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| 1 | Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model显示文摘人的间充质的干细胞(hMSCs ) 装家到肿瘤地点并且禁止肿瘤细胞的生长。很少对内在的分子的机制被知道连接 hMSCs 到肿瘤房间的指向的抑制。在这研究,我们从 hMSCs 用一个动物移植模型,一个合作文化系统和调节媒介在二根人的 hepatoma 房间线(H7402 和 HepG2 ) 上调查了 hMSCs 的效果。当 SCID 老鼠与 H7402 细胞和 Z3 hMSCs 的一个相等的数字被注射时,动物移植研究证明肿瘤形成的潜伏的时间被延长并且肿瘤尺寸更小。当 co 有教养时与 Z3 房间, H7402 细胞增殖减少了,增加的 apoptosis,和 Bcl-2 的表示, c-Myc,原子抗原(PCNA ) 和 survivin 低是的增殖的房间调整了。在有调节媒介的处理源于 Z3 hMSC 文化以后, H4702 房间出现了减少的形成殖民地的能力和减少的增长。Immunoblot 分析证明 beta-catenin, Bcl-2, c-Myc, PCNA 和 survivin 表示是在 H7402 和 HepG2 房间调整的 down。总起来说,我们的调查结果证明 hMSCs 禁止 H7402 和 HepG2 人的肝癌症房间线的恶意的显型,它包括增长,形成殖民地的能力和 oncogene 表示试管内和体内。而且,我们的研究提供表明小径的 Wnt 可以在调停 hMSC 的指向和肿瘤房间抑制有一个角色的证据。 | Ling Qiao Zhili Xu Tiejun Zhao Zhigang Zhao Mingxia Shi Robert C Zhao Lihong Ye Xiaodong Zhang | 2008 | Cell Research2008，18，4： | 68 |
| 2 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 3 | Impact of social isolation and resident intruder stress on aggressive behavior in the male rat显示文摘Stress studies frequently utilize physical stressors to establish animal models of stress.In the majority of cases,these models are not consistent with human circumstances.The present study simulated a social isolation plus resident intruder stress model in the rat.The rats were subjected to daily social isolation and resident intruder stress for 2 weeks.Behaviors were then tested.Rats subjected to social stress exhibited different aggressive behavior styles;some rats had greater scores on composite aggression behaviors,as well as locomotor and exploratory activity,but lower scores on latency than others.The high-aggressive group exhibited predominantly anger-out,while the low-aggressive group exhibited anger-in.Results suggest that social isolation plus resident intruder may serve as an appropriate model for anger-in and anger-out emotion modeling in the rat. | Sheng Wei Huiyun Zhang Jie Gao Ling Xue Peng Sun Yubin Chao Gang Xue Mingqi Qiao | 2010 | Neural Regeneration Research2010，5，15： | 23 |
| 4 | Application of Traditional Chinese Medicine injection in treatment of primary liver cancer:a review显示文摘OBJECTIVE:To investigate the application of Traditional Chinese Medicine Injections(TCMIs) for treatment of primary liver cancer(PLC).METHODS:A literature review was conducted using PubMed/Medline,Cochrane Library Controlled Clinical Trials Database,China National Knowledge Infrastructure(CNKI),China Scientific Journal Database(CSJD) and China Biology Medicine(CBM).Online websites including journal websites and databases of ongoing trials,as well as some Traditional Chinese Medicine journals that are not indexed in the electronic databases were also searched.RESULTS:The literature review showed that TCMIs as adjunctive medication for the treatment of PLC could regulate patient immunity,reduce bone marrow suppression,relieve clinical symptoms,and improve quality of life,as well as control disease progression and prolong survival time.CONCLUSION:Within the limitations of this review,we conclude that application of TCMIs as adjunctive medication may provide benefits for patients with PLC.Further large,high-quality trials are warranted. | Mouduo Li Cuixia Qiao Liping Qin Junyong Zhang Changquan Ling | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 22 |
