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| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | Decratonic gold deposits显示文摘The North China Craton(NCC) hosts numerous gold deposits and is known as the most gold-productive region of China. The gold deposits were mostly formed within a few million years in the Early Cretaceous(130–120 Ma), coeval with widespread occurrences of bimodal magmatism, rift basins and metamorphic core complexes that marked the peak of lithospheric thinning and destruction of the NCC. Stable isotope data and geological evidence indicate that ore-forming fluids and other components were largely exsolved from cooling magma and/or derived from mantle degassing during the period of lithospheric extension. Gold mineralization in the NCC contrasts strikingly with that of other cratons where gold ore-forming fluids were sourced mostly from metamorphic devolatization in compressional or transpressional regimes. In this paper, we present a summary and discussion on time-space distribution and ore genesis of gold deposits in the NCC in the context of the timing, spatial variation, and decratonic processes. Compared with orogenic gold deposits in other cratonic blocks, the Early Cretaceous gold deposits in the NCC are quite distinct in that they were deposited from magma-derived fluids under extensional settings and associated closely with destruction of cratonic lithosphere. We argue that Early Cretaceous gold deposits in the NCC cannot be classified as orogenic gold deposits as previously suggested, rather, they are a new type of gold deposits, termed as 'decratonic gold deposits' in this study. The westward subduction of the paleo-West Pacific plate(the Izanagi plate) beneath the eastern China continent gave rise to an optimal tectonic setting for large-scale gold mineralization in the Early Cretaceous. Dehydration of the subducted and stagnant slab in the mantle transition zone led to continuous hydration and considerable metasomatism of the mantle wedge beneath the NCC. As a consequence, the refractory mantle became oxidized and highly enriched in large ion lithophile elements and chalcophile elements(e.g., Cu, Au, Ag and Te). Partial melting of such a mantle would have produced voluminous hydrous, Au- and S-bearing basaltic magma, which, together with crust-derived melts induced by underplating of basaltic magma, served as an important source for ore-forming fluids. It is suggested that the Eocene Carlin-type gold deposits in Nevada, occurring geologically in the deformed western margin of the North America Craton, are comparable with the Early Cretaceous gold deposits of the NCC because they share similar tectonic settings and auriferous fluids. The NCC gold deposits are characterized by gold-bearing quartz veins in the Archean amphibolite facies rocks, whereas the Nevada gold deposits are featured by fine-grained sulfide dissemination in Paleozoic marine sedimentary rocks. Their main differences in gold mineralization are the different host rocks, ore-controlling structures, and ore-forming depth. The similar tectonic setting and ore-forming fluid source, however, indicate that the Carlin-type gold deposits in Nevada are actually analogous to decratonic gold deposits in the NCC. Gold deposits in both the NCC and Nevada were formed in a relatively short time interval(<10 Myr) and become progressively younger toward the subduction zone. Younging of gold mineralization toward subduction zone might have been attributed to retreat of subduction zone and rollback of subducted slab. According to the ages of gold deposits on inland and marginal zones, the retreat rates of the Izanagi plate in the western Pacific in the Early Cretaceous and the Farallon plate of the eastern Pacific in the Eocene are estimated at 8.8 cm/yr and 3.3 cm/yr, respectively. | ZHU RiXiang FAN HongRui LI JianWei MENG QingRen LI ShengRong ZENG QingDong | 2015 | Science China Earth Sciences2015，58，9： | 37 |
