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77篇 您的检索式:作者名="Han Ben"
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1Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics显示文摘An amphiphilic polymer bearing tetraphenylethene (TPE) moiety was synthesized by convenient reactions. The polymer exhibits unique aggregation-induced emission (AIE) characteristics and can self-assemble to size-tunable particles in DMF/water mixtures. The polymer nanoparticles can be used for cell imaging, which provides a potential stable fluorescent tool to monitor the distribution of drugs and bioconjugates in living cells.QIN AnJun ZHANG Ya HAN Ning MEI Ju SUN JingZhi FAN WeiMin TANG Ben Zhong 2012Science China Chemistry2012,55,5:16
22018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI显示文摘East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed.Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen Guosheng Fu Yundai Chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-Soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge 2019Science Bulletin2019,64,3:12
3A comparative study of totally laparoscopic distal gastrectomy versus laparoscopic-assisted distal gastrectomy in gastric cancer patients: Short-term operative outcomes at a high-volume center显示文摘Objective: Laparoscopic gastrectomy has been established as a standard treatment for early gastric cancer, and its use is increasing recently. Compared with the conventional laparoscopy-assisted distal gastrectomy(LADG), totally laparoscopic distal gastrectomy(TLDG) involves intracorporeal reconstruction, which can avoid the additional incision, resulting in pain reduction and early recovery. This study aimed to compare the short-term postoperative outcomes of TLDG vs. LADG in gastric cancer in a high-volume center.Methods: A retrospective cohort study was conducted on 1,322 patients who underwent laparoscopic distal gastrectomy from June 2012 to June 2017 at the National Cancer Center, Korea. LADG was performed in the early period before July 2015, and TLDG was applied in the later period. Postoperative short-term outcomes were compared in terms of complication and clinical course between the two groups. Pain score was measured by rating the pain intensity from 0 to 10 points on postoperative day(POD) 1 and 3.Results: A total of 667 patients underwent LADG and 655 patients underwent TLDG. Clinicopathologic characteristics were not different in both groups. Intraoperative estimated blood loss(EBL) was significantly lower in the TLDG group(P<0.001). Postoperative pain scores were significantly lower in the TLDG group than in the LADG group on POD 1(5.1±1.5 vs. 4.8±1.4, P=0.015). First flatus passage after operation was significantly earlier in the TLDG group(3.4±0.8 d vs. 3.2±0.6 d, P<0.001). There were no differences in postoperative complications and hospital stay between the two groups.Conclusions: Based on the reported short-term postoperative outcomes, TLDG is safe and feasible as well as LADG. Moreover, compared with LADG, TLDG can reduce intraoperative EBL and postoperative pain and enhance the bowel motility in gastric cancer surgery.Won Ho Han Amir Ben Yehuda Deok-Hee Kim Seung Geun Yang Bang Wool Eom Hong Man Yoon Young-Woo Kim Keun Won Ryu 2018Chinese Journal of Cancer Research2018,30,5:11
4Flame-retardant concentrated electrolyte enabling a Li F-rich solid electrolyte interface to improve cycle performance of wide-temperature lithium–sulfur batteries显示文摘Lithium–sulfur batteries have been regarded as the most promising high-energy electrochemical energy storage device owing to the high energy density, low cost and environmental friendliness. However, traditional lithium–sulfur batteries using ether-based electrolytes often suffer from severe safety risks(i.e. combustion). Herein, we demonstrated a novel kind of flame-retardant concentrated electrolyte(6.5 M lithium bis(trifluoromethylsulphonyl)imide/fluoroethylene carbonate) for highly-safe and widetemperature lithium–sulfur batteries. It was found that such