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| 1 | Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model显示文摘人的间充质的干细胞(hMSCs ) 装家到肿瘤地点并且禁止肿瘤细胞的生长。很少对内在的分子的机制被知道连接 hMSCs 到肿瘤房间的指向的抑制。在这研究,我们从 hMSCs 用一个动物移植模型,一个合作文化系统和调节媒介在二根人的 hepatoma 房间线(H7402 和 HepG2 ) 上调查了 hMSCs 的效果。当 SCID 老鼠与 H7402 细胞和 Z3 hMSCs 的一个相等的数字被注射时,动物移植研究证明肿瘤形成的潜伏的时间被延长并且肿瘤尺寸更小。当 co 有教养时与 Z3 房间, H7402 细胞增殖减少了,增加的 apoptosis,和 Bcl-2 的表示, c-Myc,原子抗原(PCNA ) 和 survivin 低是的增殖的房间调整了。在有调节媒介的处理源于 Z3 hMSC 文化以后, H4702 房间出现了减少的形成殖民地的能力和减少的增长。Immunoblot 分析证明 beta-catenin, Bcl-2, c-Myc, PCNA 和 survivin 表示是在 H7402 和 HepG2 房间调整的 down。总起来说,我们的调查结果证明 hMSCs 禁止 H7402 和 HepG2 人的肝癌症房间线的恶意的显型,它包括增长,形成殖民地的能力和 oncogene 表示试管内和体内。而且,我们的研究提供表明小径的 Wnt 可以在调停 hMSC 的指向和肿瘤房间抑制有一个角色的证据。 | Ling Qiao Zhili Xu Tiejun Zhao Zhigang Zhao Mingxia Shi Robert C Zhao Lihong Ye Xiaodong Zhang | 2008 | Cell Research2008，18，4： | 68 |
| 2 | Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2显示文摘肝炎 B 病毒 X 蛋白质(HBx ) 在 hepatocellular 癌的发展起一个关键作用。这里,我们寻求了识别 HBx 由调停的机制肝房间增长。我们发现那 HBx upregulated cyclooxygenase-2 (COX-2 ) 的层次, 5-lipoxygenase (5 哈鱼) 和 phosphorylated 在肝房间的细胞外的调整信号的蛋白质 kinases 1/2 (p-ERK1/2 ) 。导致 HBx 的 p-ERK1/2 被 Gi/o 蛋白质,艇长或哈鱼的抑制废除。另外, HBx 增加了前列腺素 E2 (PGE2 ) 的数量,免除房间线的 leukotriene B4 (LTB4 ) 源于 hepatocytes。而且,这些释放 arachidonic 酸代谢物能激活 ERK1/2。有趣地,激活 ERK1/2 能 upregulate 以一种积极反馈方式的 COX-2 和 5 哈鱼的表示。在结论, HBx 经由包含 COX-2, 5 哈鱼,释放 arachidonic 酸代谢物, Gi/o 蛋白质和 p-ERK1/2 的一个积极反馈环提高并且维持肝房间增长。 | Changliang Shan Fuqing Xu Shuai Zhang Jiacong YOU Xiaona You Liyan Qiu Jie Zheng Lihong Ye Xiaodong Zhang | 2010 | Cell Research2010，20，5： | 15 |
| 3 | Study on magnetic memory signals of medium carbon steel specimens with surface crack precut during loading process显示文摘Static tensile test and tensile-tensile fatigue test of medium carbon steel sheet specimens with surface crack precut were performed on MTS810 hydraulic testing machine to clear the meaning of the point of Hp(y) value zero. Magnetic memory signals were measured during the test process. The results show that only one point of Hp(y) zero value exists in all measured magnetic signal curves during the loading process, which should be a sign of intersection of positive-negative magnetic poles after magnetic ordered state appears and does not indicate the position of surface crack precut. The analysis shows that the surface crack precut can not interrupt the magnetic ordered state occurred during the test completely, hence its Hp(y) value is not zero. However, the crack extending to a penetrated defect at the instant of specimen′s fracture leads to the discontinuance of magnetic ordered state. | DONG Lihong XU Binshi DONG Shiyun YE Minghui CHEN Qunzhi | 2006 | Rare Metals2006，25，z1： | 9 |
| 4 | Effect of electrolyte anions on the cycle life of a polymer electrode in aqueous batteries显示文摘Redox polymers are a class of high-capacity, low-cost electrode materials for electrochemical energy storage, butthe mechanisms governing their cycling stability are not well understood. Here we investigate the effect of anionson the longevity of a p-dopable polymer through comparing two aqueous zinc-based electrolytes. Galvanostaticcycling studies reveal the polymer has better capacity retention in the presence of triflate anions than that withsulfate anions. Based on electrode microstructural analysis and evolution profiles of the cell stacking pressure, theorigin of capacity decay is ascribed to mechanical fractures induced by volume change of the polymer activematerials during repeated cycling. The volume change of the polymer with the triflate anion is 61% less than thatwith the sulfate anion, resulting in fewer cracks in the electrodes. The difference is related to the different anionsolvation structures—the triflate anion has fewer solvated water molecules compared with the sulfate anion,leading to smaller volume expansion. This work highlights that anions with low solvation degree are preferablefor long-term cycling. | Ye Zhang Lihong Zhao Yanliang Liang Xiaojun Wang Yan Yao | 2022 | eScience2022，2，1： | 4 |
