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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Cu_2O nanowires as anode materials for Li-ion rechargeable batteries显示文摘Li-ion batteries are a key technology for multiple clean energy applications.In this study,Cu2O nanowires were obtained by the reduction of cupric acetate with pyrrole.The resulting Cu2O nanowires exhibited excellent reversible capacities of 470mAh g-1 at rate of 1 C after 100 cycles.The results show that the Cu2O nanowires had more capacity than materials previously reported.No fading was observed over 100 cycles of charging and discharging.The compound metal Cu and incorporation of the conducting polymer polypyrrole(PPy)improved the conductivity of Cu2O and enhanced the stability of the electrode during cycling.The results from this study imply that Cu2O nanowires with high capacity and good cycle retention could be excellent candidates as anode materials for Li-ion rechargeable batteries. | CHEN Rui WANG Ying NULI YanNa YU Yuan GAO PengFei CHEN Qiang WEI LiangMing HU NaTao YANG Zhi GAO RunGang ZHANG LiLing ZHANG YaFei | 2014 | Science China(Technological Sciences)2014，57，6： | 3 |
| 3 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5ho6wk5wvqqv6566xu.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 4 | Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019(COVID-19):a population-based surveillance study显示文摘In this population-based study,we identified 307 confirmed COVID-19 cases from massive surveillance,including 129551 individuals screened at fever clinics or returning from Hubei and 3710 close contacts of confirmed COVID-19 patients.Among them,17 patients were asymptomatic at initial clinical assessment.These asymptomatic patients on admission accounted for a small proportion of all patients(5.54%)with relatively weak transmissibility,and the detection rate was 0.35 per 100 close contacts.Moreover,the dynamics of symptoms of the 307 patients showed that the interval from symptom remission to the final negativity of viral nucleic acid was 5.0 days(interquartile range 2.0 to 11.0 days),with 14 patients(4.56%)having re-detectable viral RNA after discharge.Overall;our findings suggested asymptomatic carriers and presymptomatic patients only accounted for a small proportion of COVID-19 patients.Also,the asymptomatic phase during recovery from COVID-19 implied that negativity in viral RNA is necessary as a de-isolation criterion and follow-up is recommended. | Xueying Zheng Sihui Luo Yong Sun Mingfeng Han Jian Liu Liangye Sun Liangming Zhang Ping Ling Yu Ding Tengchuan Jin Zhirong Liu Jianping Weng | 2020 | National Science Review2020，7，10： | 2 |
| 5 | Design and analysis of recurrent neural network models with non-linear activation functions for solving time-varying quadratic programming problems显示文摘A special recurrent neural network(RNN),that is the zeroing neural network(ZNN),is adopted to find solutions to time-varying quadratic programming(TVQP)problems with equality and inequality constraints.Howevet,there are some weaknesses in activation functions of traditional ZNN models,including convex restriction and redundant formulation.With the aid of different activation functions,modified ZNN models are obtained to overcome the drawbacks for solving TVQP problems.Theoretical and experimental research indicate that the proposed models are better and more effective at solving such TVQP problems. | Xiaoyan Zhang Liangming Chen Shuai Li Predrag Stanimirovic Jiliang Zhang Long Jin | 2021 | CAAI Transactions on Intelligence Technology2021，6，4： | 2 |
| 6 | Novel Nanotrees of Crystalline Nickel Formed via Electrolytic Approach显示文摘Tree-shaped nickel nanocrystals with long main trunk and highly ordered branches were prepared via electrolytic method in ethylene glycol solution. The morphology and structures of nanotrees of crystalline nickel can be controlled by the processing of the surfactant(PVP) and electrolytic voltage. Magnetic property measurements at room temperature indicated that the as-prepared nanotrees of crystalline nickel possess higher saturation magnetism(MS) and coercivity(HC) than those of corresponding bulk nickel materials. | Jian Wang Liying Zhang Liangming Wei Chuanhai Jiang Yafei Zhang | 2011 | Nano-Micro Letters2011，3，4： | 1 |
