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| 1 | Epstein–Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature显示文摘A 19-year-old female was diagnosed with ulcerative colitis when she presented with persistent melena, and has been treated with 5-aminosalicylic acid for 4 years,with additional azathioprine for 2 years at our hospital.The patient experienced high-grade fevers, chills, and cough five d prior to presenting to the outpatient unit.At first, the patient was suspected to have developed neutropenic fever; however, she was diagnosed with Epstein-Barr virus-associated hemophagocytic syndrome(EB-VAHS) upon fulfilling the diagnostic criteria after bone marrow aspiration. When patients withinflammatory bowel disease treated with immunomodulators, such as thiopurine preparations, develop fever, EB-VAHS should be considered in the differential diagnosis. | Kazuya Miyaguchi Minoru Yamaoka Yoshikazu Tsuzuki Keigo Ashitani Hideki Ohgo Yoshitaka Miyagawa Keisuke Ishizawa Hidekazu Kayano Hidetomo Nakamoto Hiroyuki Imaeda | 2018 | World Journal of Clinical Cases2018，6，14： | 3 |
| 2 | Applicability of second‐generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study显示文摘 | Naoki Hosoe Katsuyoshi Matsuoka Makoto Naganuma Yosuke Ida Yuka Ishibashi Kayoko Kimura Kazuaki Yoneno Shingo Usui Kazuhiro Kashiwagi Tadakazu Hisamatsu Nagamu Inoue Takanori Kanai Hiroyuki Imaeda Haruhiko Ogata Toshifumi Hibi | 2013 | J Gastroenterol Hepatol2013，，7： | 3 |
| 3 | Percutaneous endoscopic gastrostomy under steadypressure automatically controlled endoscopy:First clinicalseries显示文摘AIM: To elucidate the safety of percutaneous endoscopic gastrostomy(PEG) under steady pressure automatically controlled endoscopy(SPACE) using carbon dioxide(CO_2).METHODS: Nine patients underwent PEG with a modified introducer method under conscious sedation. A T-tube was attached to the channel of an endoscope connected to an automatic surgical insufflator. The stomach was inflated under the SPACE system. The intragastric pressure was kept between 4-8 mmH g with a flow of CO_2 at 35 L/min. Median procedure time, intragastric pressure, median systolic blood pressure, partial pressure of CO_2, abdominal girth before and immediately after PEG, and free gas and small intestinal gas on abdominal X-ray before and after PEG were recorded. RESULTS: PEG was completed under stable pneumostomach in all patients, with a median procedural time of 22 min. Median intragastric pressure was 6.9 mmH g and median arterial CO_2 pressure before and after PEG was 42.1 and 45.5 Torr(NS). The median abdominal girth before and after PEG was 68.1 and 69.6 cm(NS). A mild free gas image after PEG was observed in two patients, and faint abdominal gas in the downstream bowel was documented in two patients.CONCLUSION: SPACE might enable standardized pneumostomach and modified introducer procedure of PEG. | Hiroyuki Imaeda Kiyokazu Nakajima Naoki Hosoe Masanori Nakahara Shinichiro Zushi Motohiko Kato Kazuhiro Kashiwagi Yasushi Matsumoto Kayoko Kimura Rieko Nakamura Norihito Wada Masahiko Tsujii Naohisa Yahagi Toshifumi Hibi Takanori Kanai Tetsuo Takehara Haruhiko Ogata | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 2 |
| 4 | Multicenter study of the long-term outcomes of endoscopic submucosal dissection for early gastric cancer in patients 80 years of age or older显示文摘 | Nobutsugu Abe Takuji Gotoda Toshiaki Hirasawa Shu Hoteya Kenji Ishido Yosuke Ida Hiroyuki Imaeda Eiji Ishii Atsushi Kokawa Chika Kusano Tadateru Maehata Satoshi Ono Hirohisa Takeuchi Masanori Sugiyama Shinichi Takahashi | 2012 | Gastric Cancer2012，，1： | 2 |
| 5 | Comparison of patient acceptance of sodium phosphate versus polyethylene glycol plus sodium picosulfate for colon cleansing in Japanese显示文摘 | Naoki Hosoe Manabu Nakashita Hiroyuki Imaeda Tomohisa Sujino Rieko Bessho Riko Ichikawa Nagamu Inoue Takanori Kanai Toshifumi Hibi Haruhiko Ogata | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 2 |
| 6 | In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope显示文摘 | Naoki Hosoe Taku Kobayashi Takanori Kanai Rieko Bessho Tetsuro Takayama Nagamu Inoue Hiroyuki Imaeda Yasushi Iwao Seiki Kobayashi Makio Mukai Haruhiko Ogata Toshifumi Hibi | 2010 | Gastrointestinal Endoscopy2010，，3： | 1 |
| 7 | Novel technique of endoscopic submucosal dissection by using external forceps for early rectal cancer (with videos)显示文摘 | Hiroyuki Imaeda Naoki Hosoe Yosuke Ida Hiromasa Nakamizo Kazuhiro Kashiwagi Takanori Kanai Yasushi Iwao Toshifumi Hibi Haruhiko Ogata | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 8 | Novel technique of endoscopic submucosal dissection by using external forceps for early rectal cancer (with videos)显示文摘 | Hiroyuki Imaeda Naoki Hosoe Yosuke Ida Hiromasa Nakamizo Kazuhiro Kashiwagi Takanori Kanai Yasushi Iwao Toshifumi Hibi Haruhiko Ogata | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 9 | Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia显示文摘AIM:To evaluate the effectiveness of trimodal imaging endoscopy(TME)to detect another lesion afterendoscopic submucosal dissection(ESD)for superficial gastric neoplasia(SGN).METHODS:Surveillance esophagogastroduodenoscopy(EGD)using a TME was conducted in 182 patients that had undergone ESD for