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| 1 | MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells显示文摘MicroRNAs regulate self renewal and differentiation of cancer stem cells.There,we sought to identify the expression of miR-181b in glioma stem cells and investigate the biological effect of miR-181b on glioma stem cells in this study.MiR-181b expression was measured by real-time PCR in glioma stem cells isolated from U87 cells by FACS sorting.After miR-181b was overexpressed in U87 glioma stem cells by miR-181b lentiviral expression vector and/or treatment of temozolomide,secondary neurosphere assay,soft agar colony assay and MTT assay were performed.Compared with U87 cells,the expression of miR-181b was significantly decreased in U87 glioma stem cells.Overexpression of miR-181b decreased neurosphere formation by U87 glioma stem cells in vitro and suppressed colony formation in soft agar,and the cell growth inhibition rates increased in a time-dependent manner in U87 glioma stem cells infected with miR-181b lentivirus.Furthermore,miR-181b had a synergistic effect on temozolomide-induced inhibition of secondary neurosphere and soft agar colony,and on cell growth inhibition rates.MiR-181b functions as a tumor suppressor that suppresses proliferation and reduces chemoresistance to temozolomide in glioma stem cells. | Ping Li Xiaoming Lu Yingyi Wang Lihua Sun Chunfa Qian Wei Yan Ning Liu Yongping You Zhen Fu | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 2 | KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer显示文摘离氨酸(K) 特定的 demethylase 4B (KDM4B ) 是 histone H3K9 demethylase 并且被报导通过染色质结构的规定激活基因抄写。以前的研究表明了 KDM4B 在 colorectal,前列腺和胃的癌症起特殊规章的作用。然而,它在胰腺的癌症的生理的角色仍然保持大部分未知。在现在的学习,它是表明的 KDM4B 戏一在在胰腺的癌症的上皮间充质的转变(EMT ) 关键。siRNA 调停了 KDM4B 的 silencing 禁止房间移植,侵略和 EMT。而且, KDM4B 被表明 epigenetically 在 TGF 调整 ZEB1 的表示 -- 导致的 EMT 过程。在胰腺的癌症病人的肿瘤纸巾, KDM4B 的蛋白质水平断然与 ZEB1 被相关。在结论,我们的结果建议 KDM4B 是在 EMT 过程的一个关键调停人,并且可以为人的胰腺的癌症的变形前进用作一个重要预示的标记和治疗学的目标。 | Shuo Li Linlin Wu Qingbing Wang Yingyi Li Xiaolin Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 8 |
| 3 | Effectiveness of external Sanjierupi Gao on mastalgia caused by mammary gland hyperplasia: a placebo controlled trial显示文摘OBJECTIVE:To evaluate the curative effect of external application of the Chinese drug,Sanjierupi Gao,on mastalgia caused by mammary gland hyperplasia.METHODS:This randomized,double-blinded,and placebo controlled study enrolled 260 patients with mammary gland hyperplasia from five hospitals.Patients were randomly and equally divided in-to a Sanjierupi Gao treatment group and a placebo control group.An adhesive plaster was applied to the most painful area on either breast for 7 h a day.Treatment lasted for two menstrual cycles without application during menstruation.Mastalgia was used as the main index of curative effect.The change before and after treatment in days of mastalgia,the time to alleviate pain,pain extent,and severe pain scores were observed.RESULTS:Compared to the control group,the treatment group had significantly fewer days of mastalgia(P<0.01),a significantly lower severe pain score(P<0.01),and significantly less subjective pain and tenderness(P<0.05 and P<0.01,respectively).Three days before the follow-up visit,the pain score in the treatment group was significantly lower than that in the control group(P<0.05).A non-parametric test was used to compare the time to alleviate mastalgia between the two groups and found no statistical difference(Z=0.313,P=0.754).CONCLUSION:Application of Sanjierupi Gao can decrease mastalgia duration in patients with mammary gland hyperplasia during menstruation and alleviate the extent of mastalgia.The time to alleviate pain is psychologically influenced. | Yingyi Fan Xiaohua Pei Zhaolan Liu Zhongyuan Xia Dongxiao Zhang Afeng Song Duo Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 7 |
