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| 1 | p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy显示文摘AIM: Esophageal squamous cell carcinoma is generally sensitive to chemoradiotherapy (CRT), but some cases are not. Using a retrospective analysis, we aimed to identify the predictors of the response by esophageal squamous cell carcinoma to definitive CRT.METHODS: The intensities of expression of p53, Ki67,Bcl-2, Bax, cyclin D1, VEGF, CDC25B, and metallothionein (MT)were evaluated immunohistochemically in the biopsy specimens obtained before CRT, and the intensities of their expression were tested for correlations with the clinical effects of CRT.RESULTS: The esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expression were found to be significantly more sensitive to CRT. In addition, p53 positivity and CDC25B positivity respomd well to CRT.CONCLUSION: Esophageal squamous cell carcinomas with negative p53,positive CDC25B, and negative MT expressions respond well to CRT. Even with p53 positivity,if with CDC25B positivity, CRT can be expected. | Fumiko Sunada Masayuki Itabashi Hisanao Ohkura Toshiyuki Okumura | 2005 | World Journal of Gastroenterology2005，11，36： | 13 |
| 2 | 早胃的癌症用的程度的诊断灵活光谱成像颜色改进显示文摘 The demarcation line between the cancerous lesion and the surrounding area could be easily recognized with flexible spectral imaging color enhancement (FICE) system compared with conventional white light images. The characteristic f inding of depressed-type early gastric cancer (EGC) in most cases was revealed as reddish lesions distinct from the surrounding yellowish non-cancerous area without magnification. Conventional endoscopic images provide little information regarding depressed lesions located in the tangential line, but FICE produces higher color contrast of such cancers. Histological f indings in depressed area with reddish col- or changes show a high density of glandular structure and an apparently irregular microvessel in intervening parts between crypts, resulting in the higher color con- trast of FICE image between cancer and surrounding area. Some depressed cancers are shown as whitish lesion by conventional endoscopy. FICE also can pro- duce higher color contrast between whitish cancerous lesions and surrounding atrophic mucosa. For nearly flat cancer, FICE can produce an irregular structuralpattern of cancer distinct from that of the surrounding mucosa, leading to a clear demarcation. Most elevated-type EGCs are detected easily as yellowish lesions with clearly contrasting demarcation. In some cases, a partially reddish change is accompanied on the tumor surface similar to depressed type cancer. In addition, the FICE system is quite useful for the detection of minute gastric cancer, even without magnif ication. These new contrasting images with the FICE system may have the potential to increase the rate of detection of gastric cancers and screen for them more effectively as well as to determine the extent of EGC. | Hiroyuki Osawa Hironori Yamamoto Yoshimasa Miura Mitsuyo Yoshizawa Keijiro Sunada Kiichi Satoh Kentaro Sugano | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 11 |
| 3 | Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine显示文摘AIM: To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine.METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, Japan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis.RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm.CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel. | Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori Yano Hiroyuki Sato Yoshikazu Hayashi Tomohiko Miyata Yutaka Sekine Akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 4 | Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy显示文摘AIM: To clarify clinical features of the NSAID-induced small bowel lesions using a new method of endoscopy.METHODS: This is a retrospective study and we analyzed seven patients with small bowel lesions while taking NSAIDs among 