, 95%CI: 0.02-0.94) and aP TT(OR = 1.30, 95%CI: 1.04-1.63) were significantly associated with mortality. All patients with total bilirubin > 5 mg/dL or aP TT > 50 s on day 3 died.CONCLUSION Monitoring of bilirubin concentrations and a PTT may help in predicting clinical outcomes in patients with acute liver injury from wild mushroom intoxication. | Taerim Kim Danbi Lee Jae Ho Lee Yoon-Seon Lee Bum Jin Oh Kyoung Soo Lim Won Young Kim | 2017 | World Journal of Gastroenterology2017，23，7： | 7 |
| 3 | Predisposing Factors of Hepatocellular Carcinoma Recurrence Following Complete Remission in Response to Transarterial Chemoembolization显示文摘 | Young-Joo Jin Young-Hwa Chung Jeong A. Kim Wonhyeong Park Don Lee Ju Hyun Shim Danbi Lee Kang Mo Kim Young-Suk Lim Han Chu Lee Yung Sang Lee Pyo Nyun Kim Kyu Bo Sung | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 4 | Encapsulation of metal layers within metal-organic frameworks as hybrid thin films for selective catalysis显示文摘 | Zhiling Xu Weina Zhang Jiena Weng Wei Huang Danbi Tian Fengwei Huo | 2016 | Nano Research2016，9，1： | 2 |
| 5 | Comparison of Chemoembolization with and without Radiation Therapy and Sorafenib for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Propensity Score Analysis显示文摘 | Gi-Ae Kim Ju Hyun Shim Sang Min Yoon Jinhong Jung Jong Hoon Kim Min-Hee Ryu Baek-Yeol Ryoo Yoon-Koo Kang Danbi Lee Kang Mo Kim Young-Suk Lim Han Chu Lee Young-Hwa Chung Yung Sang Lee | 2014 | Journal of Vascular and Interventional Radiology2014，，： | 2 |
| 6 | Reappraisal of serum alpha‐foetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment显示文摘 | Gi‐Ae Kim Chang Hyeon Seock Jang Won Park Jihyun An Kwang‐Sun Lee Jee Eun Yang Young‐Suk Lim Kang Mo Kim Ju Hyun Shim Danbi Lee Han Chu Lee | 2015 | Liver Int2015，，1： | 2 |
| 7 | Responses of white spruce (Picea glauca) to experimental warming at a subarctic alpine treeline显示文摘 | Danby R K Hik D S | | 0，，13： | 1 |
| 8 | H istopatholoy of psoriasis treated with zinc pyrithione显示文摘 | Row lands CG Danby FW | 2000 | Am J Dermatopathol2000，22，3： | 1 |
| 9 | SC print quality influenced by fiber length, fabric structures and machine drainage characteristics显示文摘 | Roger Danby | 2002 | TAPPI Journal2002，，9： | 1 |
| 10 | Skin barrier breakdown:a renaissance in emollient therapy显示文摘 | Cork MJ Danby S | 2009 | Br J Nuts2009，18，14： | 1 |
| 11 | Histopathology of psoriasis treated with zinc pyrithione显示文摘 | Rowiands CG Danby FW | 2000 | Am J Dermatopathol2000，22，3： | 1 |
| 12 | Nutrition and aging skin: sugar and glycation显示文摘 | Danby FW | 2010 | Clin Dermatol2010，28，4： | 1 |
| 13 | Impact of a bronchiolitis clinical care pathway on treatment and hospital stay 显示文摘 | Walker C Danby S Turner S | 2012 | EurJPediatr2012，171，5： | 1 |
| 14 | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic der-matitis显示文摘 | Danby SG Chittock J Brown K | 2014 | Br J Dermatol2014，170，4： | 1 |
| 15 | ESR of thermoluminescent centres in CaSO4 single crystals显示文摘 | Danby RJ | 1982 | J Phys C1982，15，： | 1 |
| 16 | Commentary: unroofing for hidradenitis suppurativa, why and how显示文摘 | Danby FW | 2010 | J Am Acad Dermatol2010，63，： | 1 |
| 17 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
| 18 | Variability, contingency and rapid change in recent subarctic alpine tree line dynamics 显示文摘 | Danby R K Hik D S | 2007 | Journal of Ecology2007，95，2： | 1 |
| 19 | Epidermal barrier dysfunction in atopic dermatitis显示文摘 | Cork MJ Danby SG Vasilopoulos Y | | 0，，08： | 1 |
| 20 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
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