| 4 | Low frequency oscillation characteristics of East China Power Grid after commissioning of Huai-Hu ultra-high voltage alternating current project显示文摘The low frequency oscillation characteristics of East China Power Grid after commissioning of the first ultra-high voltage alternating current(UHVAC)project-the Huai-Hu UHVAC project are studied.Several low frequency oscillation cases occurred in East China Power Grid in the past few years are reviewed and summarized.Based on the analysis of the different typical operation modes,the main low frequency oscillation modes in East China Power Grid in the early stages of development of ultra-high voltage(UHV)are summarized,and the impacts of the significant power grid maintenance on low frequency oscillation characteristics are analyzed.Besides,the oscillation mode of UHV generators to East China Power Grid is researched,and the importance of the power system stabilizator(PSS)is emphasized.Furthermore,the comparative analysis between the time domain and the frequency domain is carried out,and the influences of the governing system on low frequency oscillation characteristics are revealed.Finally,both the focus and the direction of low frequency oscillation research are presented. | Chao WANG Yang LV Hongyang HUANG Jing ZHANG Jihong LI Yingyi LI Weizhen SUN Yong CHANG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 6 |
| 5 | Control of the morphology of micro/nanostructures of polycarbonate via electrospinning显示文摘Many of the applications proposed for bioassays, scaffolds for tissue engineering, filtrations, and supports for catalysts require polymeric membranes with large specific surface areas. Polycarbonate (PC) is a possible candidate for these applications because of its excellent mechanical performance and good biocompatibility. Electrospinning is a simple and effective method for large-scale fabrication of micro-/nanofibrous membranes with large specific surface areas. How to control the morphology of electrospun PC fibers, however, has not been systematically investigated. We describe the controllable fabrication of continuous and uniform PC fibers. We electrospin PC/chloroform solutions doped with different types of surfactants including anionic, zwitterionic, nonionic and cationic surfactants. Only cationic surfactants can lead to the successful fabrication of uniform PC fibers. After the analysis of the correlation between solution properties such as viscosity, surface tension, and conductivity and the morphology of electrospun fibers, we conclude that the addition of cationic surfactants such as cetane trimethyl ammonium bromide (CTAB) that leads to a decrease in viscosity is the main factor responsible for the formation of PC fibers. The demonstration of the fabrication of uniform PC fibers will lend experience to processing other polymers into fibers via electrospinning. | YANG Da Yong WANG Yang ZHANG DongZhou LIU YingYi JIANG XingYu | 2009 | Chinese Science Bulletin2009，54，17： | 6 |
| 6 | Ambient volatile organic compounds at a receptor site in the Pearl River Delta region:Variations,source apportionment and effects on ozone formation显示文摘We present the continuously measurements of volatile organic compounds(VOCs)at a receptor site(Wan Qing Sha,WQS)in the Pearl River Delta(PRD)region from September to November of 2017.The average mixing ratios of total VOCs(TVOCs)was 36.3±27.9 ppbv with the dominant contribution from alkanes(55.5%),followed by aromatics(33.3%).The diurnal variation of TVOCs showed a strong photochemical consumption during daytime,resulting in the formation of ozone(O_(3)).Five VOC sources were resolved by the positive matrix factorization(PMF)model,including solvent usage(28.6%),liquid petroleum gas(LPG)usage(24.4%),vehicle exhaust(21.0%),industrial emissions(13.2%)and gasoline evaporation(12.9%).The regional transport air masses from the upwind cities of south China can result in the elevated concentrations of TVOCs.Low ratios of TVOCs/NO_(x)(1.53±0.88)suggested that the O_(3) formation regime at WQS site was VOC-limited,which also confirmed by a photochemical box model with the master chemical mechanism(PBM-MCM).Furthermore,the observation on high-O_(3) episode days revealed that frequent O_(3) outbreaks at WQS were mainly caused by the regional transport of anthropogenic VOCs especially for aromatics and the subsequent photochemical reactions.This study provides valuable information for policymakers to propose the effective control strategies on photochemical pollution in a regional perspective. | Yao Meng Junwei Song Lewei Zeng Yingyi Zhang Yan Zhao Xufei Liu Hai Guo Liuju Zhong Yubo Ou Yan Zhou Tao Zhang Dingli Yue Senchao Lai | 2022 | Journal of Environmental Sciences2022，34，1： | 5 |
