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| 1 | Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis显示文摘AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic therapy.Sixty outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing medications.Clinical symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal microflora.RESULTS: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis. | Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada Yasuo Suzuki | 2015 | World Journal of Gastroenterology2015，21，19： | 21 |
| 2 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 3 | Centrifuge modeling of buried continuous pipelines subjected to normal faulting显示文摘Seismic ground faulting is the greatest hazard for continuous buried pipelines.Over the years,researchers have attempted to understand pipeline behavior mostly via numerical modeling such as the finite element method.The lack of well-documented field case histories of pipeline failure from seismic ground faulting and the cost and complicated facilities needed for full-scale experimental simulation mean that a centrifuge-based method to determine the behavior of pipelines subjected to faulting is best to verify numerical approaches.This paper presents results from three centrifuge tests designed to investigate continuous buried steel pipeline behavior subjected to normal faulting.The experimental setup and procedure are described and the recorded axial and bending strains induced in a pipeline are presented and compared to those obtained via analytical methods.The influence of factors such as faulting offset,burial depth and pipe diameter on the axial and bending strains of pipes and on ground soil failure and pipeline deformation patterns are also investigated.Finally,the tensile rupture of a pipeline due to normal faulting is investigated. | Majid Moradi Mahdi Rojhani Abbas Galandarzadeh Shiro Takada | 2013 | Earthquake Engineering and Engineering Vibration2013，12，1： | 11 |
| 4 | Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial显示文摘 | Tetsuya Mitsudomi Satoshi Morita Yasushi Yatabe Shunichi Negoro Isamu Okamoto Junji Tsurutani Takashi Seto Miyako Satouchi Hirohito Tada Tomonori Hirashima Kazuhiro Asami Nobuyuki Katakami Minoru Takada Hiroshige Yoshioka Kazuhiko Shibata Shinzoh Kudoh Ei | 2010 | Lancet Oncology2010，，2： | 8 |
| 5 | Inhibitory effects of carbon dioxide insufflation on pneumoperitoneum and bowel distension after percutaneous endoscopic gastrostomy显示文摘AIM:To evaluate the inhibitory effects of carbon dioxide (CO2) insufflation on pneumoperitoneum and bowel distension after percutaneous endoscopic gastrostomy (PEG).METHODS:A total of 73 consecutive patients who were undergoing PEG were enrolled in our study.After eliminating 13 patients who fitted our exclusion criteria,60 patients were randomly assigned to either CO2 (30 patients) or air insufflation (30 patients) groups.PEG was performed by pull-through technique after threepoint fixation of the gastric wall to the abdominal wall using a gastropexy device.Arterial blood gas analysis was performed immediately before and after the procedure.Abdominal X-ray was performed at 10 min and at 24 h after PEG to assess the extent of bowel distension.Abdominal computed tomography was performed at 24 h after the procedure to detect the presence of pneumoperitoneum.The outcomes of PEG for 7 d postprocedure were also investigated.RESULTS:Among 30 patients each for the air and the CO2 groups,PEG could not be conducted in 2 patients of the CO2 group,thus they were excluded.Analyses of the remaining 58 patients showed that the patients' backgrounds were not significantly different between the two groups.The elevation values of