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| 1 | Interleukin 10 inhibits interferon γ- and tumor necrosis factor α-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon显示文摘 | Mai Kamizato Kensei Nishida Kiyoshi Masuda Keiko Takeo Yuta Yamamoto Tomoko Kawai Shigetada Teshima-Kondo Toshihito Tanahashi Kazuhito Rokutan | 2009 | Journal of Gastroenterology2009，，12： | 2 |
| 2 | Structure of the metabotropic glutamate receptor显示文摘 | Hisato J Shigetada N Kosuke M | 2003 | Current Opinion in Neurobiology2003，13，： | 1 |
| 3 | Effects of a soy protein diet on exercise-induced muscle protein catabolism in rats显示文摘 | Takeshi Nikawa Madoka Ikemoto Takashi Sakai Mihoko Kano Takako Kitano Tsukasa Kawahara Shigetada Teshima Kazuhito Rokutan Kyoichi Kishi | 2002 | Nutrition2002，，6： | 1 |
| 4 | Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system显示文摘 | Shigetada T Kazuhito R Takeshi N | 1998 | Gastroenterology1998，115，5： | 1 |
| 5 | Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract显示文摘 | Kazuhito Rokutan Tsukasa Kawahara Yuki Kuwano Kumiko Tominaga Keisei Nishida Shigetada Teshima-Kondo | 2008 | Seminars in Immunopathology2008，，3： | 1 |
| 6 | Cloning, Sequencing and Expression in Escherichia Coli of cDNA for a Non-A, Non-B Hepatitis-associated Microtubular Aggregates Protein显示文摘 | KAZUHIRO T NAOMI K TATSUROU S MICHIRU K RIE M YOSHIKO Y TOSHIRO M JUN K YOSHIKAZU H EI Y YOHKO K S YUTAKA T I and SHIGETADA N | 1990 | J Gen Virol1990，71，： | 1 |
| 7 | Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine显示文摘 | Takatoshi H Yasuji K Ira P Shigetada N | 2003 | Proceedings of the National Academy of America2003，100，： | 1 |
| 8 | The Group A Streptococcus Interleukin-8 Protease SpyCEP Promotes Bacterial Intracellular Survival by Evasion of Autophagy显示文摘Autophagy serves an innate immune function in defending the host against invading bacteria,including group A Streptococcus(GAS).Autophagy is regulated by numerous host proteins,including the endogenous negative regulator calpain,a cytosolic protease.Globally disseminated serotypeM1T1 GAS strains associated with high invasive disease potential express numerous virulence factors and resist autophagic clearance.Upon in vitro infection of human epithelial cell lines with representative wild-type GAS M1T1 strain 5448(M1.5448),we observed increased calpain activation linked to a specific GAS virulence factor,the interleukin-8 protease SpyCEP.Calpain activation inhibited autophagy and decreased capture of cytosolic GAS in autophagosomes.In contrast,the serotype M6 GAS strain JRS4(M6.JRS4),which is highly susceptible to host autophagy-mediated killing,expresses low levels of SpyCEP and does not activate calpain.Overexpression of SpyCEP in M6.JRS4 stimulated calpain activation,inhibited autophagy,and significantly decreased bacterial capture in autophagosomes.These paired loss-and gain-of-function studies reveal a novel role for the bacterial protease SpyCEP in enabling GAS M1 evasion of autophagy and host innate immune clearance. | RenéBergmann Giuseppe Gulotta Federica Andreoni Tomoko Sumitomo Shigetada Kawabata Annelies S.Zinkernagel Gursharan S.Chhatwal Victor Nizet Manfred Rohde Satoshi Uchiyama | 2022 | Infectious Microbes & Diseases2022，4，3： | 1 |
| 9 | Chronic inhibition of tumor cell - derived VEGF enhances the malignant phenotype of eolorectal cancer cells 显示文摘 | Naoko Yamagishi Shigetada Teshima - Kondo Kiyoshi Masuda | 2013 | BMC Cancer2013，13，： | 1 |
| 10 | Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach显示文摘 | Kumiko Tominaga Tsukasa Kawahara Toshiaki Sano Kazunori Toida Yuki Kuwano Hideyuki Sasaki Tomoko Kawai Shigetada Teshima-Kondo Kazuhito Rokutan | 2007 | Free Radical Biology and Medicine2007，，12： | 1 |
| 11 | Targeted salivary gland imminization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin Gantibodies in mice 显示文摘 | Shigetada K Yutaka T Taku F | 1999 | Infection and Immunity1999，67，11： | 1 |
