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| 1 | Arabidopsis STAY-GREEN2 Is a Negative Regulator of Chlorophyll Degradation during Leaf Senescence显示文摘叶绿素(Chl ) 降级在老朽期间或在压力条件下面引起叶 yellowing。为 Chl 故障, STAY-GREEN1 (SGR1 ) 在 thylakoid 膜与 Chl 分解代谢的酶(CCE ) 和轻收获的复杂 II (LHCII ) 交往, possiblyto 允许新陈代谢的 channeling 潜在地 phototoxic Chl 故障中介。在这些 Chl 分解代谢的部件之中, SGR1 充当叶 yellowing 的一个关键管理者。除了 SGR1 (At4g22920 ) , Arabidopsis thaliana 染色体包含一个另外的相当或相同的事物, SGR2 (At4g11910 ) ,谁的生物功能遗体逃犯。在导致老朽的条件下面, SGR2 表示是高度起来调整的,同样到 SGR1 表示。这里,我们证明那 SGR2 功能在叶 Chl 降级抵抗 SGR1 活动;SGR2-overexpressing 植物保持绿色和 sgr2-1 大美人异种展出了早叶 yellowing 未成年 -- ,黑暗 -- ,并且导致压力的老朽条件。象 SGR1 一样,有 LHCII 的 SGR2interacted 但是与 SGR1 相对照,和 CCE 的 SGR2 相互作用很被限制。而且, SGR1 和 SGR2formed 人 -- 或 heterodimers,强烈在否定地调整 Chl 降级由为 SGR2 建议一个角色可能 interferingwith SGR1 的建议招募 CCE 功能。我们的数据在 Arabidopsis 显示 SGR1 andSGR2 的函数的对抗进化与拆除在叶绿体平衡 Chl 分解代谢并且在 senescingleaf cells.Key 词另外的细胞的部件重新动员: | Yasuhito Sakuraba So-Yon Park Ye-Sol Kim Seung-Hyun Wang Soo-Cheul Yoo Stefan Hortensteiner Nam-Chon Paek | 2014 | Molecular Plant2014，7，8： | 15 |
| 2 | Contrast-enhanced intraoperative ultrasonography equipped with late Kupffer-phase image obtained by sonazoid in patients with colorectal liver metastases显示文摘AIM: To find occult metastases during hepatectomy in patients with colorectal cancer liver metastases (CRCLM), contrast-enhanced intraoperative ultrasonography (CE-IOUS) was performed using a new microbubble agent, sonazoid, which provides a parenchyma-specific contrast image based on its accumulation in the Kupffer cells. METHODS: Eight patients with CRCLM underwent CE- IOUS using sonazoid before hepatectomy. The liver was investigated during a late Kupffer-phase imaging, which is a valuable characteristic of sonazoid. RESULTS: CE-IOUS using sonazoid provided the early vascular- and sinusoidal-phase images for 10 min followed by the late Kupffer-phase image up to 30 min after the injection of sonazoid. IOUS did not provide new findings of metastatic lesion in the 8 patients. However, during the late Kupffer-phase image of sonazoid, a metastatic lesion was newly found in two of the 8 patients. These newly detected lesions were removed by an additional hepatectomy and histopathologically diagnosed as a metastasis. CONCLUSION: CE-IOUS using sonazoid can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively. | Hiroshi Nakano Yasuo Ishida Toshiyuki Hatakeyama Kazuma Sakuraba Masahiro Hayashi Osamu Sakurai Kiyoshi Hataya | 2008 | World Journal of Gastroenterology2008，14，20： | 10 |
| 3 | Mutation of Oryza sativa CORONATINE INSENSITIVE 1b(OsCOI1b) delays leaf senescence显示文摘Jasmonic acid(JA) functions in plant development,including senescence and immunity. Arabidopsis thaliana CORONATINE INSENSITIVE 1 encodes a JA receptor and functions in the JA-responsive signaling pathway. The Arabidopsis genome harbors a single COI gene, but the rice(Oryza sativa) genome harbors three COI homologs, Os COI1 a,Os COI1 b, and Os COI2. Thus, it remains unclear whether each Os COI has distinct, additive, synergistic, or redundant functions in development. Here, we use the oscoi1b-1 knockout mutants to show that Os COI1 b mainly affects leaf senescence under senescence-promoting conditions. oscoi1b-1 mutants stayed green during dark-induced and natural senescence,with substantial retention of chlorophylls and photosynthetic capacity. Furthermore, several senescence-associated genes were downregulated in oscoi1b-1 mutants, including homologs of