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| 1 | Optic radiation injury in patients with aneurismal subarachnoid hemorrhage: a preliminary diffusion tensor imaging report显示文摘Visual field defect is one of the various clinical manifestations in patients with subarachnoid hemorrhage(SAH). Little is known about the pathogenic mechanism of visual field defect in SAH. In the current study, we investigated the diffusion tensor imaging(DTI) finding of the optic radiation in patients with SAH following rupture of a cerebral artery aneurysm. We recruited 21 patients with aneurismal SAH(12 males, 9 females, mean age, 52.67 years; range, 41–68 years) who showed no definite lesion along the visual pathway. Twenty-one age-and sex-matched normal control subjects were also recruited. DTI data were acquired at an average of 5.9 weeks(range: 3–12 weeks) after onset and reconstruction of the optic radiation was performed using DTI-Studio software. The fractional anisotropy value, apparent diffusion coefficient value,and fiber number of the optic radiation were measured. The fractional anisotropy value of the optic radiation was significantly decreased, and the apparent diffusion coefficient value was significantly increased, in patients with aneurismal SAH than in normal control subjects. However, there was no significant difference in the fiber number of the optic radiation between patients with aneurismal SAH and normal control subjects. The decrement of fractional anisotropy value and increment of apparent diffusion coefficient value of the optic radiation in patients with aneurismal SAH suggest optic radiation injury. Therefore, we recommend a thorough evaluation for optic radiation injury in patient with aneurismal SAH. | Sung Ho Jang Chul Hoon Chang Young Jin Jung Seong Ho Kim Jeong Pyo Seo | 2018 | Neural Regeneration Research2018，13，3： | 9 |
| 2 | Intraoperative radiofrequency ablation with or without tumorectomy for hepatocellular carcinoma in locations difficult for a percutaneous approach显示文摘BACKGROUND:Although hepatic resection is widely accepted as a proper modality for treating hepatocellular carcinoma(HCC),a majority of patients are unable to undergo surgical resection due to various tumor and patient factors.Radiofrequency ablation(RFA)has mostly been used as a therapeutic alternative to resection for treating HCC.The objective of this study was to evaluate the results of intraoperative RFA for HCCs in locations difficult for a percutaneous approach.METHODS:Eight patients(male,seven;age,49-67 years) with 8 HCCs in difficult locations were treated by intraoperative RFA.Six of the patients had local tumor progression after initial transarterial chemoembolization or ultrasound(US)guided percutaneous RFA.The locations of the tumors were hepatic dome in six patients,posterior subcapsule in one,and caudate lobe in one.The tumor size was 2.0 to 6.4 cm(mean,3.9 cm).Intraoperative RFA was performed at the tumor itself and an anticipated resection line under US guidance with 3 cm monopolar single or clustered internally cooled electrodes.Tumor resection was performed in six patients.One month later,treatment response was assessed by contrast material-enhanced computed tomography(CT).CT studies were performed every 2 or 3 months after RFA.RESULTS:RFA was technically successful in all tumors,and the contrast-enhanced CT images acquired one month later showed complete disappearance of tumor enhancement.One pneumothorax occurred.After a median follow-up of 18 months(range,6-30 months),no tumors showed local progression.During the follow-up period,four new recurrent tumors were observed in three patients.Four patients were alive at the time of this report and the other four died of hepatorenal syndrome,liver failure,and progression of new recurrent tumors.CONCLUSION:Intraoperative RFA with tumor resection can be an alterative treatment option for HCC in locations difficult for a percutaneous approach. | Hyung Ook Kim Seung Kwon Kim Byung Ho Son Chang Hak Yoo Hyun Pyo Hong Yong Kyun Cho Byung Ik Kim | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 9 |
