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| 1 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 2 | Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion显示文摘AIM: Nitrative and oxidative DNA damage such as 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine(8-oxodG) formation has been implicated in initiation and/or promotion of inflammation-mediated carcinogenesis.The aim of this study is to clarify whether these DNA lesions participate in the progression of intrahepatic cholangiocarcinoma.METHODS: We investigated the relation of the formation of 8-nitroguanine and 8-oxodG and the expression of hypoxia-inducible factor-1α (HIF-1α) with tumor invasion in 37 patients with intra-hepatic cholangiocarcinoma.RESULTS: Immunohistochemical analyses revealed that 8-nitroguanine and 8-oxodG formation occurred to a much greater extent in cancerous tissues than in non-cancerous tissues. HIF-1α could be detected in cancerous tissues in all patients, suggesting low oxygen tension in the tumors.HIF-1α expression was correlated with inducible nitric oxide synthase (iNOS) expression (r= 0.369 and P = 0.025)and 8-oxodG formation (r = 0.398 and P = 0.015).Double immunofluorescence study revealed that iNOS and HIF-1α co-localized in cancerous tissues. Notably, the formation of 8-oxodG was correlated significantly with lymphatic invasion (r = 0.386 and P= 0.018). Moreover, 8-nitroguanine and 8-oxodG in non-cancerous tissues were associated significantly with neural invasion (P = 0.042and P = 0.026, respectively). These results suggest that reciprocal activation between HIF-1α and iNOS mediates persistent DNA damage, which induces tumor invasiveness via mutations, resulting in poor prognosis.CONCLUSION: The formation of 8-nitroguanine and 8-oxodG plays an important role in multiple steps of genetic changes leading to tumor progression, including invasiveness. | Somchai Pinlaor Banchob Sripa Ning Ma Yusuke Hiraku Puangrat Yongvanit Sopit Wongkham Chawalit Pairojkul Vajarabhongsa Bhudhisawasdi Shinji Oikawa Mariko Murata Reiji Semba Shosuke Kawanishi | 2005 | World Journal of Gastroenterology2005，11，30： | 9 |
| 3 | Diffusion-weighted MRI in abdominal oncology:Clinical applications显示文摘Diffusion-weighted magnetic resonance imaging(DWI) provides image contrast that is different from that obtained by conventional magnetic resonance techniques.Although previously,DWI has been used to evaluate various diseases of the central nervous system,several technical advances have expanded the clinical applications of DWI beyond the central nervous system.As a result,many reports have been published on the use of DWI in abdominal diseases.Particularly,abdominal DWI has now being focused on evaluation of patients with abdominal cancer.DWI can be used for pretreatment tumor detection,characterization including predicting tumor response to therapy,monitoring tumor response during therapy,and follow-up study after treatment to detect possible tumor recurrence. | Reiji Sugita Kei Ito Naotaka Fujita Shoki Takahashi | 2010 | World Journal of Gastroenterology2010，16，7： | 8 |
| 4 | Pancreaticobiliary reflux as a high-risk factor for biliary malignancy:Clinical features and diagnostic advancements显示文摘Pancreaticobiliary junction is composed of complex structure with which biliary duct and pancreatic duct assemble and go out into the ampulla of Vater during duodenum wall surrounding the sphincter of Oddi.Although the sphincter of Oddi functionally prevents the reflux of pancreatic juice,pancreaticobiliary reflux(PBR) occurs when function of the sphincter of Oddi halt.The anatomically abnormal junction is termed pancreaticobiliary maljunction(PBM) and is characterized by pancreatic and bile ducts joining outside of the duodenal wall.PBM is an important anatomical finding because many studies have revealed that biliary malignancies are related due to the carcinogenetic effect of the pancreatic back flow on the biliary mucosa.On the other hand,several studies have been published on the reflux of pancreatic juice into the bile duct without morphological PBM,and the correlation of such cases with biliary diseases,especially biliary malignancies,is drawing considerable attention.Although it has long been possible to diagnose PBM by various imaging modalities,PBR without PBM has remained difficult to assess.Therefore,the pathological features of PBR without PBM have not been yet fully elucidated.Lately,a new method of diagnosing PBR without PBM has appeared,and the features of PBR without PBM should soon be better understood. | Reiji Sugita | 2015 | World Journal of Hepatology2015，7，13： | 6 |
