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| 1 | Trends of foodborne diseases in China: lessons from laboratory- based surveillance since 2011显示文摘Foodborne 疾病是世界范围的最重要的公共健康问题之一。中国在食物链的所有方面面对各种各样、崭新的挑战。从从 2013 ~ 2016 的基于实验室的 foodborne 疾病监视系统的数据,以及不同区域和年龄,能在与多样的特征检测的病原体的模式与差别一起被发现。Vibrio parahaemolyticus 是在中国的传染腹泻的领先的原因,特别在在沿海的区域的成年人之中。沙门氏菌是为实质的社会经济的负担负责的严肃、广泛地分布式的病原体。Shigella 主要在 5 年下面在孩子之中与开发更少的区域在西北中国和内陆省(河南省) 被识别。从从 2011 ~ 2016 报导系统的 foodborne 疾病爆发的数据证明有毒的动物和为大多数死亡负责的植物因素在在西南区域的遥远的区域是有毒的蘑菇(54.7%) 。引起了报导的大多数案例(42.3%) 的生物危险被归因于 V。parahaemolyticus, foodborne 爆发的领先的原因。在这评论,我们在中国总结最近的监视途径到 foodborne 疾病并且在发达国家把结果与那些作比较。 | Jikai Liu Li Bai Weiwei Li Haihong Han Ping Fu Xiaochen Ma Zhenwang Bi Xiaorong Yang Xiuli Zhang Shiqi Zhen Xiaoling Deng Xiumei Liu Yunchang Guo | 2018 | Frontiers of Medicine2018，12，1： | 55 |
| 2 | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy显示文摘The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism.Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases. | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 18 |
| 3 | Creative Industries Agglomeration,Regional Innovation and Productivity Growth in China显示文摘This paper falls into the broad area of economic geography and economics of creativity,and it presents an alternative approach to explain why total factor productivity(TFP)growth is different across China′s regions.It establishes an empirical model to estimate the spatial agglomeration effects of creative industries on regional TFP growth,using China′s provincial panel data during the period of 2003 to 2010.We found that the creative industries agglomeration(CIA)has significant and positive impact on regional TFP growth.The result also implies that the CIA can facilitate regional TFP growth through promoting regional innovation instead of improving regional efficiency.Therefore,we argue that policy makers should take some measures to retain and establish more creative zones. | HONG Jin YU Wentao GUO Xiumei ZHAO Dingtao | 2014 | Chinese Geographical Science2014，24，2： | 18 |
| 4 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 5 | A lumbrokinase isozyme targets hepatitis B e-antigen显示文摘Dear Editor, Hepatitis B Virus(HBV)infection remains a major health problem worldwide despite the availability of a highly ef- fective preventive vaccine.HBV genome codes several distinct proteins,among which the non-particulate e-antigen(HBeAg)is one of the important markers in HBV infection. Sera containing HBeAg are highly infectious but those with anti-HBeAg have little infectivity. | Yuan Zhou Xiumei Wang Shichao Fan Rongqiao He | 2018 | Science China(Life Sciences)2018，61，12： | 12 |
| 6 | Advanced fabrication for electrospun three-dimensional nanofiber aerogels and scaffolds显示文摘Electrospinning is a versatile strategy for creating nanofiber materials with various structures,which has broad application for a myriad of areas ranging from tissue engineering,energy harvesting,filtration and has become one of the most important academic and technical activities in the field of material science in recent years.In addition to playing a significant role in the construction of two-dimensional(2D)nanomaterials,electrospinning holds great promise as a robust method for producing three-dimensional(3D)aerogels and scaffolds.This article reviews and summarizes the recent advanced methods for fabricating electrospun three-dimensional nanofiber aerogels and scaffolds,including gas foaming,direct electrospinning of 3D nanofibrous scaffold,short nanofibers assembling into 3D aerogels/scaffolds,3D printing,electrospray,origami and cell sheet engineering,centrifugal electrospinning,and other methods.Besides,intriguing formation process,crosslinking pathway,properties,and applications of 3D aerogels and scaffolds are also introduced.Taken together,these aerogels and scaffolds with various excellent features present tremendous potential in various fields. | Yujie Chen Muhammad Shafiq Mingyue Liu Yosry Morsi Xiumei Mo | 2020 | Bioactive Materials2020，5，4： | 12 |