concentrated electrolyte showed superior flame retardancy, high lithium-ion transference number(0.69) and steady lithium plating/stripping behavior(2.5 m Ah cm^(-2) over 3000 h). Moreover, lithium–sulfur batteries using this flame-retardant concentrated electrolyte delivered outstanding cycle performance in a wide range of temperatures(-10 °C, 25 °C and 90 °C). This superior battery performance is mainly attributed to the LiF-rich solid electrolyte interphase formed on lithium metal anode, which can effectively suppress the continuous growth of lithium dendrites. Above-mentioned fascinating characteristics would endow this flame-retardant concentrated electrolyte a very promising candidate for highly-safe and wide-temperature lithium–sulfur batteries.Zhe Yu Jianjun Zhang Chao Wang Rongxiang Hu Xiaofan Du Ben Tang Hongtao Qu Han Wu Xin Liu Xinhong Zhou Xiaoyan Yang Guanglei Cui 2020Journal of Energy Chemistry2020,29,12:7
5Flame-retardant quasi-solid polymer electrolyte enabling sodium metal batteries with highly safe characteristic and superior cycling stability显示文摘Con ventio nal liquid electrolytes based sodium metal batteries suffer from severe safety hazards owing to electrolyte leakage,in flammability and dendritic sodium deposit!on.Herein,we report a flame-retardant quasi-solid polymer electrolyte with poly(methyl vinyl ether-alt-maleic an hydride)(P(MVE-alt-MA))as host,bacterial cellulose(BC)as reinforceme nt,and triethyl phosphate/vinyle ne carb on ate/sodium perchlorate(TEP/VC/NaClO4)as plasticizer for highly safe sodium metal batteries.The as-obtained quasi-solid polymer electrolyte exhibits superior flame retardancy(self-extinguish within 1 s),complete non-leakage property and wide electrochemical windows(4.4 V).More importantly,Na3V2(PO4)3/Na metal batteries using such polymer electrolyte delivers superior I on g-term cycli ng stability(84.4%capacity rete ntion after 1000 cycles)which is significantly better than that(only 2%after 240 cycles)of liquid electrolyte.In addition,this flame-retardant quasi-solid polymer electrolyte provides favorable cycle performance(80.2%capacity retention after 70 cycles at 50°C and 84.8%capacity retention after 50 cycles at-10°C)for Na3V2(PO4)3/Na metal batteries.And this battery also displayed a normal charge/discharge property even at-15°C.These fascinating cycle properties are mainly ascribed to the effective pro怕ctive layers formed on Na3V2(PC>4)3 cathode and sodium metal ano de.More thorough in vestigati on elucidates that such flame-retardant quasi-solid polymer electrolyte plays a multif unctional role in the adva need sodium metal batteries:(1)being in volved in the formatio n of a favorable cathode electrolyte in terface(CEI)to inhibit the dissolutio n of van adium and maintai n the structure integrity of the Na3V2(PO4)3;(2)participati ng in building a stable solid electrolyte in terface(SEI)to suppress the growth of Na dendrites;(3)integrating flame-retardanee into polymer sodium batteries to enhance flame-resistanee,eliminate electrolyte leakage,and thus improve safety of sodium batteries.Based on these results,we further assembled Na3V2(PO4)3/MoS2 pouch cell which can withsta nd harsh conditions(be nded or cut off a corn er),confirming the obtai ned polymer electrolyte with superior non-leakage property.In all,these outstanding characteristics would endow this flame-retardant quasi-solid polymer electrolyte a very promising can didate for highly-safe sodium metal batteries.Jinfeng Yang Min Zhang Zheng Chen Xiaofan Du Suqi Huang Ben Tang Tiantian Dong Han Wu Zhe Yu Jianjun Zhang Guanglei Cui 2019Nano Research2019,12,9:4