| 3 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 4 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 5 | Self-monitoring of blood glucose in type 2 diabetic patients in China:current status and influential factors显示文摘 | Yuan Li Guo Xiaohui Xiong Zhenzhen Lou Qingqing Shen Li Zhao Fang Sun Zilin Li Jianwei | 2014 | Chinese Medical Journal2014，，2： | 21 |
| 6 | Antiviral activities against influenza virus(FM1) of bioactive fractions and representative compounds extracted from Banlangen(Radix Isatidis)显示文摘OBJECTIVE: To study the antiviral activities of clemastanin B(CB), epigoitrin, phenylpropanoids portion(PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions(PEP+ALK+OA)from Banlangen(Radix Isatidis).METHODS: The experiment consisted of four parts:therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect(CPE) and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) were used to assess antiviral activity.RESULTS: CB, epigoitrin, PEP and PEP + ALK + OA fractions from Banlangen(Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions(P < 0.01). Pretreated with either pure compounds or chemical frac-tions of Banlangen(Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells(P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.CONCLUSION: CB, epigoitrin, PEP and PEP+ALK+OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP + ALK + OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin. | Xiao Ping Ye Weiyang Chen Jianwei Li Xiang | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 21 |
| 7 | Direct-impact of sieving coal and gangue显示文摘Gangue from underground separation of coal can directly be used for filling mined out areas, saving transport capacity and reducing the amount of waste polluting the environment above the ground. We introduced a structure and operating principle of an underground direct-impact sieving device by which a separation experiment was carried out. By means of high speed conveyer belts, coal and gangue impacted the breaking board at high speeds ranging from 6 to 14 m/s. Given the differences of hardness between coal and gangue, after selective crushing, the gangue with the higher hardness was crushed less and coal with lower hardness crushed more, which could be separated by a 50 mm sieving plate. The material above the sieving plate was disposed of as gangue and the material below as coal. The results indicate that the crush ratio below the 50 mm sieving plate increases linearly with an increase in impact velocity and decays exponentially with an increase in hardness. Employing this equipment to separate coal and gangue, the hardness of coal f should be <2. This separation device provides relatively good effect in separating coal and gangue with a relatively wide difference of hardness. | LI Jianping DU Changlong BAO Jianwei | 2010 | Mining Science and Technology2010，20，4： | 19 |
| 8 | Chemical characterization of size-resolved aerosols in four seasons and hazy days in the megacity Beijing of China显示文摘Size-resolved aerosol samples were collected by MOUDI in four seasons in 2007 in Beijing. The PM10 and PM1.8mass concentrations were 166.0 ± 120.5 and 91.6 ± 69.7 μg/m^3, respectively,throughout the measurement, with seasonal variation: nearly two times higher in autumn than in summer and spring. Serious fine particle pollution occurred in winter with the PM1.8/PM10 ratio of 0.63, which was higher than other seasons. The size distribution of PM showed obvious seasonal and diurnal variation, with a smaller fine mode peak in spring and in the daytime. OM(organic matter = 1.6 × OC(organic carbon)) and SIA(secondary inorganic aerosol) were major components of fine particles, while OM, SIA and Ca_2+were major components in coarse particles. Moreover, secondary components, mainly