Arabidopsis thaliana ETHYLENE INSENSITIVE 3 and ORESARA 1, important regulators of leaf senescence. These results suggest that crosstalk between JA signaling and Resea ethylene signaling affects leaf senescence. The Arabidopsis coi1-1 plants containing 35S:Os COI1 a or 35S:Os COI1 b rescued the delayed leaf senescence during dark incubation, suggesting that both Os COI1 a and Os COI1 b are required for promoting leaf senescence in rice. oscoi1b-1 mutants showed significant decreases in spikelet fertility and grain weight,leading to severe reduction of grain yield, indicating that Os COI1-mediated JA signaling affects spikelet fertility and grain filling. | Sang-Hwa Lee Yasuhito Sakuraba Taeyoung Lee Kyu-Won Kim Gynheung An Han Yong Lee Nam-Chon Paek | 2015 | Journal of Integrative Plant Biology2015，57，6： | 9 |
| 4 | Risk of hepatitis B virus reactivation in patients with autoimmune diseases undergoing non-tumor necrosis factor-targeted biologics显示文摘Hepatitis B virus reactivation(HBVr)can occur in patients treated with immunosuppressive medications.Risk stratification for HBVr based on hepatitis B virus(HBV)serology and viral load is an important strategy to determine appropriate HBV monitoring and antiviral prophylaxis use.Recent advances in the understanding of pathophysiology of autoimmune diseases have led the development of cytokine-targeted therapies.Tumor necrosis factor(TNF)-αinhibitors have been widely used for patients with inflammatory bowel disease,psoriasis,and rheumatic diseases.Further,the clinical benefits of interleukin(IL)-12/23,IL-17,or Janus kinases inhibitors have been demonstrated in these patients.It is well known that TNF-αinhibitor use can lead to HBVr,however,the risk of HBVr in patients undergoing non-TNF-targeted biologics have not been fully understood.In this review,we discuss the risk of HBVr in patients treated with non-TNF-targeted biologics,and immunological mechanisms of these medications causing HBVr. | Shintaro Akiyama Thomas G Cotter Atsushi Sakuraba | 2021 | World Journal of Gastroenterology2021，27，19： | 4 |
| 5 | Systemic review and network meta-analysis:Prophylactic antibiotic therapy for spontaneous bacterial peritonitis显示文摘BACKGROUND Spontaneous bacterial peritonitis(SBP)is an important prognostic factor for outcomes in patients with cirrhosis.Antibiotic prophylaxis is recommended in patients at high risk for developing SBP,but the choice of antibiotics remains unclear.AIM To evaluate the efficacy of various antibiotics for prophylaxis of SBP based on randomized control trials(RCTs).METHODS Electronic databases were searched through November 2018 for RCTs evaluating the efficacy of therapies for primary or secondary prophylaxis of SBP.The primary outcome was the development of SBP.Sensitivity analyses limited to studies of primary or secondary prophylaxis and studies reported after 2010 were performed.The secondary outcome was the risk of all-cause mortality or transplant.The outcomes were assessed by rank of therapies based on network meta-analyses.Individual meta-analyses were also performed.RESULTS Thirteen RCTs(1742 patients)including norfloxacin,ciprofloxacin,rifaximin,trimethoprim-sulfamethoxazole(TMP-SMX),or placebo/no comparator were identified.Individual meta-analyses showed superiority of rifaximin over norfloxacin as well as norfloxacin and TMP-SMX over placebo.Network metaanalysis demonstrated the rank of efficacy in reducing the risk of SBP as:Rifaximin,ciprofloxacin,TMP-SMX,norfloxacin,and