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| 1 | Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2显示文摘肝炎 B 病毒 X 蛋白质(HBx ) 在 hepatocellular 癌的发展起一个关键作用。这里,我们寻求了识别 HBx 由调停的机制肝房间增长。我们发现那 HBx upregulated cyclooxygenase-2 (COX-2 ) 的层次, 5-lipoxygenase (5 哈鱼) 和 phosphorylated 在肝房间的细胞外的调整信号的蛋白质 kinases 1/2 (p-ERK1/2 ) 。导致 HBx 的 p-ERK1/2 被 Gi/o 蛋白质,艇长或哈鱼的抑制废除。另外, HBx 增加了前列腺素 E2 (PGE2 ) 的数量,免除房间线的 leukotriene B4 (LTB4 ) 源于 hepatocytes。而且,这些释放 arachidonic 酸代谢物能激活 ERK1/2。有趣地,激活 ERK1/2 能 upregulate 以一种积极反馈方式的 COX-2 和 5 哈鱼的表示。在结论, HBx 经由包含 COX-2, 5 哈鱼,释放 arachidonic 酸代谢物, Gi/o 蛋白质和 p-ERK1/2 的一个积极反馈环提高并且维持肝房间增长。 | Changliang Shan Fuqing Xu Shuai Zhang Jiacong YOU Xiaona You Liyan Qiu Jie Zheng Lihong Ye Xiaodong Zhang | 2010 | Cell Research2010，20，5： | 15 |
| 2 | Experimental investigation on color variation mechanisms of structural light in Papilio maackii ménétriès butterfly wings显示文摘The body color in animals results from billions of years of their natural evolution in order to evade natural enemies, catch quarries or display themselves beauty, in-vestigation on mechanisms of structural light is an important aspect of bionics. Based on the phenomenon of Papilio maackii ménétriès’ blue scales changing into green ones immediately after dropping some alcohol aqua on the underwing sur-face and soon returning back to the original color, the relationship between micro-structure, optics characteristic of scales and changing color effect were studied using the Olympus Stereomicroscope, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Ultraviolet (UV)-Visible Spectropho-tometer. The color variation mechanisms of blue scales of Papilio maackii mé-nétriès in Chinese Northeast were revealed in this paper. When visible lights trav-eled through the concaver structure with multilayer reflector and the filled medium with different refractive indices, the reflected lights in definite wavelengths pro-duced interference and color at that wavelength came into being. It has important academic reference value to biomimetics design of video stealth materials. | REN LuQuan QIU ZhaoMei HAN ZhiWu GUAN HuiYing WU LiYan | 2007 | Science China(Technological Sciences)2007，50，4： | 13 |
| 3 | Microstructure and structural color in wing scales of butterfly Thaumantis diores显示文摘The butterfly Thaumantis diores is a species in the Northeast of China. There are two kinds of scales on its wings, which overlap like roof tiles and completely cover the membrane. The SEM results showed that only Type-I scales play a key role in forming the blue structural color. Type-II scales have black chemical color. The cross section micro-configuration of scales is achieved by using the transmission electron microscopy (TEM). The brilliant blue generated through the multilayer microstructure is explained by the photonic crystal reason. The multilayer microstructure of the ridges is optimized to 1D Bragg stack for simulation. The reflectivity of the wing is measured by a spectrometer, and the experimental graph accord with the simulation curves basically. When this species fly, the wing's color and brightness can change because of the transform between structural color and chemical color. The bionic color-changing design and the significance of this effect in video stealth or other fields are discussed at the end of the paper. | HAN ZhiWu WU LiYan QIU ZhaoMei REN LuQuan | 2009 | Chinese Science Bulletin2009，54，4： | 5 |
| 4 | Preface显示文摘前言 | ZhiWu Han LiYan Wu ZhaoMei Qiu LuQuan Ren | 2010 | Chinese Science Bulletin2010，55，30： | 3 |
