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| 1 | Downregulation of miR-130a contributes to cisplatin resistance in ovarian cancer cells by targeting X-linked inhibitor of apoptosis (XIAP) directly显示文摘MicroRNAs (miRNAs ) 是短的,高度保存了小非编码的 RNA 分子,它 post-transcriptionally 调整基因表示并且在多样的生物进程起关键作用。最近的研究证明了 miRNAs 的 dysregulation 可能调制癌症房间的电阻到化学疗法的代理人。为了在人的卵巢的癌症房间在 cisplatin 电阻的发展调查 miR-130a 的可能的角色,衬里 A2780,我们由量的即时反向的抄写聚合酶链反应在房间计算了 microRNA-130a (miR-130a ) 的表达式。结果证明 miR-130a 在 cisplatin 抵抗的卵巢的癌症房间是显著地下面调整的。MTT 试金和流动 cytometry (FCM ) 结果证明 miR-130a 的在表示上调整了 apoptotic 活动,并且从而 cisplatin chemosensitivity,在卵巢的癌症房间。而且,我们发现 miR-130a 能直接指向 XIAP,并且参予 apoptosis 的规定。miR-130a 的起来规定在 XIAP mRNA 层次和蛋白质层次导致了重要减少。XIAP 在卵巢的癌症房间线 A2780 在 cisplatin 抵抗起一个重要作用。我们的调查结果建议 miR-130a 能在卵巢的癌症房间线 A2780 在 cisplatin 抵抗的发展起一个作用,至少部分地由经由指向 XIAP 的 apoptosis 的调整。 | Xi'an Zhang Lingna Huang Yinglin Zhao Wuhong Tan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 16 |
| 2 | A Multifunctional Anti-Proton Electrolyte for High-Rate and Super-Stable Aqueous Zn-Vanadium Oxide Battery显示文摘Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide battery.In this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those issues.Theoretical and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the electrolyte.Then,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such electrolyte.Besides,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen evolution.Owing to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),respectively.Such“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery. | Yangwu Chen Dingtao Ma Kefeng Ouyang Ming Yang Sicheng Shen Yanyi Wang Hongwei Mi Lingna Sun Chuanxin He Peixin Zhang | 2022 | Nano-Micro Letters2022，14，9： | 3 |
| 3 | Pm67, a new powdery mildew resistance gene transferred from Dasypyrum villosum chromosome 1V to common wheat(Triticum aestivum L.)显示文摘Powdery mildew, caused by the biotrophic fungus Blumeria graminis f. sp. tritici(Bgt), is a global disease that poses a serious threat to wheat production. To explore additional resistance gene, a wheatDasypyrum villosum 1 V#5(1 D) disomic substitution line NAU1813(2 n = 42) with high level of seedling resistance to powdery mildew was used to generate the recombination between chromosomes 1 V#5 and1 D. Four introgression lines, including t1 VS#5 ditelosomic addition line NAU1815, t1 VL#5 ditelosomic addition line NAU1816, homozygous T1 DL·1 VS#5 translocation line NAU1817, and homozygous T1 DS·1 VL#5 translocation line NAU1818 were developed from the selfing progenies of 1 V#5 and 1 D double monosomic line that derived from F1 hybrids of NAU1813/NAU0686. All of them were characterized by fluorescence in situ hybridization, genomic in situ hybridization, 1 V-specific markers analysis, and powdery mildew tests at different developmental stages. A new powdery mildew resistance gene named Pm67 was physically located in the terminal bin(FL 0.70–1.00) of 1 VS#5. Lines with Pm67 exhibited seedling stage immunity and tissue-differentiated reactions at adult plant stage. The sheaths, stems, and spikes of the Pm67 line were still immune, but the leaves showed a low degree of susceptibility.Microscopic observation showed that most penetration attempts were stopped in association with papillae on the sheath, and colonies cannot form conidia on the susceptible leaf of Pm67 line at adult plant stage, suggesting that the defence layers of the Pm67 line is tissue-differentiated. Thus, the T1 DL·1 VS#5 translocation line NAU1817 provides a new germplasm in wheat breeding for improvement of powdery mildew resistance. | Ruiqi Zhang Chuanxi Xiong Huanqing Mu Ruonan Yao Xiangru Meng Lingna Kong Liping Xing Jizhong Wu Yigao Feng Aizhong Cao | 2021 | The Crop Journal2021，9，4： | 3 |
| 4 | Study on W-band Sheet Electron Beam Sine Waveguide Traveling-Wave Tube显示文摘 | XU Xiong WEI Yanyu SHEN Fei GONG Yubin YUE Lingna TANG Tao ZHAO Guoqing WANG Wenxiang | 2012 | Chinese Journal of Electronics2012，21，1： | 3 |
| 5 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 6 | Multicolor luminescence of hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) microcrystals with tunable morphology under 940 nm excitation for temperature-responsive anti-counterfeiting显示文摘In this study,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) microcrystals were synthesized controllably,and upconversion luminescence excited at 940 nm and its application in temperature-responsive anti-counterfeiting are reported.It is clarified that the Ln^(3+)(Ln=Y+Yb+Ho+Ce)density ratio of bottom plane to side plane in the unit cell can be regulated by Ce^(3+) doping.It is also proved that the energy transfer of Yb^(3+) to Ho^(3+) is responsible for the activation of Ho^(3+)under 940 nm