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| 1 | Esophageal cancer: Risk factors,screening and endoscopic treatment in Western and Eastern countries显示文摘Esophageal cancer is one of the most unknown and deadliest cancers worldwide,mainly because of its extremely aggressive nature and poor survival rate.Esophageal cancer is the 6th leading cause of death from cancer and the 8th most common cancer in the world.The 5-year survival is around 15%-25%.There are clear differences between the risk factors of both histological types that affect their incidence and distribution worldwide.There are areas of high incidence of squamous cell carcinoma(some areas in China) that meet the requirements for cost-effectiveness of endoscopy for early diagnosis in the general population of those areas.In Europe and United States the predominant histologic subtype is adenocarcinoma.The role of early diagnosis of adenocarcinoma in Barrett's esophagus remains controversial.The differences in the therapeutic management of early esophageal carcinoma(high-grade dysplasia,T1 a,T1 b,N0) between different parts of the world may be explained by the number of cancers diagnosed at an early stage.In areas where the incidence is high(China and Japan among others) early diagnoses is more frequent and has led to the development of endoscopic techniques for definitive treatment that achieve very effective results with a minimum number of complications and preserving the functionality of the esophagus. | María José Domper Arnal ángel Ferrández Arenas ángel Lanas Arbeloa | 2015 | World Journal of Gastroenterology2015，21，26： | 116 |
| 2 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 3 | Colorectal cancer population screening programs worldwide in 2016: An update显示文摘Colorectal cancer(CRC)is the third most commonly diagnosed cancer in the world.The incidence and mortality show wide geographical variations.Screening is recommended to reduce both incidence and mortality.However,there are significant differences among studies in implementation strategies and detection.This review aimed to present the results and strategies of different screening programs worldwide.We reviewed the literature on national and international screening programs published in Pub Med,on web pages,and in clinical guidelines.CRC Screening programs are currently underway in most European countries,Canada,specific regions in North and South America,Asia,and Oceania.The most extensive screening strategies were based on fecal occult blood testing,and more recently,the fecal immunochemical test(FIT).Participation in screening has varied greatly among different programs.The Netherlands showed the highest participation rate(68.2%)and some areas of Canada showed the lowest(16%).Participation rates were highest among women and in programs that used the FIT test.Men exhibited the greatest number of positive results.The FIT test has been the most widely used screening program worldwide.The advent of this test has increased participation rates and the detection of positive results. | Mercedes Navarro Andrea Nicolas Angel Ferrandez Angel Lanas | 2017 | World Journal of Gastroenterology2017，23，20： | 43 |
| 4 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 5 | Sphincter of Oddi dysfunction: Managing the patient with chronic biliary pain显示文摘Oddi 机能障碍(草皮) 的括约肌由于在 Oddi 的括约肌的水平的 pancreaticobiliary 流动的功能的阻塞是长期的胆汁的疼痛或周期性的胰腺炎的症候群。Milwaukee 分类成层病人根据他们的临床的图画基于腹的疼痛的提高的肝酶,扩大胆总管和存在。类型我病人们象反常的肝酶和扩大胆总管一样有疼痛。类型 II 草皮由疼痛和仅仅发现的一个目的组成,并且类型 III 仅仅由胆汁的疼痛组成。这个分类是有用的指导 Oddi 机能障碍的括约肌的诊断和管理。为诊断的当前的标准答案是测压法检测提高的括约肌压力,它与结果相关到括约肌切开术。然而,测压法不是广泛地可得到的并且是有胰腺炎的风险的一个侵略过程。包括丰满的饭 ultrasonography 和 scintigraphy,非侵略的测试方法与压力计的调查结果显示出有限关联,但是可能在预言结果到括约肌切开术有用。波特淋毒素的内视镜的注射嗯毒素出现到预言随后的结果到括约肌切开术,并且能在为治疗的病人的选择有用,特别在测压法是无法获得的背景。 | Lana Bistritz Vincent G Bain | 2006 | World Journal of Gastroenterology2006，12，24： | 19 |
| 6 | Role of gastrin-peptides in Barrett's and colorectal carcinogenesis显示文摘Gastrin is the main hormone responsible for the stimulation of gastric acid secretion;in addition,gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell types.Gastrin synthesis and secretion are increased in certain situations,for example,when proton pump inhibitors are used.The impact of sustained hypergastrinemia is currently being investigated.In vitro experiments and animal models have shown that prolonged hypergastrinemia may be related with higher cancer rates;although,this relationship is less clear in human beings.Higher gastrin levels have been shown to cause hyperplasia of several cell types;yet,the risk for developing cancer seems to be the same in normo-and hypergastrinemic patients.Some tumors also produce their own gastrin,which can act in an autocrine manner promoting tumor growth.Certain cancers