| 3 | Trends in the incidence of cryptorchidism and hypospadias of registry-based data in Korea: a comparison between industrialized areas of petrochemical estates and a non-industrialized area显示文摘这研究试图在朝鲜在 cryptorchidism 和 hypospadias 的全国性的发生代表最近的趋势,并且决定是否有在发生的空间异质的证据。发生在一张人口在实时出生以后在开始的 4 年期间作为最新诊断的病人(男性) 的数字被计算,全国地并且地区性(一个非工业化的区域(Chuncheon ) 和石油化学的房地产(Yeocheon 和 Ulsan )) ,在 2000 和 2005 之间。为新病人的数据(分子) 从国家健康保险评论机构被获得,并且为居民登记人口的数据(分母) 从国家统计办公室。在 2000 和 2005 之间, cryptorchidism 和 hypospadias 的国家发生每 10 从 5.01 ~ 17.43 有一个增加的趋势; 000 个人并且从 1.40 ~ 3.28 每 10 000 个人分别地。cryptorchidism 的发生在 Yeocheon 是显著地更高的(在整个学习时期) 并且在 Ulsan (2001, 2002, 2004 和 2005 ) 比国家发生,而在 Chuncheon 的发生在 2001 和 2002 是显著地更低的。因为盒子的小数字,每年并且地区性比较 hypospadias 的率是困难的。在结论, cryptorchidism 的发生最近在朝鲜增加了。石油化学的房地产, Yeocheon 和 Ulsan,比国家发生有 cyptorchidism 的显著地更高的发生,它建议进一步的学习被需要在异例的发生获得趋势的一个更精确的评价并且证实在 petrochemicals 和异例之间的协会。 | Sae Chul Kim Su Kyoung Kwon Yeon Pyo Hong | 2011 | Asian Journal of Andrology2011，13，5： | 9 |
| 4 | One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients显示文摘Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up. | Yeon Pyo Yoo Ki-Woon Kang Hyeon Soo Yoon Jin Cheol Myung Yu Jeong Choi Won Ho Kim Sang Hyun Park Kyung Tae Jung Myung Ho Jeong | 2013 | Journal of Geriatric Cardiology2013，10，3： | 7 |
| 5 | Effects of Bacillus subtilis CSL2 on the composition and functional diversity of the faecal microbiota of broiler chickens challenged with Salmonella Gallinarum显示文摘Background: The chicken gastrointestinal tract contains a diverse microbiota whose composition and structure play important roles in gut functionality. In this study, microbial shifts resulting from feed supplementation with Bacillus subtilis CSL2 were evaluated in broilers challenged and unchallenged with Salmonella Gallinarum. To analyse bacterial community composition and functionality, 454 GS-FLX pyrosequencing of 16 S r RNA gene amplicons was performed.Results: The Quantitative Insights into Microbial Ecology(QIIME) pipeline was used to analyse changes in the faecal microbiota over a 24-h period. A total of 718,204 sequences from broiler chickens were recorded and analysed. At the phylum level, Firmicutes, Bacteroidetes, and Proteobacteria were the predominant bacterial taxa. In Salmonellainfected chickens(SC), Bacteroidetes were more highly abundant compared to control(NC) and Bacillus-treated(BT)chickens. At the genus level, in the NC and BT groups, Lactobacil us was present at high abundance, and the abundance of Turicibacter, unclassified Enterobacteriaceae, and Bacteroides increased in SC broilers. Furthermore, taxon-independent analysis showed that the SC and BT groups were compositional y distinct at the end of the 24-h period. Further analysis of functional properties showed that B. subtilis CSL2 administration increased gut-associated energy supply mechanisms(i.e. carbohydrate transport and metabolism) to maintain a stable microbiota and protect gut integrity.Conclusions: This study demonstrated that S. Gallinarum infection and B. subtilis CSL2 supplementation in the diet of broiler chickens influenced the diversity, composition, and functional diversity of the faecal microbiota. Moreover, the findings offer significant insights to understand potential mechanisms of Salmonel a infection and the mode of action of probiotics in broiler chickens. | Ju Kyoung Oh Edward Alain B.Pajarillo Jong Pyo Chae In Ho Kim Dong Soo Yang Dae-Kyung Kang | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 6 |