| 7 | Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients显示文摘 | Naicui Zhai Xiumei Chi Tianyang Li Hongxiao Song Haijun Li Xia Jin Ian Nicholas Crispe Lishan Su Junqi Niu Zhengkun Tu | 2015 | Cellular & Molecular Immunology2015，12，6： | 10 |
| 8 | Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling fourdimensional separation and characterization of the multicomponents from white ginseng and red ginseng显示文摘Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification.A dimension-enhanced strategy,by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(2 D-LC/IM-QTOF-MS)enabling four-dimensional separations(2 D-LC,IM,and MS),is proposed.In combination with in-house database-driven automated peak annotation,this strategy was utilized to characterize ginsenosides simultaneously from white ginseng(WG)and red ginseng(RG).An offline 2 DLC system configuring an Xbridge Amide column and an HSS T3 column showed orthogonality 0.76 in the resolution of ginsenosides.Ginsenoside analysis was performed by data-independent high-definition MSE(HDMSE)in the negative ESI mode on a Vion?IMS-QTOF hybrid high-resolution mass spectrometer,which could better resolve ginsenosides than MSEand directly give the CCS information.An in-house ginsenoside database recording 504 known ginsenosides and 58 reference compounds,was established to assist the identification of ginsenosides.Streamlined workflows,by applying UNIFI?to automatedly annotate the HDMSEdata,were proposed.We could separate and characterize 323 ginsenosides(including 286 from WG and 306 from RG),and 125 thereof may have not been isolated from the Panax genus.The established 2 D-LC/IM-QTOF-HDMSEapproach could also act as a magnifier to probe differentiated components between WG and RG.Compared with conventional approaches,this dimensionenhanced strategy could better resolve coeluting herbal components and more efficiently,more reliably identify the multicomponents,which,we believe,offers more possibilities for the systematic exposure and confirmative identification of plant metabolites. | Tiantian Zuo Chunxia Zhang Weiwei Li Hongda Wang Ying Hu Wenzhi Yang Li Jia Xiaoyan Wang Xiumei Gao Dean Guo | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 9 |
| 9 | Use of calcein and alizarin red S for immersion marking of black rockfish Sebastes schlegelii juveniles显示文摘Black rockfi sh Sebastes schlegelii juveniles(30–40 mm total length) were immersed in a range of calcein(CAL) solutions at concentrations ranging from 50 to 250 mg/L and alizarin red S(ARS) solutions at concentrations ranging from 100 to 500 mg/L in fi ltered seawater(salinity 30) for 24 h. Fluorescent marks were detected in otoliths(sagittae, asteriscus), scales, fi n rays(dorsal, pectoral, ventral, anal, and caudal fi n rays), and fi n spines(dorsal, ventral, and anal fi n spines) after a 60-d growth experiment. With the exception of 50–100 mg/L CAL, acceptable marks were produced in the otoliths and fi n spines by all concentrations of CAL and ARS. In particular, marks were clearly visible under normal light in the sagittae, asteriscus, and fi n spines of fi sh immersed in 200–500 mg/L, 300–500 mg/L, and 200–500 mg/L ARS, respectively. Scales and fi n rays had acceptable marks at much higher concentrations(≥50 mg/L CAL, ≥300 mg/L ARS for scales and ≥50 mg/L CAL, ≥200 mg/L ARS for fi n rays). The mark quality was highest(i.e., acceptable marks were observed in all sampled structures after immersion marking) in fi sh immersed in 150–250 mg/L CAL or 300–500 mg/L ARS. In addition, there was no signifi cant difference in survival and growth of marked fi sh compared with controls 60 d post-marking( P >0.05). | Lü Hongjian ZHANG Xiumei XI Dan GAO Tianxiang | 2014 | Chinese Journal of Oceanology and Limnology2014，32，1： | 8 |