arterial partial pressure of CO2 in the air group and the CO2 group were 2.67 mmHg and 3.32 mmHg,respectively (P = 0.408).The evaluation of bowel distension on abdominal X ray revealed a significant decrease of small bowel distension in the CO2 group compared to the air group (P < 0.001) at 10 min and 24 h after PEG,whereas there was no significant difference in large bowel distension between the two groups.Pneumoperitoneum was observed only in the air group but not in the CO2 group (P = 0.003).There were no obvious differences in the laboratory data and clinical outcomes after PEG between the two groups.CONCLUSION:There was no adverse event associated with CO2 insufflation.CO2 insufflation is considered to be safer and more comfortable for PEG patients because of the lower incidence of pneumoperitoneum and less distension of the small bowel. | Shinji Nishiwaki Hiroshi Araki Motoshi Hayashi Jun Takada Masahide Iwashita Atsushi Tagami Hiroo Hatakeyama Takao Hayashi Teruo Maeda Koshiro Saito | 2012 | World Journal of Gastroenterology2012，18，27： | 7 |
| 6 | 武汉地区不同人群血清HCV感染状况研究显示文摘采用Ortho抗HCV ELISA C100-3试剂对武汉地区不同人群进行了抗HCV筛选。部分阳性标本作了RIBA证实实验及HCV RNA分析。并分析了5例HCV或HBV/HCV感染者的HCV基因型。结果表明:①在献血人群中,经RIBA证实抗HCV检出率为1.20%,HCV病毒血症者为0.80%;②多次受血治疗组抗HCV检出率为13.64%;③肝病组,重症肝炎为32.00%,HCC为22.86%,CPH和轻型CAH为4.05%,婴儿肝炎综合征中为5.00%;④亚基因探针杂交结果显示:武汉地区肝病患者感染的HCV主要为HCV-K2型(60.00%)。表明:经HBsAg和ALT筛选的合格献血员血清中HCV感染率仍较高,除接受血治疗外,重症肝炎和HCC患者对HCV易感性也较高,在婴儿肝炎综合征中约5%为HCV感染引起;初步结果提示武汉地区HCV的基因型主要为HCV-K2型。 | 郝连杰 郭林生 张永东 Theilmann L 杨泽川 Takada A | 1992 | 同济医科大学学报1992，21，3： | 6 |
| 7 | Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection显示文摘AIM: To compare the safety and efficacy of carbon dioxide(CO2) and air insufflation during gastric endoscopic submucosal dissection(ESD).METHODS: This study involved 116 patients who underwent gastric ESD between January and December 2009.After eliminating 29 patients who fit the exclusion criteria,87 patients,without known pulmonary dysfunction,were randomized into the CO2 insufflation(n = 36) or air insufflation(n = 51) groups.Standard ESD was performed with a CO2 regulation unit(constant rate of 1.4 L/min) used for patients undergoing CO2 insufflation.Patients received diazepam for conscious sedation and pentazocine for analgesia.Transcutaneous CO2 tension(Ptc CO2) was recorded 15 min before,during,and after ESD with insufflation.Ptc CO2,the correlation between Ptc CO2 and procedure time,and ESD-related complications were compared between the two groups.Arterial blood gases were analyzed after ESD in the first 30 patients(12 with CO2 and 18 with air insufflation) to assess the correlation between arterial blood CO2 partial pressure(Pa CO2) and Ptc CO2.RESULTS: There were no differences in respiratoryfunctions,median sedative doses,or median procedure times between the groups.Similarly,there was no significant difference in post-ESD blood gas parameters,including Pa CO2,between the CO2 and air groups(44.6 mm Hg vs 45 mm Hg).Both groups demonstrated median p H values of 7.36,and none of the patients exhibited acidemia.No significant differences were observed between the CO2 and air groups with respect to baseline Ptc CO2(39 mm Hg vs 40 mm Hg),peak Ptc CO2 during ESD(52 mm Hg vs 51 mm Hg),or median Ptc CO2 after ESD(50 mm Hg vs 50 mm Hg).There was a strong correlation between Pa CO2 and Ptc CO2(r = 0.66; P < 0.001).The incidence of Mallory-Weiss tears was significantly lower with CO2 insufflation than with air insufflation(0% vs 15.6%,P = 0.013).CO2 insufflation did not cause any adverse events,such as CO2 narcosis or gas embolisms.CONCLUSION: CO2 insufflation during gastric ESD results in similar blood gas levels as air insufflation,and also reduces the incidence