| 7 | NUMERICAL GEODYNAMIC MODELLING OF COUPLED MECHANO-THERMO-HYDROLOGICAL PROCESSES AND ITS APPLICATION IN PREDICTIVE EXPLORATION IN THE FENGHUANGSHAN ORE FIELD, TONGLING显示文摘Mineralisation is the result of the coupled multi-geodynamic processes in the crust. The coupled mechano-thermo-hydrological (MTH) processes are the basic physical processes that govern the location of the hydrothermal mineralization, which can be simulated in the computer by using of the numerical codes, such as FLAC. The numerical modeling results can be used not only to explain the features of existing ore deposits, but also to predict the favorable mineralization locations. This paper has summarized the basic equations describing coupled MHT processes in the water-saturated porous rocks, the principles of FLAC, and its application to the MHT processes related to copper mineralization in the Fenghuangshan ore field. We used the FLAC to simulate the syn-deformation cooling and fluid flowing evolution after the intrusion was emplaced and solidified. The modeling results suggest a most prospective exploration area where the subsequent exploration supported the prediction and the test bore hole disclosed the high quality copper ore bodies in the target, demonstrating a positive role of the numerical MTH modeling in facilitating predictive ore discovery. | LIU Liangming PENG Shenglin ZHANG Yanhua | 2005 | Geotectonica et Metallogenia2005，29，2： | 1 |
| 8 | In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen–hydroxyapatite layered scaffolds显示文摘 | Jiaan Zhou Caixia Xu Gang Wu Xiaodong Cao Liangming Zhang Zhichen Zhai Zhiwen Zheng Xiaofeng Chen Yingjun Wang | 2011 | Acta Biomaterialia2011，，11： | 1 |
| 9 | Reconstitute the damaged heart via the dual reparative roles of pericardial adipose-derived flk-1 + stem cells显示文摘 | Xiaoming Wang Xueqing Liu Hui Zhang Liangming Nie Min Chen Zhaoping Ding | 2016 | International Journal of Cardiology2016，，： | 1 |
| 10 | Numerical simulation of a thermal-bubble actuated diffuser-nozzle valveless pump显示文摘A valveless micropump actuated by thermal bubbles which are generated by an electrode heater mounted with a pair of diffuser nozzles has been numerically studied by commercial CFD software FLUENT. The relationships between the net flow rate and the superheating and heat supplying frequency have been investigated. The depth of the diffuser-nozzle micropump is 200 μm, the diameter of the actuating chamber is 1 mm, and a pair of diffuser nozzles whose gap has been expanded from 30 μm to 274 μm with an open angle of 7° are connected to the actuating chamber. The working fluid is methanol. In the numerical simulation, the flow pattern is laminar. The results show that the pump has different optimal driving frequencies at different superheating. A cycle resulting from bubble growth and shrinking costs more time at higher superheating temperature; different superheating has different optimal driving frequency; when the superheating increases, the maximum volume flow rate and the maximum pump pressure will increase simultaneously, and the optimal driving frequency decreases as well, the maximum volume flow rate and pump pressure also have the same tendency; in the condition of uncontrolled condensing, the bubble shrinking process is longer than the growth process, thus it is the determining factor to affect the pump performance. The maximum volume flow rate is 9.02 μL/min at △T = 15℃, and the maximum pump pressure is 680 Pa. With the increase of wall superheat, cycle including the bubble growth and condensation will become longer, resulting in a significant impact on the pumping flow; different wall superheat has different optimized frequency, increasing superheat will bring increased pumping flow and pump pressure, the optimized driving frequency will be reduced; liquid supply phase is longer than pumping phase. | PAN LiangMing DENG JieWen YUAN DeWen CHEN DeQi ZHANG JunQi | 2009 | Science China(Technological Sciences)2009，52，10： | 1 |