SOA(secondary organic aerosol) and SIA,accounted for 46%–96% of each size bin in fine particles, which meant that secondary pollution existed all year. Sulfates and nitrates, primarily in the form of(NH_4)_2SO_4, NH_4NO_3, Ca SO_4, Na_2SO_4 and K_2SO_4, calculated by the model ISORROPIA II, were major components of the solid phase in fine particles. The PM concentration and size distribution were similar in the four seasons on non-haze days, while large differences occurred on haze days, which indicated seasonal variation of PM concentration and size distribution were dominated by haze days. The SIA concentrations and fractions of nearly all size bins were higher on haze days than on non-haze days, which was attributed to heterogeneous aqueous reactions on haze days in the four seasons. | Kang Sun Xingang Liu Jianwei Gu Yunpeng Li Yu Qu Junling An Jingli Wang Yuanhang Zhang Min Hu Fang Zhang | 2015 | Journal of Environmental Sciences2015，27，6： | 19 |
| 9 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 10 | ERA modal identification method for hydraulic structures based on order determination and noise reduction of singular entropy显示文摘Modal parameter has been considered as one of the indices in assessing the working state of hydraulic structures. The method for obtaining the modal parameter indices is crucial for health monitoring of hydraulic structures. Traditionally, model parameters are measured from the prototype dynamic test under the excitation of special equipment. The preparation is time-consuming and the method is difficult to carry out. We propose a method in this paper to denoise, reconstruct, determine the order and identify modal parameters based on singular entropy (SE) of eigenmatrix. It can be used to solve the problem of system eigenmatrix order determination, and to identify the modal order and the characteristics of structures under the working state. Finally, this method is applied to identify the operational modal parameters of Ertan arch dam under different flood discharging states and vibration frequencies of the powerhouse with a two-row placed unit in Lijiaxia hydropower station during the unit halting process. This new method provides a simple way to identify the modal parameters of large-scale hydraulic structures under ambient excitation. | LIAN JiJian LI HuoKun ZHANG JianWei | 2009 | Science China(Technological Sciences)2009，52，2： | 16 |
| 11 | A new bone repair scaffold combined with chitosan/ hydroxyapatite and sustained releasing icariin显示文摘Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering. | WU Tao NAN KaiHui CHEN JingDi JIN Dan JIANG Shan ZHAO PeiRan XU JunChang DU Hao ZHANG XiaoQiang LI JianWei PEI GuoXian | 2009 | Chinese Science Bulletin2009，54，17： | 14 |
| 12 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 13 | Monodisperse core-shell structured magnetic mesoporous aluminosilicate nanospheres with large dendritic mesochannels显示文摘合理设计和有一个定制的活跃核心和大、树枝状的、修改 mesoporous 的多功能的混合 nanostructures 的精确合成组织了壳能支持催化作用,精力存储,和生物应用。这里,油水双相层化涂层策略被开发了准备 monodisperse 磁性的树枝状的 mesoporous 硅石核心壳结构化的 nanospheres。这些复杂 Fe 3 O 4@SiO2@dendritic-mSiO2 nanospheres 特征大树枝状的开的毛孔(2.7 和 10.3 nm ) 。显著地,硅石壳能与未改变的孔, 14 的 Si/Al 臼齿的比率,和显著地强壮的酸的地点被变换成树枝状的 mesoporous 铝矽酸盐框架,通过一条合成以后的途径。另外,结果的磁性的树枝状的 mesoporous 铝矽酸盐 nanospheres 展览在从废水的磷酸盐移动的突出的性质和有希望的申请。 | Jianping Yang Dengke Shen Yong Wei Wei Li Fan Zhang Biao Kong Shaohua Zhang Wei Teng Jianwei Fan Weixian Zhang Shixue Dou Dongyuan Zhao | 2015 | Nano Research2015，8，8： | 11 |
| 14 | A matched cohort study of laparoscopy-assisted and open total gastrectomy for advanced proximal gastric cancer without serosa invasion显示文摘 | Lin Jianxian Huang Changming Zheng Chaohui Li Ping Xie Jianwei Wang Jiabin Lu Jun | 2014 | Chinese Medical Journal2014，，3： | 11 |