of Mallory-Weiss tears. | Jun Takada Hiroshi Araki Fumito Onogi Takayuki Nakanishi Masaya Kubota Takashi Ibuka Masahito Shimizu Hisataka Moriwaki | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 8 | Proposal of criteria to select candidates with colorectal liver metastases for hepatic resection:Comparison of our scoring system to the positive number of risk factors显示文摘AIM: To select accurately good candidates of hepatic resection for colorectal liver metastasis. METHODS: Thirteen clinicopathological features, which were recognized only before or during surgery, were selected retrospectively in 81 consecutive patients in one hospital (GroupⅠ). These features were entered into a multivariate analysis to determine independent and significant variables affecting long-term prognosis after hepatectomy. Using selected variables, we created a scoring formula to classify patients with colorectal liver metastases to select good candidates for hepatic resection. The usefulness of the new scoring system was examined in a series of 92 patients from another hospital (Group Ⅱ), comparing the number of selected variables. RESULTS: Among 81 patients of GroupⅠ, multivariate analysis, i.e. Cox regression analysis, showed that multiple tumors, the largest tumor greater than 5 cm in diameter, and resectable extrahepatic metastases were significant and independent prognostic factors for poor survival after hepatectomy (P < 0.05). In addition, these three factors: serosa invasion, local lymph node metastases of primary cancers, and post- operative disease free interval less than 1 year including synchronous hepatic metastasis, were not significant, however, they were selected by a stepwise method of Cox regression analysis (0.05 < P < 0.20). Using these six variables, we created a new scoring formula to classify patients with colorectal liver metastases. Finally, our new scoring system not only classified patients in GroupⅠvery well, but also that in Group Ⅱ, according to long-term outcomes after hepatic resection. The positive number of these six variables also classified them well.CONCLUSION: Both, our new scoring system and the positive number of significant prognostic factors are useful to classify patients with colorectal liver metastases in the preoperative selection of good candidates for hepatic resection. | Ikuo Nagashima Tadahiro Takada Miki Adachi Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 9 | 活体肝移植术后胆管并发症的处理与预防显示文摘目的探讨活体肝移植术后胆管并发症的防治。方法84例活体肝移植,成人56例,小儿28例;良性终末期肝病66例,肝细胞肝癌18例。供受体胆管端端吻合重建50例,供体肝管与受体肝管端端和胆总管端侧吻合重建1例,供体肝管与受体肝管和胆囊管吻合1例,供体胆管与受体卒肠Roux—en-Y吻合重建32例,所有胆管重建后均置入4Fr或6Fr内支架管从受体胆总管前壁或空肠袢盲端侧肠壁引出体外。结果术后发生胆管并发症24例,发生率为28.5%,胆管胆管吻合与肝管宅肠Roux—en-Y吻合胆漏发生率差异显著(8.3%vs16.7%,P〈0.05)。胆管胆管吻合与肝管空肠Roux-en—Y吻合胆管狭窄发生率差异显著(50%vs16.7%,P〈0.05)。单支胆管与多支胆管发生胆管并发症差异娃著(20.8%vs79.2%,P〈0.05)。胆漏者保守治疗治愈4例,再次手术治疗治愈4例;胆管狭窄内镜下球囊扩张和鼻胆管引流治疗治愈4例,好转2例,再次手术胆管空肠Roux-en—Y吻合治疗治愈6例,经皮肝脏穿刺胆管狭窄球囊扩张治疗支架管引流治疗好转4例。该组资料无因胆管并发症死亡病例。结论良好的胆管血供和吻合技术,选择恰当的胆管重建方式,足降低活体肝移植术后胆管并发症的重要措施。 | 秦建民 Yasutsugu Takada Shinji Uemoto Koichi Tanaka | 2008 | 中华肝胆外科杂志2008，14，10： | 5 |
| 10 | Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis显示文摘Eosinophilic cholangiopathy is a rare condition characterized by eosinophilic infiltration of the biliary tract and causes sclerosing cholangitis.We report a patient with secondary sclerosing cholangitis with eosinophilic cholecystitis.A 46-year-old Japanese man was admitted to our hospital with jaundice. Computed tomography revealed dilatation of both the intrahepatic and extrahepatic bile ducts,diffuse thickening of the wall of the extrahepatic bile duct,and thickening of the gallbladder wall.Under the diagnosis of lower bile duct carcinoma,he underwent