|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 2 | Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes显示文摘Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell labeling, and can be detectable by both magnetic resonance and near infrared (NIR) fluorescence imaging. Multiple hydrophobic superparamagnetic iron oxide (SPIO) nanocrystals are self-assembled into nanocomposites in water phase with the help of partially alkylated hyperbranched polycation, polyethylenimine (PEI), which already conjugated with the indocyanine dye Cy5.5 and can be used for cell imaging under NIR fluorescence imaging. The amphiphilic PEI/SPIO nanocomposites have a strong T 2 relaxivity. The iron uptake process in MCF-7/Adr displays a time dependent behavior. Confocal laser scanning microscopy reveals that the nanoprobes are internalized into the cytoplasm of MCF-7/Adr after 24 h labeling. Both MR and NIR fluorescence imaging showed strong image contrast against unlabeled cells. Under a clinical MRI scanner, labeled cells in gelatin phantom present much darker images than controlled ones. The T2 relaxation rate of the labeled cells is 98.2 s 1 , significantly higher than that of the control ones of 2.3 s 1 . This study provides an important alternative to label MCF-7/Adr at optimized low dosages with high efficiency, and may be useful to label other biologically important cells and track their behaviors in vivo. | WANG Dan SU HongYing LIU yanHong WU ChangQiang XIA ChunChao SUN JiaYu GAO FaBao GONG QiYong SONG Bin AI Hua | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 3 | Attractive nanofiber structure based on Cu-Ti/metal sandwich film with excellent electrocatalytic performance for ethanol oxidation显示文摘The support materials are an important part of catalysts and they are the dispersant,adhesive,and support for other components.In this study,three types of thin films with different structures were used as the precursor to prepare loading Pd catalysts.The one-step dealloying method was used to prepare a semiconductor nanofiber film(NFF)support material with upward directional growth from the substrate.Pd/NFF and Pd/Ni O/NFF loaded Pd catalysts were prepared using NFF as the support material,and the electrochemical catalytic properties for ethanol oxidation in alkaline media were studied.Cyclic votammetry showed that the NFF support material effectively inhibited agglomeration of palladium,increased the number of active sites of Pd,and improved the electrocatalytic properties of Pd for ethanol oxidation.In addition,the Pd/Ni O/NFF loaded Pd catalyst obtained by modification with nickel oxide significantly improved the electrocatalytic performance for ethanol oxidation compared with the Pd/NFF loaded Pd catalyst.These results show that Ni O is conductive to absorption of oxygen-containing groups on the surface of the catalyst and can further improve the electrocatalytic ability of Pd for ethanol oxidation.All of the above results demonstrate that the support material prepared by the dealloying method has application prospects in load-type catalysts. | Qingzhuo Hu Fabao Zhang Jinjun Zhang Wei Jiang Bo Zhang | 2020 | Journal of Materials Science & Technology2020，58，23： | 2 |
| 4 | Manganese(Ⅲ) acetate-mediated radical reaction of [60]fullerene with bromoacetic acid,3-chloropropionic acid or 1-naphthylacetic acid显示文摘The manganese(Ⅲ) acetate-mediated radical reaction of [60]fullerene (C60) with three carboxylic acids,that is,bromoacetic acid,3-chloropropionic acid,and 1-naphthylacetic acid,was investigated. The reaction of C60 with bromoacetic acid in the presence of 4-(dimethylamino)pyridine afforded the anticipated C60-fused lactone,while the reaction with 3-chloropropionic acid unexpectedly led to the formation of a novel C60-fused lactone with the loss of one molecule of HCl. Interestingly,the reaction with 1-naphthylacetic acid under similar conditions gave both C60-fused lactone and 1,4-adduct,yet each of them could be selectively obtained by controlling reaction conditions. It was also observed that the C60-fused lactone bearing a bulky naphthyl group existed as two isomers. | LI FaBao ZHU SanE WANG GuanWu | 2010 | Chinese Science Bulletin2010，55，25： | 2 |
| 5 | Evolution of microbial community diversity and enzymatic activity during composting显示文摘 | Yumei He Kaizhi Xie Peizhi Xu Xu Huang Wenjie Gu Fabao Zhang Shuanhu Tang | 2012 | Research in Microbiology2012，，： | 1 |
| 6 | Periodic solutions for a Rayleigh type e- quation with a variable coefficient ahead of the nonlinear term 显示文摘 | GAO Fabao LU Shiping | 2009 | Nonlinear Analysis : Real World Applications2009，10，： | 1 |
| 7 | Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT显示文摘 | Fabao Liu Xiaona You Xiumei Chi Tao Wang Lihong Ye Junqi Niu Xiaodong Zhang | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 8 | Cardiac magnetic resonance imaging of systemic amyloidosis patients with normal left ventricular ejection frac- tion : An initial study 显示文摘 | Rui X Fabao G Jiayu S | 2013 | Pak J Med Sci2013，29，6： | 1 |
| 9 | Existence and uniqueness of periodic solutions for a p-Laplacian Duffing equation with a deviating argument 显示文摘 | Gao Fabao Lu Shiping Zhang Wei | 2009 | Nonlinear Anal2009，70，10： | 1 |
| 10 | Periodic solutions for a p-Laplacian-like NFDE system显示文摘 | Gao Fabao Zhang Wei | 2011 | Journal of the Franklin Institute2011，348，6： | 1 |