61 patients who had undergone doubleballoon endoscopy because of gastro-intestinal bleeding or anemia between September 2000 and March 2004, at Jichi Medical School Hospital in Japan. Neither conventional EGD nor colonoscopy revealed any lesions of potential bleeding sources including ulcerations. Double-balloon endoscopy was carried out from oral approach in three patients, from anal approach in three patients, and from both approaches in one patient.RESULTS: Ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively.The ulcers were multiple in all the patients with different features from tiny punched out ulcers to deep ulcerations with oozing hemorrhage or scar. All the patients recovered uneventfully and had full resolution of symptoms after suspension of the drug.CONCLUSION: NSAIDs can induce injuries in the small bowel even in patients without any lesions in both the stomach and colon. | Yoshikazu Hayashi Hironori Yamamoto Hiroto Kita Keijiro Sunada Hiroyuki Sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Takaaki Iwaki Yoshiyuki Kawamura Hironari Ajibe Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，31： | 6 |
| 5 | Laterally spreading tumors:Limitations of computed tomography colonography显示文摘AIM:To prospectively investigate the detection rate of laterally spreading tumors(LSTs)of the colorectum by computed tomography(CT)colonography(CTC).METHODS:Patients with LSTs measuring≥20 mm detected during colonoscopy were prospectively enrolled in the study.All patients underwent colonoscopy and subsequent CTC on the same day.CTC was performed using multi-detector CT without contrast in the prone and supine positions.Two radiologists blinded to the existence of LSTs read the virtual endoscopic images as well as 2-D images.LSTs were classified into granular and non-granular types based on colonoscopic appearance.RESULTS:Forty-seven pathologically proven LSTs were evaluated prospectively.Histology included adenomas in 19,mucosal cancers in 19 and T1 cancers in 9.The mean diameter of the LSTs was 35.1 mm.Twenty-eight(60%)LSTs were correctly identified by CTC,and the configuration was similar to the colonoscopic appearance in most cases.Detection rate for the granular type was significantly higher than that for the nongranular type(71%vs 31%,P=0.013).Detection rate of adenomas was significantly lower than mucosal cancers(32%vs 79%,P=0.008)and T1 cancers(32%vs 78%,P=0.042).CONCLUSION:The detection rate of LSTs by CTC,particularly the non-granular type was not acceptable.Practitioners should be aware of the relatively low detection rate when using CTC. | Kazutomo Togashi Kenichi Utano Shigeyoshi Kijima Yosuke Sato Hisanaga Horie Keijirou Sunada Alan T Lefor Hideharu Sugimoto Yoshikazu Yasuda | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 6 | Endoscopic submucosal dissection using sodium hyaluronate, a new technique for en bloc resection of a large superficial tumor in the colon显示文摘 | H. Kita H. Yamamoto T. Miyata K. Sunada M. Iwamoto T. Yano M. Yoshizawa K. Hanatsuka M. Arashiro T. Omata K. Sugano | 2007 | Inflammopharmacology2007，，3： | 3 |
| 7 | Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small-intestinal diseases显示文摘 | Hironori Yamamoto Hiroto Kita Keijiro Sunada Yoshikazu Hayashi Hiroyuki Sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Hironari Ajibe Kenichi Ido Kentaro Sugano | 2004 | Clinical Gastroenterology and Hepatology2004，，11： | 2 |
| 8 | Universal single-mode lasing in fully chaotic two-dimensional microcavity lasers under continuous-wave operation with large pumping power [Invited]显示文摘For a fully chaotic two-dimensional(2D) microcavity laser, we present a theory that guarantees both the existence of a stable single-mode lasing state and the nonexistence of a stable multimode lasing state, under the assumptions that the cavity size is much larger than the wavelength and the external pumping power is sufficiently large. It is theoretically shown that these universal spectral characteristics arise from the synergistic effect of two different kinds of nonlinearities: deformation of the cavity shape and mode interaction due to a lasing medium. Our theory is based on the linear stability analysis of stationary states for the Maxwell–Bloch equations and accounts for single-mode lasing phenomena observed in real and numerical experiments of fully chaotic 2D microcavitylasers. | TAKAHISA HARAYAMA SATOSHI SUNADA SUSUMU SHINOHARA | 2017 | Photonics Research2017，5，6： | 2 |