| 6 | Acute mediastinitis arising from pancreatic mediastinal fistula in recurrent pancreatitis显示文摘Acute mediastinitis is a fatal disease that usually originates from esophageal perforation and surgical infection.Rare cases of descending necrotizing mediastinitis can occur following oral cavity and pharynx infection or can be a complication of pancreatitis.The most common thoracic complications of pancreatic disease are reactive pleural effusion and pneumonia,while rare complications include thoracic conditions,such as pancreaticopleural fistula with massive pleural effusion or hemothorax and extension of pseudocyst into the mediastinum.There have been no reports of acute mediastinitis originating from pancreatitis in South Korea.In this report,we present the case of a 50-year-old female suffering from acute mediastinitis with pleural effusion arising from recurrent pancreatitis that improved after surgical intervention. | In Soo Choe Yong Seok Kim Tae Hee Lee Sun Moon Kim Kyung Ho Song Hoon Sup Koo Jung Ho Park Jin Sil Pyo Ji Yeong Kim In Seok Choi | 2014 | World Journal of Gastroenterology2014，20，40： | 6 |
| 7 | Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea显示文摘AIM: To investigate associations between the tumor necrosis factor alpha(TNF-α)-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A polymorphisms and HCC in Korea.METHODS: Hepatocellular carcinoma(HCC) cases were diagnosed at CHA Bundang Medical Center from June 1996 to August 2008. The association between TNF-α polymorphisms and HCC was analyzed in 157HCC patients and 201 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. We investigated five TNF-α polymorphisms,which are TNF-α-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A. The TNF-α genotype frequencies,genotype combinations and haplotypes were analyzed to disclose the association with HCC.RESULTS: None of the TNF-α polymorphisms was significantly associated with HCC. However,nine genotype combinations had associations with increased likelihood of HCC. Among them,TNF-α-1031/-857/-238 TT/CC/GA(AOR = 18.849,95%CI: 2.203-161.246,P = 0.007),TNF-α-1031/-308/-238 TT/GG/GA(AOR = 26.956,95%CI: 3.071-236.584,P = 0.003),and TNF-α-1031/-238 TT/GA(AOR = 21.576,95%CI: 2.581-180.394,P = 0.005) showed marked association with HCC. There were five haplotypes of TNF-α polymorphisms which were significantly associated with HCC. They are TNF-α-1031/-863/-857/-308/-238 T-C-C-G-A(OR = 25.824,95%CI: 1.491-447.223,P = 0.0005),TNF-α-1031/-857/-308/-238 T-C-G-A(OR = 12.059,95%CI: 2.747-52.950,P < 0.0001),TNF-α-1031/-857/-238 T-C-A(OR = 10.696,95%CI: 2.428-47.110,P = 0.0001),TNF-α-1031/-308/-238 T-G-A(OR = 7.556,95%CI: 2.173-26.280,P = 0.0002) and TNF-α-1031/-238 T-A(OR = 10.865,95%CI: 2.473-47.740,P = 0.0001). Moreover,HCC Okuda stage Ⅲ cases with the TNF-α-1031 CC genotype had better survival than those with the TT genotype(AOR = 5.795,95%CI: 1.145-29.323). CONCLUSION: Although no single TNF-α polymorphism is associated with HCC in this study,some TNF-α genotype combinations and haplotypes are associated with HCC. In addition,HCC Okuda stage Ⅲ cases with the TNF-α-1031 TT genotype may have a better prognosis than those with the CC genotype. | Suk Pyo Shin Nam Keun Kim Ju Hwan Kim Ju Ho Lee Jung Oh Kim Sung Hwan Cho Hana Park Mi Na Kim Kyu Sung Rim Seong Gyu Hwang | 2015 | World Journal of Gastroenterology2015，21，46： | 5 |
| 8 | s Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?显示文摘Background: Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia. Methods: In total, 547 out-patients aged 18-5 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4^th Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator. Results: Early-onset MDD (EOD, 〈30 years) was associated with longer illness (P - 0.003), unmarried status (P 〈 0.001), higher neuroticism (P 〈 0.002) based on the SCL-90-R, and more limited social function and mental health (P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients with younger onset ages. Special clinical features and more impaired social function and quality of life were associated with EOD, as in western studies. Conclusions: EOD often follows higher levels of neuroticism. Age of onset of MDD may be a predictor of clinical features and impaired social function, allowing earlier diagnosis and treatment. | Yan-Hong Liu Lin Chen Yun-Ai Su Yi-Ru Fang Manit Srisurapanont Jin Pyo Hong Ahmad Hatim Hong Choon Chua Dianne Bautista Tian-Mei Si | 2015 | Chinese Medical Journal2015，，6： | 5 |