| 11 | Ferric perchlorate-promoted reaction of [60]fullerene with β-keto esters显示文摘The ferric perchlorate-promoted reaction of [60]fullerene (C60) with ethyl 2-methylacetoacetate generates fullerenyl hemiketal as a mixture of trans and cis isomers,while the reaction with ethyl acetoacetate gives a C 60-fused dihydrofuran derivative.A possible reaction mechanism for the formation of these products is proposed. | FaBao Li SanE Zhu Xun You GuanWu Wang | 2012 | Chinese Science Bulletin2012，57，18： | 1 |
| 12 | Effect of Overexpression C-erbB2 to Selecting Postoperative Chemotherapy Regimen of Breast Cancer Cell 显示文摘 | Fabao Tang Yong Xia | 2006 | Chin Gen Surg(in Chinese)2006，21，： | 1 |
| 13 | Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging显示文摘 | Jian Lu Shuli Ma Jiayu Sun Chunchao Xia Chen Liu Zhiyong Wang Xuna Zhao Fabao Gao Qiyong Gong Bin Song Xintao Shuai Hua Ai Zhongwei Gu | 2009 | Biomaterials2009，，15： | 1 |
| 14 | Periodic solutions for a Rayleigh type equation with a variable coefficient ahead of the nonlinear term 显示文摘 | GAO Fabao LU Shiping | 2009 | Nonlinear Analysis : Real World Applications2009，10，： | 1 |
| 15 | Hepatitis B Virus X Protein Inhibits Tumor Suppressor miR-205 through Inducing Hypermethylation of miR-205 Promoter to Enhance Carcinogenesis显示文摘 | Tao Zhang Junping Zhang Ming Cui Fabao Liu Xiaona You Yumei Du Yuen Gao Shuai Zhang Zhanping Lu Lihong Ye Xiaodong Zhang | 2013 | Neoplasia2013，，11： | 1 |
| 16 | A flow injection chemiluminescence method for the determination of fluoroquinolone derivative using the reaction of luminol and hydrogen peroxide catalyzed by gold nanoparticles显示文摘 | Lun Wang Ping Yang Yongxin Li Hongqi Chen Maoguo Li Fabao Luo | 2007 | Talanta2007，，3： | 1 |
| 17 | Periodic solutions for p-Laplacian neutral Lienard equation with a sign-variable coefficient 显示文摘 | Fabao Gao Shiping Lu Wei Zhang | 2009 | NonlinearAnalysis2009，70，： | 1 |
| 18 | Solid-gas carbonate formation during dust events on Mars显示文摘For half a century,Mars missions have gathered abundant geological evidence for a wet,warm climate in the early history of Mars more than 3 billion years ago,including various fluvial landforms and exposed aqueous alteration minerals.It was supposed that Mars once had a dense,CO_(2)-rich atmosphere.However,present-day Mars has a much thinner atmosphere dominated by CO_(2). | Wenshuo Mao Xiaohui Fu Zhongchen Wu Jiang Zhang Zongcheng Ling Yang Liu Yu-Yan Sara Zhao Hitesh G.Changela Yuheng Ni Fabao Yan Yongliao Zou | 2023 | National Science Review2023，10，4： | 0 |
| 19 | Mediator complex subunit 12 is a gatekeeper of SARS-CoV-2 infection in breast cancer cells显示文摘Cancer patients are at increased risk for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and mortality.Like other viruses in the SARS family,SARS-CoV-2 employs two host proteins,angiotensin-converting enzyme 2(ACE2)and transmembrane serine protease 2(TMPRSS2),for viral entry.1 Recent studies showed that many of the host proteins identified as potential targets for developing COVID therapies are dysregulated in cancer,2 prompting us to investigate whether human cancer cells are susceptible to SARS-CoV-2 infection,and whether chemotherapy could modulate a cancer patient's risk for infection. | Shengjie Zhang Fabao Liu Peter Halfmann Ryan TBehrens Peng Liu Sean JMcilwain Irene MOng Kristine Donahue Yidan Wang Yoshihiro Kawaoka Nathan Sherer Wei Xua | 2022 | Genes & Diseases2022，9，1： | 0 |
| 20 | Electrocatalytic CO_(2) reduction to C_(2)H_(4): From lab to fab显示文摘The global concerns of energy crisis and climate change,primarily caused by carbon dioxide(CO_(2)),are of utmost importance.Recently,the electrocatalytic CO_(2) reduction reaction(CO_(2)RR) to high value-added multi-carbon(C_(2+)) products driven by renewable electricity has emerged as a highly promising solution to alleviate energy shortages and achieve carbon neutrality.Among these C_(2+) products,ethylene(C_(2)H_(4))holds particular importance in the petrochemical industry.Accordingly,this review aims to establish a connection between the fundamentals of electrocatalytic CO_(2) reduction reaction to ethylene(CO_(2)RRto-C_(2)H_(4)) in laboratory-scale research(lab) and its potential applications in industrial-level fabrication(fab).The review begins by summarizing the fundamental aspects,including the design strategies of high-performance Cu-based electrocatalysts and advanced electrolyzer devices.Subsequently,innovative and value-added techniques are presented to address the inherent challenges encountered during the implementations of CO_(2)RR-to-C_(2)H_(4) in industrial scenarios.Additionally,case studies of the technoeconomic analysis of the CO_(2)RR-to-C_(2)H_(4) process are discussed,taking into factors such as costeffectiveness,scalability,and market potential.The review concludes by outlining the perspectives and challenges associated with scaling up the CO_(2)RR-to-C_(2)H_(4) process.The insights presented in this review are expected to make a valuable contribution in advancing the CO_(2)RR-to-C_(2)H_(4) process from lab to fab. | Zeyu Guo Fabao Yang Xiaotong Li Huiwen Zhu Hainam Do Kam Loon Fow Jonathan D.Hirst Tao Wu Qiulin Ye Yaqi Peng Hao Bin Wu Angjian Wu Mengxia Xu | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员