| 10 | Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients显示文摘To examine the clinical effects of a new bone cement composed of poly(methyl methacrylate)(PMMA)and mineralized collagen(MC)compared with pure PMMA bone cement in treating osteoporotic vertebral compression fractures(OVCFs)in patients aged over 80.In all,32 cases using pure PMMA bone cement and 31 cases using MC-modified PMMA(MC-PMMA)bone cement for OVCFs between June 2014 and March 2016 were screened as PMMA group and MC-PMMA group,respectively,with an average age of over 80.The operation duration,intraoperative blood loss,hospital stay,oswestry disability index(ODI),visual analogue scale(VAS),anterior vertebral height(AVH),intermediate vertebral height(IVH)and posterior vertebral height(PVH)of injured vertebrae,vertebral computed tomography value,re-fracture rate of adjacent vertebrae,correction rate of spinal kyphotic angle and wedge-shaped vertebra angle and surgical complications were compared between the two groups.In the early post-operative period,the VAS,ODI,AVH and IVH in MC-PMMA group were comparable to those in the traditional PMMA group.Moreover,the MC-PMMA group showed better effects compared with the PMMA group 12months after surgery.Thus,this new bone cement has superior clinic effects in the long term. | Kefeng Luo Guoqiang Jiang Jinjin Zhu Bin Lu Jiye Lu Kai Zhang Xiumei Wang Fu-Zhai Cui | 2020 | Regenerative Biomaterials2020，7，1： | 8 |
| 11 | Correlation of CD105 and Vascular Endothelial Growth Factor in Laser-induced Choroidal Neovascularization in Rats显示文摘Purpose: Choroidal neovascularization (CNV) plays an important role in pathogenesis of age-related macular degeneration (AMD), ocular histoplasmosis syndrome (OHS) and so on. However, mechanisms of CNV formation are not fully understood. The aim of this study is to investigate the correlation between expressions of CD105 and vascular endothelial growth factor (VEGF) in experimental laser-induced CNV in rats. Methods: CNV model was established by 532 nm laser photocoagulation in Brown-Norway rats. The expression of CD105 and VEGF in CNV was observed by immunohistochemistry at 3, 7, 14, 21, 28 and 56 days after laser photocoagulation. The image analysis was performed with the professional software of Image-Pro Plus. Results: Fluorescein angiography showed fluorescein leakage in CNV from days 7 to 56 after photocoagulation. VEGF expression was mainly observed in vascular endothelial cells, ganglion cells, inner nuclear layers and retinal pigment epithelial cells in normal retina and vascular endothelial cells in normal choroid of the rats. On day 3 after photocoagulation, VEGF began to express in laser-induced lesions. VEGF was strongly expressed in CNV after 7 days (P<0.05) and decreased after 14 days (P>0.05). CD105 was initially presented in CNV at 7 days and obviously expressed at 14 days after photocoagulation (P<0.05). Four weeks later, when angiogenesis tended toward inactive status, expression of CD105 was markedly decreased (P>0.05). There was notablely direct correlation between CD105-positive-microvessel density and positively semiquantitative scoring of VEGF in the CNV(r=0.989, P<0.01). Conclusions: There is direct correlation between the expression of CD105 and VEGF in the laser-induced CNV in rat. It suggests that CD105 and VEGF might participate in the new blood vessel formation and promote the growth of CNV. | Jianfeng Xu Yusheng Wang Xiumei Yang Peng Zhang Lijun Chen | 2006 | 眼科学报2006，22，3： | 8 |
| 12 | Current status and future of acid rain in China显示文摘As a part of the national key project of acid rain research, chemical element analysis of rainwater has been carried out based on observation of acid rain network in Chinese MeteorologicalAdministration over the years of 1992 and 1993. Samples of precipitation collected from eachacid rain station were taken according to the standard established by Chinese MeteorologicalAdministration. pH value was measured with pH meter (accuracy of 0. 01) made in | DING Guo’an, XU Xiaobing, FANG Xiumei, JIN Shaping, XU Xia, Tang Jie, LIU Qijun, WANG Shufeng and WANG Wenxing1. Chinese Academy of Meteorological Sciences, Beijing 100081, China 2. Chinese Academy of Environment Sciences, Beijing 100012, China | 1997 | Chinese Science Bulletin1997，42，24： | 8 |