| 7 | Functional analysis of a novel C-glycosyltransferase in the orchid Dendrobium catenatum显示文摘Flavonoids,which are a diverse class of phytonutrients,are used by organisms to respond to nearly all abiotic stresses and are beneficial for human health.Glycosyltransferase,used during the last step of flavonoid biosynthesis,is important in flavonoid enrichment.However,little is known about glycosyltransferase in the orchid Dendrobium catenatum(D.officinale).In this study,we isolated a novel C-glycosyltransferase(designated DcaCGT)from the orchid D.catenatum by identifying and analyzing 82 putative genes in the GT1 family.DcaCGT could specifically catalyze not only di-C-glycosylation but also O-glycosylation.Apart from the normal function of catalyzing 2-hydroxynaringenin and phloretin to the respective di-C-glycosides,DcaCGT also catalyzes apigenin to cosmosiin.Targeted metabolic profiling of the substrates(2-hydroxynaringenin,phloretin,and apigenin)and products(vitexin,isovitexin,vicenin-2,nothofagin,3’,5’-di-C-glucosylphloretin,and cosmosiin)in different tissues showed that vicenin-2 was the most abundant product of this novel enzyme.Cosmosiin was detected in flowers and flower buds.We also established that DcaCGT functions expanded throughout the evolution of D.catenatum.Residual OGT activity may help D.catenatum resist drought stress.Our study illustrates the function,origin,and differentiation of DcaCGT and provides insights into glycosylation and molecular propagation processes,which can be used to improve the production of flavonoids by the cultivated medicinal plant D.catenatum. | Zhiyao Ren Xiaoyu Ji Zhenbin Jiao Yingyi Luo Guo-Qiang Zhang Shengchang Tao Zhouxi Lei Jing Zhang Yuchen Wang Zhong-Jian Liu Gang Wei | 2020 | Horticulture Research2020，7，1： | 5 |
| 8 | Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features显示文摘Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. | Xiaojun Yang Lei Wu Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang | 2020 | Chinese Journal of Cancer Research2020，32，2： | 4 |
| 9 | Study of Oxygen Vacancies on Different Facets of Anatase TiO2显示文摘Anatase TiO2 samples with different ratios of {101} to {001} facets were prepared with hydrothermal method and further treated under three specific calcination atmospheres (air,H2,N2).The characterization results indicate that {001} facets may generate more oxygen vacancies and more Ti3+ species than {101} facets. | Yanan Wu Yingyi Fu Li Zhang Yuanhang Ren Xueying Chen Bin Yue Heyong He | 2019 | Chinese Journal of Chemistry2019，37，9： | 4 |
| 10 | Retinoschisis and intravitreal ranibizumab treatment for myopic choroidal neovascularization显示文摘 | Huang Jianfeng Chen Tong Lu Yingyi Long Li Dai Hong | 2014 | Chinese Medical Journal2014，，11： | 3 |
| 11 | The Oncoprotein HBXIP Uses Two Pathways to Up-regulate S100A4 in Promotion of Growth and Migration of Breast Cancer Cells显示文摘 | Shuangping Liu Leilei Li Yingyi Zhang Yiwen Zhang Yu Zhao Xiaona You Zhenhua Lin Xiaodong Zhang Lihong Ye | 2012 | Journal of Biological Chemistry2012，，36： | 3 |
| 12 | Federalism, Chinese Style: The Political Basis for Economic Success in China显示文摘 | Gabriella Montinola Yingyi Qian Barry R. Weingast | 1995 | World Politics1995，，1： | 3 |
| 13 | Regional decentralization and fiscal incentives: Federalism, Chinese style显示文摘 | Hehui Jin Yingyi Qian Barry R. Weingast | 2005 | Journal of Public Economics2005，，9： | 3 |
