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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | B‐cell surface marker analysis for improvement of rituximab prophylaxis in ABO‐incompatible adult living donor liver transplantation显示文摘 | Hiroto Egawa Katsuyuki Ohmori Hironori Haga Hiroaki Tsuji Kimiko Yurugi Aya Miyagawa‐Hayashino Fumitaka Oike Akinari Fukuda Jun Yoshizawa Yasutsugu Takada Koichi Tanaka Taira Maekawa Kazue Ozawa Shinji Uemoto | 2007 | Liver Transpl2007，，4： | 1 |
| 3 | Huid How in a Continuous Casting Mold Driven by Linera Induction Motors 显示文摘 | Kensuke Okazawa Takehiko Toh Jun fukuda | 2001 | ISIJ International2001，41，8： | 1 |
| 4 | Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer显示文摘BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical aspects.Several studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal surgery.However,no study has shown the association between postoperative complications and long-term survival of patients with EGJ cancer.AIM To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ cancer.METHODS A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this study.We examined the association between complications and long-term oncologic outcomes.RESULTS In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic leakage.However,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic anastomosis.Cervical anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage. | Masashi Takeuchi Hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya Takeuchi Yuko Kitagawa | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 5 | Does the Intraoperative Tranexamic Acid Decrease Operative Blood Loss During Posterior Spinal Fusion for Treatment of Adolescent Idiopathic Scoliosis?显示文摘 | Mitsuru Yagi Jun Hasegawa Narihito Nagoshi Shingo Iizuka Shinjiro Kaneko Kentaro Fukuda Masakazu Takemitsu Masanobu Shioda Masafumi Machida | 2012 | Spine2012，，21： | 1 |
| 6 | Leptin Promotes the Development of Mouse Preimplantation Embryos in Vitro 显示文摘 | Kazuhiro Kawamura Naoki sato Jun Fukuda Hideya Kodama Jin Kumagai Hideo Tanikawa Akira Nakamura Toshinobu Tanaka | 2002 | Endocrinology2002，143，5： | 1 |
| 7 | Macrophage migration inhibitory factor has a proinflammatory activity via the p38 pathway in glucocorticoid-resistant ulcerative colitis显示文摘 | Yoh Ishiguro Tatsuya Ohkawara Hirotake Sakuraba Kazufumi Yamagata Hiroto Hiraga Satoko Yamaguchi Shinsaku Fukuda Akihiro Munakata Akio Nakane Jun Nishihira | 2006 | Clinical Immunology2006，，3： | 1 |
| 8 | High-efficiency recovery of target cells using improved yeast display system for detection of protein–protein interactions显示文摘 | Nobuo Fukuda Jun Ishii Seiji Shibasaki Mitsuyoshi Ueda Hideki Fukuda Akihiko Kondo | 2007 | Applied Microbiology and Biotechnology2007，，1： | 1 |
| 9 | 显示文摘 | Minoru Ishifuro Jun Horiguchi Aya Nakashige Akihisa Tamura Kazushi Marukawa Hiroshi Fukuda Chiaki Ono Yuji Akiyama Toshio Kushima Katsuhide Ito | 2002 | European Radiology2002，，10： | 1 |
| 10 | Essential role of gastric gland mucin in preventing gastric cancer in mice显示文摘 | Karasawa Fumitoshi Shiota Akira Goso Yukinobu Kobayashi Motohiro Sato Yoshiko Masumoto Junya Fujiwara Maiko Yokosawa Shuichi Muraki Takashi Miyagawa Shinichi Ueda Masatsugu Fukuda Michiko N Fukuda Minoru Ishihara Kazuhiko Nakayama Jun | 2012 | EN2012，，3： | 1 |
| 11 | Particle Size of powders under hydrothermal conditions显示文摘 | Li Wen jun Shi Er-wei TsuGuo Fukuda | 2003 | Cryst Res Technol2003，38，10： | 1 |
| 12 | Phase-contrast radiographs of nonstained rat cerebellar specimen显示文摘 | Atsushi Momose Jun Fukuda | 1995 | Medical Physics1995，22，4： | 1 |
| 13 | Trophinin what embryo implantation teaches us about human cancer 显示文摘 | Michiko N Fukuda Kazuhiro Sugihara Jun Nakayama | 2008 | Cancer Biology & Therapy2008，7，8： | 1 |
| 14 | Characterization of TrcMADS1 gene of Trillium camtschatcense (Trilliaceae) reveals functional evolution of the SOC1/TM3-like gene family显示文摘 | Toru Nakamura In-Ja Song Tatsuya Fukuda Jun Yokoyama Masayuki Maki Toshinori Ochiai Toshiaki Kameya Akira Kanno | 2005 | Journal of Plant Research2005，，3： | 1 |
| 15 | Ultrasound Safety with Mid Frequency Transcranial Sonothrombolysis:Preliminary Study on Normal Macaca Monkey Brain 显示文摘 | Jun S J Fukuda T Abe T | 2012 | Ultrasound Med Biol2012，2，： | 1 |
| 16 | Comparison of Corneal and Aqueous Humor Penetration of Moxifloxacin, Gatifloxacin and Levofloxacin during Keratoplasty显示文摘 | Masahiko Fukuda Masakazu Yamada Shigeru Kinoshita Tsutomu Inatomi Yuichi Ohashi Toshihiko Uno Jun Shimazaki Yoshiyuki Satake Naoyuki Maeda Yuichi Hori Kohji Nishida Akira Kubota Toru Nakazawa Yoshikazu Shimomura | 2012 | Advances in Therapy2012，，4： | 1 |
| 17 | Structural dynamics of dendritic spines in memory and cognition显示文摘 | Haruo Kasai Masahiro Fukuda Satoshi Watanabe Akiko Hayashi-Takagi Jun Noguchi | 2010 | Trends in Neurosciences2010，，： | 1 |
| 18 | Increased von Willebrand factor in the endocardium as a local predisposing factor for thrombogenesis in overloaded human atrial appendage显示文摘 | Mitsumasa Fukuchi Jun Watanabe Koji Kumagai Yukio Katori Shigeo Baba Koji Fukuda Takuya Yagi Atsushi Iguchi Hitoshi Yokoyama Masahito Miura Yutaka Kagaya Shigekazu Sato Koichi Tabayashi Kunio Shirato | 2001 | Journal of the American College of Cardiology2001，，： | 1 |
| 19 | Evaluation of the pigmentation stages and body proportions from the glass eel to yellow eel in Anguilla japonica显示文摘 | Nobuto Fukuda Michael J. Miller Jun Aoyama Akira Shinoda Katsumi Tsukamoto | 2013 | Fisheries Science2013，，3： | 1 |
| 20 | Fluid flow in a continuous casting mold driven by linear induction motors显示文摘 | Kensuke Okazawa Takehiko Toh Jun Fukuda | | 0，，8： | 1 |
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