| 5 | Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy显示文摘Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). More severe vision loss is typically associated with the wet form. Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic to AMD is established to 46%–71% of disease contribution, with CFH and ARMS2/HTRA1 to be the two most notable risk loci among the 103 identified AMD associated loci so far. Chronic cigarette smoking is the most proven consistently risk living habits for AMD. Deep learning algorithm has been developed based on image recognition to distinguish wet AMD and normal macula with high accuracy. Currently, anti-vascular endothelial growth factor (VEGF) therapy is highly effective at treating wet AMD. Several new generation AMD drugs and iPSC-derived RPE cell therapy are in the clinical trial stage and are promising to improve AMD treatment in the near future. | Yanhui Deng Lifeng Qiao Mingyan Du Chao Qu Ling Wan Jie Li Lulin Huang | 2022 | Genes & Diseases2022，9，1： | 17 |
| 6 | Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells显示文摘瞄准:到 investigat 肝炎 B X 交往的效果蛋白质(HBXIP ) oncell proliferation.Methods:对 HBXIP 的兔子抗体是 HBXIP 基因的 generated.The RNA 干扰( RNAi )碎片在编码 HBXIP 基因和 pSilencer-hbxip weretransfected 进人的胸癌 MCF-7 房间, hepatoma H7402 房间,和正常的 pcDNA3-hbxip 的 pSilencer-3.0-H1 向量 termedpSilencer-hbxip.Plasmids 被构造 humanhepatic 房间线 L-O2 ,respectively.3-[ 4,5-dimethylthiazol-2-yl ] -2,5-diphenyltetrazolium 溴化物( MTT )试金和 5-bromo-2-deoxyuridine 加入试金被用于 dete HBXIP 的功能之一是它在房间增长的参与。 | Feng-ze WANG Li SHA Wei-ying ZHANG Lian-ying WU Ling QIAO Nan LI Xiao-dong ZHANG Li-hong YE | 2007 | Acta Pharmacologica Sinica2007，28，3： | 16 |
| 7 | Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China显示文摘Objective: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the risk of Down syndrome in China. Methods: Genomic DNA was isolated from the peripheral lymphocytes of 64 mothers of children with Down syndrome and 70 age matched control subjects. Polymerase chain reaction and restriction fragment length polymorphism were used to examine the polymorphisms of MTHFR 677C→T, MTRR 66A→G and the relationship between these genotypes and the risk of Down syndrome was analyzed. Results: The results show that the MTHFR 677C→T polymorphism is more prevalent among mothers of children with Down syndrome than among control mothers, with an odds ratio of 3.78 (95% confidence interval (CI), 1.78~8.47). In addition, the homozygous MTRR 66A→G polymorphism was independently associated with a 5.2-fold increase in estimated risk (95% CI, 1.90~14.22). The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than the presence of either alone, with an odds ratio of 6.0 (95% CI, 2.058~17.496). The two polymorphisms appear to act without a multiplicative interaction. Conclusion: MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome. | Shao-shuai WANG Fu-yuan QIAO Ling FENG Juan-juan LV | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，2： | 16 |
| 8 | NF-κB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells显示文摘目的: 干细胞对到肿瘤发生的家有能力并且禁止肿瘤房间的增长,这被报导了。我们的学习的目的是表明肝细胞瘤房间的禁止的增长的分子的机制,乳癌房间由人的间充质的干细胞( hMSCs )调停了 .Methods : H7402 人的肝细胞瘤房间和 MCF-7 人的增长乳癌房间被 5-bromodeoxyuridine ( BrdU )测量加入试金并且流动在有从 hMSCs 文化的调节媒介的治疗以后的血细胞计数试金,例如 Z3 房间或 BMMS-03 房间。 NF-KAPPA B 的角色或禁止者 kappa B 高山的磷酸化哈( p-I kappa B 高山哈)在从 Z3 与调节媒介对待的肝细胞瘤或乳癌房间的消沉,房间或 BMMS-03 房间被记者基因试金,量的即时 PCR ,和西方的污点分析检验, respectively.Results : H7402 房间和 MCF-7 房间的增长被 BrdU 加入试金和流动血细胞计数试金术后疗法显著地减少。transcriptional 活动和 NF-KAPPA B 的 mRNA 水平低以一种剂量依赖者方式由记者基因试金和量的实时 PCR 在对待的房间调整了。在蛋白质水平, NF-KAPPA B 和 p-lKBoc 由西方的污点 analysis.Conclusion 在对待的房间减少了: 从 hMSCs 的调节媒介能在规定下面禁止肿瘤 cells.NF-KAPPA B 的增长为肿瘤房间增长的消沉的原因之一被 hMSCs 调停。 | Ling QIAO Tie-jun ZHAO Feng-ze WANG Chang-liang SHAN Li-hong YE Xiao-dong ZHANG | 2008 | Acta Pharmacologica Sinica2008，29，3： | 12 |
| 9 | A novel, stable and reproducible acute lung injury model induced by oleic acid in immature piglet显示文摘背景小孩子产生肺的损害,并且尖锐的肺损害(所有)经常在小儿科的 patients.A 导致高死亡和金融费用好所有模型将帮助我们获得真实 pathophysiological 图画的更好的理解并且更精确地评估新奇处理途径到尖锐呼吸悲痛症候群( ARDS ), liberally.This 学习瞄准到在油的 acid.Methods 导致的小猪与所有建立一个血液动力学地稳定。 | ZHU Yao-bin LIU Ai-jun LIU Ying-long LING Feng ZHANG Yan-bo WANG Qiang LIU Dong-hai QIAO Chen-hui | 2011 | Chinese Medical Journal2011，，24： | 11 |