| 9 | Clinical characteristics of peptic ulcer perforation in Korea显示文摘AIM To elucidate the epidemiological characteristics and associated risk factors of perforated peptic ulcer(PPU).METHODS We retrospectively reviewed medical records of patients who were diagnosed with benign PPU from 2010 through 2015 at 6 Hallym university-affiliated hospitals.RESULTS A total of 396 patients were identified with postoperative complication rate of 9.1% and mortality rate of 0.8%. Among 174(43.9%) patients who were examined for Helicobacter pylori(H. pylori) infection, 78(44.8%) patients were positive for H. pylori infection, 21(12.1%) were on non-steroidal anti-inflammatory drugs(NSAIDs) therapy, and 80(46%) patients were neither infected of H. pylori nor treated by any kinds of NSAIDs. Multivariate analysis indicated that older age(OR = 1.09, 95%CI: 1.04-1.16) and comorbidity(OR = 4.11, 95%CI: 1.03-16.48) were risk factors for NSAID-associated PPU compared with non-H. pylori, non-NSAID associated PPU and older age(OR = 1.04, 95%CI: 1.02-1.07) and alcohol consumption(OR = 2.08, 95%CI: 1.05-4.13) were risk factors for non-H. pylori, non-NSAID associated PPU compared with solely H. pylori positive PPU.CONCLUSION Elderly patients with comorbidities are associated with NSAIDs-associated PPU. Non-H. pylori, non-NSAID peptic ulcer is important etiology of PPU and alcohol consumption is associated risk factor. | Young Joo Yang Chang Seok Bang Suk Pyo Shin Tae Young Park Ki Tae Suk Gwang Ho Baik Dong Joon Kim | 2017 | World Journal of Gastroenterology2017，23，14： | 4 |
| 10 | HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer显示文摘AIM To investigated the relationships between HER2, c-Jun N-terminal kinase(JNK) and protein kinase B(AKT) with respect to metastatic potential of HER2-positive gastric cancer(GC) cells.METHODS Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively. Transwell assay, Western blot, semi-quantitative reverse transcriptionpolymerase chain reaction and immunofluorescence staining were used in cell culture experiments. RESULTS In GC specimens, HER2, JNK, and AKT activations were positively correlated with each other. In vitro analysis revealed a positive regulatory feedback loop between HER2 and JNK in GC cell lines and the role of JNK as a downstream effector of AKT in the HER2/AKT signaling pathway. JNK inhibition suppressed migratory capacity through reversing EMT and dual inhibition of JNK and AKT induced a more profound effect on cancer cell motility.CONCLUSION HER2, JNK and AKT in human GC specimens are positively associated with each other. JNK and AKT, downstream effectors of HER2, co-operatively contribute to the metastatic potential of HER2-positive GC cells. Thus, targeting of these two molecules in combination with HER2 downregulation may be a good approach to combat HER2-positive GC. | Yiseul Choi Young San Ko Jinju Park Youngsun Choi Younghoon Kim Jung-Soo Pyo Bo Gun Jang Douk Ho Hwang Woo Ho Kim Byung Lan Lee | 2016 | World Journal of Gastroenterology2016，22，41： | 4 |
| 11 | Unusual neural connection between injured cingulum and brainstem in a patient with subarachnoid hemorrhage显示文摘The human brain is known to have six cholinergic nuclei(Selden et al.,1998;Nieuwenhuys et al.,2008).The cerebral cortex obtains cholinergic innervation mainly from the basalis nucleus of Meynert(Ch 4)in the basal forebrain through the medial and lateral cholinergic pathways(Selden et al.,1998;Mesulam et al.,1983).The cingulum,the neural fiber bundle connecting the basal forebrain and the medial temporal lobe,contains | Jeong Pyo Seo Sung Ho Jang | 2014 | Neural Regeneration Research2014，9，5： | 3 |