| 12 | Fba,a novel fibronectin-binding protein from Streptococcus pyogenes,promotes bacterial entry into epithelial cells,and the fba gene is positively transcribed under the Mga regulator显示文摘 | Yutaka terao Shigetada Kawabata Eiji kunitomo | | Mol Microbiol0，7586，： | 1 |
| 13 | Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity显示文摘 | Hiroshi Kawasaki Kenji Mizuseki Satomi Nishikawa Satoshi Kaneko Yoshihisa Kuwana Shigetada Nakanishi Shin-Ichi Nishikawa Yoshiki Sasai | 2000 | Neuron2000，，1： | 1 |
| 14 | Targeted salivary gland imminization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin Gantibodies in mice显示文摘 | Shigetada K Yutaka T Taku F | 1999 | Infection and Immunity1999，67，11： | 1 |
| 15 | Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019显示文摘Invasive infection caused by Streptococcus pyogenes emm89 strains has been increasing in several countries linked to a recently emergent clade of emm89 strains,designated clade 3.In Japan,the features of emm89 S.pyogenes strains,such as clade classification,remains unknown.In this study,we collected emm89 strains isolated from both streptococcal toxic shock syndrome(STSS)(89 STSS isolates)and noninvasive infections(72 non-STSS isolates)in Japan from 2011 to 2019,and conducted wholegenome sequencing and comparative analysis,which resulted in classification of a large majority into clade 3 regardless of disease severity.In addition,invasive disease-associated factors were found among emm89 strains,including mutations of control of virulence sensor,and absence of the hylP1 gene encoding hyaluronidase.These findings provide new insights into genetic features of emm89 strains. | Yujiro Hirose Masaya Yamaguchi Norihiko Takemoto Tohru Miyoshi-Akiyama Tomoko Sumitomo Masanobu Nakata Tadayoshi Ikebe Tomoki Hanada Takahiro Yamaguchi Ryuji Kawahara Rumi Okuno Hitoshi Otsuka Yuko Matsumoto Yuji Terashima Yu Kazawa Noriko Nakanishi Kaoru Uchida Yumi Akiyama Kaori Iwabuchi Chikara Nakagawa Kazunari Yamamoto Victor Nizet Shigetada Kawabata | 2020 | Infectious Microbes & Diseases2020，2，4： | 0 |
| 16 | Long-term survival of salivary streptococci on dental devices made of ethylene vinyl acetate显示文摘Bacterial infection associated with the use of medical or dental devices is a serious concern.Although devices made of ethylene vinyl acetate(EVA) are often used in the oral cavity,there are no established standards for their storage.We investigated bacterial survival on EVA sheets under various storage conditions to establish a standard for hygienic storage of such dental devices.Bacterial counts were evaluated,which showed a significant decrease after washing with sterilized water,mechanical brushing and rinsing,and using Mouthguard Cleaner as compared to untreated samples.In addition,no bacteria were detected on samples stored 2 days or longer in a ventilated environment,whereas they were detected for up to 14 days on samples without any cleaning stored in a closed environment.Bacterial counts for the untreated samples gradually declined,while surviving bacteria on samples treated with sterilized water and mechanical brushing showed a rapid decrease.Additionally,bacterial identification using polymerase chain reaction(PCR) revealed that Streptococcus oralis was dominantly detected on salivary samples after 14 days of storage among both two subjects.For effective hygienic storage of dental devices made of EVA,washing with sterilized water is important to remove absorbed salivary compounds along with storage in a ventilated environment. | Taiji Ogawa Sayaka Yamasaki Mariko Honda Yutaka Terao Shigetada Kawabata Yoshinobu Maeda | 2012 | International Journal of Oral Science2012，4，1： | 0 |
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