| 14 | Impact of Ion Current on Total Electric Field Measurement Under HVDC Transmission Line显示文摘The total electric field(TEF) at ground level induced by high-voltage direct current(HVDC) overhead transmission lines is one of the important indexes for evaluating the lines' electromagnetic environment.Based on analyzing the existing TEF sensors and the measurement principle of ion-current density,the influence from ions on TEF measurements is quantitively studied.The results show that the ions generated by the corona from a HVDC transmission line in operation cause errors in the measurement of TEF.This error is determined through analyzing the component of total measuring current on the filed mill's sensing electrode: if no appropriate approach taken,the maximum measurement error reaches up to 4.3%.Furthermore,a method that can eliminate such error,and hence improve the accuracy of TEF sensors is designed. | CUI Yong YUAN Haiwen LU Jiayu JU Yong LIU Yingyi | 2013 | 高电压技术2013，39，10： | 2 |
| 15 | Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators显示文摘The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase,sirtuin 6(SIRT6)has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases.However,the mechanism underlying allosteric activation of SIRT6 by the activator MDL-801 remains largely elusive because no major conformational changes are observed upon activator binding.By combining molecular dynamics simulations with biochemical and kinetic analyses of wild-type SIRT6 and its variant M136 A,we show that conformational rotation of 2-methyl-4-fluoro-5-bromo substituent on the right phenyl ring(R-ring)of MDL-801,which uncovers previously unseen hydrophobic interactions,contributes to increased activating deacetylation activity of SIRT6.This hypothesis is further supported by the two newly synthesized MDL-801 derivatives through the removal of the 5-Br atom on the R-ring(MDL-801-D1)or the restraint of the rotation of the R-ring(MDL-801-D2).We further propose that the 5-Br atom serves as an allosteric driver that controls the ligand allosteric efficacy.Our study highlights the effect of allosteric enzyme catalytic activity by activator binding and provides a rational approach for enhancing deacetylation activity. | Shaoyong Lu Yingyi Chen Jiacheng Wei Mingzhu Zhao Duan Ni Xinheng He Jian Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 16 | Biological receptor-inspired flexible artificial synapse based on ionic dynamics显示文摘The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is constructed.The protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,respectively.Smooth changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic emulation.The memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO nanosheets.The channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO nanosheets.The transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are demonstrated.Overall,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Yingyi Wang Mingming Hao Zihao Wang Shuqi Wang Ting Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 17 | Growth monitoring of greenhouse lettuce based on a convolutional neural network显示文摘Growth-related traits,such as aboveground biomass and leaf area,are critical indicators to characterize the growth of greenhouse lettuce.Currently,nondestructive methods for estimating growth-related traits are subject to limitations in that the methods are susceptible to noise and heavily rely on manually designed features.In this study,a method for monitoring the growth of greenhouse lettuce was proposed by using digital images and a convolutional neural network(CNN).Taking lettuce images as the input,a CNN model was trained to learn the relationship between images and the corresponding growth-related traits,i.e.,leaf fresh weight(LFW),leaf dry weight(LDW),and leaf area(LA).To compare the results of the CNN model,widely adopted methods were also used.The results showed that the values estimated by CNN had good agreement with the actual measurements,with R^(2) values of 0.8938,0.8910,and 0.9156 and normalized root mean square error(NRMSE)values of 26.00,22.07,and 19.94%,outperforming the compared methods for all three growth-related traits.The