| 11 | Genetic dissection of top three leaf traits in rice using progenies from a japonica × indica cross显示文摘The size of the top three leaves of rice plants is strongly associated with yield; thus, it is important to consider quantitative traits representing leaf size(e.g.,length and width) when breeding novel rice varieties.It is challenging to measure such traits on a large scale in the field, and little is known about the genetic factors that determine the size of the top three leaves. In the present study, a population of recombinant inbred lines(RILs) and reciprocal single chromosomal segment substitution lines(SSSLs) derived from the progeny of a japonica Asominori ? indica IR24 cross were grown under four diverse environmental conditions. Six morphological traits associated with leaf size were measured,namely length and width of the flag, second and third leaves. In the RIL population, 49 QTLs were identified that clustered in 30 genomic region. Twenty-three of these QTLs were confirmed in the SSSL population. A comparison with previously reported genes/QTLs revealed eight novel genomic regions that contained uncharacterized ORFs associated with leaf size. The QTLs identified in this study can be used for markerassisted breeding and for fine mapping of novel genetic elements controlling leaf size in rice. | Changbin Yin Huihui Li Zhigang Zhao Zhiquan Wang Shijia Liu Liangming Chen Xi Liu Yunlu Tian Juan Ma Lidong Xu Dashuang Zhang Susong Zhu Danting Li Jianmin Wan Jiankang Wang | 2017 | Journal of Integrative Plant Biology2017，59，12： | 1 |
| 12 | Fish diversity and molecular taxonomy in the Prydz Bay during the 29th CHINARE显示文摘In 2013, the 29th Chinese National Antarctic Research Expedition(CHINARE) prospected the Prydz Bay on the Antarctic continental shelf, and the Chinese R/V Xuelong icebreaker sampled all of the examined locations. The nature of Antarctic fish diversity in the high-latitude Prydz Bay is virtually unknown, and the accuracy of relevant estimates has not been established. Thus, it is necessary to evaluate this diversity and propose protective measures. In total, ninety-nine specimens were collected from various locations. To overcome uncertainties associated with identifying species based on morphology, DNA barcoding(COI gene) was employed to reconstruct phylogenetic relationships with delimited references from NCBI. Twenty-two species representing six families were unambiguously identified from a neighbor-joining(NJ) tree and barcoding gaps. With the morphological identification, thirteen species were identified correctly, five species were identified correctly at the genus level, and four species were identified at the close sister species level. Notothenioid dominance was not evident in the Prydz Bay, in contrast to other published studies. The low species diversity and catch biomass during this CHINARE were severely constrained by limited fishing methods and localized sites, which led to biased underestimation. Our analyses indicate that DNA barcoding is an effective tool for the identification of fish species in the Prydz Bay. The identification and distribution of Antarctic fish should be an integral component of understanding Antarctic fish biodiversity and biogeography, and large-scale studies are necessary for the further taxonomic identification of Antarctic fish. | LI Yuan ZHANG Liyan SONG Puqing ZHANG Ran WANG Liangming LIN Longshan | 2018 | Acta Oceanologica Sinica2018，37，8： | 1 |
| 13 | Research e-infrastructures for open science: The national example of CSTCloud in China显示文摘This paper focuses on research e-infrastructures in the open science era.We analyze some of the challenges and opportunities of cloud-based science and introduce an example of a national solution in the China Science and Technology Cloud(CSTCloud).We selected three CSTCloud use cases in deploying open science modules,including scalable engineering in astronomical data management,integrated Earth-science resources for SDG-13 decision making,and the coupling of citizen science and artificial intelligence(AI)techniques in biodiversity.We conclude with a forecast on the future development of research e-infrastructures and introduce the idea of the Global Open Science Cloud(GOSC).We hope this analysis can provide some insights into the future development of research e-infrastructures in support of open science. | Lili Zhang Jianhui Li Paul F.Uhlir Liangming Wen Kaichao Wu Ze Luo Yude Liu | 2023 | Data Intelligence2023，5，2： | 1 |