| 5 | A study of peroxyacetyl nitrate at a rural site in Beijing based on continuous observations from 2015 to 2019 and the WRFChem model显示文摘Peroxyacetyl nitrate(PA N)is one of the most important photochemical pollutants and has aroused much concern in China in recent decades.However,few studies described the long-term variations in PAN in China.In this study,we continuously monitored the PAN,03 and NOx concentrations at a regional background site near Beijing from August 2015 to February 2019.Based on the observed concentrations and climate data,w e analyzed the seasonal PAN variations.The results revealed that the monthly mean PAN concentration ranged from 0.33-2.41 ppb,with an average value of 0.94 ppb.The PAN concentration exhibited a distinct seasonal variation,with high values in spring and low values in winter.After analyzing the corresponding meteorological data,we found that stronger ultraviolet(UV)radiation,a relatively longer lifetime and a higher background PAN concentration contributed to the high PAN concentrations in spring.In addition,with the utilization of the WRF-Chem(Weather Research and Forecasting with Chemistry)model,the cause of the extremely high PAN concentration in spring 2018 wa s determined.The model results demonstrated that an anomalously low pressure and the southwesterly winds in northern China might be the main causes of the increased PAN concentration in Beijing and its surrounding area in spring 2018. | Yulu Qiu Zhiqiang Ma Weili Lin Weijun Quan Weiwei Pu Yingruo Li Liyan Zhou Qingfeng Shi | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 3 |
| 6 | A novel purification technique for noble gas isotope analyses of authigenic minerals显示文摘高贵、活跃的气体为高贵煤气的同位素分析在煤气的抽取期间被免除地质的样品。活跃气体应该为分析在 inletting 前被移开到集体分光计。准备系统能在很地质的样品上面清洗的正常高贵气体。然而,从油 / 气体地里的沉积岩石的 authigenic 矿物质包含有机物,它不能被正常准备系统清理并且因此影响高贵煤气的分析。我们介绍一个新奇煤气的纯化系统(中华人民共和国专利没有。ZL201320117751.2 ) ,它与不同吸收并且排除包括几可逆纯化泵温度。它能很好清理水蒸气,二氧化碳和器官的气体。云母矿物质经常为 40Ar/39 标明日期的 Ar。不能被正常准备系统与二 SAES NP10 ? getters 清理的一件白云母样品(2082MS ) ,在这研究为一个比较实验成为测试样品。实验与接着关上 / 打开的器官的煤气的移动系统(OGRS ) 被分配进 4 节。当 OGRS 为纯化仅仅与二 NP10 getters 被关上时, 40 因为杂质, Ar 紧张与入口时间在曲线增加, 40Ar/39 关于瑥潲潬楧慣?洠湩牥污杯捩污愠摮朠潥档浥捩污攠楶敤据 e 的 Ar | HE LiYan QIU HuaNing SHI HeSheng ZHU JunZhang BAI XiuJuan YUN JianBing | 2016 | Science China Earth Sciences2016，59，1： | 2 |
| 7 | Self-assembled honokiol-loaded micelles based on poly(?-caprolactone)-poly(ethylene glycol)-poly(?-caprolactone) copolymer显示文摘 | XiaWei Wei ChangYang Gong Shuai Shi ShaoZhi Fu Ke Men Shi Zeng XiuLing Zheng MaLing Gou LiJuan Chen LiYan Qiu ZhiYong Qian | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 8 | Polyphosphazene nanop- articles for cytoplasmic release of dox with improved cytotox- icity against DOX-resistant tumor cells显示文摘 | Zheng Cheng Xu Jing Qiu Liyan | 2011 | Journal of Colloid and Interface Science2011，355，2： | 1 |
| 9 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 10 | Thermodynamic investigations of zeolites nax and nay显示文摘 | Qiu Liyan Laws Patricia A Zban Bi-Zeng White Mary Anne | 2006 | Canadian Journal of Chemistry2006，84，： | 1 |
| 11 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 12 | pH-Responsive supramolecular micelle based on host-guest interaction of poly(β-amino ester) derivatives and adamantyl-terminated poly(ethylene glycol) for cancer inhibition显示文摘Supramolecular structures have received growing attention and been widely applied in many fields.Herein, we synthesized hydrophobic β-cyclodextrin-contained poly(β-amino ester)(PAE-β-CD) and hydrophilic adamantyl-terminated poly(ethylene glycol)(PEG-AD) to form a supramolecular micelle via the host-guest interaction. The micelle displayed pH responsive structure change due to the transform of hydrophobic PAE core to hydrophilic form in weakly acid condition. After the anticancer drug curcumin(Cur) was loaded into the micelle, the drug release behavior of the Cur-loaded micelle was studied, and it turned out that the Cur-loaded supramolecular micelle could effectively unload the drug at pH 5.5.Furthermore, the antitumor efficiency of the Cur-loaded micelle was also examined both in vitro and in vivo, indicating considerable inhibition ratio as high as 62.14% against mouse sarcoma 180. | Zhuting Yang Yan Peng Liyan Qiu | 2018 | Chinese Chemical Letters2018，29，12： | 1 |