are extremely dependent on gastrin to proliferate.Initial research focused only on the effects of amidated gastrins,but there has been an interest in intermediates of gastrin in the last few decades.These intermediates aren't biologically inactive;in fact,they may exert greater effects on proliferation and apoptosis than the completely processed forms.In certain gastrin overproduction states,they are the most abundant gastrin peptides secreted.The purpose of this review is to examine the gastrin biosynthesis process and to summarize the results from different studies evaluating the production,levels,and effects of the main forms of gastrin in different overexpression states and their possible relationship with Barrett's and colorectal carcinogenesis. | Eduardo Chueca Angel Lanas Elena Piazuelo | 2012 | World Journal of Gastroenterology2012，18，45： | 19 |
| 7 | Molecular mechanisms of salinity tolerance in rice显示文摘Salinity is one of the major abiotic stresses which impose constraints to plant growth and production.Rice(Oryza sativa L.)is one of the most important staple food crops and a model monocot plant.Its production is expanding into regions that are affected by soil salinity,requiring cultivars more tolerant to saline conditions.Understanding the molecular mechanisms of such tolerance could lay a foundation for varietal improvement of salt tolerance in rice.In spite of extensive studies exploring the mechanism of salt tolerance,there has been limited progress in breeding for increased salinity tolerance.In this review,we summarize the information about the major molecular mechanisms underlying salinity tolerance in rice and further discuss the limitations in breeding for salinity tolerance.We show that numerous gene families and interaction networks are involved in the regulation of rice responses to salinity,prompting a need for a comprehensive functional analysis.We also show that most studies are based on whole-plant level analyses with only a few reports focused on tissue-and/or cell-specific gene expression.More details of salt-responsive channel and transporter activities at tissue-and cell-specific level still need to be documented before these traits can be incorporated into elite rice germplasm.Thus,future studies should focus on diversity of available genetic resources and,particular,wild rice relatives,to reincorporate salinity tolerance traits lost during domestication. | Tianxiao Chen Sergey Shabala Yanan Niu Zhong-Hua Chen Lana Shabala Holger Meinke Gayatri Venkataraman Ashwani Pareek Jianlong Xu Meixue Zhou | 2021 | The Crop Journal2021，9，3： | 11 |
| 8 | Protons pump inhibitor treatment and lower gastrointestinal bleeding: Balancing risks and benefits显示文摘Proton pump inhibitors(PPIs) represent a milestone in the treatment of acid-related diseases, and are the mainstay in preventing upper gastrointestinal bleeding in high-risk patients treated with nonsteroidal antiinflammatory drugs(NSAIDs) or low-dose aspirin. However, this beneficial effect does not extend to the lower gastrointestinal tract. PPIs do not prevent NSAID or aspirin-associated lower gastrointestinal bleeding(LGB). PPIs may increase both small bowel injury related to NSAIDs and low-dose aspirin treatment and the risk of LGB. Recent studies suggested that altering intestinal microbiota by PPIs may be involved in the pathogenesis of NSAID-enteropathy. An increase in LGB hospitalization rates may occur more frequently in older patients with more comorbidities and are associated with high hospital resource utilization, longer hospitalization, and increased mortality. Preventive strategies for NSAID and aspirin-associated gastrointestinal bleeding should be directed toward preventing both upper and lower gastrointestinal damage. Future research should be directed toward identifying patients at low-risk for gastrointestinal events associated with the use of NSAIDs or aspirin to avoid inappropriate PPI prescribing. Alternatively, the efficacy of new pharmacologic strategies should be evaluated in high-risk groups, with the aim of reducing the risk of both upper and lower gastrointestinal bleeding in these patients. | Alberto Lué Angel Lanas | 2016 | World Journal of Gastroenterology2016，22，48： | 9 |