6Prospective study found that peripheral lymph node sampling reduced the false-negative rate of sentinel lymph node biopsy for breast cancer显示文摘Background:Although sentinel lymph node biopsy(SLNB) can accurately predict the status of axillary lymph node(ALN) metastasis,the high false?negative rate(FNR) of SLNB is still the main obstacle for the treatment of patients who receive SLNB instead of ALN dissection(ALND).The purpose of this study was to evaluate the clinical significance of SLNB combined with peripheral lymph node(PLN) sampling for reducing the FNR for breast cancer and to discuss the effect of 'skip metastasis' on the FNR of SLNB.Methods:At Shandong Cancer Hospital Affiliated to Shandong University between March 1,2012 and June 30,2015,the sentinel lymph nodes(SLNs) of 596 patients with breast cancer were examined using radiocolloids with blue dye tracer.First,the SLNs were removed;then,the area surrounding the original SLNs was selected,and the visible lymph nodes in a field of 3–5 cm in diameter around the center(i.e.,PLNs) were removed,avoiding damage to the structure of the breast.Finally,ALND was performed.The SLNs,PLNs,and remaining ALNs underwent pathologic examination,and the relationship between them was analyzed.Results:The identification rate of SLNs in the 596 patients was 95.1%(567/596);the metastasis rate of ALNs was 33.7%(191/567);the FNR of pure SLNB was 9.9%(19/191);and after the SLNs and PLNs were eliminated,the FNR was 4.2%(8/191),which was significantly decreased compared with the FNR before removal of PLNs(P Aected number(N) of SLNs,the patients were divided into four groups of N = 0.028).ccording to the det= 1,2,3,and ≥4;the FNR in these groups was 19.6,9.8,7.3,and 2.3%,respectively.For the patients with removal of PLNs was significantly decreased compared with that before remo≤2 or val of P≤3 detected SLNs,the FNR afterLNs(N 3:12.2% vs.4.7%,P ≤ 2:14.0% vs.4.7%,P = 0.019;N ≤ nt(P = 0.021),whereas for patients with ≥4 detected SLNs,the decrease in FNR was not statistically significa= 1.000).In the entire cohorts,the 'skip metastasis' rate was 2.5%(15/596);the FNR caused by 'skip metastasis' was 2.1%(4/191).Conclusions:The FNR of SLNB was associated with the number of SLNs.For patients with mpling can reduce the FNR of SLNB to an acceptable level of less than 5%.Because of the≤3 detected SLNs,PLN sa existence of the 'skip metastasis' and distinct metastasis patterns,the FNR of SLNB cannot be completely eliminated.Chao Han Ben Yang Wen-Shu Zuo Yan-Song Liu Gang Zheng Li Yang Mei-Zhu Zheng 2016Chinese Journal of Cancer2016,35,6:4
7Efficacy and safety of drug-eluting stent implantation for the treatment of in-stent restenosis occurring within bare-metal stent and drug-eluting stent显示文摘Objective:Although drug-eluting stent(DES) implantation is the primary treatment modality for bare-metal stent(BMS) in-stent restenosis(ISR),little is known about the efficacy and safety profile of DES in the treatment of DES-ISR.The goal of this study was to compare the clinical outcomes following DES treatment for BMS-ISR and DES-ISR.Methods:Rates of major adverse cardiac events(MACE) were compared in 97 consecutive patients who underwent DES implantation for the treatment of ISR(56 BMS-ISR and 41 DES-ISR) from January 2004 to December 2008.Results:Baseline clinical and procedural characteristics were comparable,except that the DES used in the BMS-ISR group was longer and had a larger diameter.The length of follow-up was(28.60±1.96) and(20.34±1.54) months for the BMS-ISR and DES-ISR groups,respectively.One patient(1.8%) experienced non-cardiac mortality and one(1.8%) had target-vessel revascularization(TVR) in the BMS-ISR group.In the DES-ISR group,three patients(7.3%) died of sudden death with a documented acute ST-segment elevation myocardial infarction,and three suffered TVR(7.3%).Kaplan-Meier analysis indicated that cumulative survival probability and MACE-free probability were both significantly lower for the DES-ISR group(log rank test P=0.047 and P=0.005,respectively).In Cox regression analysis,DES-ISR remained an independent predictor for future MACE occurrence after adjustment for other factors(compared with BMS-ISR,risk ratio(RR)=8.743,95% confidence interval(CI) 1.54-49.54,P=0.014).Switching to a different type of DES to treat DES-ISR did not improve the prognosis.Conclusion:DES-ISR patients had a poorer prognosis than BMS-ISR patients after DES therapy.Heng GE Qing ZHANG WeiZHOU Qing HE Zhi-hua HAN Ben HE 2010Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010,11,8:3