| 5 | Magnetic resonance evaluations of biliary malignancy and condition at high-risk for biliary malignancy:Current status显示文摘Tumors of the biliary tree are relatively rare; but their incidence is rising worldwide. There are several known risk factors for bile duct cancers, and these are seem to be associated with chronic inflammation of the biliary epithelium. Herein, 2 risk factors have been discussed, primary sclerosing cholangitis and reflux of pancreatic juice into the bile duct, as seen in such as an abnor- mal union of the pancreatic-biliary junction because magnetic resonance imaging(MRI) is used widely and effectively in the diagnosis of these diseases. When biliary disease is suspected, MRI can often help dif- ferentiate between benignity and malignancy, stage tumors, select surgical candidates and guide surgical planning. MRI has many advantages over other modali- ties. Therefore, MRI is a reliable noninvasive imaging tool for diagnosis and pre-surgical evaluation of bile duct tumors. Nowadays remarkable technical advances in magnetic resonance technology have expanded the clinical applications of MRI in case of biliary diseases. In this article, it is also discussed how recent develop- ments in MRI contributes to the diagnosis of the bile duct cancer and the evaluation of patients with risk fac- tors affecting bile duct cancer. | Reiji Sugita | 2013 | World Journal of Hepatology2013，5，12： | 5 |
| 6 | Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer显示文摘 | Minoru Oshima Keiichi Okano Shinobu Muraki Reiji Haba Takashi Maeba Yasuyuki Suzuki Shinichi Yachida | 2013 | Annals of Surgery2013，，2： | 4 |
| 7 | A novel extra-wide-angle–view colonoscope: a simulated pilot study using anatomic colorectal models显示文摘 | Toshio Uraoka Shinji Tanaka Takayuki Matsumoto Takahisa Matsuda Shiro Oka Tomohiko Moriyama Reiji Higashi Yutaka Saito | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 8 | High b-value diffusion-weighted MRI for detecting gallbladder carcinoma: preliminary study and results显示文摘 | Reiji Sugita Tetsuro Yamazaki Akemi Furuta Kei Itoh Naotaka Fujita Shoki Takahashi | 2009 | European Radiology2009，，7： | 2 |
| 9 | PiggyBac transposon-mediated gene delivery efficiently generates stable transfectants derived from cultured primary human deciduous tooth dental pulp cells(HDDPCs) and HDDPC-derived iPS cells显示文摘The ability of human deciduous tooth dental pulp cells(HDDPCs) to differentiate into odontoblasts that generate mineralized tissue holds immense potential for therapeutic use in the field of tooth regenerative medicine. Realization of this potential depends on efficient and optimized protocols for the genetic manipulation of HDDPCs. In this study, we demonstrate the use of a Piggy Bac(PB)-based gene transfer system as a method for introducing nonviral transposon DNA into HDDPCs and HDDPC-derived inducible pluripotent stem cells. The transfection efficiency of the PB-based system was significantly greater than previously reported for electroporation-based transfection of plasmid DNA. Using the neomycin resistance gene as a selection marker, HDDPCs were stably transfected at a rate nearly 40-fold higher than that achieved using conventional methods. Using this system, it was also possible to introduce two constructs simultaneously into a single cell. The resulting stable transfectants, expressing td Tomato and enhanced green fluorescent protein, exhibited both red and green fluorescence. The established cell line did not lose the acquired phenotype over three months of culture. Based on our results, we concluded that PB is superior to currently available methods for introducing plasmid DNA into HDDPCs. There may be significant challenges in the direct clinical application of this method for human dental tissue engineering due to safety risks and ethical concerns. However, the high level of transfection achieved with PB may have significant advantages in basic scientific research for dental tissue engineering applications, such as functional studies of genes and proteins. Furthermore, it is a useful tool for the isolation of genetically engineered HDDPC-derived stem cells for studies in tooth regenerative medicine. | Emi Inada Issei Saitoh Satoshi Watanabe Reiji Aoki Hiromi Miura Masato Ohtsuka Tomoya Murakami Tadashi Sawami Youichi Yamasaki Masahiro Sato | 2015 | International Journal of Oral Science2015，7，3： | 2 |
