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| 1 | Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands显示文摘Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG. | Shigeo Manabe Ken-ichi Mukaisho Takayuki Yasuoka Fumitaka Usui Tatsuzo Matsuyama Ikuhiro Hirata Yoshio Boku Shuji Takahashi | 2017 | World Journal of Gastroenterology2017，23，38： | 6 |
| 2 | Endoscopic submucosal dissection as excisional biopsy for anorectal malignant melanoma:A case report显示文摘BACKGROUND Anorectal malignant melanoma (AMM) is a rare disorder with an extremely poor prognosis. Although there is currently no consensus on the treatment methods for AMM, surgical procedures have been the most common treatment methods used until now. We recently encountered a case of AMM that we diagnosed using endoscopic submucosal dissection (ESD). To our knowledge, this is the first case of ESD for AMM, suggesting that ESD can potentially be a diagnostic and treatment method for AMM. CASE SUMMARY A 77-year-old woman visited our hospital with a chief complaint of anal bleeding and a palpable rectal mass. Colonoscopy revealed a 20-mm protruded lesion in the lower rectum. After obtaining biopsy specimens from the lesion, although a malignant rectal tumor was suspected, a definitive diagnosis was not made. Endoscopic ultrasonography revealed tumor invasion into the submucosal layer but not the muscular layer. Therefore, we performed an excisional biopsy using ESD. Immunohistochemical examination of the ESD-resected specimen revealed tumor cells positive for Human Melanin Black-45, Melan-A, and S-100. Moreover, the tumor cells lacked melanin pigment;thus, a diagnosis of amelanotic AMM was made. Although the AMM had massively invaded the submucosal layer and both lymphatic and venous invasion were present, we closely monitored the patient without any additional therapy on the basis of her request. Six months after ESD, local recurrence was detected, and the patient consented to wide local excision. CONCLUSION It is suggested that ESD is a potential diagnostic and treatment method for AMM. | Shigeo Manabe Yoshio Boku Michiyo Takeda Fumitaka Usui Ikuhiro Hirata Shuji Takahashi | 2019 | World Journal of Clinical Cases2019，7，13： | 6 |
| 3 | A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer显示文摘 | Yoon-Koo Kang Kei Muro Min-Hee Ryu Hirofumi Yasui Tomohiro Nishina Baek-Yeol Ryoo Yukimasa Kamiya Shiro Akinaga Narikazu Boku | 2014 | Investigational New Drugs2014，，2： | 5 |
| 4 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 5 |
| 5 | Comparison of HER2 gene amplification assessed by fluorescence in situhybridization and HER2 protein expression assessed by immunohistochemistry ingastric cancer显示文摘 | Tomonori Yano Toshihiko Doi Atsushi Ohtsu Narikazu Boku Kaoru Hashizume Mamoru Nakanishi Atsushi Ochiai | 2006 | Oncology Reports2006，，1： | 4 |
| 6 | A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms显示文摘 | Shin’ichi Miyamoto Manabu Muto Yasuo Hamamoto Narikazu Boku Atsushi Ohtsu Satoshi Baba Motoki Yoshida Masana Ohkuwa Kouichi Hosokawa Hisao Tajiri Shigeaki Yoshida | 2002 | Gastrointestinal Endoscopy2002，，4： | 3 |
| 7 | HER2-positive gastric cancer显示文摘 | Narikazu Boku | 2014 | Gastric Cancer2014，，1： | 2 |
| 8 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer:a randomised phase 3 study显示文摘 | Boku N Yamamoto S Fukuda H | | 0，，11： | 2 |
| 9 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study 显示文摘 | Boku N Yamamoto S Fukuda H | 2009 | Lancet Oncol2009，10，11： | 1 |
| 10 | Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study) 显示文摘 | Muro K Boku N Shimada Y | 2010 | Lancet Oneol2010，11，9： | 1 |
| 11 | Randomized phase III study of 5-fluorouracil (5-FU) alone versus combination of irinotecan and cisplatin (CP) versus S-1 alone in advanced gastric cancer (JCOG9912)显示文摘 | Boku N Yamamoto S Shirao K | | Proc Am Soc Clin Oncol0，25，： | 1 |
| 12 | Randomized phaseⅢstudy of 5-fluorouracil(5-FU)alone versus combination of irinotecanand cisplatin(CP)versus S-1 alone in advanced gastric cancer(JCOG9912)显示文摘 | Boku N Yamamoto S Shirao K | 2007 | Proc Am Soc Clin Oncol2007，25，18： | 1 |
| 13 | Phase Ⅱ study of a combination of Cddp and CPT-11 in metastatil gastric cancer: CPT-11 study group for gastric cancer ( meeting abstract) 显示文摘 | Boku N obtsu A Schimada Y | 1997 | Proc Annu meet Am Soc Clin Oncol1997，16，： | 1 |
| 14 | Irinotecan plus S-1(I-RIS)versus fluorouracil and folinic acid plus irinotecan(FOLFI-RI)as second-line chemotherapy for metastatic colomctal cancer:a randomised phase2/3non-inferiority study(FIRIS study)显示文摘 | Muro K Boku N ShimadaY et a1 | 2010 | Lancet Oncol2010，11，9： | 1 |
| 15 | Safety and efficacy of S-1 monotherapy in elderly patients with advanced gastric cancer显示文摘 | Tsushima T Hironaka S Boku N | 2010 | Gastric Cancer2010，13，4： | 1 |
| 16 | Quantitative analysis of nodal involvement with respect to survival rate after curative gastrectomy for carcinoma显示文摘 | Okusa T Nakane Y Boku T | 1990 | Surgery Gynecology and Obstetrics1990，，06： | 1 |
| 17 | JASPAC 01: Ran- domized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 for patients with resected pancre- atic cancer: Japan Adjuvant Study Group of Pancreatic Cancer (JASPAC-01)显示文摘 | Maeda A Boku N Fukutomi A | 2013 | Jpn J Clin Oncol2013，38，3： | 1 |
| 18 | Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase显示文摘 | Maekawa M Ishizaki T Boku S | 1999 | Science1999，285，5429： | 1 |
| 19 | A retrospective study of second-line chemotherapy for unrespectable or recurrent squamous cell carcinoma of the esophagus refractory to chemotherapy with 5-fluorouracil plus platinum显示文摘 | Yamazaki K Hironaka S Boku N | 2008 | Int J Clin Oncol2008，13，2： | 1 |
| 20 | Phase Ⅱ study of S-1 plus leu- covorin in patients with metastatic colorectal cancer 显示文摘 | Koizumi W Boku N Yamaguchi K | 2010 | Ann Oncol2010，21，4： | 1 |
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