| 12 | Monolayer Graphitic Carbon Nitride as Metal-Free Catalyst with Enhanced Performance in Photo- and Electro-Catalysis显示文摘The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic level.It has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics communities.In this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step routes.The atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic analyses.In addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine units.Compared to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction reaction.In addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4). | Huiyan Piao Goeun Choi Xiaoyan Jin Seong‑Ju Hwang Young Jae Song Sung‑Pyo Cho Jin‑Ho Choy | 2022 | Nano-Micro Letters2022，14，3： | 3 |
| 13 | Pattern of instent neointimal formation compared to native atherosclerosis in the coronary bifurcation lesions: volumetric intravascular ultrasound analysis显示文摘 | XU Jian-qiang Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Jin-Ho Choi LU Cheng-zhi Sang Hoon Lee Kyung Pyo Hong Jeung Euy Park Hyeon-Cheol Gwon | 2013 | Chinese Medical Journal2013，，18： | 3 |
| 14 | 利用桑木人工栽培药用真菌灵芝(Phellinus linteus)的研究(英文)显示文摘比较了利用无菌短木接种法、钻孔接种法和端木夹心接种法等接种方法接种桑树段木后Phellinus linteus的菌丝生长和定殖状况。研究表明利用灭菌的短木接种P.linteus,生长和定殖良好,传统的钻孔接种法和端木夹心接种法菌丝生长定殖不好。P.linteus在20 cm长的桑木上生长和定殖所需的最适的含水量为42%,接种后12 h,P.linteus立即进入快速生长期。接种后的桑木埋入土壤中需要5~6个月产生担子果,在培养室内温度为31~35℃,相对湿度大于96%时有利于子实体的形成。 | Hong In Pyo Sung Gyoo Byung Nam Hack Woo | 2004 | 华中农业大学学报2004，23，1： | 3 |
| 15 | Multiplex real-time RT-PCR for the simultaneous detection and quantification of transmissible gastroenteritis virus and porcine epidemic diarrhea virus显示文摘 | Seong-Hee Kim In-Joong Kim Hyun-Mi Pyo Dong-Seob Tark Jae-Young Song Bang-Hun Hyun | 2007 | Journal of Virological Methods2007，，1： | 3 |
| 16 | Incidence of coronary artery disease before valvular surgery in isolated severe aortic stenosis显示文摘 | Eun Jeong Cho Sung-Ji Park Sung-A Chang Dong Seop Jeong Sang-Chol Lee Seung Woo Park Pyo Won Park | 2014 | Chinese Medical Journal2014，，22： | 3 |
| 17 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 18 | 利用AFLP构建大白菜高密度遗传连锁图谱显示文摘以大白菜根肿病抗性材料CR Shinki DH系和感病性材料大白菜自交系94sK杂交F2的138个单株作为构建遗传图谱的群体。利用AFLP技术通过45对引物筛选共获得835个AFLP标记,应用其中608个AFLP标记和6个与抗根肿病基因CRb紧密连锁的AFLP标记转化成的SCAR标记构建了一张包含556个标记位点、10个连锁群、覆盖基因组长度为795eM的连锁图谱。该图谱中每个连锁群上的标记数在10—83个之间,平均图距在0.86—4.34cM之间,连锁群长度在43.4~120。9cM之间。CRb基因定位于第3连锁群9cM的范围内。 | 王剑 许磊 Su Ryun Choi Yong Pyo Lim 朴钟云 | 2010 | 江苏农业科学2010，38，1： | 3 |
| 19 | Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant显示文摘Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical properties.Platycodon grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East Asia.The oleanane-type TSs,platycosides,are a major component of the P.grandiflorus root extract.Recent studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy properties.However,the evolutionary history of platycoside biosynthesis genes remains unknown.In this study,we sequenced the genome of P.grandiflorus and investigated the genes involved in platycoside biosynthesis.The draft genome of P.grandiflorus is 680.1 Mb long and contains 40,017 protein-coding genes.Genomic analysis revealed that the CYP716 family genes play a major role in platycoside oxidation.The CYP716 gene family of P.grandiflorus was much larger than that of other Asterid species.Orthologous gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in P.grandiflorus,which was confirmed by tissue-specific gene expression.In these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside biosynthesis.In addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in P.grandiflorus,suggesting that epigenetic modification of these two gene families affects platycoside biosynthesis.Thus whole-genome,transcriptome,and methylome data of P.grandiflorus provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families. | Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee Jae-Pil Choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo Hong Jong Bhak Chang-Kug Kim | 2020 | Horticulture Research2020，7，1： | 2 |
| 20 | CT Colonography: Perforation Rates and Potential Radiation Risks显示文摘 | A. Berrington de Gonzalez Kwang Pyo Kim Judy Yee | 2010 | Gastrointestinal Endoscopy Clinics of North Americ2010，，2： | 2 |
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