| 10 | Health-related quality of life evaluated by tumor node metastasis staging system in patients with hepatocellular carcinoma显示文摘AIM: To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC). METHODS: A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study. One hundred and thirty-five (96.5%) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection, 73 (54.07%) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4%), hepatitis C (1.4%) or cryptogenic (0.7%). All subjects were fully aware of their diagnosis and provided informed consent. HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACT-Hep) questionnaire. Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients. One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages. Scores for all FACT-Hep items were analyzed by frequency analyses. The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated. RESULTS: The mean FACT-Hep scores were reduced significantly from TNM StageⅠto Stage Ⅱ, Stage ⅢA, Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44, P = 0.001). Regarding the physical and emotional well-being subscales, scores decreased gradually from Stage Ⅰ to Stage ⅢB (P = 0.002 vs Stage Ⅰ; P = 0.032 vs Stage Ⅱ; P = 0.033 vs Stage ⅢA). Mean FACT-Hep scores varied by Child-Pugh class, especially in the subscales of physical well-being, functional well-being and the hepatobiliary cancer (P = 0.001 vs Stage I; P = 0.036 vs Stage Ⅱ; P = 0.032 vs Stage ⅢA). For the social and family well-being subscale, only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P = 0.035). For the subscales of functional well-being and hepatobiliary cancer, there were significant differences for Stages ⅡΙ, ⅢA and ⅢB (P = 0.002vs StageⅠ). CONCLUSION: HRQoL of patients with HCC worsens gradually with progression of TNM stages. The most impaired subscales of HRQoL, as measured by FACT-Hep, were physical and emotional well-being. | Cui-Xia Qiao Xiao-Feng Zhai Chang-Quan Ling Qing-Bo Lang Hui-Juan Dong Qun Liu Mou-Duo Li | 2012 | World Journal of Gastroenterology2012，18，21： | 11 |
| 11 | Simultaneous determination of 14β-lactam antibiotics in cosmetic products by liquid chromatography tandem mass spectrometry method显示文摘在这研究,一个简单、快速的高效的液体 chromatographytandem 团 spectrometry ( HPLCMS/MS )方法被建立并且验证了在化妆产品决定 14 酮抗菌素,包括 1 ( ceftazidime ), 2 ( cefaclor ), 3 ( cefdinir ), 4 (氨比西林), 5 ( cefalexin ), 6 ( ceftezole ), 7 ( cefotaxim ), 8 ( cefradine ), 9 ( cefuroxime ), 10 ( cephazoline ), 11 ( cefathiamidine ), 12 ( cefoperazone ), 13 ( cafalotin ), 14 ( piperacillin )。 | Cai Sheng Wu Jin Lan Zhang Yan Ling Qiao Yi Lin Wang Zhi Rong Chen | 2011 | Chinese Chemical Letters2011，22，3： | 10 |
| 12 | Waxy allelic diversity in common millet(Panicum miliaceum L.) in China显示文摘A set of 132 accessions of common millet,Panicum miliaceum L.,from 12 provinces of China were assessed for endosperm starch type(waxy or non-waxy)using I_2-KI staining,amylose and amylopectin contents using the dual-wavelength colorimetric method,and genotype of Waxy genes conditioning amylose content by gene sequencing.Endosperm starch content varied from57.69%to 74.70%,while the amylose and amylopectin contents of the starch ranged from 0 to23.29%and from 41.99%to 70.24%,respectively.Sequencing two Wx genes,including Wx-L(intron 5-exon 7 and intron 8–9)and Wx-S(exon 9–intron 10)revealed several polymorphisms(S_0,S_(-15),L_C,L_F,L_Y).Marker M5-R11 linking to the Wx-S gene may be used to discriminate waxy common millet accessions from non-waxy ones.Among the 132 accessions,68 with the S_(-15)allele had waxy endosperm starch with the amylose content range 0–2.58%and 64 accessions with the S_0allele had non-waxy endosperm starch with amylose content range 3.94%–23.29%.Five genotypes including S_(-15)/L_F(45%of the accessions),S_0/L_F(25%),S_0/L_Y(12%),S_0/L_C(11%),and S_(-15)/L_Y(7%)were identified.Six new SNPs were detected at the Wx-L locus.These results will facilitate common millet breeding,especially of cultivars free of amylose. | Ruiyun Wang Haigang Wang Xiaohuan Liu Xu Ji Ling Chen Ping Lu Minxuan Liu Bin Teng Zhijun Qiao | 2018 | The Crop Journal2018，6，4： | 10 |