8Investigation on the interface of Cu/Al couples during isothermal heating显示文摘The evolutionary process and intermetallic compounds of Cu/Al couples during isothermal heating at a constant bonding temperature of 550°C were investigated in this paper. The interfacial morphologies and microstructures were examined by optical microscopy, scanning electron microscopy equipped with energy dispersive X-ray spectroscopy, and X-ray diffraction. The results suggest that bonding is not achieved between Cu and Al at 550°C in 10 min due to undamaged oxide films. Upon increasing the bonding time from 15 to 25 min, however, metallurgical bonding is obtained in these samples, and the thickness of the reactive zone varies with holding time. In the interfacial region, the final microstructure consists of Cu9Al4, CuAl, CuAl2, and α-Al + CuAl2. Furthermore, these results provide new insights into the mechanism of the interfacial reaction between Cu and Al. Microhardness measurements show that the chemical composition exerts a significant influence on the mechanical properties of Cu/Al couples.Yan-qiu Han Li-hua Ben Jin-jin Yao Shu-wei Feng Chun-jing Wu 2015International Journal of Minerals,Metallurgy and Materials2015,22,3:3
9Carbonation of calcium-containing mineral and industrial by-products显示文摘The use of carbon dioxide(CO_(2))and calciumcontaining by-products from industrial activities is receiving increasing interest as a route to valuable carbonate materials while reducing CO_(2) emissions and saving natural resources.In this work,wet-chemical experimental data was assessed,which involved the carbonation of three types of materials in aqueous solutions,namely,1)wollastonite,a calcium silicate mineral,2)steelmaking slag,a by-product of steel production,and 3)paper bottom ash(PBA)from waste paper incineration.Aims were to achieve either a high carbonation degree and/or a pure carbonate product with potential commercial value.Producing a pure precipitated calcium carbonate(PCC)material that may find use in paper industry products puts strong requirements on purity and brightness.The parameters investigated were particle size,CO_(2)pressure,temperature,solid/liquid ratio,and the use of additives that affect the solubilities of CO_(2)and/or calcium carbonate.Temperatures and pressures were varied up to 180℃and 4 MPa.Data obtained with the wollastinite mineral allowed for a comparison between natural resources and the industrial by-product materials,the latter typically being more reactive.With respect to temperature and pressure trends reported by others were largely confirmed,with temperatures above 150℃introducing thermodynamic limitations depending on CO_(2)pressure.The influence of additives showed some promise,although costs may make recycling and reuse of additives a necessity for a largescale process.When using steelmaking slag,magnetic separation may remove some iron-containing material from the process(although this is far from perfect),while the addition of bicarbonate supported the removal of phosphorous,aside from improving calcium extraction.The experiments with paper bottom ash(PBA)gave new data,showing that its reactivity resembles that of steelmaking slag,while its composition results in relatively pure carbonate product.Also,with PBA no additives were needed to achieve this.Ron ZEVENHOVEN Anders WIKLUND Johan FAGERLUND Sanni ELONEVA Ben IN’T VEEN Hans GEERLINGS Gert VAN MOSSEL Harold BOERRIGTER 2010Frontiers of Chemical Science and Engineering2010,4,2:2