| 9 | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness显示文摘 | Takayuki Kondo Masashi Asai Kayoko Tsukita Yumiko Kutoku Yutaka Ohsawa Yoshihide Sunada Keiko Imamura Naohiro Egawa Naoki Yahata Keisuke Okita Kazutoshi Takahashi Isao Asaka Takashi Aoi Akira Watanabe Kaori Watanabe Chie Kadoya Rie Nakano Dai Watanabe Kei | 2013 | Cell Stem Cell2013，，4： | 2 |
| 10 | Successful En-Bloc Resection of Large Superficial Tumors in the Stomach and Colon Using Sodium Hyaluronate and Small-Caliber-Tip Transparent Hood显示文摘 | H. Yamamoto H. Kawata K. Sunada A. Sasaki K. Nakazawa T. Miyata Y. Sekine T. Yano K. Satoh K. Ido K. Sugano | 2003 | Endoscopy2003，，08： | 2 |
| 11 | 湄公河流域人口增长与自然资源压力显示文摘湄公河流域拥有该地区最大的潜在水资源及相关资源,这些支撑着正在进行的经济发展和流域内的社区生计。当前,它正在见证一个巨大的人口转变,这个转变既创造了机会,也带来了挑战。通过对人口结构变化及其对自然资源基础的影响之间复杂关系的分析,我们证实了开采资源不仅仅是为了满足内需增长,也为了其它既得利益。无论是现在还是在将来,人口和其它主要驱动力一起,如制度、市场和技术等,将对湄公河流域丰富资源的开发和分配方式产生很强的影响。湄公河流域丰富的资源,以及从中获得的利益在时间和空间上的分布都不是均衡的。此外,由于起因和影响与政治界限无关,所以湄公河流域国家需要共同制定可替代的管理策略,从而在湄公河流域自然资源基础所能承受的范围之内,满足预计的需求。 | Sokhem Pech Kengo Sunada 刘琪(译) 王大伟(译) | 2008 | AMBIO-人类环境杂志2008，37，3： | 2 |
| 12 | Double-balloon endoscopy: past, present, and future显示文摘 | Keijiro Sunada Hironori Yamamoto | 2009 | Journal of Gastroenterology2009，，1： | 2 |
| 13 | Double‐balloon endoscopy in clinical practice: Where are we now?显示文摘 | Emanuele Rondonotti Keijiro Sunada Tomonori Yano Silvia Paggi Hironori Yamamoto | 2012 | Digestive Endoscopy2012，，4： | 2 |
| 14 | Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate显示文摘 | Hironori Yamamoto Hiroshi Kawata Keijiro Sunada Kiichi Satoh Yoshinari Kaneko Kenichi Ido Kentaro Sugano | 2002 | Gastrointestinal Endoscopy2002，，4： | 2 |
| 15 | Nonsurgical management of small-bowel polyps in Peutz–Jeghers syndrome with extensive polypectomy by using double-balloon endoscopy显示文摘 | Hirotsugu Sakamoto Hironori Yamamoto Yoshikazu Hayashi Tomonori Yano Tomohiko Miyata Naoyuki Nishimura Hakuei Shinhata Hiroyuki Sato Keijiro Sunada Kentaro Sugano | 2011 | Gastrointestinal Endoscopy2011，，2： | 2 |
| 16 | Repair Effect of Hot Work Tool Steel by Laser-Melting Process显示文摘Both wear and crack due to heat checking in hot work tool steel are major failure modes. It is desirable to find amethod to lengthen the tool life while reducing manufacturing cost. This paper suggests a method to improve toollife for hot work tool steel (SKD6) with crack by laser-melting process. The method has been evaluated using theimpact and fatigue test results. It is demonstrated that a repair of the crack by a laser-melting process is effectivefor life extension of the damaged tool. | Yahong SUN Satoshi HANAKI Hitoshi UCHIDA Hisakichi SUNADA Nobuhiro TSUJII | 2003 | Journal of Materials Science & Technology2003，19，z1： | 2 |
| 17 | Slitventricle syndrome aftercyst-peritonealshunt ing fortempo- ralarachnoid cystin children-a clinicalentity difficultto detecton neuroimaging study 显示文摘 | Sunami K Saeki N Sunada S | 2002 | Brain Dev2002，，24： | 1 |
| 18 | Influence of formulation change on drug release kinetics from hydroxypropylmethylcellulose matrix tablets 显示文摘 | Xu Gj Sunada H | 1995 | Chem Pharm Bull1995，43，3： | 1 |
| 19 | Effect of Si and Al Content on Core Loss in Fe-Si-Al Powder Cores显示文摘 | Yanagimoto K Majima K Sunada S | 2004 | IEEE Trans Magn2004，40，3： | 1 |
| 20 | Electrical Conductivity and Electromagnetic Interference Shielding Efficiency of Carbon Nanotubecellulose Composite Paper显示文摘 | Fugetsu B Sano E Sunada M | 2008 | Carbon2008，46，9： | 1 |
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