SGN.Autofluorescence imaging(AFI)was conducted after white-light imaging(WLI).When SGN was suspicious,magnifying endoscopy with narrow-band imaging(ME-NBI)was conducted.Final diagnoses were made by histopathologic findings of biopsy specimens.The detection rates of lesions in WLI,AFI,and NBI,and the characteristics of lesions detected by WLI and ones missed by WLI but detected by AFI were examined.The sensitivity,specificity,and accuracy of endoscopic diagnosis using WLI,AFI and ME-NBI were evaluated.RESULTS:In 242 surveillance EGDs,27 lesions were determined pathologically to be neoplasias.Sixteen early gastric cancers and 6 gastric adenomas could be detected by WLI.Sixteen lesions were reddish and 6were whitish.Five gastric neoplasias were missed by WLI but were detected by AFI,and all were whitish and protruded gastric adenomas.There was a significant difference in color and pathology between the two groups(P=0.006).Sensitivity,specificity and accuracy in MENBI were higher than those in both WLI and AFI.Specificity and accuracy in AFI were lower than those in WLI.CONCLUSION:Surveillance using trimodal imaging endoscopy might be useful for detecting another lesion after endoscopic submucosal dissection for superficial gastric neoplasia. | Hiroyuki Imaeda Naoki Hosoe Kazuhiro Kashiwagi Yosuke Ida Rieko Nakamura Hidekazu Suzuki Yoshimasa Saito Naohisa Yahagi Yasushi Iwao Yuko Kitagawa Toshifumi Hibi Haruhiko Ogata Takanori Kanai | 2014 | World Journal of Gastroenterology2014，20，43： | 1 |
| 10 | In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope显示文摘 | Naoki Hosoe Taku Kobayashi Takanori Kanai Rieko Bessho Tetsuro Takayama Nagamu Inoue Hiroyuki Imaeda Yasushi Iwao Seiki Kobayashi Makio Mukai Haruhiko Ogata Toshifumi Hibi | 2010 | Gastrointestinal Endoscopy2010，，3： | 1 |
| 11 | Irritable bowel syndrome evaluation using computed tomography colonography显示文摘AIM To evaluate the morphology of the colon in patients with irritable bowel syndrome(IBS) by using computed tomography colonography(CTC).METHODS Twelve patients with diarrhea type IBS(IBS-D), 13 patients with constipation type IBS(IBS-C), 12 patients with functional constipation(FC) and 14 control patients underwent colonoscopy following CTC. The lengths of the rectosigmoid colon, transverse colon and the total colon were measured. The diameters of the rectum, sigmoid colon, descending colon, transverse colon, and ascending colon were measured.RESULTS The mean length of the total colon was 156.5 cm in group C, 158.9 cm in group IBS-D, 172.0 cm in group IBS-C, and 188.8 cm in group FC. The total colon in group FC was significantly longer than that in group C(P < 0.05). The mean length of the rectosigmoid colon was 56.2 cm, 55.9 cm, 63.6cm, and 77.4 cm(NS). The mean length of the transverse colon was 49.9 cm, 43.1 cm, 57.0 cm, and 55.0 cm. The transverse colonin group IBS-D was significantly shorter than that in group IBS-C(P < 0.01) and that in group FC(P = 0.02). The mean diameter of the sigmoid colon was 4.0 cm, 3.3 cm, 4.2 cm, and 4.3 cm(NS). The mean diameter of the descending colon was 3.6 cm, 3.1 cm, 3.8 cm, and 4.3 cm. The descending colon diameter in group IBS-D was significantly less than that in group IBS-C(P = 0.03) and that in group FC(P < 0.001). The descending colon diameter in group FC was significantly greater than that in group C(P = 0.04). The mean diameter of the transverse colon was 4.4 cm, 3.3 cm, 4.2 cm, and 5.0 cm(NS).CONCLUSION CT colonography might contribute the clarification of subtypes of IBS. | Hideki Ohgo Hiroyuki Imaeda Minoru Yamaoka Kazuaki Yoneno Naoki Hosoe Takeshi Mizukami Hidetomo Nakamoto | 2016 | World Journal of Gastroenterology2016，22，42： | 0 |
| 12 | Artificial intelligence for endoscopy显示文摘In recent times,there has been progressive development in artificial intelligence(AI)following the introduction of deep learning in the medical field including gastroenterology and endoscopy.Most of the reported studies were based on retrospective data.Several prospective studies of real-time diagnosis of moving images using the AI system are expected to match the real clinical situation and to aid the endoscopists in the detection and diagnosis of neoplasms without missing any lesion.AI can read a large number of endoscopic images in a few minutes and make a diagnosis;therefore,it is expected to cover the lack of support for the screening esophagogastroduodenoscopy in the health check-up and a large number of capsule images,thereby freeing the endoscopists from this burden.AI can help make the diagnosis during the endoscopic procedure and thereby prevent an unnecessary biopsy for patients taking antithrombotic drugs.AI can also be useful for education and training in endoscopy.Trainees can learn to perform endoscopy and the detection and diagnosis of lesions by the support of AI.In the near future,real-time endoscopic diagnosis using AI is expected to lessen the burden of endoscopists,to enhance the quality level of endoscopists,to overcome the miss of lesions and to make optimal diagnosis. | Hiroyuki Imaeda Yoshikazu Tsuzuki Kazuya Miyaguchi Keigo Ashitani Hideki Ohgo Hidetomo Nakamoto | 2019 | World Journal of Meta-Analysis2019，7，7： | 0 |
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