10Nutrition Education for Cancer Patients:Theory,Programs,Evaluation,and Future Perspectives显示文摘Nutrition education is an essential component of nutrition intervention and a preferred method of nutrition therapy.Although the development of nutrition education programs for cancer patients follows the basic principles of nutrition education for the general population,it includes more targeted points and is richer in its contents.Such a program should include,but is not limited to,the following ten aspects:1)answer questions from the patient/family/caregivers;2)outline the aims of obtaining a nutrition diagnosis;3)provide dietary nutrition and function evaluations;4)review laboratory and instrumental tests;5)provide dietary and nutrition suggestions;6)clarify cancer pathophysiology;7)schedule nutrition intervention(s);8)explain the possible complications of nutrition intervention and provide solutions;9)predict the outcome of nutrition intervention;10)plan and carry out nutrition follow-up.Studies have shown that providing nutrition education for cancer patients is an economical,practical,and effective measure in clinical oncology.The purpose of nutrition education is not only to impart knowledge about diet and nutrition,but also to train the patients on how to improve their nutrition status,modulate eating behavior,and form good habits regarding diet and nutrition.Therefore,nutrition education is a long-term process.Due to the high malnutrition rates and the complex causes and outcomes,cancer patients need long-term and comprehensive nutrition education,aiming to shorten the length of hospital stay,reduce the complications of both the disease and its treatments,improve clinical outcomes,and finally improve the quality of life and survival.Han Ping Shi Qian Kun Zhu Xin Wang Wen Zhi Zhao Ben Qiang Rao Bo Jiang Yong Bing Chen Zhan Zhi Zhang Xiao Wei Zhang 2018Journal of Nutritional Oncology2018,3,3:2
11Facile Synthesis of Functional Poly(methyltriazolylcarboxylate)s by Solvent-and Catalyst-free Butynoate-Azide Polycycloaddition显示文摘The copper-catalyzed and metal-free azide-alkyne click polymerizations have become efficient tools for polymer synthesis. However,the 1,3-dipolar polycycloadditions between internal alkynes and azides are rarely employed to construct functional polymers. Herein, the polycycloadditions of dibutynoate(1) and tetraphenylethene-containing diazides(2) were carried out at 100 °C for 12 h under solvent-and catalyst-free conditions, producing soluble poly(methyltriazolylcarboxylate)s(PMTCs) with high molecular weights in high yields. The resultant polymers were thermally stable with 5% weight loss temperatures up to 377 °C. The PMTCs showed aggregation-induced emission(AIE)properties. They could work as fluorescent sensors for detecting explosive with high sensitivity, and generate two-dimensional fluorescent photopatterns with high resolution. Furthermore, their triazolium salts could be utilized for cell-imaging applications.Wei-Wen Chi Rong-Yuan Zhang Ting Han Jian Du Hong-Kun Li Wei-Jie Zhang Yong-Fang Li Ben Zhong Tang 2020Chinese Journal of Polymer Science2020,38,1:2
12Synthesis of Functional Hyperbranched Poly(methyltriazolylcarboxylate)s by Catalyst-free Click Polymerization of Butynoates and Azides显示文摘Azide-alkyne click polymerization has become a powerful tool for polymer synthesis.However,the click polymerization between internal alkynes and azides is rarely utilized to prepare functional polymers.In this work,the polymerization reactions of activated internal alkyne monomers of tris(2-butynoate)s(1)with tetraphenylethene-containing diazides(2)were performed in dimethylformamide(DMF)under simple heating,affording four hyperbranched poly(methyltriazolylcarboxylate)s(hb-PMTCs)with high molecular weights(A4W up to 2.4 x 104)and regioregularities(up to 83.9%)in good yields.The hb-PMTCs are soluble in common organic solvents,and thermally stable with 5%weight loss temperatures up to 400℃.They are non-emissive in dilute solution,but become highly emissive in aggregated state,exhibiting aggregationinduced emission characteristics.The polymers can generate fluorescent photopatterns with high resolution,and can work as fluorescent sensors to detect nitroaromatic explosive with high sensitivity.Mu-Ning Lang Wei-Wen Chi Ting Han Qing-Zhen Zhao Hong-Kun Li Ben Zhong Tang Yong-Fang Li 2020Chinese Journal of Polymer Science2020,38,11:2
