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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Esomeprazole for Prevention and Resolution of Upper Gastrointestinal Symptoms in Patients Treated With Low-dose Acetylsalicylic Acid for Cardiovascular Protection: The OBERON Trial显示文摘 | James M. Scheiman Johan Herlitz Sander J. Veldhuyzen van Zanten Angel Lanas Stefan Agewall Emma C. Nauclér Lars-Erik Svedberg Péter Nagy | 2013 | Journal of Cardiovascular Pharmacology2013，，： | 1 |
| 3 | Vitreous:a barrier to nonviral ocular gene therapy显示文摘 | Peeters L Sanders NN Braeckmans K Boussery K Johan Voorde VD Smedt SC | | 0，，10： | 1 |
| 4 | Direct demonstration of enhanced diffusion in mesoporous ZSM 5 zeolite obtained via controlled desilication 显示文摘 | Groen C Johan Zhu Weidong Brouwer Sander | 2007 | J Am Chem Soc2007，129，2： | 1 |
| 5 | Improving Jatropha curcas seed protein recovery by using counter current multistage extraction显示文摘 | Dianika Lestari Wim Mulder Johan Sanders | 2010 | Biochemical Engineering Journal2010，，1： | 1 |
| 6 | Differential effects of mineral and organic acids on the kinetics of arabinose degradation under lignocellulose pretreatment conditions显示文摘 | A. Maarten J. Kootstra Nathan S. Mosier Elinor L. Scott Hendrik H. Beeftink Johan P.M. Sanders | 2008 | Biochemical Engineering Journal2008，，1： | 1 |
| 7 | Development and validation of a new LC–MS/MS method for the simultaneous determination of six major ergot alkaloids and their corresponding epimers. Application to some food and feed commodities显示文摘 | José Diana Di Mavungu Svetlana V. Malysheva Melanie Sanders Daria Larionova Johan Robbens Peter Dubruel Carlos Van Peteghem Sarah De Saeger | 2012 | Food Chemistry2012，，： | 1 |
| 8 | Different Time Frames for the Occurrence of Elevated Levels of Cardiac Troponin T and C-Reactive Protein in Patients with Acute Myocardial Infarction显示文摘 | Robbert J. de Winter Johan C. Fischer Thyra de Jongh Jan P. van Straalen Radha Bholasingh Gerard T. B. Sanders | 2000 | Clinical Chemistry and Laboratory Medicine2000，，： | 1 |
| 9 | Enzyme assisted protein extraction from rapeseed, soybean, and microalgae meals显示文摘 | Yessie W. Sari Marieke E. Bruins Johan P.M. Sanders | 2013 | Industrial Crops & Products2013，，： | 1 |
| 10 | Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation显示文摘 | Jér?me N. Feige Marie Lagouge Carles Canto Axelle Strehle Sander M. Houten Jill C. Milne Philip D. Lambert Chikage Mataki Peter J. Elliott Johan Auwerx | 2008 | Cell Metabolism2008，，5： | 1 |
| 11 | Alpha-Synuclein Pathology and Axonal Degeneration of the Peripheral Motor Nerves Innervating Pharyngeal Muscles in Parkinson Disease显示文摘 | Liancai Mu Stanislaw Sobotka Jingming Chen Hungxi Su Ira Sanders Charles H. Adler Holly A. Shill John N. Caviness Johan E. Samanta Thomas G. Beach | 2013 | Journal of Neuropathology & Experimental Neurology2013，，2： | 1 |
| 12 | Comparison of dilute mineral and organic acid pretreatment for enzymatic hydrolysis of wheat straw显示文摘 | A. Maarten J. Kootstra Hendrik H. Beeftink Elinor L. Scott Johan P.M. Sanders | 2009 | Biochemical Engineering Journal2009，，2： | 1 |
| 13 | Alpha-Synuclein Pathology and Axonal Degeneration of the Peripheral Motor Nerves Innervating Pharyngeal Muscles in Parkinson Disease显示文摘 | Liancai Mu Stanislaw Sobotka Jingming Chen Hungxi Su Ira Sanders Charles H. Adler Holly A. Shill John N. Caviness Johan E. Samanta Thomas G. Beach | 2013 | Journal of Neuropathology & Experimental Neurology2013，，2： | 1 |
| 14 | Parkinson Disease Affects Peripheral Sensory Nerves in the Pharynx显示文摘 | Liancai Mu Stanislaw Sobotka Jingming Chen Hungxi Su Ira Sanders Themba Nyirenda Charles H. Adler Holly A. Shill John N. Caviness Johan E. Samanta Lucia I. Sue Thomas G. Beach | 2013 | Journal of Neuropathology & Experimental Neurology2013，，7： | 1 |
| 15 | Metabolic engineering ofRhizopus oryzoe for the production of platform chemicals显示文摘 | Bas J Meussen Leo H de Graaff Johan P M Sanders | 2012 | Appl Microbiol Biotechnol2012，94，4： | 1 |
| 16 | Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation显示文摘 | Jér?me N. Feige Marie Lagouge Carles Canto Axelle Strehle Sander M. Houten Jill C. Milne Philip D. Lambert Chikage Mataki Peter J. Elliott Johan Auwerx | 2008 | Cell Metabolism2008，，5： | 1 |
| 17 | Improving Jatropha cur-cas seed protein recovery by using counter current multistage extraction显示文摘 | Dianika Lestari Wim Mulder Johan Sanders | 2010 | Biochemical Engineering Journal2010，50，： | 1 |
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