| 14 | Sensitivity-Enhanced Hot-Wire Anemometer by Using Cladding-Etched Fiber Bragg Grating显示文摘A sensitivity-enhanced hot-wire anemometer based on a cladding-etched optical fiber Bragg grating(FBG)coated with a layer of silver film and optically heated by using a 1480nm laser diode is demonstrated.The silver film absorbs the laser power to heat the FBG to a certain high temperature and the airflow cools down the FBG hot-wire with the cooling effect and hence the Bragg wavelength of the FBG is determined by the airflow velocity.Experimental measurement results show that the heating efficiency of the FBG hot wire is improved by 3.8times in magnitude by etching the fiber cladding from 125μm down to 73.4μm,and the achieved airflow velocity sensitivities,under a laser power of 200mW,are–3180pm/(m/s),–889pm/(m/s),–268pm/(m/s),and–8.7pm/(m/s)at different airflow velocities of 0.1m/s,0.5m/s,1.5m/s,and 17m/s,respectively.In comparison,the sensitivities are only–2193 pm/(m/s),–567 pm/(m/s),–161 pm/(m/s),and–4.9pm/(m/s)for the reference anemometer without cladding etching even at a much higher heating laser power of 530mW.These results prove that the method by using a cladding-etched FBG to improve sensitivity of FBG-based hot-wire anemometers works and the sensitivity is improved significantly. | Yuhan TANG Xuke CHEN Jiarui ZHANG Dajuan LV Liangming XIONG Xinyong DONG | 2023 | Photonic Sensors2023，13，3： | 0 |
| 15 | Treatment of Peripheral T-cell Lymphoma by Chidamide and Literature Analysis显示文摘[Objectives] To analyze the dosage,curative effect,and adverse effect of Chidamide in treating peripheral T-cell lymphoma( PTCL). [Methods]A case of treating peripheral T-cell lymphoma by Chidamide was reported,including the treatment process,dosage,curative effect,and adverse effect. Literature review was made and searched in Wanfang Digital Database,China National Knowledge Infrastructure( CNKI),and Pubmed database,using the key word chidamide in Chinese and English separately. Disease and case number of patients,Chidamide observation indicator,curative effect,and adverse effects were recorded in detail. The search was carried out as of September,2016. [Results] It searched 3 articles related to clinical application and 111 cases of patients. [Conclusions] Chidamide has excellent curative effect in treating peripheral T-cell lymphoma and is suitable for clinical application. | Xuerong NIE Liangming ZHANG Dongmei GENG Minghua SUI Xuan ZHAO | 2017 | Medicinal Plant2017，8，2： | 0 |
| 16 | Otolith Microstructure Analysis Reveals Different Growth Histories of Japanese Sardine (Sardinops melanostictus) in the Oyashio Waters显示文摘After decades of low year classes,the stock of Japanese sardine(Sardinops melanostictus)has begun to recover since the mid-2000s.The hatch dates and otolith growth rates of age-0 juvenile sardine,which were collected in the subarctic Oyashio waters in autumn 2018,were determined from an otolith microstructure analysis.The sardines were hatched from late January to late April,while mostly in February and March.The otolith growth rate increased continuously up to 60 d after hatching and thereafter de-creased.The revealed growth rate in a crucial growth period is faster than that reported for juvenile sardines collected in the 1990s,which is coincided with the recent recovery trend of the sardine stock.Two groups with different hatch dates,growth histories,and migration routes were identified using unsupervised random forest clustering analysis.They were considered inshore and offshore migration individuals in accordance with recent researches.In the offshore group,a high proportion of sardine juveniles hatched late and grew faster in the Kuroshio-Oyashio transitional waters,a finding consistent with the hypothesis of growth-rate-dependent re-cruitment.This finding on the population composition and growth rate of juvenile sardine in the Oyashio waters can be a basis for an improved prediction of their survival and provides us with valuable information on the recruitment processes of this stock during the period of stock recovery. | LIU Chunlin ZHANG Chi TIAN Yongjun WANG Liangming LIN Longshan LI Yuan WATANABE Yoshiro | 2022 | Journal of Ocean University of China2022，21，1： | 0 |