| 9 | Aspirin, cyclooxygenase inhibition and colorectal cancer显示文摘Colorectal cancer(CRC)is the third most common type of cancer worldwide.Screening measures are far from adequate and not widely available in resourcepoor settings.Primary prevention strategies therefore remain necessary to reduce the risk of developing CRC.Increasing evidence from epidemiological studies,randomized clinical trials and basic science supports the effectiveness of aspirin,as well as other non-steroidal anti-inflammatory drugs,for chemoprevention of several types of cancer,including CRC.This includes the prevention of adenoma recurrence and reduction of CRC incidence and mortality.The detectable benefit of daily low-dose aspirin(at least 75 mg),as used to prevent cardiovascular disease events,strongly suggests that its antiplatelet action is central to explaining its antitumor efficacy.Daily low-dose aspirin achieves complete and persistent inhibition of cyclooxygenase(COX)-1 in platelets(in pre-systemic circulation)while causing alimited and rapidly reversible inhibitory effect on COX-2and/or COX-1 expressed in nucleated cells.Aspirin has a short half-life in human circulation(about 20 minutes);nucleated cells have the ability to resynthesize acetylated COX isozymes within a few hours,while platelets do not.COX-independent mechanisms of aspirin have been suggested to explain its chemopreventive effects but this concept remains to be demonstrated in vivo at clinical doses. | Carlos Sostres Carla Jerusalen Gargallo Angel Lanas | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，1： | 8 |
| 10 | Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: Old question new insights显示文摘Previous reports clearly demonstrated that Helicobacter pylori(H.pylori)infection,nonsteroidal anti-inflammatory drugs(NSAID)or low dose aspirin(ASA)use significantly and independently increased the risk for the development of peptic ulcer disease.Today,the presence of H.pylori infection associated with low dose ASA and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important implications.Whether NSAID intake in the presence of H.pylori infection may further increase the risk of peptic ulcer carried by the presence of only one risk factor is still a matter of debate.Studies on the interaction between the two risk factors yielded conflicting data and no consensus has been reached in the last years.In addition,the interaction between H.pylori infection and low-dose ASA remains even more controversial.In real clinical practice,we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk factors.These huge variety of possible combinations greatly hinder the decision making process of physicians. | Carlos Sostres Carla Jerusalen Gargallo Angel Lanas | 2014 | World Journal of Gastroenterology2014，20，28： | 8 |
| 11 | K^+ retention in leaf mesophyll, an overlooked component of salinity tolerance mechanism:A case study for barley显示文摘Plant salinity tolerance is a physiologically complex trait, with numerous mechanisms contributing to it. In this work,we show that the ability of leaf mesophyll to retain Kt represents an important and essentially overlooked component of a salinity tolerance mechanism. The strong positive correlation between mesophyll Ktretention ability under saline conditions(quantified by the magnitude of Na Cl-induced Kt efflux from mesophyll) and the overall salinity tolerance(relative fresh weight and/or survival or damage under salinity stress) was found while screening 46 barley(Hordeum vulgare L.) genotypes contrasting in their salinity tolerance. Genotypes with intrinsically higher leaf Ktcontent under control conditions were found to possess better Ktretention ability under salinity and, hence, overall higher tolerance. Contrary to previous reports for barley roots, Ktretention in mesophyll was not associated with an increased Ht-pumping in tolerant varieties but instead correlated negatively with this trait. These findingsare explained by the fact that increased Htextrusion may be needed to charge balance the activity and provide the driving force for the high affinity HAK/KUP Kttransporters required to restore cytosolic Kthomeostasis in salt-sensitive genotypes. | Honghong Wu Min Zhu Lana Shabala Meixue Zhou Sergey Shabala | 2015 | Journal of Integrative Plant Biology2015，57，2： | 7 |
| 12 | Education-based approach to addressing non-evidence-based practice in preventing NSAID-associated gastrointestinal complications显示文摘AIM:To evaluate an evidence-based educational program for improving strategies for prevention of non-steroidal anti-inflammatory drug(NSAID)-associated gastrointestinal(GI)complications. METHODS:Four hundred and fifty-six specialists replied to a questionnaire that covered issues related to NSAID-induced adverse effects.They also collected data from their last five consecutive patients before and after they had attended an evidence-based seminar on GI prevention strategies. RESULTS:Four hundred and forty-one of 456 specialists(96.7%)participated in the survey,and 382(83.7%)in the education-based study that recorded data from 3728 patients.The specialists overestimated the risk of GI complications with NSAIDs,underestimated the GI safety profile of coxibs,but were aware of the risk factors and of the current prevention strategies.Proton pump inhibitors were co-prescribed with NSAIDs in>80% of patients with and without risk factors.The educational program had little impact on prescribing habits.CONCLUSION:Specialists are informed of advances in NSAID-associated adverse effects and have high rates of GI-prevention therapy.Our educational program did not alter these rates. | Angel Lanas Juan V Esplugues Javier Zapardiel Eduardo Sobreviela | 2009 | World Journal of Gastroenterology2009，15，47： | 5 |