pyloruspreserving pancreatoduodenectomy and liver biopsy. On histopathological examination,conspicuous fibrosis was seen in the lower bile duct wall.In the gallbladder wall,marked eosinophilic infiltration was seen.Liver biopsy revealed mild portal fibrosis.He was diagnosed as definite eosinophilic cholecystitis with sclerosing cholangitis with unknown etiology.The possible etiology of sclerosing cholangitis was consequent fibrosis from previous eosinophilic infiltration in the bile duct.The clinicopathological findings of our case and a literature review indicated that eosinophilic cholangiopathy could cause a condition mimicking primary sclerosing cholangitis(PSC).Bile duct wall thickening in patientswith eosinophilic cholangitis might be due to fibrosis of the bile duct wall.Eosinophilic cholangiopathy might be confused as PSC with eosinophilia. | Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Junichi Fukushima Fukuo Kondo Hajime Takikawa | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 11 | TG13 flowchart for the management of acute cholangitis and cholecystitis显示文摘 | Fumihiko Miura Tadahiro Takada Steven M. Strasberg Joseph S. Solomkin Henry A. Pitt Dirk J. Gouma O. James Garden Markus W. Büchler Masahiro Yoshida Toshihiko Mayumi Kohji Okamoto Harumi Gomi Shinya Kusachi Seiki Kiriyama Masamichi Yokoe Yasutoshi Kimura | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，1： | 4 |
| 12 | 用于液晶盒偶氮染料光致取向层的合成和性质显示文摘我们研究了可用于光致取向液晶(LCs)偶氮染料的合成和性质,提出了偶氮染料的结构与合成过程。偶氮染料光致取向完全是因为分子吸收振子垂直于UV光偏振方向的再取向。讨论了在偏振光场中,偶氮染料分子旋转扩散现象的定性模型。测量了波长为372nm时,偏振吸收光谱的有序参数S=-0.4(80%的最大绝对值Sm=-0.5)。对一个偶氮染料膜,利用在正常的正入射偏振光之后,紧跟一个斜入射的非偏振光两步曝光,可以获得温度稳定的5.3°预倾角。光致取向基片的方位角锚定能为Aφ≈10-4Jm-2,这与摩擦聚酰亚胺(PI)层的锚定能相同。我们发现,光致取向液晶盒的电压保持率甚至比摩擦PI层取向的还高,因此,偶氮染料完全可以用作有源矩阵液晶显示器的取向层。光致取向偶氮染料层的热稳定性很高,但UV稳定性需通过诸如聚合等来改良。于是,我们设想了一种新的基于聚合偶氮染料层的LCD取向技术。 | 郭海成 Vladimir Chigrinov Elena Prudnikova Vladimir Kozenkov Hidenari Akiyama Tatsuo Kawara Hirokazu Takada Haruyoshi Takatsu | 2003 | 现代显示2003，，4： | 4 |
| 13 | 采用病毒受体基因转移技术建立EB病毒细胞感染模型显示文摘EB病毒感染人上皮细胞是受到许多条件限制的。通过补体受体(CR2)使EB病毒感染人上皮细胞是研究EB病毒与鼻咽癌关系的重要手段之一。我们把CR2基因的cDNA(3219bp)片段重组于真核表达载体*C5中,并使之在人羊膜细胞(WBh)和人鼻咽癌肿瘤组织传代细胞(CNE3)中表达。CR2基因在细胞中的最高表达率可达总细胞数的5%。最后用EB病毒B95-8株感染上述两种细胞,病毒在细胞中增殖成功。在病毒感染细胞后的2-25天中,可以不同程度地在细胞中检出EB病毒相关抗原。抗原检出高峰出现在细胞被感染后的第4天。通过我们的实验,成功地建立了EB病毒细胞感染模型。为进一步研究EB病毒与鼻咽癌的关系建立了条件。 | 纪志武 李保民 曾毅 K Takada | 1994 | 病毒学报1994，10，2： | 4 |
| 14 | Real-time color holographic video reconstruction using multiple-graphics processing unit cluster acceleration and three spatial light modulators显示文摘We demonstrate real-time three-dimensional(3D)color video using a color electroholographic system with a cluster of multiple-graphics processing units(multi-GPU)and three spatial light modulators(SLMs)corresponding respectively to red,green,and blue(RGB)-colored reconstructing lights.The multi-GPU cluster has a computer-generated hologram(CGH)display node containing a GPU,for displaying calculated CGHs on SLMs,and four CGH calculation nodes using 12 GPUs.The GPUs in the CGH calculation node generate CGHs corresponding to RGB reconstructing lights in a 3D color video using pipeline processing.Real-time color electroholography was realized for a 3D color object comprising approximately 21,000 points per color. | Shohei Ikawa Naoki Takada Hiromitsu Araki Hiroaki Niwase Hiromi Sannomiya Hirotaka Nakayama Minoru Oikawa Yuichiro Mori Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito | 2020 | Chinese Optics Letters2020，18，1： | 4 |
| 15 | Early and late complications of pylorus-preserving pancreatoduodenectomy in Japan 1998显示文摘 | Koji Yamaguchi Masao Tanaka Kazuo Chijiiwa Takukazu Nagakawa Masayuki Imamura Tadahiro Takada | 1999 | Journal of Hepato - Biliary - Pancreatic Surgery1999，，3： | 3 |
