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| 1 | Portal vein thrombosis and arterioportal shunts:Effects on tumor response after chemoembolization of hepatocellular carcinoma显示文摘AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization. METHODS: A retrospective study included 39 patients (mean age: 66.4 years, range: 45-79 years, SD: 7) with unresectable hepatocellular carcinoma (HCC) who were treated with repetitive transarterial chemoembolization (TACE) in the period between March 2006 and October 2009. The effect of portal vein thrombosis (PVT) (in 19 out of 39 patients), the presence of arterioportal shunt (APS) (in 7 out of 39), the underlying liver pathology,Child-Pugh score, initial tumor volume, number of tumors and tumor margin definition on imaging were correlated with the local tumor response after TACE. The initial and end therapy local tumor responses were evaluated according to the response evaluation criteria in solid tumors (RECIST) and magnetic resonance imaging volumetric measurements. RESULTS: The treatment protocols were well tolerated by all patients with no major complications. Local tumor response for all patients according to RECIST criteria were partial response in one patient (2.6%), stable disease in 34 patients (87.1%), and progressive disease in 4 patients (10.2%). The MR volumetric measurements showed that the PVT, APS, underlying liver pathology and tumor margin definition were statistically significant prognostic factors for the local tumor response (P = 0.018, P = 0.008, P = 0.034 and P = 0.001, respectively). The overall 6-, 12- and 18-mo survival rates from the initial TACE were 79.5%, 37.5% and 21%, respectively. CONCLUSION: TACE may be exploited safely for palliative tumor control in patients with advanced unresectable HCC; however, tumor response is significantly affected by the presence or absence of PVT and APS. | Thomas J Vogl Nour-Eldin Nour-Eldin Sally Emad-Eldin Nagy NN Naguib Joerg Trojan Hans Ackermann Omar Abdelaziz | 2011 | World Journal of Gastroenterology2011，17，10： | 20 |
| 2 | Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients显示文摘AIM To evaluate the clinical value and efficiency of transarterial chemoperfusion(TACP) in patients with liver metastases from breast cancer(BC) and colorectal cancer(CRC).METHODS We treated 36 patients with liver metastases of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) with repeated TACP. The treatment interval was 4 wk. TACP was performed with gemcitabine(1000 mg/m2) and mitomycin(10 mg/m2), administered within 1 h after positioning the catheter tip in the hepatic artery. Before treatment, the size, location, tumour volume, vascularization and number of liver tumours were evaluated using magnetic resonance imaging(MRI). Tumour response was evaluated according to the Response Evaluation Criteria in Solid Tumors guidelines.RESULTS TACP using gemcitabine and mitomycin for metastases from CRC and BC was performed without any serious side effects. The follow-up MRI showed a therapeutic response in 84.2% of the BC patients-stable disease 47.4% and partial response 36.8%. A progression was seen in 15.8%.CRC patients showed a therapeutic response in 52.9% of cases. A progression of the disease was documented in 47.1% of the patients with CRC. These data show that TACP in patients with liver metastases of BC leads to a significantly better therapeutic response compared with CRC patients(P = 0.042). The median survival time was 13.2 mo for the BC patients, which is significantly longer than for CRC patients at 9.3 mo(P = 0.001).CONCLUSION TACP for liver metastases of BC appears to be a safe and effective palliative treatment with improved outcomes in comparison to patients with CRC. | Tatjana Gruber-Rouh Marcel Langenbach Nagy NN Naguib Nour-Eldin M Nour-Eldin Thomas J Vogl Stephan Zangos Martin Beeres | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 3 | 怎样使用相对渗透率相关关系:相对渗透率连载文章之二显示文摘 | Moli.,NN 徐振章 | 1990 | 油气田开发工程译丛1990，，3： | 2 |