obtained results showed that the CNN demonstrated superior estimation performance for the flat-type cultivars of Flandria and Tiberius compared with the curled-type cultivar of Locarno.Generalization tests were conducted by using images of Tiberius from another growing season.The results showed that the CNN was still capable of achieving accurate estimation of the growth-related traits,with R2 values of 0.9277,0.9126,and 0.9251 and NRMSE values of 22.96,37.29,and 27.60%.The results indicated that a CNN with digital images is a robust tool for the monitoring of the growth of greenhouse lettuce. | Lingxian Zhang Zanyu Xu Dan Xu Juncheng Ma Yingyi Chen Zetian Fu | 2020 | Horticulture Research2020，7，1： | 2 |
| 18 | China’s transition to markets: market-preserving federalism, chinese style显示文摘 | Yingyi Qian Barry R. Weingast | 1996 | Journal of Economic Policy Reform1996，，2： | 2 |
| 19 | Effects of Application of Cassava Alcohol Anaerobic Fermentation Liquid and Mulching of Film on Overwintering and Next Year's Growth and Yield of Banana显示文摘The effects of application of cassava alcohol anaerobic fermentation liquid and mulching of film on overwintering and next year's growth and yield of banana were investigated in this study.The results showed that the application of cassava alcohol anaerobic fermentation liquid with COD concentration of 1 200-2 000 mg/L(900 m^3/hm^2) and mulching of film significantly increased the soil organic matter and available potassium contents in banana orchard,improved the cold resistance of banana seedlings,increased the pseudostem height,pseudostem circumference,green leaf number and chlorophyll content of next year's banana seedlings,brought the flower bud emergence period and harvest period forward,and significantly increased the yield per plant. | Yunchuan MO Yingyi DENG Xu ZHENG Yixin YE Ganhui MO Minzheng WEI Weiliu LI Feng LI Jiechun PAN Chanchan QIN Meiling SU Yao FU | 2016 | Agricultural Science & Technology2016，17，7： | 2 |
| 20 | Ecological functions of uncultured microorganisms in the cobaltrich ferromanganese crust of a seamount in the central Pacific are elucidated by fosmid sequencing显示文摘Cobalt-rich ferromanganese is an important seafloor mineral and is abundantly present in the seamount crusts.Such crusts form potential hotspots for biogeochemical activity and microbial diversity, yet our understanding of their microbial communities is lacking. In this study, a cultivation-independent approach was used to recover genomic information and derive ecological functions of the microbes in a sediment sample collected from the cobalt-rich ferromanganese crust of a seamount region in the central Pacific. A total of 78 distinct clones were obtained by fosmid library screening with a 16 SrRNA based PCR method. Proteobacteria and MGI Thaumarchaeota dominated the bacterial and archaeal 16 SrRNA gene sequence results in the microbial community. Nine fosmid clones were sequenced and annotated. Numerous genes encoding proteins involved in metabolic functions and heavy metal resistance were identified, suggesting alternative metabolic pathways and stress responses that are essential for microbial survival in the cobalt-rich ferromanganese crust. In addition, genes that participate in the synthesis of organic acids and exoploymers were discovered. Reconstruction of the metabolic pathways revealed that the nitrogen cycle is an important biogeochemical process in the cobalt-rich ferromanganese crust. In addition, horizontal gene transfer(HGT) events have been observed, and most of them came from bacteria, with some occurring in archaea and plants. Clone W4-93 a, belonging to MGI Thaumarchaeota, contained a region of gene synteny. Comparative analyses suggested that a high frequency of HGT events as well as genomic divergence play important roles in the microbial adaption to the deep-sea environment. | HUO Yingyi CHENG Hong Anton F.Post WANG Chunsheng JIANG Xiawei PAN Jie WU Min XU Xuewei | 2015 | Acta Oceanologica Sinica2015，34，4： | 2 |
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