| 5 | Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesis显示文摘Opium poppy(Papaver somniferum)is a source of morphine,codeine,and semisynthetic derivatives,including oxycodone and naltrexone.Here,we report the de novo assembly and genomic analysis of P.somniferum traditional landrace‘Chinese Herbal Medicine’.Variations between the 2.62 Gb CHM genome and that of the previously sequenced high noscapine 1(HN1)variety were also explored.Among 79,668 protein-coding genes,we functionally annotated 88.9%,compared to 68.8%reported in the HN1 genome.Gene family and 4DTv comparative analyses with three other Papaveraceae species revealed that opium poppy underwent two whole-genome duplication(WGD)events.The first of these,in ancestral Ranunculales,expanded gene families related to characteristic secondary metabolite production and disease resistance.The more recent species-specific WGD mediated by transposable elements resulted in massive genome expansion.Genes carrying structural variations and large-effect variants associated with agronomically different phenotypes between CHM and HN1 that were identified through our transcriptomic comparison of multiple organs and developmental stages can enable the development of new varieties.These genomic and transcriptomic analyses will provide a valuable resource that informs future basic and agricultural studies of the opium poppy. | Li Pei Baishi Wang Jian Ye Xiaodi Hu Lihong Fu Kui Li Zhiyu Ni Zhenlong Wang Yujie Wei Luye Shi Ying Zhang Xue Bai Mengwan Jiang Shuhui Wang Chunling Ma Shujin Li Kaihui Liu Wanshui Li Bin Cong | 2021 | Horticulture Research2021，8，1： | 4 |
| 6 | Pulmonary toxicity induced by three forms of titanium dioxide nanoparticles via intra-tracheal instillation in rats显示文摘Titanium dioxide (TiO2) nanoparticles are in wide commercial use worldwide. To evaluate if acute pulmonary toxicity can be induced by nano-TiO2 particles, rats were intra-tracheally instilled with 0.5, 5, or 50 mg/kg of 5, 21, and 50 nm TiO2 primary particles. Toxic effects were determined with the coefficients of lung tissues to body weight, histopathology, biochemical parameters of blood, activity of lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and acid phosphatase (ACP) in tissues, and the phagocytotic ability of alveolar macrophages (AMs). All the indicators were observed in sacrificed rats one week post-exposure. There was a significant difference of coefficients of pulmonary tissues between the high-dose group and the low-or moderate-dose groups with an exposure of 5 nm TiO2. At the same time, 5 nm TiO2 primary particles increased the activity of LDH and ALP when exposure dose was >5 mg/kg. A significant difference in LDH and ALP activity was observed between the 50 mg/kg group and 0.5 or 5 mg/kg group with exposure of 5 nm TiO2. Lung tissues showed increased ALP activity only if treated with 5 and 50 mg/kg of 21 nm TiO2 particles. There was no significant difference in LDH and ALP activity in the 50 nm TiO2 group and control group. Histo-pathologic examination of lung tissues indicated that the pulmonary response to exposure to TiO2 particles in rats manifested as dose-dependent inflammatory lesions, which mainly consisted of inflltration of inflammatory cells and interstitial thickening. Analysis of uptake of neutral red dye showed that 50 nm TiO2 particles significantly increased phagocytotic ability of AMs compared with controls (P<0.05), whereas exposure with 5 nm TiO2 reduced the phagocytotic ability of AMs when the exposure dose was 50 mg/kg. These results suggest that particle size and exposure dose may have important roles in pulmonary toxicity. The toxic effect of TiO2 nanopar-ticles in lung tissue exhibited a dose-response relationship. After exposure with TiO2 particles of >5.0 mg/kg, 5 and 21 nm TiO2 particles induced standing pulmonary lesions; and 5 nm TiO2 particles may suppress the phagocytotic ability of AMs if exposure dose was P50 mg/kg. Pulmonary toxicity caused by 5 nm TiO2 particles was more severe than that caused by 21 and 50 nm TiO2 particles. | Ran Liu Lihong Yin Yuepu Pu Geyu Liang Juan Zhang Yaoyao Su Zhiping Xiao Bing Ye | 2009 | Progress in Natural Science:Materials International2009，19，5： | 3 |