| 4 | 人工全膝关节置换术后单纯金属底座髌骨假体的翻修显示文摘目的分析带金属底座髌骨假体失败的原因,并观察单纯髌骨假体翻修的临床疗效。方法对 22例 (30膝 )人工全膝关节置换术后因金属底座髌骨假体失败而行单纯髌骨假体翻修者进行回顾性分析。假体均为同一类型的后十字韧带保留型假体,以金属底座髌骨假体置换髌骨。应用膝关节 KSS评分标准评价翻修术后的临床转归。结果髌骨假体失败时间在人工全膝关节置换术后的 26~ 96个月,平均 62.3个月,主要症状有金属摩擦感 (80% )和膝关节疼痛 (70% )。术中发现 23膝 (76.7% )聚乙烯完全磨损、金属底座外露; 9膝髌骨倾斜或半脱位; 2膝完全脱位。 30膝均成功施行骨水泥全聚乙烯髌骨翻修术,随访时间 24~ 81个月,平均 42.5个月。所有患者主诉症状消失,可独立行走活动,膝关节评分从术前的平均 73分( 27~ 88分)增加至 87分( 60~ 100分);膝关节屈曲度由术前的平均 91°增加至 99.5°。结论 (1)金属底座髌骨假体早期失败率较高; (2)髌骨位线不良和异常滑动轨迹是导致带金属底座髌骨假体失败的诱发因素; (3)单纯髌骨假体翻修可获满意的临床结果,其发生并发症的潜在危险和人工全膝关节翻修术相似,应予以重视。 | 张先龙 SJ Yue NN Lo KH Seow SK Tan | 2001 | 中华骨科杂志2001，21，1： | 2 |
| 5 | MicroRNA-181b通过调节金属蛋白酶组织抑制因子3和弹性蛋白影响动脉粥样硬化和动脉瘤显示文摘动脉粥样硬化和动脉瘤是全世界人口的主要致死原因。微小RNA(microRNAs,miR)是基因和蛋白表达的关键决定因素,miR异常表达与许多心血管病有关。目前对它们在动脉粥样硬化斑块和腹主动脉瘤(abdominal aortic aneurysm,AAA)稳定性中的作用了解甚少。 | 刘莉 叶鹏 Di Gregoli K Mohamad Anuar NN Bianco R White SJ Newby AC George SJ Johnson JL | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 6 | Theophylline inhibits the late asthmatic response to nighttime antigen challenge in patients with mild atopic asthma显示文摘 | Jarjiour NN Lacouture PG Busse WW | 1998 | Ann Allergy Asth ma Immunol1998，81，3： | 2 |
| 7 | VEGF mediates angiogenic activity during the priliferative phase of wound healing显示文摘 | Nissen NN Polverini PJ Koch AE | 1998 | Am J Pathol1998，152，6： | 2 |
| 8 | Long-term effects of hypnotherapy in patients with refractory irritable bowel syndrome显示文摘 | Perjohan Lindfors Peter Unge Henry Nyhlin Brjánn Ljótsson Einar S. Bj?rnsson Hasse Abrahamsson Magnus Simrén | 2012 | Scandinavian Journal of Gastroenterology2012，，4： | 2 |
| 9 | Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis显示文摘 | Peter K.Burkhardt PeterBeyer JoachimWünn AndreasKl?ti Gregory A.Armstrong MichaelSchledz JohannesLintig IngoPotrykus | | The Plant Journal0，，： | 2 |
| 10 | Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets显示文摘 | T. A. Dayeh A. H. Olsson P. Volkov P. Almgren T. R?nn C. Ling | 2013 | Diabetologia2013，，5： | 2 |
| 11 | 余甘子的化学成分及其作为食品资源的潜力显示文摘 | Bart.,NN 莫治雄 | 1992 | 热带作物译丛1992，，6： | 2 |
| 12 | Comparison of supine and prone scanning separately and in combination at CT colonoraphy显示文摘 | Yee J Kumar NN Hung RK | 2003 | Radiology2003，226，3： | 1 |
| 13 | The harris hip score:comparison of patient self-report with surgeon assessment显示文摘 | Mahomed NN Arndt DC Mc grory BJ et a1 | 2001 | Arthmplasty2001，16，5： | 1 |
| 14 | Antiarrhythmic effects of HOE642,anovel Na^+ 2H^+ exchange inhibitor,on ventricul arrhythmias in animal hearts显示文摘 | Xue YX Aye NN Hashimoto K | 1996 | Eur J Pharmcol1996，317，23： | 1 |
| 15 | Impact of magnetic resonance imaging versus CT on nasopharyngeal carcinoma: primary tumor target delineation for radiotherapy显示文摘 | Ting LL Hsu WC | 2004 | Head Neck2004，26，： | 1 |
| 16 | Splicing of a critical exon of human survival motor neuron is regulated by a unique silencer element located in the last intron显示文摘 | Singh NN Androphy EJ | 2006 | Mol Cell Biol2006，26，4： | 1 |
| 17 | Are temporary inferior vena cava filters really temporary显示文摘 | Kirilcuk NN Herget EJ Dicker RA | 2005 | Am J Surg2005，190，6： | 1 |
| 18 | Intrauterine device use and some issues related to sexually transmitted disease screening and occur- fence 显示文摘 | Hodoglugil NN Asian D Bertan M | 2000 | Contraception2000，61，6： | 1 |
| 19 | Inhibition of vascular smooth muscle cell proliferation in vitro by genetically engineered marrow stromal cells secreting calcitonin gene-related peptide显示文摘 | DENG W STHILAIRE RC CHATTERGOON NN | 2006 | Life Sci2006，78，16： | 1 |
| 20 | Fibroblast percusors in normal and irradiated mouse hematopoietic organs显示文摘 | Friedenstein A J Corskaja JF Kulagina NN | 1976 | Exp Hemator1976，4，5： | 1 |
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