| 13 | An update on the function and regulation of methylerythritol phosphate and mevalonate pathways and their evolutionary dynamics显示文摘Isoprenoids are among the largest and most chemically diverse classes of organic compounds in nature and are involved in the processes of photosynthesis, respiration, growth, development,and plant responses to stress. The basic building block units for isoprenoid synthesis-isopentenyl diphosphate and its isomer dimethylallyl diphosphate-are generated by the mevalonate (MVA) and methylerythritol phosphate(MEP) pathways. Here, we summarize recent advances on the roles of the MEP and MVA pathways in plant growth, development and stress responses, and attempt to define the underlying gene networks that orchestrate the MEP and MVA pathways in response to developmental or environmental cues.Through phylogenomic analysis, we also provide a new perspective on the evolution of the plant isoprenoid pathway. We conclude that the presence of the MVA pathway in plants may be associated with the transition from aquatic to subaerial and terrestrial environments, as lineages for its core components are absent in green algae. The emergence of the MVA pathway has acted as a key evolutionary event in plants that facilitated land colonization and subsequent embryo development, as well as adaptation to new and varied environments. | Xiaojun Pu Xiumei Dong Qing Li Zexi Chen Li Liu | 2021 | Journal of Integrative Plant Biology2021，63，7： | 8 |
| 14 | Free-standing porous carbon electrodes derived from wood for high-performance Li-O2 battery applications显示文摘 | Jingru Luo Xiahui Yao Lei Yang Yang Han Liao Chen Xiumei Geng Vivek Vattipalli Qi Dong Wei Fan Dunwei Wang Hongli Zhu | 2017 | Nano Research2017，10，12： | 7 |
| 15 | N_2O Emission from Paddy Field under Different Rice Planting Modes显示文摘Measurements of N2O emissions from conventional rice cultivation (CRC), CRC with straw mulching, system of rice intensification (SRI) and SRI with plastic film mulching were conducted through static chamber/gas-chromatography techniques. The results show that daily fluctuation of N2O emissions in jointing stage are much higher than in others. A type peak of N2O seasonal emission presented between jointing and bearing stages companying with high daily average temperature and low precipitation. Biomass and leaf stomatal conductance were observed. Total quantities of N2O emission were budgeted. The results showed that after jointing stage the average N2O emission flux of SRI with plastic film mulching increased significantly than CRC with straw mulching and SRI, the leaf stomatal conductance of those showed the same trend (p< 0.05 ). Yield and total quantity of N2O emission in CRC with straw mulching enhanced 13.7% and 10.7% compared with those of CRC, respectively. The total quantity of N2O emissions reduced 3.6% in SRI with plastic film mulching compared with CRC, however, the yield increase of that was not significant. | WANG Yuying ZHU Bo WANG Yanqiang GAO Meirong MA Xiumei | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 7 |
| 16 | The Intelligent Control System of Traffic Light Based on Fog Computing显示文摘The continuous increase of city motors with the improvement of society has introduced extraordinary demanding situations for the traffic situation of the town.Intelligent traffic has proposed a diversity of solutions to relieve urban traffic accidents and congestion and other troubles. It cannot regulate the cycle of traffic light in real time in keeping with the occurring traffic flux which additionally, may produce the traffic jam to result in the increase for the range of automobiles and the longer of passage time. In purpose to surmount the shortcomings of traditional traffic light control, this paper is presenting a form of intelligent control system for traffic light founding on fog computing. It calculates and shares the traffic flux situation at the intersection and the surrounding intersection through fog computing platform. Regarding the traffic flow at the intersection and the traffic flow at the surrounding intersection as the parameters, the intelligent control algorithm of traffic light is designed for achieving mutual coordination and mutual influence between different intersections, so that the traffic efficiency of each intersection is improved and the traffic flow of the entire transport network is alleviated. The simulation results showed this intelligent control system progress the traffic efficiency of every intersection and relieve the traffic flow of the whole transport network. | WU Qiong HE Fanfan FAN Xiumei | 2018 | Chinese Journal of Electronics2018，27，6： | 7 |