placebo/no comparator.Rifaximin ranked highest in sensitivity analyses limited to studies of primary or secondary prophylaxis and studies reported after 2010.Similarly,rifaximin ranked highest in reducing the risk of death/transplant.CONCLUSION The present comprehensive network meta-analysis provides RCT based evidence for superior efficacy of rifaximin compared to other antibiotics for the prophylaxis of SBP and reducing risk of death/transplant.Further RCTs are warranted to confirm our findings. | Nolan Faust Akihiro Yamada Haider Haider Yuga Komaki Fukiko Komaki Dejan Micic Atsushi Sakuraba | 2020 | World Journal of Hepatology2020，12，5： | 3 |
| 6 | Waxy wheat as a functional food for human consumption显示文摘 | Shuzo Fujita Takako Kumagai Mashimi Yanagimachi Suguru Sakuraba Ryuichi Sanpei Mika Yamoto Haruka Tohara | 2012 | Journal of Cereal Science2012，，3： | 2 |
| 7 | Genotoxicity of microcystin-LR in human lymphoblastoid TK6 ceils 显示文摘 | Zhan L Sakamoto H Sakuraba M | 2004 | Mutation Research2004，，： | 1 |
| 8 | Postoperative complications after simultaneous vitrectomy and cataract surgry显示文摘 | Suzuki Y Sakuraba T Mizutani H | 2001 | Ophthalmic Surg Laser2001，32，5： | 1 |
| 9 | Combination Therapy with Infliximab and Thiopurine Compared to Infliximab Monotherapy in Maintaining Remission of Postoperative Crohn's Disease显示文摘 | Sakuraba A Okamoto S Matsuoka K | 2015 | Digestion2015，91，3： | 1 |
| 10 | The rice faded green leaf locus encodes protochlorophyllide oxidoreductase B and is essential for chlorophyll synthesis under high light conditions显示文摘 | Sakuraba Y Rahman M L Cho S H | 2013 | Plant Journal2013，74，1： | 1 |
| 11 | Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese TypeⅡdiabetic patients显示文摘 | Sakuraba H Mizukami H Yagihashi N | 2002 | Diabetologia2002，45，1： | 1 |
| 12 | Diagnostic value of thoracoscopic pleural biopsy for pleurisy under local an- aes-thesia显示文摘 | Sakuraba M Masuda K Hebisawa A | 2006 | ANZ J Surg2006，76，1： | 1 |
| 13 | Pleural effusion adenosine deaminase(ADA)level and occult tuberculous pleurisy显示文摘 | Sakuraba M Masuda K Hebisawa A | 2009 | Ann Thorac Cardiovasc Surg2009，15，5： | 1 |
| 14 | Giant tunneling magnetoresistance in Coe MnSi/AI-O/Co2 MnSi magnetic tun- nel junctions 显示文摘 | Sakuraba Y Hattori M Oogane M | 2006 | Applied Physics Letters2006，88，19： | 1 |
| 15 | A new mutation(LIPA Tyr22X)of lysosomal acid lipase gene in a Japanese patient with Wolman disease显示文摘 | Fujiyama J Sakuraba H Kuriyama M | | 0，，04： | 1 |
| 16 | Accelerated loss of islet -cells in sucrose-fed Goto-Kakizaki rats,a genetic model of non-insulin-dependent diabetes mellitus显示文摘 | Koyama M Wada R Sakuraba H | 1998 | Am J Pathol1998，153，： | 1 |
| 17 | Neural mechanisms of sevoflurane-induced respira- tory depression in newborn rats显示文摘 | KURIBAYASHI J SAKURABA S KASHIWAGI M | 2008 | Anesthesiology2008，109，2： | 1 |
| 18 | Prognostic factors in patients with inoperable non- small cell lung cancer-an analysis of long-term survival patients 显示文摘 | Ohashi R Takahashi K Miura K Ishiwata T Sakuraba S Fukuchi Y | 2006 | Gan To Kagaku Ryoho2006，33，： | 1 |
| 19 | Postoperative refractive error after simultaneous vitrectomy and cataract surgery显示文摘 | Suzuki Y Sakuraba T Mizutani H | 2000 | Ophthalmic Surg Laser2000，31，4： | 1 |
| 20 | MACC1 as a marker for vascular invasive hepatocellular carcinoma显示文摘 | Shirahata A Fan W Sakuraba K | 2011 | Anticancer Res2011，31，3： | 1 |
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