excitation,while the cross relaxation between Ho^(3+)and Ce^(3+)participates in the redistribution of electron population of^(5)S_(2)/^(5)F_(4)and^(5)F_(5)levels.Both theory and experiment confirm that the intensity ratio of red to green emission(I_(R)/I_(G))as a function of temperature as an independent variable has good linear characteristics in the temperature range of 300-500 K.Due to the good responsiveness of multicolor luminescence to temperature,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) with tunable morphology is a promising candidate for advanced temperature-responsive upconversion anti-counterfeiting.Our results provide a new pathway for the controllable synthesis of hexagonal NaYF_(4)microcrystals as well as the regulation of upconversion luminescence that is excited by wavelengths other than 980 nm and its application in anti-counterfeiting. | Lingna Xu Hongyan Zheng Tao Pang Junwen Mao | 2022 | Journal of Rare Earths2022，40，3： | 2 |
| 7 | Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells显示文摘 | Yang M Li Lingna Jiang P | 2003 | Proc Natl Acad Sci U S A2003，100，14： | 1 |
| 8 | Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice显示文摘 | Yasuyuki Amoh Michael Bouvet Lingna Li Kazuhiko Tsuji A. R. Moossa Kensei Katsuoka Robert M. Hoffman | 2006 | Clinical & Experimental Metastasis (-)2006，，7： | 1 |
| 9 | Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways显示文摘 | Dexi Zhou Cheng Huang Zhen Lin Shuxiang Zhan Lingna Kong Chengbo Fang Jun Li | 2014 | Cellular Signalling2014，，2： | 1 |
| 10 | Analysis of Coaxial Ridged Disk-Loaded Slow-Wave Structures for Relativistic Traveling Wave Tubes显示文摘 | Yue Lingna Wang Wenxiang Gong Yubin | 2004 | IEEE Trans on Plasma Science2004，32，3： | 1 |
| 11 | The Synthesis and Photoluminescent Properties of Calcium Tungstate Nanocrystals显示文摘 | Sun Lingna Cao Minhua Wang Yonghui | 2006 | Journal of Crystal Growth2006，289，： | 1 |
| 12 | Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats显示文摘 | Ruchun Dai Yulin Ma Zhifeng Sheng Yan Jin Yuhai Zhang Lingna Fang Huijie Fan Eryuan Liao | 2008 | Journal of Bone and Mineral Metabolism2008，，4： | 1 |
| 13 | The synthesis and photoluminescent properties of calcium tungstate nanocrystals显示文摘 | Lingna Sun Minhua Cao Yonghui Wang Genban Sun Changwen Hu | 2005 | Journal of Crystal Growth2005，，1： | 1 |
| 14 | Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells显示文摘 | Yang M Lingna LI Ping J | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 15 | Nestin expression in hair follicle sheath progenitor cells 显示文摘 | Lingna LI Mignone J Yang M | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 16 | Discrimination and analysis of microwave modes in high power systems显示文摘 | Wang Wenxiang Yue Lingna Zhao Guoqing | 2005 | Internatio-nal Journal of Infrared and Millimeter Waves2005，26，2： | 1 |
| 17 | Expressional profiling study revealed unique expressional patterns and dramatic expressional divergence of maize α-zein super gene family显示文摘 | Lingna Feng Jia Zhu Gang Wang Yuanping Tang Hanjun Chen Weibo Jin Fei Wang Bing Mei Zhengkai Xu Rentao Song | 2009 | Plant Molecular Biology2009，，6： | 1 |
| 18 | A Novel Slow-Wave Structure-Folded Rectangular Groove Waveguide for Millimeter-Wave TWT显示文摘 | Yue Lingna Xu Jin Wang Wenxiang | | 0，，02： | 1 |
| 19 | Research on weak signal extraction and noise removal for GPR data based on principal component analysis显示文摘The ground penetrating radar( GPR) detection data is a wide band signal,always disturbed by some noise,such as ambient random noise and multiple reflection waves. The noise affects the target identification of underground medium seriously. A method based on principal component analysis( PCA) was proposed to extract the target signal and remove the uncorrelated noise. According to the correlation of signal,the authors get the eigenvalues and corresponding eigenvectors by decomposing the covariance matrix of GPR data and make linear transformation for the GPR data to get the principal components( PCs). The lower-order PCs stand for the strong correlated target signals of the raw data,and the higher-order ones present the uncorrelated noise.Thus the authors can extract the target signal and filter uncorrelated noise effectively by the PCA. This method was demonstrated on real ultra-wideband through-wall radar data and simulated GPR data. Both of the results show that the PCA method can effectively extract the GPR target signal and remove the uncorrelated noise. | CHEN Lingna ZENG Zhaofa LI Jing YUAN Yuan | 2015 | Global Geology2015，18，3： | 1 |
| 20 | V-Shape Folded Rectangular Groove Waveguide for MillimeterWave Traveling-Wave Tube显示文摘 | Liu Yang Yue Lingna Tian Yanyan | | 0，，04： | 1 |
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