| 10 | Preparation and the functional properties of water extract and alkaline extract of royal jelly显示文摘 | Takeshi Nagai Reiji Inoue | 2003 | Food Chemistry2003，，2： | 2 |
| 11 | Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia显示文摘 | Masashi Ikeda Yoshio Yamanouchi Yoko Kinoshita Tsuyoshi Kitajima Reiji Yoshimura Shuji Hashimoto Michael C O&rsquor Donovan Jun Nakamura Norio Ozaki Nakao Iwata | 2008 | Pharmacogenomics2008，，10： | 1 |
| 12 | Detection of Verotoxigenic Escherichia coli O157 and O26 in food by plating methods and LAMP method: A collaborative study显示文摘 | Yukiko Hara-Kudo Noriko Konishi Kayoko Ohtsuka Reiji Hiramatsu Hiroyuki Tanaka Hirotaka Konuma Kosuke Takatori | 2007 | International Journal of Food Microbiology2007，，1： | 1 |
| 13 | Assessment of Coronary Artery Disease Using Magnetic Resonance Coronary Angiography显示文摘 | Shingo Kato Kakuya Kitagawa Nanaka Ishida Masaki Ishida Motonori Nagata Yasutaka Ichikawa Kazuhiro Katahira Yuji Matsumoto Koji Seo Reiji Ochiai Yasuyuki Kobayashi Hajime Sakuma | 2010 | Journal of the American College of Cardiology2010，，12： | 1 |
| 14 | Scavenging capacities of pollen extracts from cistus ladaniferus on autoxidation, superoxide radicals, hydroxyl radicals, and DPPH radicals显示文摘 | Takeshi Nagai Reiji Inoue Hachiro Inoue Nobutaka Suzuki | 2002 | Nutrition Research2002，，4： | 1 |
| 15 | Correlation of 18F-FLT and 18F-FDG uptake on PET with Ki-67 immunohistochemistry in non-small cell lung cancer显示文摘 | Yuka Yamamoto Yoshihiro Nishiyama Shinya Ishikawa Jun Nakano Sung Soo Chang Shuji Bandoh Nobuhiro Kanaji Reiji Haba Yoshio Kushida Motoomi Ohkawa | 2007 | European Journal of Nuclear Medicine and Molecular Imaging2007，，10： | 1 |
| 16 | Troglitazone(CS045) ameliorates albuminuria in streptozotocin induced diabetic rats显示文摘 | Mitsuhiro F Reiji T Makiko Y et ai | 1997 | Metabolism1997，46，： | 1 |
| 17 | Periamullary tumors; high-spatial resolution MR imaging and histopathologic findings in ampullary region specimens显示文摘 | Reiji S Akemi F Kei I | 2004 | Radiology2004，231，3： | 1 |
| 18 | Three dimensional deformation and stress distribution in an analytical/computational model of the anterior cruciate ligament 显示文摘 | Shunji H Reiji T | 2012 | J Biomech2012，33，9： | 1 |
| 19 | Current-source a-Si:H thin-film transistor circuit for active-matrix organic light-emitting displays显示文摘 | Reiji Hattori Jerzy Kanicki | 2000 | IEEE Electron Device Letters2000，21，12： | 1 |
| 20 | Automatic registration of MLS point clouds and SfM meshes of urban area显示文摘Recent advances in 3D scanning technologies allow us to acquire accurate and dense 3D scan data of large-scale environments efficiently.Currently,there are various methods for acquiring largescale 3D scan data,such as Mobile Laser Scanning(MLS),Airborne Laser Scanning,Terrestrial Laser Scanning,photogrammetry and Structure from Motion(SfM).Especially,MLS is useful to acquire dense point clouds of road and road-side objects,and SfM is a powerful technique to reconstruct meshes with textures from a set of digital images.In this research,a registration method of point clouds from vehicle-based MLS(MLS point cloud),and textured meshes from the SfM of aerial photographs(SfM mesh),is proposed for creating high-quality surface models of urban areas by combining them.In general,SfM mesh has non-scale information;therefore,scale,position,and orientation of the SfM mesh are adjusted in the registration process.In our method,first,2D feature points are extracted from both SfM mesh and MLS point cloud.This process consists of ground-and building-plane extraction by region growing,random sample consensus and least square method,vertical edge extraction by detecting intersections between the planes,and feature point extraction by intersection tests between the ground plane and the edges.Then,the corresponding feature points between the MLS point cloud and the SfM mesh are searched efficiently,using similarity invariant features and hashing.Next,the coordinate transformation is applied to the SfM mesh so that the ground planes and corresponding feature points are adjusted.Finally,scaling Iterative Closest Point algorithm is applied for accurate registration.Experimental results for three data-sets show that our method is effective for the registration of SfM mesh and MLS point cloud of urban areas including buildings. | Reiji Yoshimura Hiroaki Date Satoshi Kanai Ryohei Honma Kazuo Oda Tatsuya Ikeda | 2016 | Geo-Spatial Information Science2016，19，3： | 1 |
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