| 15 | 黔西南卡林型金矿床与区域古油藏的关系:来自流体包裹体气相组成和沥青拉曼光谱特征的证据显示文摘黔西南地区是世界第二大卡林型金矿床集中区,同时也发育有大量古油藏,二者空间关系密切,但是否具有成因联系目前尚不清楚且存在较大争议。本文报道该区典型金矿床与成矿有关的热液矿物中流体包裹体的气相组成和高品位金矿石中沥青的激光拉曼光谱分析结果,以探讨含有机质流体与金成矿作用之间的关系。研究表明,虽然含砷富金黄铁矿、石英、方解石、萤石和雄黄等热液矿物形成于不同的成矿阶段,但其中流体包裹体的有机气相组分种类、含量及相对比例整体较为一致,表明成矿流体中的有机络离子团在成矿作用过程中没有发生明显的分解或重组,进而说明黔西南卡林型金矿成矿作用过程中有机质并未以有机络离子团的形式对金进行有效搬运或其搬运金的能力非常有限。在N2/Ar—CO2/CH4流体来源判别图解中,各蚀变矿物中的流体包裹体气相组成主要落在循环的大气降水区域,经大气水区域向岩浆流体区域延伸,整体上构成一条非常好的线性分布趋势,暗示成矿流体可能起源于深部岩浆但在演化过程中有大量循环大气水的加入。水银洞金矿床的1件石英样品偏离上述趋势线并向有机流体方向偏移,可能反映了流体迁移过程中有机质的加入。该区金矿床的矿石中均不同程度地发育浸染状沥青,不同矿床中沥青的激光拉曼光谱特征基本一致,说明该区金矿床中的沥青具有相同成因。根据沥青激光拉曼光谱特征地质温度计反演计算的成矿早阶段流体温度为317~336℃,明显高于区域古地温温度(160~250℃)以及区域古油藏的流体包裹体均一温度(73~175℃),说明该区卡林型金矿床的成矿热源与区域古地温无关。对区域地质及近年来地球物理与地球化学最新成果的综合分析表明,该区卡林型金矿床可能是叠加在区域古地温场之上的深部岩浆活动远端低温热液成矿作用的产物,与金矿床空间关系密切的有机质可能为来自先存古油藏并沿控矿构造发生逃逸的油气物质裂解产物,金成矿与区域古油藏之间不存在成因联系。 | 靳晓野 李建威 HOFSTRA Albert MARSH Erin 刘建中 杨梧 JIN XiaoYe LI JianWei LIU JianZhong YANG Wu | 2016 | 岩石学报2016，32，11： | 11 |
| 16 | Characterization and cloning of a brittle culm mutant (bc88) in rice (Oryza sativa L.)显示文摘This study characterizes a brittle culm (bc88) mutant of rice (Oryza sativa L.) obtained by ethylene methylsulfonate (EMS)-induced mutagenesis of Wuyunjing 7. The bc88 mutant exhibits a diversity of pleiotropic phenotypes, including brittle culm at the whole-plant growth stages, withered leaf tips at the seedling stage, and 18-d delay in heading date at the mature stage. Genetic analysis indicates that the bc88 mutant is controlled by a single recessive nuclear gene. The mutated bc88 gene isolated by map-based cloning contains only one point mutation in the 5th exon relative to its wild-type BC88 (LOC_Os09g25490 and Os09g0422500), leading to an amino acid change from P to L in bc88 plants. Alignment of the putative protein sequence with its homologs indicates that the mutation is located in the conserved region of the sequence. Detection of the transcription level of BC88 in rice plants shows that the expression level of BC88 is higher in spikes and culms than in leaves, roots, and leaf sheaths. These contribute to understanding of the molecular mechanism of cellulose synthesis. The target gene BC88 can be a useful tool in molecular marker-assisted selection for rice culm trait breeding. | RAO YuChun YANG YaoLong XIN DeDong LI XiaoJing ZHAI KaiEn MA BoJun PAN JianWei QIAN Qian ZENG DaLi | 2013 | Chinese Science Bulletin2013，58，24： | 11 |
| 17 | Role of JWA in acute promye-locytic leukemia cell differentiation and apoptosis triggered by retinoic acid,12-tetradecanoylphorbol-13- acetate and arsenic trioxide显示文摘JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecano-ylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10-6 mol/L) and As2O3 (10-6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10-6mol/L) and TPA (10-7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ | CAO Haixia XIA Wei SHEN Qun LU Hua YE Jian LI Aiping ZOU Changping ZHOU Jianwei | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 18 | An Energy-Efficient Data Collection Scheme Using Denoising Autoencoder in Wireless Sensor Networks显示文摘As one of the key operations in Wireless Sensor Networks(WSNs), the energy-efficient data collection schemes have been actively explored in the literature. However, the transform basis for sparsifing the sensed data is usually chosen empirically, and the transformed results are not always the sparsest. In this paper, we propose a Data Collection scheme based on Denoising Autoencoder(DCDA) to solve the above problem. In the data training phase, a Denoising AutoEncoder(DAE) is trained to compute the data measurement matrix and the data reconstruction matrix using the historical sensed data. Then, in the data collection phase, the sensed data of whole network are collected along a data collection tree. The data measurement matrix is utilized to compress the sensed data in each sensor node, and the data reconstruction matrix is utilized to reconstruct the original data in the sink.Finally, the data communication performance and data reconstruction performance of the proposed scheme are evaluated and compared with those of existing schemes using real-world sensed data. The experimental results show that compared to its counterparts, the proposed scheme results in a higher data compression rate, lower energy consumption, more accurate data reconstruction, and faster data reconstruction speed. | Guorui Li Sancheng Peng Cong Wang Jianwei Niu Ying Yuan | 2019 | Tsinghua Science and Technology2019，24，1： | 9 |