| 13 | A Multi-Generation Schmakeria poplesia Culturing System for Use in Ecotoxicological Study显示文摘Crustacean zooplankton form the keystone link between primary producers and fish stocks in marine and estuary ecosystems. We have established a multi-generation cultivation system for zooplankton with which future experiments on the biological effects of pollutants in marine and estuary environments can be better performed. A population of calanoid copepod, Schmakeria poplesia, was collected in December 2003 and maintained in a static system through all stages (eggs to adults). The population exhibited an average developmental time of 13.6 d in conditions corresponding to the natural environment (water temperature 20℃, salinity 15). A series of experiments were performed to examine copepod egg production and hatching success as functions of food type and feeding concentration. Results in our study showed that Isochrysis galbana was more favored for the reproduction of copepods than Phaeodactylum tricornutum, and 10×104cells mL-1 was the most practical algae concentration. We have demonstrated that the Schmakeria poplesia population can be maintained in the laboratory through multiple generations. In addition, methods to control egg production through changes in food concentration have been established, making it feasible to control the start date of exposure experiments or the timing of the collection of offspring to initiate a new generation. | HUANG Ying ZHU Liyan QIU Xuchun QI Benjin ZHANG Tianwen | 2009 | Journal of Ocean University of China2009，8，1： | 1 |
| 14 | Polymer architecture and drug delivery显示文摘 | Qiu Liyan Bae YH | 2006 | Pharmaceutical Research2006，23，： | 1 |
| 15 | Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/ Alu core sequence/subtelomeric DNA显示文摘 | Xuan Zhang Xiaona You Nan Li Weiying Zhang Sarantis Gagos Qi Wang Aggelos Banos Na Cai Huakun Zhang Hang Zhang Xuezhi Zhang Changliang Shan Liyan Qiu Shuai Zhang Na Lv Minshan Chen Yumei Du Jianchuan Xia Lihong Ye Xiaodong Zhang | 2012 | FEBS Letters2012，，19： | 1 |
| 16 | Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice显示文摘Hearing impairment constitutes a global public health problem with severe social,political,and economic consequences,and the World Health Organization estimates that about 466 million individuals globally have some degree of hearing loss.Genetic factors account for about half of all deafness cases.Currently,more than 100 genes are known to be involved in hearing loss,but the underlying molecular mechanisms behind these deafness genes have not been fully characterized.The main clinical treatment for deafness is hearing aids and cochlear implants,but their efficacy depends heavily on the quantity and quality of residual hair cells(HCs)and spiral ganglion neurons and has only limited auditory effects. | Cheng Cheng Jieyu Qi Liyan Zhang He Li Jie Lu Siyu Li Zhong Zhang Yue Qiu Chen Zhang Lulu Jiang Chaorong Yu Xia Gao Phillip I.Bird Renjie Chai | 2023 | Journal of Genetics and Genomics2023，50，2： | 0 |
| 17 | Corrigendum to“Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice”[Journal of Genetics and Genomics(2023)50,122-125]显示文摘This corrigendum clarifies information in the article'Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice'by Cheng et al.(2023).In the author list,the author'Cheng Cheng'should be corrected into'Cheng Cheng'. | Cheng Cheng Jieyu Qi Liyan Zhang He Li Jie Lu Siyu Li Zhong Zhang Yue Qiu Chen Zhang Lulu Jiang Chaorong Yu Xia Gao Philip I.Bird Renjie Chai | 2023 | Journal of Genetics and Genomics2023，50，6： | 0 |