| 13 | High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease显示文摘AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood culture.RESULTS:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot assays.All 69 cultures were negative by acid-fast Ziehl-Neelsen staining.Viable MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD controls.No association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide polymorphisms.CONCLUSION:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD patients.However,MAP spheroplasts were only found in CD patients. | Juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre Juan J Picazo Manuel Díaz-Rubio | 2010 | World Journal of Gastroenterology2010，16，36： | 5 |
| 14 | Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus显示文摘AIM: To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to adenocarcinoma.METHODS: In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase (SOD) or vehicle and followed up for 4 mo. Rat's esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DNA oxidative damage.RESULTS: All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyondthe anastomotic area (9% 1st mo and 50% 4th mo) (94% at the anastomotic level) and adenocarcinoma(11% 1st mo and 60% 4th mo). These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DNA oxidative damage and a significant decrease in SOD levels (P<0.05). Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area (odds ratio = 0.326; 95%CI: 0.108-0.981; P = 0.046),and esophageal adenocarcinoma (odds ratio = 0.243;95%CI: 0.073-0.804; P = 0.021).CONCLUSION: Superoxide dismutase prevents the progression of esophagitis to Barrett's esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma. | Elena Piazuelo Carmelo Cebrián Alfredo Escartín Pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 15 | Numerical modeling of failure mechanisms in phyllite mine slopes in Brazil显示文摘This paper presents three case studies comprising failure mechanisms in phyllite mine slopes at Quadrilá-tero Ferrífero, State of Minas Gerais, Brazil. Numerical modeling techniques were used in this study. Failure mechanisms involving discontinuities sub parallel to the main foliation are very common in these mines. Besides, failure through the rock material has also been observed due to the low strength of phyllites in this site. Results of this work permitted to establish unknown geotechnical parameters which have significant influence in failure processes, like the in situ stress field and the discontinuity stiffness. | Lana Milene Sabino | 2014 | International Journal of Mining Science and Technology2014，24，6： | 5 |
| 16 | Mycobacterium avium subspecies paratuberculosis and its relationship with Crohn's disease显示文摘The hypothesis postulating that Mycobacterium avium paratuberculosis(MAP) is the cause of Crohn's disease(CD) has been circulating for many years.Advances in molecular techniques,such as polymerase chain reaction and culture methods,have enabled researchers to demonstrate that there is an association between MAP and CD.Recently,genome-wide association studies have identified novel susceptibility genes for CD,which are critical for generation of an adaptive immune response that is protective against intracellular pathogens,including M.tuberculosis infection.However,the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in CD patients.Accordingly,this review sought neither to confirm nor refute this,but instead to survey recent literature on the role of MAP in CD. | Juan Luis Mendoza Raquel Lana Manuel Díaz-Rubio | 2009 | World Journal of Gastroenterology2009，15，4： | 4 |