| 7 | The Oncoprotein HBXIP Uses Two Pathways to Up-regulate S100A4 in Promotion of Growth and Migration of Breast Cancer Cells显示文摘 | Shuangping Liu Leilei Li Yingyi Zhang Yiwen Zhang Yu Zhao Xiaona You Zhenhua Lin Xiaodong Zhang Lihong Ye | 2012 | Journal of Biological Chemistry2012，，36： | 3 |
| 8 | Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice显示文摘亲爱的编辑, | Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu | 2015 | Protein & Cell2015，6，2： | 3 |
| 9 | Effects of Root Zone Temperature on Growth and Photosynthetic Parameters of Grafted Cucumber显示文摘Taking Cucurbita maxima and Cucurbita moschata as root stocks,and‘Jinyou No 3'cucumber as scion,the effects of different root zone temperature conditions optimal temperature( CK)( 18-20 ℃),suboptimal temperature( 13-15 ℃) and low temperature( 8-10 ℃) on the growth and photosynthesis indexes were studied. The results showed that,compared with optimal temperature( CK),suboptimal temperature and low temperature produced a significant inhibition of growth on cucumbers. The plant height,stem diameter,leaf area,number of leaves and dry weight of aboveground part were all reduced,dry weight of underground part and root shoot ratio all increased,while the inhibition was more significant at low temperature. Low and suboptimal temperature conditions also reduced SPAD value,net photosynthetic rate,transpiration rate,intercellular CO_2 concentration and stomatal conductance of the grafted cucumber. And there were differences between different grafted seedlings,and seedlings with‘black seeds' as stock performed better than those with‘white seeds' as stock at low temperature. | shijun sun shimao cui yang song chongyi fu lihong ye yu gao | 2018 | Agricultural Biotechnology2018，7，2： | 2 |
| 10 | Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis显示文摘Impairment of glucose(Glu)uptake and storage by skeletal muscle is a prime risk factor for the development of metabolic diseases.Heterogeneous nuclear ribonucleoprotein A1(hnRNP Al)is a highly abundant RNA-binding protein that has been implicated in diverse cellular functions.The aim of this study was to investigate the function of hnRNP A1 on muscle tissue insulin sensitivity and systemic Glu homeostasis.Our results showed that conditional deletion of hnRNP Al in the muscle gave rise to a severe insulin resistance phenotype in mice fed a high-fat diet(HFD).Conditional knockout mice fed a HFD showed exacerbated obesity,insulin resistance,and hepatic steatosis.In vitro interference of hnRNP Al in C2C12 myotubes impaired insulin signal transduction and inhibited Glu uptake,whereas hnRNP Al overexpression in C2C12 myotubes protected against insulin resistance induced by supraphysiological concentrations of insulin.The expression and stability of glycogen synthase(gysl)mRNA were also decreased in the absence of hnRNP A l.Mechanistically,hnRNP Al interacted with gys l and stabilized its mRNA,thereby promoting glycogen synthesis and maintaining the insulin sensitivity in muscle tissue.Taken together,our findings are the first to show that reduced expression of hnRNP Al in skeletal muscle affects the metabolic properties and systemic insulin sensitivity by inhibiting glycogen synthesis. | Mingxia Zhao Lihong Shen Zijun Ouyang Manru Li Guoliang Deng Chenxi Yang Wei Zheng Lingdong Kong Xuefeng Wu Xudong Wu Wenjie Guo Ye Yin Qiang Xu Yang Sun | 2020 | Journal of Molecular Cell Biology2020，12，4： | 2 |