| 13 | Carbon dioxide capture using polyethylenimine-loaded mesoporous carbons显示文摘A high efficiency sorbent for CO2 capture was developed by loading polyethylenimine (PEI) on mesoporous carbons which possessed well-developed mesoporous structures and large pore volume. The physicochemical properties of the sorbent were characterized by N2 adsorption/desorption, scanning electron microscopy (SEM), thermal gravimetric analysis (TG) and Fourier transform infrared spectroscopy (FT-IR) techniques followed by testing for CO2 capture. Factors that affected the sorption capacity of the sorbent were studied. The sorbent exhibited extraordinary capture capacity with CO2 concentration ranging from 5% to 80%. The optimal PEI loading was determined to be 65 wt.% with a CO2 sorption capacity of 4.82 mmol-CO2 /g-sorbent in 15% CO2 /N2 at 75°C, owing to low mass-transfer resistance and a high utilization ratio of the amine compound (63%). Moisture had a promoting effect on the sorption separation of CO2 . In addition, the developed sorbent could be regenerated easily at 100°C, and it exhibited excellent regenerability and stability. These results indicate that this PEI-loaded mesoporous carbon sorbent should have a good potential for CO2 capture in the future. | Jitong Wang Huichao Chen Huanhuan Zhou Xiaojun Liu Wenming Qiao Donghui Long Licheng Ling | 2013 | Journal of Environmental Sciences2013，25，1： | 9 |
| 14 | Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP显示文摘Honokiol (HNK ) 是与众多的药理学活动从木兰花植物孤立的自然混合物,包括禁止上皮间充质的转变(EMT ) ,它作为一个吸引人的目标被建议了让反肿瘤药阻止肿瘤移植。在这研究,我们在 vitro 和相关发信号 mechanisms.Methods 在人的 NSCLC 房间在 EMT 上调查了 HNK 的效果:在有 TGF-1 (5 ng/mL ) 的联合的 TNF-(25 ng/mL ) 被用来刺激人的 NSCLC A549 和 H460 房间的 EMT。房间增长用 sulforhodamine B 试金被分析。愈合创伤的试金和 transwell 试金被执行检验房间活动性。西方的弄污被用来检测相关蛋白质的表示层次。siRNAs 被用来将 c 扭动和 N-cadherin 的基因表示击倒。c 扭动 L (H157 扭动 L ) 或紫胶 Z (H157 紫胶 Z ) 的稳定的 overexpression 也是 performed.Results:有 TNF-+TGF-1 的处理显著地提高了 A549 和 H460 房间,增加的 c 扭动, N-cadherin (一个间充质的标记) ,蜗牛(一个 transcriptional 调节的人) 和 p-Smad2/3 表示的移植,并且减少在房间的 IB 层次;这些变化被合作处理与 HNK (30 mol/L ) 废除。进一步的研究证明 c 扭动的那表示水平高度与 NSCLC 房间的运动和迁居被相关,并且 c 扭动发信号的下游的受动器是 NF-B 发信号并且 N-cadherin/snail 发信号,当发信号的 Smad 可能躺着时 c-FLIP.Conclusion 在上游:HNK 由指向 c 扭动在 vitro 禁止人的 NSCLC 房间的调停 EMT 的活动性和移植,它能为癌症治疗作为一个有希望的目标被利用,当 HNK 可以成为潜在的反转移药或铅化合物时。 | Xiao-qin LV Xin-ran QIAO Ling SU Shu-zhen CHEN | 2016 | Acta Pharmacologica Sinica2016，37，12： | 9 |
| 15 | Adenomyosis-derived extracellular vesicles endow endometrial epithelial cells with an invasive phenotype through epithelial-mesenchymal transition显示文摘Extracellular vesicles from highly metastatic tumor cells have been shown to mediate epithelial-mesenchymal transition(EMT)-related events in recipient cells.In endometrial epithelial cells,EMT processes are known to be involved in the development of adenomyosis.We aimed to investigate whether adenomyosis-derived extracellular vesicles(AMEVs)are able to induce an EMT process in endometrial epithelial cells.In this study,AMEVs were isolated from patients with adenomyosis and characterized by transmission electron microscopy,Western blot,and nanoparticle tracking.Primary endometrial epithelial cells(EECs)were derived from normal endometrium tissues from