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| 1 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 2 | Different natural courses of chronic hepatitis B with genotypes B and C after the fourth decade of life显示文摘AIM: To investigate the different impact of genotypes B and C on the development of liver cirrhosis (LC) among different age groups of patients with chronic hepatitis B (CH-B). METHODS: We examined the outcome of 121 patients with CH-B, divided by age and genotype. Univariate analyses were used to compare different groups. The Cox proportional hazard model was employed to evaluate factors affecting the development of LC. RESULTS: In patients < 30 years old, there were no significant predictors for development of LC. However, in patients ≥ 30 years old, genotype C was the only significant predictor. In the genotype C group, 8 of 12 patients who progressed to LC were 30-49 years old at initial diagnosis of chronic hepatitis (7 patients were positive for HBeAg). In the genotype B group, 4 of 8 patients who developed LC were ≥ 50 years old at initial diagnosis and were HBeAg-negative. CONCLUSION: The rate of development of LC was comparable in patients infected with genotypes B and C when CH-B occurred at < 30 years old. However, CH-B patients infected with genotype C showed poor prognosis if they were 30-49 years old and were positive for HBeAg. Age-specific natural course of CH-B should be considered when patients with CH-B are treated with antiviral drugs. | Tatsuji Maeshiro Shingo Arakaki Takako Watanabe Hajime Aoyama Joji Shiroma Tsuyoshi Yamashiro Tetsuo Hirata Akira Hokama Fukunori Kinjo Tomofumi Nakayoshi Tomokuni Nakayoshi Masashi Mizokami Jiro Fujita Hiroshi Sakugawa | 2007 | World Journal of Gastroenterology2007，13，34： | 7 |
| 3 | Long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation for bile duct stones显示文摘 | Ichiro Yasuda Naotaka Fujita Hiroyuki Maguchi Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro Tomoko Tada Takeshi Tsujino Yutaka Komatsu | 2010 | Gastrointestinal Endoscopy2010，，6： | 2 |
| 4 | Endoscopic sphincterotomy and endoscopic papillary balloon dilatation for bile duct stones: a prospective randomized controlled multicenter trial显示文摘 | Naotaka Fujita Hiroyuki Maguchi Yutaka Komatsu Ichiro Yasuda Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro | 2003 | Gastrointestinal Endoscopy2003，，2： | 2 |
| 5 | Current diagnosis and treatment of early pancreatic cancer显示文摘 | Ryu S Maeshiro K Yasunami Y | 1996 | Nippon Rinsho1996，，54： | 1 |
| 6 | Difference in prognosis between patients infected with hepatitis B viras with genotype B and those with genotype C in the Okinawa Island:a prospective study显示文摘 | Nakayoshi J Maeshiro T Nakayoshi T | 2003 | Med Virol2003，70，3： | 1 |
| 7 | Diagnosis of mucin-producing tumor of the pancreas by balloon- catheter endoscopic retrograde pancreatography - compression study显示文摘 | Maeshiro K Nakayama Y Yasunami Y | 1998 | Hepatogastroenterology1998，45，24： | 1 |
| 8 | Balloon-catheter endoscopic retrograde pancreatography-compression study for diagnosis of early-stage pancreatitis 显示文摘 | Maeshiro K Ikeda S Yasunami Y | 2007 | Gastroenterol2007，4217，： | 1 |
| 9 | Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands:A prospective study显示文摘 | Nakayoshi T Maeshiro T Nakasone H | 2003 | J Med Viral2003，70，： | 1 |
| 10 | Segmental pancreatectomy for the diagnosis and treatment of small lesions in the neck or body of the pancreas显示文摘 | Ikeda S Matsumoto S Maeshiro K | 1995 | Hepatogastroenterology1995，42，5： | 1 |
| 11 | Shear banding in a sedimentary soft mudstone subjected to plane strain compression显示文摘 | Hayano K Maeshiro T Tatsuoka F | 1999 | Geotechnical Testing Journal ASTM1999，22，1： | 1 |
| 12 | Difference in prognosis between patients infective with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: a prospective study 显示文摘 | Nakayoshi T Maeshiro T Nakayoshi T | 2003 | J Med Virol2003，70，3： | 1 |
| 13 | Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: a prospective study显示文摘 | Nakayoshi T Maeshiro T Nakayoshi H | 2003 | J Med Virol2003，70，： | 1 |
| 14 | Difference in prognosis between patients infectecl with hepatitis B virus with genotype B and those with genotyp EC in the Okinawa Islands:a prospective study显示文摘 | Nakayojhi T Maeshiro T Nakasone H | 2003 | J Med Virol2003，10，3： | 1 |
| 15 | Shear banding in sedimentary soft mudstone subjected to plane strain compression显示文摘 | Hayano K Maeshiro T Tatsuoka F | 1999 | Geotechnical Testing Journal1999，22，： | 1 |
| 16 | Incidence of recurrence after hepatic resection and prophylactic hepatic arterial infusi on chemotherapy for liver metastases from colon cancer显示文摘 | Umekita N Maeshiro T Miyamoto S | 1999 | Gan To Kagaku Ryoho1999，26，12： | 1 |
| 17 | The role of robustness and changeability on the origin and evolution of genetic codes 显示文摘 | Maeshiro T Kimura M | 1998 | PNAS1998，95，： | 1 |
| 18 | The role of robustness and changeability on the origin and evolution of genetic codes显示文摘 | Maeshiro T Kimura M | 1998 | PNAS1998，95，： | 1 |
| 19 | The role of robustness and changeability on the origin and evolution of genetic codes显示文摘 | Maeshiro T Kimura M | 1998 | PNAS1998，95，： | 1 |
| 20 | Interventional treatment of biliary stricture显示文摘 | IKEDA S MAESHIRO K | 2004 | Nippon Geka Gakkai Zasshi2004，105，： | 1 |
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