| 19 | Kinetic studies of gas hydrate formation with low-dosage hydrate inhibitors显示文摘Pipeline blockage by gas hydrates is a serious problem in the petroleum industry.Low-dosage inhibitors have been developed for its cost-effective and environmentally acceptable characteristics.In a 1.072-L reactor with methane,ethane and propane gas mixture under the pressure of about 8.5 MPa at 4 °C,hydrate formation was investigated with low-dosage hydrate inhibitors PVP and GHI1,the change of the compressibility factor and gas composition in the gas phase was analyzed,the gas contents in hydrates were compared with PVP and GHI1 added,and the inhibition mechanism of GHI1 was discussed.The results show that PVP and GHI1 could effectively inhibit the growth of gas hydrates but not nucleation.Under the experimental condition with PVP added,methane and ethane occupied the small cavities of the hydrate crystal unit and the ability of ethane entering into hydrate cavities was weaker than that of methane.GHI1 could effectively inhibit molecules which could more readily form hydrates.The ether and hydroxy group of diethylene glycol monobutyl ether have the responsibility for stronger inhibition ability of GHI1 than PVP. | TANG CuiPing 1,2,DAI XingXue 1,2,DU JianWei 1,2,LI DongLiang 1,2,ZANG XiaoYa 1,2,YANG XiangYang 1 & LIANG DeQing 1 1 Guangzhou Institute of Energy Conversion,Key Laboratory of Renewable Energy and Gas Hydrate,Chinese Academy of Sciences,Guangzhou 510640,China 2 Graduate University of the Chinese Academy of Sciences,Beijing 100039,China | 2010 | Science China Chemistry2010，53，12： | 9 |
| 20 | Reconstruction of flood events over the last 150 years in the lower reaches of the Changjiang River显示文摘The reconstruction of paleofloods in the Holocene has become one research highlight for the present global change study.The core sediments from one newly-emerged bar in the lower Changjiang River(Yangtze River)mainstream were collected for grain size and organic elemental measurements,with aim to reconstruct the flood events over the past 150 years.Major grain size parameters such as mean grain size,probability cumulative curve and C-M diagram of the core sediments clearly indicate the flood event deposition.Furthermore,the TOC/TN ratios in the sediments can indicate flood events considering that during the flash floods,strong surface erosion in the upper and lower reaches of the Changjiang River can transport a large amount of undecomposed plant debris and organic components with relatively low C/N ratios into the lower mainstream.Based on 210Pb dating and sedimentary geochemical results,the research profile recorded several large floods happened from 1850 to 1954,which agrees well with the historical documents and hydrological observations.Interesting to note that the flood events since the 1960s cannot be distinctly recognized on the basis of sediment grain size and organic elemental compositions of the profile,which mainly reflects the intensive human activities over the last fifty years,especially condense dam construction,have significantly changed the characters of suspended sediment into the lower mainstream. | ZHAN Wang YANG ShouYe LIU XiaoLi LI JianWei CHOI ManSik | 2010 | Chinese Science Bulletin2010，55，21： | 9 |
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