patients with leiomyoma and co-cultured with AMEVs in vitro.AMEV uptake was examined by fluorescence confocal microscopy.The invasion of EECs was confirmed by Transwell assay.Immunohistochemistry,Western blot,and qRT-PCR were performed on EECs to illustrate the expression levels of cytokeratin 19,E-cadherin,vimentin,and zinc finger E-boxbinding homeobox 1(ZEB1).The results indicated that the cellular fluorescence intensity gradually increased after 48 h of co-culture,but decreased after 72 h.After co-culturing with AMEVs for 72 h,EECs expressed significantly lower levels of cytokeratin 19 and E-cadherin,and significantly higher levels of vimentin and ZEB1.Together these results demonstrated that AMEVs induce an EMT process and enhance the invasion of EECs.These changes may contribute to the pathogenesis and progression of adenomyosis. | Dayong Chen Hai Qiao Yiting Wang Ling Zhou Na Yin Liaoqiong Fang Zhibiao Wang | 2020 | Genes & Diseases2020，7，4： | 8 |
| 16 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 17 | Mobile Web Augmented Reality in 5G and Beyond:Challenges, Opportunities, and Future Directions显示文摘The popularity of wearable devices and smartphones has fueled the development of Mobile Augmented Reality(MAR),which provides immersive experiences over the real world using techniques,such as computer vision and deep learning.However,the hardware-specific MAR is costly and heavy,and the App-based MAR requires an additional download and installation and it also lacks cross-platform ability.These limitations hamper the pervasive promotion of MAR.This paper argues that mobile Web AR(MWAR)holds the potential to become a practical and pervasive solution that can effectively scale to millions of end-users because MWAR can be developed as a lightweight,cross-platform,and low-cost solution for end-to-end delivery of MAR.The main challenges for making MWAR a reality lie in the low efficiency for dense computing in Web browsers,a large delay for real-time interactions over mobile networks,and the lack of standardization.The good news is that the newly emerging 5G and Beyond 5G(B5G)cellular networks can mitigate these issues to some extent via techniques such as network slicing,device-to-device communication,and mobile edge computing.In this paper,we first give an overview of the challenges and opportunities of MWAR in the 5G era.Then we describe our design and development of a generic service-oriented framework(called MWAR5)to provide a scalable,flexible,and easy to deploy MWAR solution.We evaluate the performance of our MWAR5 system in an actually deployed 5G trial network under the collaborative configurations,which shows encouraging results.Moreover,we also share the experiences and insights from our development and deployment,including some exciting future directions of MWAR over 5G and B5G networks. | Xiuquan Qiao Pei Ren Guoshun Nan Ling Liu Schahram Dustdar Junliang Chen | 2019 | China Communications2019，16，9： | 7 |
| 18 | Induction of embryonic stem cells to hematopoietic cells in vitro显示文摘In order to get hematopoietic cells from embryonic stem (ES) cells and to study development mechanisms of hematopoietic cells, the method of inducing embryonic stem cells to hematopoietic cells was explored by differenciating mouse ES cells and human embryonic cells in three stages. The differentiated cells were identified by flow cytometry, immunohistochemistry and Wright’s staining. The results showed that embryoid bodies (EBs) could form when ES cells were cultured in the medium with 2-mercaptoethanol (2-ME). However, cytokines, such as stem cell factor (SCF), thrombopoietin (TPO), interleukin-3 (IL-3), interleukin-6 (IL-6), erythropoietin (EPO) and granular colony stimulating factor (G-CSF), were not helpful for forming EBs. SCF, TPO and embryonic cell conditional medium were useful for the differentiation of mouse EBs to hematopoietic progenitors. Eighty-six percent of these cells were CD34+ after 6-d culture. Hematopoietic progenitors differentiated to B lymphocytes when they were cocultured | XU Ling QIAO Chunping HUANG Shaoliang LI Shunong WU Xuan | 2000 | Chinese Science Bulletin2000，45，18： | 6 |