13Microstructural characterization of Cu/Al composites and effect of cooling rate at the Cu/Al interfacial region显示文摘Cu/Al composites are of vital importance in industrial applications because of their numerous advantages.The influence of bonding temperature and cooling rate on the microstructure and morphology of Cu/Al composites was investigated in this paper.The interfacial morphology and constituent phases at the Cu/Al interface were analyzed by optical microscopy and field-emission scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy.The results indicate that effective Cu-Al bonding requires a higher bonding temperature to facilitate interdiffusion between the two metals.The microstructural characteristics are associated with various bonding temperatures,which impact the driving force of interdiffusion.It is observed that cooling rate exerts a significant influence on the morphology and amount of the intermetallic compounds at the interfacial region.Meanwhile,microhardness measurements show that hardness varies with the bonding temperature and rate of cooling.Yan-qiu Han Li-hua Ben Jin-jin Yao Chun-jing Wu 2015International Journal of Minerals,Metallurgy and Materials2015,22,1:2
14The Energy Consumption of Heatingin the Northeast Rural Area of China from the Perspective of the Kang and Agricultural Waste显示文摘In China,the heating energy consumption patterns of rural housing are changing due to economic development.This study investigated domestic heating in rural areas of Dalian,a city in northeast China.In rural areas of the country,heating devices such as coal boiler,radiator,and/or air-conditioner are typically used.The Kang,as the main heating system,has been used together with other heating methods for a long time in detached houses,one-story buildings,and quadrangles.Use of the Kang in collective housing is no longer observed.In addition to coal,agricultural wastes have been used to fuel the Kang;the associated CO2 emissions with agricultural fuels are lower than from other heating equipment.Even when a combination of the Kang and other equipment is used,with agricultural waste as fuel,CO2 emissions remain relatively low.Han Ben Kondo Kayoko 2015Meteorological and Environmental Research2015,6,1:2
15Current treatment of dysfunctional uterine bleeding显示文摘Marlies Y Ben WJ Hans AM 2004Maturitas2004,14,3:1
16The effect of dehydration and ion stress on carbon dioxide fixation in drought-tolerant phototrophic micro-organisms 显示文摘Ben De W Hans C P W Luuc R M 1990FEMS Microhiol Lett1990,74,1:1
17Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen 1997The Lancet1997,,9074:1
18Time - dependent quantum wave packet studies of the F + HCl and F+ DCI reactions显示文摘TANG Bi - yu YANG Ben - hui HAN Ke - li 2000J Chem Phys2000,,10:1
19Lab-in-cell based on spontaneous amino-yne click polymerization显示文摘Unnatural reaction in the living cells is a powerful tool for biological research. However, the polymerization inside cells is rarely reported. In this work, a lab-in-cell is illustrated based on our developed spontaneous amino-yne click polymerization. Carbonyl group activated terminal diyne can spontaneously polymerize with tetraphenylethene(TPE)-containing primary diamine inside cells, and polymer with weight-average molecular weight of 7,300 was yielded. By utilizing this in vivo amino-yne click polymerization and taking advantage of the aggregation-induced emission feature of TPE, a 'turn-on' cell imaging was realized,and in-situ killing of cells was also acquired by destroying the structures of actin and tubulin, which cannot be realized by preprepared polymer. This strategy provides a useful platform and holds great promise in biochemistry and therapy applications.Rong Hu Xu Chen Taotao Zhou Han Si Benzhao He Ryan T. K. Kwok Anjun Qin Ben Zhong Tang 2019Science China Chemistry2019,62,9:1
20Optical damageresistance of Ce:Fe:LiNb03 crystals with various Li/Nb ratios显示文摘Xu Zhaopeng Ben Yongzhi Han Ying 2012OpHk2012,123,15:1
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