| 17 | Evolution of Siderian juvenile crust to Rhyacian high Ba-Sr magmatism in the Mineiro Belt, southern S?o Francisco Craton显示文摘Plutonic rocks from the Mineiro Belt, Brazil record a delayed onset of the transition from TTG to sanukitoid-type magmatism(high Ba-Sr), starting during the Siderian magmatic lull when little juvenile magma was added to the continental crust. Rocks mostly belong to the calc-alkaline series, meta-to peraluminous and originally 'Ⅰ-type',meaning that oxidized magmas were formed by partial melting of subducted material. The temporal distribution and apparent secular changes of the magmas are consistent with the onset of subduction-driven plate tectonics due to an increase of the subduction angle and opening of the mantle wedge. New isotopic analyses(Sm-Nd whole rock and Lu-Hf in zircon)corroborate the restricted juvenile nature of the Mineiro Belt and confirm the genetic link between the Lagoa Dourada Suite,a rare ca. 2350 Ma high-Al tonalite-trondhjemite magmatic event, and the sanukitoid-type ca. 2130 Ma Alto Maranhao Suite. U-Pb dating of zircon and titanite constrain the crystallisation history of plutonic bodies; coupled with major and trace element analyses of the host rocks, they distinguish evolutionary trends in the Mineiro Belt. Several plutons in the region have ages close to 2130 Ma but are distinguished by the lower concentration of compatible elements in the juvenile high Ba-Sr suite. | Hugo Moreira Luís Seixas Craig Storey Mike Fowler Stephanie Lasalle Ross Stevenson Cristiano Lana | 2018 | Geoscience Frontiers2018，9，4： | 3 |
| 18 | Sao Francisco-Congo Craton break-up delimited by U-Pb-Hf isotopes and trace-elements of zircon from metasediments of the Aracuaí Belt显示文摘Detrital zircon U-Pb geochronology combined with Hf isotopic and trace element data from metasedimentary rocks of the Aracuai Belt in southeastern Brazil provide evidence for break-up of the Congo-Sao Francisco Craton. The U-Pb age spectra of detrital zircons from metasediments of the Rio Doce Group(RDG) range from 900-650 Ma and define a maximum depositional age of ca. 650 Ma. Zircon trace element and whole rock data constrain an oceanic island arc as source for the deposition setting of the protoliths to the metasediments. Zircon ε_(Hf)(t) values from these rocks are positive between +1 and +15, supporting previous evidence of a Neoproterozoic extensional phase and oceanic crust formation in a precursor basin to the Aracuai Belt. Recrystallization of detrital zircon at ca. 630 Ma is compatible with a regional metamorphic event associated with terrane accretion to the Paleoproterozoic basement after transition from an extensional to a convergent regime. The juvenile nature, age spectra and trace element composition recorded in detrital zircons of metasediments from the Aracuai Belt correspond with zircons from metasedimentary rocks and oceanic crust remnants of other orogenic belts to its south. This suggests that rifting and oceanic crust formation of the entire orogenic system, the so-called Mantiqueira Province, was contemporaneous, most likely related to the opening of a large ocean. It further indicates that the cratonic blocks involved in the orogenic evolution of the Mantiqueira Province were spatially connected as early as 900 Ma. | Mathias Schannor Cristiano Lana Marco A.Fonseca | 2019 | Geoscience Frontiers2019，10，2： | 2 |
| 19 | Hypoxia-induced increase in GABA content is essential for restoration of membrane potential and preventing ROS-induced disturbance to ion homeostasis显示文摘When plants are exposed to hypoxic conditions,the level of g-aminobutyric acid(GABA)in plant tissues increases by several orders of magnitude.The physiological rationale behind this elevation remains largely unanswered.By combining genetic and electrophysiological approach,in this work we show that hypoxia-induced increase in GABA content is essential for restoration of membrane potential and preventing ROS-induced disturbance to cytosolic K+homeostasis and Ca^(2+)signaling.We show that reduced O_(2) availability affects H+-ATPase pumping activity,leading to membrane depolarization and K+loss via outward-rectifying GORK channels.Hypoxia stress also results in H_(2)O_(2) accumulation in the cell that activates ROS-inducible Ca^(2+)uptake channels and triggers self-amplifying'ROS-Ca hub,'further exacerbating K^(+)loss via non-selective cation channels that results in the loss of the cell’s viability.Hypoxia-induced elevation in the GABA level may restore membrane potential by pH-dependent regulation of H^(+)-ATPase and/or by generating more energy through the activation of the GABA shunt pathway and TCA cycle.Elevated GABA can also provide better control of the ROS-Ca^(2+)hub by transcriptional control of RBOH genes thus preventing over-excessive H_(2)O_(2) accumulation.Finally,GABA can operate as a ligand directly controlling the open probability and conductance of K+efflux GORK channels,thus enabling plants adaptation to hypoxic conditions. | Qi Wu Nana Su Xin Huang Jin Cui Lana Shabala Meixue Zhou Min Yu Sergey Shabala | 2021 | Plant Communications2021，2，3： | 2 |
| 20 | Application of high-resolution DNA melting for genotyping and variant scanning of diploid and autotetraploid potato显示文摘 | David De Koeyer Katheryn Douglass Agnes Murphy Sean Whitney Lana Nolan Yong Song Walter De Jong | 2010 | Molecular Breeding2010，，1： | 2 |
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