| 19 | Major Mid-Late Holocene Cooling in the East China Sea Revealed by an Alkenone Sea Surface Temperature Record显示文摘Although the mid-late Holocene cold and dry event about 4000 years ago(the 4 ka event) has been observed almost globally, it was most prominent in terrestrial climate proxies from the lower latitudes. Here we evaluate the oceanic response to this event in terms of a Holocene sea surface temperature(SST) record reconstructed using the K'37U index for Core B3 on the continental shelf of the East China Sea. The record reveals a large temperature drop of about 5℃ from the mid-Holocene(24.7℃ at 5.6 ka) to the 4 ka event(19.2℃ at 3.8 ka). This mid-late Holocene cooling period in Core B3 correlated with(i) decreases in the East Asia summer monsoon intensity and(ii) the transition period with increased El Nino/Southern Oscillation activities in the Equatorial Pacific. Our SST record provides oceanic evidence for a more global nature of the mid-late Holocene climate change, which was most likely caused by a southward migration of the Intertropical Converge Zone in response to the decreasing summer solar insolation in the Northern Hemisphere. However, the large SST drop around Core B3 indicates that the mid-late Holocene cooling was regionally amplified by the initiation/strengthening of eddy circulation/cold front which caused upwelling and resulted in additional SST decrease. Upwelling during the mid-late Holocene also enhanced with surface productivity in the East China Sea as reflected by higher alkenone content around Core B3. | ZHAO Meixun DING Ling XING Lei QIAO Shuqing YANG Zuosheng | 2014 | Journal of Ocean University of China2014，13，6： | 6 |
| 20 | Night Sleep Duration and Risk of Cognitive Impairment in a Chinese Population: A Cross-sectional Study显示文摘Objective Although sleep is one of the most important health-related behavioral factors,the association between night sleep duration and cognitive impairment has not been fully understood.A cross-sectional study was conducted with a random sample of 2,514 participants(≥40 years of age;46.6% women) in China to examine the association between night sleep duration and cognitive impairment.Methods Night sleep duration was categorized as ≤ 5,6,7,8,or ≥9 h per night.Cognitive function was measured using the Mini-Mental State Examination.A multivariate regression analysis was used to analyze the association of night sleep duration with cognitive impairment.A total of 122 participants were diagnosed with cognitive impairment.Results A U-shaped association between night sleep duration and cognitive impairment was found.The odds ratios(95% confidence intervals) of cognitive impairment(with 7 h of daily sleep being considered as the reference) for individuals reporting ≤ 5,6,8,and ≥9 h were 2.14(1.20-3.83),1.13(0.67-1.89),1.51(0.82-2.79),and 5.37(1.62-17.80),respectively(P≤0.01).Conclusion Short or long night sleep duration was an important sleep-related factor independently associated with cognitive impairment and may be a useful marker for increased risk of cognitive impairment. | SONG Qiao Feng LIU Xiao Xue HU Wan Ning HAN Xiao Chen ZHOU Wen Hua LU Ai Dong WANG Xi Zhu WU Shou Ling | 2017 | Biomedical and Environmental Sciences2017，30，10： | 5 |
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