| 11 | Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China显示文摘 | Qi Wang Tao Zhang Lihong Ye Wenhui Wang Xiaodong Zhang | 2011 | Cancer Epidemiology2011，，4： | 2 |
| 12 | The influence of the impurities on the flotation behaviors of synthetic ZnS显示文摘 | CHEN Ye CHEN Jianhua LAN Lihong | 2012 | Minerals Engineering2012，2728，： | 1 |
| 13 | Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT显示文摘 | Fabao Liu Xiaona You Xiumei Chi Tao Wang Lihong Ye Junqi Niu Xiaodong Zhang | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 14 | The t001 t facets-dependent high photoactivity of BiOC1 nanosheets 显示文摘 | Ye Liqun Zan Ling Tian Lihong | 2011 | Chemical Communications2011，47，24： | 1 |
| 15 | Proliferation and migration mediated by Dkk-1/Wnt/β-catenin cascade in a model of hepatocellular carcinoma cells显示文摘 | Xiaoran Qin Hang Zhang Xiaolei Zhou Changye Wang Huizhong Zhang Xiaodong Zhang Lihong Ye | 2007 | Translational Research2007，，： | 1 |
| 16 | TiO 2 /carbon nanotube hybrid nanostructures: Solvothermal synthesis and their visible light photocatalytic activity显示文摘 | Lihong Tian Liqun Ye Kejian Deng Ling Zan | 2011 | Journal of Solid State Chemistry2011，，6： | 1 |
| 17 | Detection of Persistent Organochlorine Pollutants in Eggs of Antarctic Seabirds Based on Gas Chromatography and Their Ecological Environment Significance显示文摘By using internal standard method based on gas chromatography-electron capture detector( GC-ECD),the contents of persistent organochlorine pollutants polychorinated biphenyls( PCBs) and organochlorine pesticides( OCPs) in eggs of seabirds( Catharacta lonnbergi,Catharacta maccormicki,Pygoscelis papua and Macronectes giganteus) breeding on King George Island,Antarctica were detected,and their ecological environment significance was discussed. The results showed that the recovery of various compounds ranged from 68. 6% to 90. 8%; relative standard deviation( RSD) was 3. 6%,and the lowest detection limits of PCBs and OCPs were 0. 8- 16 and 2- 12 pg respectively,which could meet the demands for the residue analysis of trace persistent organochlorine pollutants in the eggs of Antarctic seabirds. The contents of PCBs,DDTs,HCB and HCHs in the eggs of Antarctic seabirds were 0. 5- 515. 5,2. 0- 304. 4,0. 5- 70. 5,and 0. 5- 2. 0 ng / g respectively. In addition,the accumulation of PCBs and OCPs in the skuas was enhanced gradually through the food chain. The maximums of persistent organochlorine pollutants appeared in the eggs of C. lonnbergi,followed by the eggs of C. maccomicki. The detection of OCPs and PCBs in the eggs of Antarctic seabirds was not interfered by other compounds containing chlorine,showing that the extraction,purification and detection method was suitable for the analysis of OCPs and PCBs in the eggs of Antarctic seabirds and has high sensitivity and reliability. | Ye Maosen Zhang Rongbao Chen Lihong Lin Bo Zheng Fangqin Lu Bing Ye Xinrong | 2016 | Meteorological and Environmental Research2016，7，1： | 1 |
| 18 | Hepatitis B Virus X Protein Inhibits Tumor Suppressor miR-205 through Inducing Hypermethylation of miR-205 Promoter to Enhance Carcinogenesis显示文摘 | Tao Zhang Junping Zhang Ming Cui Fabao Liu Xiaona You Yumei Du Yuen Gao Shuai Zhang Zhanping Lu Lihong Ye Xiaodong Zhang | 2013 | Neoplasia2013，，11： | 1 |
| 19 | N-linked glycosylation of dipeptidyl peptidase IV(CD26):Effects on enzyme activity homodimer formation and adenosine deaminase binding Protein显示文摘 | Kathleen Aertgeerts Sheng ye Lihong SHI | 2004 | Science2004，13，： | 1 |
| 20 | Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/ Alu core sequence/subtelomeric DNA显示文摘 | Xuan Zhang Xiaona You Nan Li Weiying Zhang Sarantis Gagos Qi Wang Aggelos Banos Na Cai Huakun Zhang Hang Zhang Xuezhi Zhang Changliang Shan Liyan Qiu Shuai Zhang Na Lv Minshan Chen Yumei Du Jianchuan Xia Lihong Ye Xiaodong Zhang | 2012 | FEBS Letters2012，，19： | 1 |
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