| 18 | Research and Reflection on Teaching of C Programming Language Design显示文摘C Language is a basic programming language and a compulsory foundation course for majors of science and engineering. Subjected to teaching periods,students have no time to do enough concrete integrated exercises. In teaching of C programming language design, both teachers and students have some problems. On the one hand teachers should change their teaching ideology, on the other hand,students should spontaneously study and improve their study motivation. In this way, students will improve their programming ability and apply what they learn comprehensively. | Hui Gao Zhaowen Qiu Di Wu Liyan Gao | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
| 19 | Thermosensitive self-assembly behaviors of novel amphi-philic polyphosphazenes显示文摘A series of amphiphilic thermosensitive poly- phosphazenes (PNIPAm-g-PPP) bearing N-isopropylacryla- mide oligomers (oligo-PNIPAm) and glycine ethyl groups (GlyEt) as co-substituents have been synthesized via polymer substitute reaction. UV-visible spectra indicated that the aqueous solution of PNIPAm-g-PPP exhibited the lower critical solution temperature (LCST). Furthermore, the LCST was seriously influenced by the substitution ratios of PNIPAm to GlyEt in the copolymer. The more GlyEt the copolymer contained, the lower LCST it had. The critical association concentration (cac) of copolymers was deter- mined by fluorescence probe method. It was found that cac was decreased with increasing GlyEt content of polyphos- phazene. Also the formation of self-assembled micelles or nano-particles was confirmed by TEM. | QIU Liyan ZHANG Jianxiang JIN Yi ZHU Kangjie | 2005 | Chinese Science Bulletin2005，50，14： | 0 |
| 20 | Expressions and clinicopathologic significance of five heat shock proteins in esophageal squamous cell carcinoma显示文摘Objective: To investigate the expressions of heat shock protein (hsp) 10, hsp27, hsp60, hsp70 and hsp90α in esophageal squamous cell carcinoma (ESCC) and normal tissues along the incisal margin (TIM), and discuss the clinico- pathologic features about their expressions. Methods: 120 specimens from ESCC and 36 specimens from TIM were made into tissue chips. The presence and the levels of expression of hsp10, hsp27, hsp60, hsp70 and hsp90α were observed on tissue chips by immunohistochemistry EnVisionTM. Their correlations to clinicopathologic features were analyzed. Results: The positive staining rates of hsp10, hsp27, hsp60, hsp70 and hsp90α in ESCC and TIM were 53.8% and 37.5%, 62.0% and 42.1%, 92.7% and 63.2%, 57.9% and 22.2%, 33.7% and 18.5% respectively. There were no statistical significances between the differential expressions of hsp10, hsp27 and hsp90α in ESCC and TIM (P > 0.05), but there were great statistical signifi- cances about hsp60 and hsp70 (P < 0.01). The level of hsp27 declined with the lower grade of differentiation of ESCC (P < 0.05). Except for hsp27, the positive expressions of the other four HSPs had no correlation to the clinicopathologic features of ESCC. Conclusion: The expressions of hsp10, hsp27, hsp60, hsp70 and hsp90α in ESCC and TIM were a common event. The levels of hsp60 and hsp70 in ESCC were higher than those in TIM. The level of hsp27 declined with the lower grade of differentiation of ESCC showed that it may be play a role in the differentiation of ESCC. | Junhui Chen Liming Chen Shaobin Wang Jiexiong Huang Qiancheng Qiu Liyan Xu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 0 |
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