| 17 | The analysis of the optimal scalar and vector intensity measurements for seismic performance assessment of deep-buried hydraulic arched tunnels显示文摘The selection of optimal intensity measures(IMs)has been recommended for generating the seismic demand models with different probabilities by researchers since the seismic IMs are closely associated with earthquake risks and structural safety.However,the seismic design code(mainly for aboveground structures)and dynamic analysis of underground structures conventionally employ the peak ground acceleration(PGA)as an optimal IM.In this paper,the research is to identify the optimal scalar and vector IMs in the fragility investigation of deep-buried hydraulic arched tunnels using the finite element method.A refinement process was performed to determine the optimal scalar IMs by comprehensively comparing their correlation,efficiency,practicality,proficiency,and sufficiency among the examined IMs.Furtherly,the optimum vector IMs were also developed,followed by the three different scalar IMs.Eventually,the dif-ferences between the fragility curves of the tunnel produced using the optimal scalar and vector IM were compared.The generated vector fragility surface can be used to estimate the seismic fragility of identical hydraulic tunnels in an approximative manner. | Benbo Sun Gangqin Zhang Binghan Xue Lei Kou Liangming Hu Weiying Liu | 2023 | Underground Space2023，，2： | 0 |
| 18 | Safety and activity of WX-0593(Iruplinalkib)in patients with ALK-or ROS1-rearranged advanced non-small cell lung cancer:a phase 1 dose-escalation and dose-expansion trial显示文摘WX-0593(Iruplinalkib)is a novel,highly selective oral ALK and ROS1 tyrosine kinase inhibitor(TKI).In this study,the safety,antitumor activity,and pharmacokinetics of WX-0593 were evaluated in advanced non-small cell lung cancer(NSCLC)patients with ALK or ROS1 rearrangement.In the dose-escalation phase and dose-expansion phase,patients were treated with WX-0593 until disease progression,unacceptable toxicity,or subject withdrawal.In the dose-escalation phase,the primary endpoints were maximum tolerated dose(MTD),dose-limiting toxicity(DLT),and safety assessed by investigators.In the dose-expansion phase,the primary endpoint was objective response rate(ORR)assessed by investigators.Between September 25,2017 and October 15,2018,a total of 153 patients received WX-0593 treatment.Two dose-limiting toxicities(DLTs)including one grade 3 QT interval prolonged and one grade 2 chronic heart failure were reported at the dose of 300 mg in one patient.MTD was not reached.Overall,140 of the 152(92%)patients experienced treatment-related adverse events(TRAEs)and 35 of the 152(23%)patients had TRAEs≥grade 3.The overall ORR was 59.3%(32 of 54)for the dose-escalation phase and 56.6%(56 of 99)for the dose-expansion phase.For patients who were ALK-rearranged and ALK TKI naive,the ORR were 81.0%(17 of 21)in the dose-escalation phase and 76.3%(29 of 38)in the dose-expansion phase,and for patients who previously received crizotinib as the only ALK TKI,the ORR were 38.1%(8 of 21)and 45.7%(21 of 46)for the two phases,respectively.For patients who were ROS1-rearranged,the ORR were 30.0%(3 of 10)in the dose-escalation phase and 44.4%(4 of 9)in the dose-expansion phase.WX-0593 showed favorable safety and promising antitumor activity in advanced NSCLC patients with ALK or ROS1 rearrangement. | Yuankai Shi Jian Fang Xuezhi Hao Shucai Zhang Yunpeng Liu Lin Wang Jianhua Chen Yi Hu Xiaosheng Hang Juan Li Chunling Liu Yiping Zhang Zhehai Wang Yanping Hu Kangsheng Gu Jian’an Huang Liangming Zhang Jinlu Shan Weiwei Ouyang Yanqiu Zhao Wu Zhuang Yan Yu Jun Zhao Helong Zhang Pei Lu Weidong Li Meimei Si Mingjing Ge Huaize Geng | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
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