| 16 | Isolated intrapancreatic Ig G4-related sclerosing cholangitis显示文摘Immunoglobulin G4-related sclerosing cholangitis(Ig G4-SC) is frequently associated with type 1 autoimmune pancreatitis(AIP). Association with AIP can be utilized in the diagnosis of Ig G4-SC. However, some cases of Ig G4-SC are isolated from AIP, which complicates the diagnosis. Most of the reported cases of isolated Ig G4-SC displayed hilar biliary strictures, whereas isolated Ig G4-SC with intrapancreatic biliary stricture is very rare. Recently, we have encountered 5 isolated intrapancreatic Ig G4-SC cases that were not associated with AIP, three of which were pathologically investigated after surgical operation. They all were males with a mean age of 74.2 years. The pancreas was not enlarged in any of these cases. No irregular narrowing of the main pancreatic duct was found. Bile duct wall thickening in lesions without luminal stenosis was detected by abdominal computed tomography in all five cases, by endoscopic ultrasonography in two out of four cases and by intraductal ultrasonography in all three cases. In three cases, serum Ig G4 levels were within the normal limits. The mean serum Ig G4 level measured before surgery was 202.1 mg/d L(4 cases). Isolated intrapancreatic Ig G4-SC is difficult to diagnose, especially if the Ig G4 level remains normal. Thus, this type of Ig G4-SC should be suspected in addition to cholangiocarcinoma and pancreatic cancer if stenosis of intrapancreatic bile duct is present. | Takahiro Nakazawa Yushi Ikeda Yoshiaki Kawaguchi Hirohisa Kitagawa Hiroki Takada Yutaka Takeda Isamu Makino Naohiko Makino Itaru Naitoh Atsushi Tanaka | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 17 | Arterio-biliary fistula as rare complication of chemoradiation therapy for intrahepatic cholangiocarcinoma显示文摘Significant hemobilia due to arterio-biliary fistula is a very rare complication of chemoradiation therapy(CRT) for unresectable intrahepatic cholangiocarcinoma(ICC).Here we report a case of arterio-biliary fistula after CRT for unresectable ICC demonstrated by angiographic examinations.This fistula was successfully treated by endovascular embolization.Hemobilia is a rare complication,but arterio-biliary fistula should be considered after CRT of ICC. | Koichi Hayano Fumihiko Miura Hodaka Amano Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Takehide Asano | 2010 | World Journal of Radiology2010，2，9： | 3 |
| 18 | Large Scale Finite Element Modeling,Simulation and Visualization for Wind Flows in Urban Area Using Virtual Reality显示文摘A large-scale finite element modeling, simulation and visualization for wind flows are presented. The modeling method using GIS/CAD data is employed. The stabilized parallel finite element method based on SUPG/PSPG method is employed for the analysis of wind flows. The present method is applied to the simulation of wind flow and contaminant spread in urban area. The visualization based on virtual reality is employed to evaluate the mesh quality and computational results. The computed results are qualitatively in agreement with the experimental results and actual phenomena. The present method is shown to be a useful tool to simulate the wind flows in urban area. | Kazuo Kashiyama Tomosato Takada Hideo Miyachi | 2008 | Tsinghua Science and Technology2008，13，S1： | 3 |