| 17 | Leaky modes and the first arrivals in cased boreholes with poorly bonded conditions显示文摘The generation mechanism of the first arrivals in the cased boreholes for the poorly bonded conditions is investigated. Based on the analyses of the Riemann surface structure of the characteristic function, the dispersion features, excitation spectra and contributions of modes excited in the cased boreholes with different cementing types are studied. The phase velocity dispersion studies of leaky modes show that high-order modes form 'plateau' regions with one approximate velocity denoted by v separated by their cutoff frequencies, in which the phase velocity changes little with a considerable frequency range, while the group velocity keeps a relatively constant high value. Usually, the operation frequency range of a specific cementing evaluation acoustic logging tool is covered by such a 'plateau' region. Mode excitation and contribution analyses show that the first arrivals in the cased boreholes for the poorly bonded conditions are the contributions from leaky modes, where the traveling velocity of the first arrivals processed by slowness time coherence(STC) method is equal to the approximated velocity v. Analyses on generation of leaky modes in the cased boreholes supplement the understanding of the generation mechanism of the first arrivals. | XiuMei Zhang XiuMing Wang HaiLan Zhang | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，2： | 7 |
| 18 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration显示文摘神经指导水管(NGC ) 是为外部神经新生的自体同源的神经的一种潜在的选择。有希望的治疗学的策略是用物理或化学的指导暗示修改神经指导水管 intraluminal 微型环境。在这研究,神经营养的 peptide-functionalized 能在 vitro 支持 PC12 细胞粘附,增长,和 neuronal 区别的自我装配的肽 nanofiber hydrogel 是在一个空 chitosan 试管(hCST ) 的腔的 prefilled 在一只老鼠加速 axonal 新生臀部的神经缺点模型。functionalized 自我装配的肽被介绍神经营养的肽开发(RGI, RGIDKRHWNSQ ) 源于导出大脑的神经营养的因素(BDNF ) 到自我装配的肽 RADA16 的 C 终点 -- 我(交流 --(RADA )4-CONH2) 。词法,组织学, electrophysiological,和功能的分析证明 RGI-functionalized,自我装配,肽 nanofiber hydrogel RAD/RGI 能生产显著地与提高的 re-myelination 和马达改进了 axonal 新生的神经营养的微型环境功能的恢复。 | Jiaju Lu Xun Sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue Sun Lingyun Zhao Xiaodan Sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang | 2018 | Nano Research2018，11，9： | 6 |
| 19 | Electrospinning nanofiber scaffolds for soft and hard tissue regeneration显示文摘Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and organs.The three fundamental pillars of tissue engineering are scaffolds,cells,and biomolecules.Electrospun nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected pores.In this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue engineering.We first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial fabrication.Next,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament applications.Finally,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas. | Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi Allison E.Fetz Gary L.Bowlin Mohamed El-Newehy Xiumei Mo | 2020 | Journal of Materials Science & Technology2020，59，24： | 5 |
| 20 | Effect of nanoheat stimulation mediated by magnetic nanocomposite hydrogel on the osteogenic differentiation of mesenchymal stem cells显示文摘Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe_3O_4 nanoparticles into chitosan/polyethylene glycol(PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field(AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells(MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications. | Zheng Cao Dan Wang Yongsan Li Wensheng Xie Xing Wang Lei Wao Yen Wei Xiumei Wang Lingyun Zhao | 2018 | Science China(Life Sciences)2018，61，4： | 5 |
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