| 19 | Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma显示文摘AIM To evaluate the usefulness of frozen section diagnosis(FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma(CCA). METHODS We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs(45 and 55 bile duct margins, respectively). The diagnosis was classified into three categories: negative, borderline(biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive. FSD in the epithelial layer, subepithelial layer, and total layer was compared with corresponding permanent section diagnosis(PSD) postoperatively.Then, association between FSD and local recurrence was analyzed with special reference to borderline.RESULTS Analysis of 100 duct margins revealed that concordance rate between FSD and PSD was 68.0% in the total layer, 69.0% in the epithelial layer, and 98.0% in the subepithelial layer. The extent of remaining biliary epithelium was comparable between FSD and PSD, and more than half of the margins lost > 50% of the entire epithelium, suggesting low quality of the samples. In FSD, the rate of negative margins decreased and that of borderline and positive margins increased according to the extent of the remaining epithelium. Diagnostic discordance between FSD and PSD was observed in 31 epithelial layers and two subepithelial layers. Alteration from borderline to negative was the most frequent(20 of the 31 epithelial layers). Patients with positive margin in the total and epithelial layers by FSD demonstrated a significantly worse local recurrence-free survival(RFS) compared with patients with borderline and negative margins, which revealed comparable local RFS. Patients with borderline and negative margins in the epithelial layer by PSD also revealed comparable local RFS. These results suggested that epithelial borderline might be regarded substantially as negative. When classifying the status of the epithelial layer either as negative or positive, concordance rates between FSD and PSD in the total, epithelial, and subepithelial layers were 95.0%, 93.0%, and 98.0%, respectively.CONCLUSION During intraoperative assessment of bile duct margin, borderline in the epithelial layer can be substantially regarded as negative, under which condition FSD is comparable to PSD. | Takayuki Shiraki Hajime Kuroda Atsuko Takada Yoshimasa Nakazato Keiichi Kubota Yasuo Imai | 2018 | World Journal of Gastroenterology2018，24，12： | 3 |
| 20 | Is biliary bile acid a good predictor for acute cellular rejection in living donor liver transplantation?显示文摘BACKGROUND:In liver transplantation,acute cellular rejection(ACR)is still a major complication that can lead to mortality.Bile secretion has been considered as a marker of early graft function. METHODS:The study included 41 adults who received living donor liver transplantation(LDLT)at Kyoto University Hospital between April 2007 and February 2008. The patients were stratified according to the presence or absence of ACR.Bile samples were collected from donors once and from recipients every other day for the first 2 weeks after transplantation.Total bile acid(BA)and taurine-conjugated bile acid(TCBA)in bile were measured by magnetic resonance spectroscopy.The recipient/donor (R/D)BA ratio and R/D TCBA ratio were calculated. RESULTS:The ACR group(n=12)showed a greater decrease in BA post-transplantation than the non-ACR group,but this difference was not statistically significant. On both day 7 and day 9 post-transplantation the R/D TCBA was significantly different between the two groups (P=0.038 on day 7 and P=0.036 on day 9).The R/D TCBA ratio≥0.5 on days 7 and 9,and≥0.38 on day 11 post- transplantation were associated with better ACR-free survival. CONCLUSION:The recipient/donor TCBA ratio can be a predictor for ACR after LDLT as early as post- transplantation day 7. | Mohammed Saied Hedaya Walid M.El Moghazy Yamamoto Yasutomo Tomioka Kiyoshi oshimi Kaido Hiroto Egawa Shinji Uemoto Yasutsugu Takada | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 3 |
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